Year |
Citation |
Score |
2023 |
Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, Gilberd P, Osikpa EC, Sun Z, Gao X. A split and inducible adenine base editor for precise in vivo base editing. Nature Communications. 14: 5573. PMID 37696818 DOI: 10.1038/s41467-023-41331-5 |
0.401 |
|
2023 |
Tao Y, Lamas V, Du W, Zhu W, Li Y, Whittaker MN, Zuris JA, Thompson DB, Rameshbabu AP, Shu Y, Gao X, Hu JH, Pei C, Kong WJ, Liu X, et al. Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo. Nature Communications. 14: 4928. PMID 37582836 DOI: 10.1038/s41467-023-40476-7 |
0.359 |
|
2023 |
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa EC, Yang Q, Peddi A, Patel A, Liu MS, Sun Z, Gao X. Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation. Journal of the American Chemical Society. PMID 36626587 DOI: 10.1021/jacs.2c09129 |
0.421 |
|
2020 |
Zhao F, Liu Z, Yang S, Ding N, Gao X. Quinolactacin Biosynthesis Involves NRPSs Catalyzed Dieckmann Condensation to Form the Quinolone-γ-lactam Hybrid. Angewandte Chemie (International Ed. in English). PMID 32663343 DOI: 10.1002/Anie.202005770 |
0.301 |
|
2020 |
Ding N, Lee S, Lieber-Kotz M, Yang J, Gao X. Advances in genome editing for genetic hearing loss. Advanced Drug Delivery Reviews. PMID 32387678 DOI: 10.1016/J.Addr.2020.05.001 |
0.307 |
|
2018 |
Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina CM, Gao X, Rees HA, Lin Z, Liu DR. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature. PMID 29512652 DOI: 10.1038/Nature26155 |
0.443 |
|
2017 |
Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. PMID 29258297 DOI: 10.1038/Nature25164 |
0.446 |
|
2016 |
Wang M, Zuris JA, Meng F, Rees H, Sun S, Deng P, Han Y, Gao X, Pouli D, Wu Q, Georgakoudi I, Liu DR, Xu Q. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929348 DOI: 10.1073/Pnas.1520244113 |
0.43 |
|
2015 |
Fan H, Wu Y, Zhou X, Xia J, Zhang W, Song Y, Liu F, Chen Y, Zhang L, Gao X, Gao H, Li J. Pathway-Based Genome-Wide Association Studies for Two Meat Production Traits in Simmental Cattle. Scientific Reports. 5: 18389. PMID 26672757 DOI: 10.1038/srep18389 |
0.32 |
|
2014 |
Jiménez-Osés G, Osuna S, Gao X, Sawaya MR, Gilson L, Collier SJ, Huisman GW, Yeates TO, Tang Y, Houk KN. The role of distant mutations and allosteric regulation on LovD active site dynamics. Nature Chemical Biology. 10: 431-6. PMID 24727900 DOI: 10.1038/Nchembio.1503 |
0.467 |
|
2013 |
Gao X, Jiang W, Jiménez-Osés G, Choi MS, Houk KN, Tang Y, Walsh CT. An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins. Chemistry & Biology. 20: 870-8. PMID 23890005 DOI: 10.1016/J.Chembiol.2013.04.019 |
0.443 |
|
2013 |
Walsh CT, Haynes SW, Ames BD, Gao X, Tang Y. Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. Acs Chemical Biology. 8: 1366-82. PMID 23659680 DOI: 10.1021/Cb4001684 |
0.407 |
|
2013 |
Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y. Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. Journal of the American Chemical Society. 135: 7138-41. PMID 23621493 DOI: 10.1021/Ja403516U |
0.431 |
|
2013 |
Haynes SW, Gao X, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. Acs Chemical Biology. 8: 741-8. PMID 23330675 DOI: 10.1021/Cb3006787 |
0.496 |
|
2012 |
Haynes SW, Gao X, Tang Y, Walsh CT. Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. Journal of the American Chemical Society. 134: 17444-7. PMID 23030663 DOI: 10.1021/Ja308371Z |
0.475 |
|
2012 |
Wang P, Kim W, Pickens LB, Gao X, Tang Y. Heterologous expression and manipulation of three tetracycline biosynthetic pathways. Angewandte Chemie (International Ed. in English). 51: 11136-40. PMID 23024027 DOI: 10.1002/Anie.201205426 |
0.666 |
|
2012 |
Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y. Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nature Chemical Biology. 8: 823-30. PMID 22902615 DOI: 10.1038/Nchembio.1047 |
0.395 |
|
2012 |
Wang P, Gao X, Tang Y. Complexity generation during natural product biosynthesis using redox enzymes. Current Opinion in Chemical Biology. 16: 362-9. PMID 22564679 DOI: 10.1016/J.Cbpa.2012.04.008 |
0.464 |
|
2011 |
Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/Bi201302W |
0.458 |
|
2011 |
Wang P, Gao X, Chooi YH, Deng Z, Tang Y. Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in Streptomyces rimosus. Microbiology (Reading, England). 157: 2401-9. PMID 21622525 DOI: 10.1099/Mic.0.048439-0 |
0.653 |
|
2011 |
Haynes SW, Ames BD, Gao X, Tang Y, Walsh CT. Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry. 50: 5668-79. PMID 21591693 DOI: 10.1021/Bi2004922 |
0.418 |
|
2011 |
Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41. PMID 21299212 DOI: 10.1021/Ja1101085 |
0.67 |
|
2010 |
Gao X, Wang P, Tang Y. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Applied Microbiology and Biotechnology. 88: 1233-42. PMID 20853106 DOI: 10.1007/S00253-010-2860-4 |
0.451 |
|
2009 |
Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y. Directed evolution and structural characterization of a simvastatin synthase. Chemistry & Biology. 16: 1064-74. PMID 19875080 DOI: 10.1016/J.Chembiol.2009.09.017 |
0.697 |
|
2009 |
Xie X, Pashkov I, Gao X, Guerrero JL, Yeates TO, Tang Y. Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity. Biotechnology and Bioengineering. 102: 20-8. PMID 18988191 DOI: 10.1002/Bit.22028 |
0.57 |
|
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