| Year |
Citation |
Score |
| 2014 |
Welsh WJ, Peng Y, Mundra JJ, Avrutik JF, Yoon TC, Meillier AM, Howells RD. Abstract 1626: Novel trisubstituted triazoles modeled from naltrindole inhibit the proliferation of human multiple myeloma cells Cancer Research. 74: 1626-1626. DOI: 10.1158/1538-7445.Am2014-1626 |
0.396 |
|
| 2013 |
Howells RD, Mundra JJ, Howells A, Howells G, Peng Y, Welsh W. Abstract 5548: Novel small-molecule delta opioid receptor ligands modeled from naltrindole inhibit the proliferation of human U266 multiple myeloma cells. Cancer Research. 73: 5548-5548. DOI: 10.1158/1538-7445.Am2013-5548 |
0.438 |
|
| 2012 |
Mundra JJ, Terskiy A, Howells RD. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. The Journal of Pharmacology and Experimental Therapeutics. 342: 273-87. PMID 22537770 DOI: 10.1124/jpet.112.194159 |
0.509 |
|
| 2012 |
Mundra JJ, Terskiy A, Howells RD. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. The Journal of Pharmacology and Experimental Therapeutics. 342: 273-87. PMID 22537770 DOI: 10.1124/jpet.112.194159 |
0.509 |
|
| 2009 |
Peng Y, Zhang Q, Arora S, Keenan SM, Kortagere S, Wannemacher KM, Howells RD, Welsh WJ. Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. Bioorganic & Medicinal Chemistry. 17: 6442-50. PMID 19646882 DOI: 10.1016/J.Bmc.2009.07.007 |
0.558 |
|
| 2008 |
Wannemacher KM, Terskiy A, Bian S, Yadav PN, Li H, Howells RD. Purification and mass spectrometric analysis of the kappa opioid receptor. Brain Research. 1230: 13-26. PMID 18656460 DOI: 10.1016/j.brainres.2008.06.121 |
0.777 |
|
| 2008 |
Wannemacher KM, Terskiy A, Bian S, Yadav PN, Li H, Howells RD. Purification and mass spectrometric analysis of the kappa opioid receptor. Brain Research. 1230: 13-26. PMID 18656460 DOI: 10.1016/j.brainres.2008.06.121 |
0.777 |
|
| 2007 |
Terskiy A, Wannemacher KM, Yadav PN, Tsai M, Tian B, Howells RD. Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins. Life Sciences. 81: 1593-601. PMID 17964607 DOI: 10.1016/J.LFS.2007.09.025 |
0.734 |
|
| 2007 |
Terskiy A, Wannemacher KM, Yadav PN, Tsai M, Tian B, Howells RD. Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins. Life Sciences. 81: 1593-601. PMID 17964607 DOI: 10.1016/J.LFS.2007.09.025 |
0.734 |
|
| 2007 |
Wannemacher KM, Yadav PN, Howells RD. A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells. The Journal of Pharmacology and Experimental Therapeutics. 323: 614-25. PMID 17720886 DOI: 10.1124/JPET.107.125500 |
0.768 |
|
| 2007 |
Wannemacher KM, Yadav PN, Howells RD. A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells. The Journal of Pharmacology and Experimental Therapeutics. 323: 614-25. PMID 17720886 DOI: 10.1124/JPET.107.125500 |
0.768 |
|
| 2006 |
Yadav PN, Chaturvedi K, Howells RD. Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells. The Journal of Pharmacology and Experimental Therapeutics. 320: 1186-94. PMID 17159161 DOI: 10.1124/jpet.106.113621 |
0.765 |
|
| 2006 |
Yadav PN, Chaturvedi K, Howells RD. Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells. The Journal of Pharmacology and Experimental Therapeutics. 320: 1186-94. PMID 17159161 DOI: 10.1124/jpet.106.113621 |
0.765 |
|
| 2006 |
Zhang Q, Keenan SM, Peng Y, Nair AC, Yu SJ, Howells RD, Welsh WJ. Discovery of novel triazole-based opioid receptor antagonists. Journal of Medicinal Chemistry. 49: 4044-7. PMID 16821764 DOI: 10.1021/Jm0601250 |
0.555 |
|
| 2006 |
Zhang Q, Keenan SM, Peng Y, Nair AC, Yu SJ, Howells RD, Welsh WJ. Discovery of novel triazole-based opioid receptor antagonists. Journal of Medicinal Chemistry. 49: 4044-7. PMID 16821764 DOI: 10.1021/Jm0601250 |
0.555 |
|
| 2005 |
Christoffers KH, Li H, Howells RD. Purification and mass spectrometric analysis of the delta opioid receptor. Brain Research. Molecular Brain Research. 136: 54-64. PMID 15893587 DOI: 10.1016/j.molbrainres.2005.01.016 |
0.67 |
|
| 2005 |
Christoffers KH, Li H, Howells RD. Purification and mass spectrometric analysis of the delta opioid receptor. Brain Research. Molecular Brain Research. 136: 54-64. PMID 15893587 DOI: 10.1016/j.molbrainres.2005.01.016 |
0.67 |
|
| 2003 |
Christoffers KH, Li H, Keenan SM, Howells RD. Purification and mass spectrometric analysis of the mu opioid receptor. Brain Research. Molecular Brain Research. 118: 119-31. PMID 14559361 |
0.535 |
|
| 2003 |
Christoffers KH, Li H, Keenan SM, Howells RD. Purification and mass spectrometric analysis of the mu opioid receptor. Brain Research. Molecular Brain Research. 118: 119-31. PMID 14559361 |
0.535 |
|
| 2002 |
Christoffers KH, Khokhar A, Chaturvedi K, Howells RD. Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin. Regulatory Peptides. 105: 9-14. PMID 11853866 DOI: 10.1016/s0167-0115(01)00382-2 |
0.62 |
|
| 2002 |
Christoffers KH, Khokhar A, Chaturvedi K, Howells RD. Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin. Regulatory Peptides. 105: 9-14. PMID 11853866 DOI: 10.1016/s0167-0115(01)00382-2 |
0.62 |
|
| 2001 |
Chaturvedi K, Christoffers KH, Singh K, Howells RD. Structure and regulation of opioid receptors. Biopolymers. 55: 334-46. PMID 11169924 DOI: 10.1002/1097-0282(2000)55:4<334::AID-BIP1006>3.0.CO;2-S |
0.573 |
|
| 2001 |
Chaturvedi K, Bandari P, Chinen N, Howells RD. Proteasome involvement in agonist-induced down-regulation of mu and delta opioid receptors. The Journal of Biological Chemistry. 276: 12345-55. PMID 11152677 DOI: 10.1074/jbc.M008054200 |
0.606 |
|
| 2001 |
Chaturvedi K, Jiang X, Christoffers KH, Chinen N, Bandari P, Raveglia LF, Ronzoni S, Dondio G, Howells RD. Pharmacological profiles of selective non-peptidic delta opioid receptor ligands. Brain Research. Molecular Brain Research. 80: 166-76. PMID 11038249 DOI: 10.1016/S0169-328X(00)00134-0 |
0.641 |
|
| 2000 |
Chaturvedi K, Shahrestanifar M, Howells RD. mu Opioid receptor: role for the amino terminus as a determinant of ligand binding affinity. Brain Research. Molecular Brain Research. 76: 64-72. PMID 10719216 DOI: 10.1016/S0169-328X(99)00332-0 |
0.601 |
|
| 1998 |
Wu G, Lu ZH, Wei TJ, Howells RD, Christoffers K, Ledeen RW. The role of GM1 ganglioside in regulating excitatory opioid effects. Annals of the New York Academy of Sciences. 845: 126-38. PMID 9668347 DOI: 10.1111/J.1749-6632.1998.TB09666.X |
0.539 |
|
| 1997 |
Shahrestanifar MS, Howells RD. Sensitivity of opioid receptor binding to N-substituted maleimides and methanethiosulfonate derivatives. Neurochemical Research. 21: 1295-9. PMID 8947919 DOI: 10.1007/BF02532370 |
0.495 |
|
| 1996 |
Shahrestanifar M, Wang WW, Howells RD. Studies on inhibition of mu and delta opioid receptor binding by dithiothreitol and N-ethylmaleimide. His223 is critical for mu opioid receptor binding and inactivation by N-ethylmaleimide. The Journal of Biological Chemistry. 271: 5505-12. PMID 8621408 DOI: 10.1074/jbc.271.10.5505 |
0.506 |
|
| 1996 |
Wang WW, Shahrestanifar M, Jin J, Howells RD. Studies on mu and delta opioid receptor selectivity utilizing chimeric and site-mutagenized receptors. Proceedings of the National Academy of Sciences of the United States of America. 92: 12436-40. PMID 8618916 DOI: 10.1073/PNAS.92.26.12436 |
0.599 |
|
| 1994 |
Tirumalai PS, Howells RD. Regulation of calbindin-D28K gene expression in response to acute and chronic morphine administration. Brain Research. Molecular Brain Research. 23: 144-50. PMID 8028477 DOI: 10.1016/0169-328X(94)90220-8 |
0.302 |
|
| 1994 |
Shahrestanifar M, Saha DP, Scala LA, Basu A, Howells RD. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. Gene. 147: 281-5. PMID 7926816 DOI: 10.1016/0378-1119(94)90082-5 |
0.304 |
|
| 1984 |
Fleminger G, Howells RD, Kilpatrick DL, Udenfriend S. Intact proenkephalin is the major enkephalin-containing peptide produced in rat adrenal glands after denervation. Proceedings of the National Academy of Sciences of the United States of America. 81: 7985-8. PMID 6595672 DOI: 10.1073/Pnas.81.24.7985 |
0.373 |
|
| 1983 |
Kilpatrick DL, Howells RD, Lahm HW, Udenfriend S. Evidence for a proenkephalin-like precursor in amphibian brain. Proceedings of the National Academy of Sciences of the United States of America. 80: 5772-5. PMID 6412233 DOI: 10.1073/Pnas.80.18.5772 |
0.402 |
|
| 1982 |
Gioannini TL, Howells RD, Miller JM, Simon EJ. Solubilization in good yield of active opiate binding sites from mammalian brain. Life Sciences. 31: 1315-1318. PMID 6292621 DOI: 10.1016/0024-3205(82)90370-8 |
0.406 |
|
| 1981 |
Ruegg UT, Cuenod S, Hiller JM, Gioannini T, Howells RD, Simon EJ. Characterization and partial purification of solubilized active opiate receptors from toad brain. Proceedings of the National Academy of Sciences of the United States of America. 78: 4635-4638. PMID 6270689 DOI: 10.1073/Pnas.78.7.4635 |
0.429 |
|
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