Kim E Nichols, MD - Publications

Affiliations: 
2012 Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine 
 2012- St Jude Children's Research Hospital, New York, NY, United States 
Area:
Oncology, Cancer Predisposition, NKT cell biology

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bloom M, Oak N, Baskin-Doerfler R, Feng R, Iacobucci I, Baviskar P, Zhao X, Stroh AN, Li C, Ozark P, Tillman H, Li Y, Verbist KC, Albeituni S, Scott DC, ... ... Nichols KE, et al. ETV6 Represses Inflammatory Response Genes and Regulates HSPC Function During Stress Hematopoiesis in Mice. Blood Advances. PMID 37522715 DOI: 10.1182/bloodadvances.2022009313  0.328
2023 Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, Piskin D, Ravelli A, Sinha R, Aletaha D, Allen C, Bassiri H, Behrens EM, Carcillo J, Carl L, ... ... Nichols KE, et al. The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Annals of the Rheumatic Diseases. PMID 37487610 DOI: 10.1136/ard-2023-224123  0.572
2023 Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, Piskin D, Ravelli A, Sinha R, Aletaha D, Allen C, Bassiri H, Behrens EM, Carcillo J, Carl L, ... ... Nichols KE, et al. The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS). Arthritis & Rheumatology (Hoboken, N.J.). PMID 37486733 DOI: 10.1002/art.42636  0.57
2023 Steen EA, Nichols KE, Meyer LK. Insights into the cellular pathophysiology of familial hemophagocytic lymphohistiocytosis. Frontiers in Immunology. 14: 1147603. PMID 36969228 DOI: 10.3389/fimmu.2023.1147603  0.367
2021 Hines MR, Keenan C, Maron Alfaro G, Cheng C, Zhou Y, Sharma A, Hurley C, Nichols KE, Gottschalk S, Triplett BM, Talleur AC. Hemophagocytic lymphohistiocytosis-like toxicity (carHLH) after CD19-specific CAR T-cell therapy. British Journal of Haematology. PMID 34263927 DOI: 10.1111/bjh.17662  0.301
2021 Li Y, Yang W, Devidas M, Winter SS, Kesserwan C, Yang W, Dunsmore KP, Smith C, Qian M, Zhao X, Zhang R, Gastier-Foster JM, Raetz EA, Carroll WL, Li C, ... ... Nichols KE, et al. Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia. The Journal of Clinical Investigation. PMID 34166225 DOI: 10.1172/JCI147898  0.327
2021 Hines MR, Nichols KE. HLH or sepsis: the truth is in the T cells. Blood. 137: 2279-2280. PMID 33914076 DOI: 10.1182/blood.2020010236  0.341
2020 Guan P, Schaub R, Nichols KE, Das R. Combination of NKT14m and Low Dose IL-12 Promotes Invariant Natural Killer T Cell IFN-γ Production and Tumor Control. International Journal of Molecular Sciences. 21. PMID 32708464 DOI: 10.3390/Ijms21145085  0.383
2020 Patel NP, Guan P, Bahal D, Hashem T, Scheuplein F, Schaub R, Nichols KE, Das R. Cancer Immunotherapeutic Potential of NKTT320, a Novel, Invariant, Natural Killer T Cell-Activating, Humanized Monoclonal Antibody. International Journal of Molecular Sciences. 21. PMID 32560408 DOI: 10.3390/Ijms21124317  0.408
2020 Meyer L, Verbist KC, Albeituni S, Scull BP, Bassett R, Stroh AN, Tillman H, Allen CE, Hermiston M, Nichols KE. JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation. Blood. PMID 32530039 DOI: 10.1182/Blood.2020006075  0.363
2020 Lesmana H, Popescu M, Lewis S, Sahoo SS, Goodings-Harris C, Onciu M, Choi JK, Takemoto C, Nichols KE, Wlodarski M. Germline Gain-of-Function JAK3 Mutation in Familial Chronic Lymphoproliferative Disorder of NK Cells Blood. 136: 9-10. DOI: 10.1182/blood-2020-142078  0.363
2019 Bahal D, Hashem T, Nichols KE, Das R. SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function. International Journal of Molecular Sciences. 20. PMID 31569599 DOI: 10.3390/Ijms20194797  0.411
2019 Albeituni S, Verbist KC, Tedrick PE, Tillman H, Picarsic J, Bassett R, Nichols KE. Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis. Blood. 134: 147-159. PMID 31015190 DOI: 10.1182/blood.2019000761  0.323
2019 Das R, Guan P, Wiener SJ, Patel NP, Gohl TG, Evans E, Zauderer M, Nichols KE. Enhancing the antitumor functions of invariant natural killer T cells using a soluble CD1d-CD19 fusion protein. Blood Advances. 3: 813-824. PMID 30858151 DOI: 10.1182/Bloodadvances.2018028886  0.333
2019 Crayne CB, Albeituni S, Nichols KE, Cron RQ. The Immunology of Macrophage Activation Syndrome. Frontiers in Immunology. 10: 119. PMID 30774631 DOI: 10.3389/fimmu.2019.00119  0.336
2019 Crayne CB, Albeituni S, Nichols KE, Cron RQ. The Immunology of Macrophage Activation Syndrome. Frontiers in Immunology. 10: 119. PMID 30774631 DOI: 10.3389/fimmu.2019.00119  0.336
2019 Meyer LK, Verbist K, Albeituni S, Bassett R, Hermiston ML, Nichols KE. The Combination of Dexamethasone and Ruxolitinib Synergistically Attenuates Disease Manifestations in a Preclinical Model of Hemophagocytic Lymphohistiocytosis Blood. 134: 81-81. DOI: 10.1182/BLOOD-2019-129112  0.327
2018 Dillon SR, Lewis KE, Verbist K, Tedrick P, Albeituni S, Swanson R, Evans LS, Levin SD, Rixon MW, Peng SL, Nichols KE, Swiderek KM. Therapeutic Candidate Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft Vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH) Blood. 132: 2037-2037. DOI: 10.1182/BLOOD-2018-99-110001  0.353
2016 Guan P, Bassiri H, Patel NP, Nichols KE, Das R. Invariant natural killer T cells in hematopoietic stem cell transplantation: killer choice for natural suppression. Bone Marrow Transplantation. PMID 26878658 DOI: 10.1038/Bmt.2015.335  0.655
2016 Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, et al. Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Science Translational Medicine. 8: 321ra7. PMID 26764158 DOI: 10.1126/Scitranslmed.Aad1565  0.386
2016 Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, et al. Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Science Translational Medicine. 8: 321ra7. PMID 26764158 DOI: 10.1126/Scitranslmed.Aad1565  0.386
2016 Churchman ML, Qian M, Zhang R, Kronnie G, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Devidas M, Raetz E, Larsen E, Martin PL, Bowman WP, ... ... Nichols KE, et al. Germline Genetic Variation in IKZF1 and Predisposition to Childhood Acute Lymphoblastic Leukemia Blood. 128: LBA-2-LBA-2. DOI: 10.1182/blood.v128.22.lba-2.lba-2  0.333
2015 Das R, Scheuplein F, Guan P, Schaub R, Nichols KE. Abstract 4294: Cancer immunotherapeutic potential of NKTT320, a novel human invariant natural killer T-cell activating monoclonal antibody Cancer Research. 75: 4294-4294. DOI: 10.1158/1538-7445.Am2015-4294  0.405
2014 Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE. iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo . Cancer Immunology Research. 2: 59-69. PMID 24563871 DOI: 10.1158/2326-6066.Cir-13-0104  0.687
2014 Das R, Scheuplein F, Patel NP, Guan P, Schaub RG, Nichols KE. Abstract 653: NKTT320, a novel monoclonal antibody activates the immuno-stimulatory functions of human invariant natural killer T cells Cancer Research. 74: 653-653. DOI: 10.1158/1538-7445.Am2014-653  0.366
2014 Cianferoni A, Barni S, Smith C, Abraham V, Guan P, Saretta F, Ruyman K, Bassiri H, Nichols KE, Spergel JM. Older Mice Intranasally Sensitized with Aspergillus Fumigatus Develop Stronger Eosinophilic Esophageal Inflammation Compared to Their Younger Counterparts The Journal of Allergy and Clinical Immunology. 133. DOI: 10.1016/J.Jaci.2013.12.912  0.547
2013 Bassiri H, Das R, Nichols KE. Invariant NKT cells: Killers and conspirators against cancer. Oncoimmunology. 2: e27440. PMID 24575380 DOI: 10.4161/Onci.27440  0.677
2013 Teachey DT, Rheingold SR, Maude SL, Zugmaier G, Barrett DM, Seif AE, Nichols KE, Suppa EK, Kalos M, Berg RA, Fitzgerald JC, Aplenc R, Gore L, Grupp SA. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood. 121: 5154-7. PMID 23678006 DOI: 10.1182/Blood-2013-02-485623  0.305
2013 Das R, Bassiri H, Guan P, Wiener S, Banerjee PP, Zhong MC, Veillette A, Orange JS, Nichols KE. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood. 121: 3386-95. PMID 23430111 DOI: 10.1182/Blood-2012-11-468868  0.686
2013 May RM, Okumura M, Hsu CJ, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T. Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood. 121: 3135-46. PMID 23407547 DOI: 10.1182/Blood-2012-12-474361  0.627
2012 Palendira U, Low C, Bell AI, Ma CS, Abbott RJ, Phan TG, Riminton DS, Choo S, Smart JM, Lougaris V, Giliani S, Buckley RH, Grimbacher B, Alvaro F, Klion AD, ... Nichols KE, et al. Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus. The Journal of Experimental Medicine. 209: 913-24. PMID 22493517 DOI: 10.1084/jem.20112391  0.324
2012 Bassiri H, Nichols KE. X-linked lymphoproliferative disease (XLP) Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/47545  0.544
2011 Rezaei N, Mahmoudi E, Aghamohammadi A, Das R, Nichols KE. X-linked lymphoproliferative syndrome: a genetic condition typified by the triad of infection, immunodeficiency and lymphoma. British Journal of Haematology. 152: 13-30. PMID 21083659 DOI: 10.1111/J.1365-2141.2010.08442.X  0.411
2010 Das R, Sant'Angelo DB, Nichols KE. Transcriptional control of invariant NKT cell development. Immunological Reviews. 238: 195-215. PMID 20969594 DOI: 10.1111/J.1600-065X.2010.00962.X  0.416
2010 Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant'Angelo DB. PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. Journal of Immunology (Baltimore, Md. : 1950). 184: 6746-55. PMID 20495068 DOI: 10.4049/jimmunol.1000776  0.4
2010 Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant'Angelo DB. Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. Journal of Immunology (Baltimore, Md. : 1950). 184: 1268-79. PMID 20038637 DOI: 10.4049/Jimmunol.0903218  0.381
2010 Harly C, Guillaume Y, Mönkkönen H, Mönkkönen J, Olive D, Bonneville M, Scotet E, Morita CT, Fang Z, Wang H, Dornmair K, Bruder J, Siewert K, Hohlfeld R, Moens E, ... ... Nichols KE, et al. Gamma-delta T cells (WS-094) Chairpersons: Yoshimasa Tanaka, Marc Bonneville International Immunology. 22. DOI: 10.1093/Intimm/Dxq351  0.315
2009 Snow AL, Marsh RA, Krummey SM, Roehrs P, Young LR, Zhang K, van Hoff J, Dhar D, Nichols KE, Filipovich AH, Su HC, Bleesing JJ, Lenardo MJ. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. The Journal of Clinical Investigation. 119: 2976-89. PMID 19759517 DOI: 10.1172/JCI39518  0.404
2009 Talaat KR, Rothman JA, Cohen JI, Santi M, Choi JK, Guzman M, Zimmerman R, Nallasamy S, Brucker A, Quezado M, Pittaluga S, Patronas NJ, Klion AD, Nichols KE. Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection. Pediatric Blood & Cancer. 53: 1120-3. PMID 19621458 DOI: 10.1002/Pbc.22185  0.307
2009 Bassiri H, Nichols KE. It's up to you Egr2. Immunology and Cell Biology. 87: 361-3. PMID 19333249 DOI: 10.1038/Icb.2009.20  0.66
2009 Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols KE, Stein PL. The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of Immunology (Baltimore, Md. : 1950). 182: 1370-8. PMID 19155483 DOI: 10.4049/Jimmunol.182.3.1370  0.675
2009 Abraham V, Jyonouchi S, Nichols K, Spergel J, Orange J, Cianferoni A. Milk-Derived Glycoshingolipids (GSL) Specifically Ligate The Invariant NKT Cell (iNKT) T Cell Receptor (TCR), Induce iNKT Proliferation And Promote Th2 Cytokine Expression Journal of Allergy and Clinical Immunology. 123: 724. DOI: 10.1016/J.Jaci.2009.01.005  0.362
2008 Bassiri H, Janice Yeo WC, Rothman J, Koretzky GA, Nichols KE. X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic Research. 42: 145-59. PMID 18815745 DOI: 10.1007/S12026-008-8048-7  0.652
2008 Nunez-Cruz S, Yeo WC, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE. Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of Immunology (Baltimore, Md. : 1950). 181: 2311-20. PMID 18684920 DOI: 10.4049/Jimmunol.181.4.2311  0.672
2008 Baev DV, Caielli S, Ronchi F, Coccia M, Facciotti F, Nichols KE, Falcone M. Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 181: 869-77. PMID 18606638 DOI: 10.4049/jimmunol.181.2.869  0.332
2007 Ma CS, Nichols KE, Tangye SG. Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annual Review of Immunology. 25: 337-79. PMID 17201683 DOI: 10.1146/annurev.immunol.25.022106.141651  0.372
2005 Ma CS, Hare NJ, Nichols KE, Dupré L, Andolfi G, Roncarolo MG, Adelstein S, Hodgkin PD, Tangye SG. Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells. The Journal of Clinical Investigation. 115: 1049-59. PMID 15761493 DOI: 10.1172/JCI23139  0.353
2005 Nichols KE, Hom J, Gong SY, Ganguly A, Ma CS, Cannons JL, Tangye SG, Schwartzberg PL, Koretzky GA, Stein PL. Regulation of NKT cell development by SAP, the protein defective in XLP. Nature Medicine. 11: 340-5. PMID 15711562 DOI: 10.1038/Nm1189  0.453
2005 Nichols KE, Ma CS, Cannons JL, Schwartzberg PL, Tangye SG. Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunological Reviews. 203: 180-99. PMID 15661030 DOI: 10.1111/j.0105-2896.2005.00230.x  0.319
2004 Cannons JL, Yu LJ, Hill B, Mijares LA, Dombroski D, Nichols KE, Antonellis A, Koretzky GA, Gardner K, Schwartzberg PL. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity. 21: 693-706. PMID 15539155 DOI: 10.1016/J.Immuni.2004.09.012  0.366
2004 Nichols KE, Hom J, Ganguly A, Ma CS, Tangye SG, Cannons JL, Schwartzberg PL, Koretzky GA, Stein PL. Regulation of NKT Cell Development by Sap, the Adaptor Mutated in X-Linked Lymphoproliferative Disease. Blood. 104: 317-317. DOI: 10.1182/Blood.V104.11.317.317  0.434
2003 Zhong XP, Hainey EA, Olenchock BA, Jordan MS, Maltzman JS, Nichols KE, Shen H, Koretzky GA. Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nature Immunology. 4: 882-90. PMID 12883552 DOI: 10.1038/Ni958  0.399
2003 Singer AL, Jordan MS, Judd BA, Myung PS, Newbrough SA, Nichols KE, Olenchock BA, Peterson EJ, Wu JN, Zhong X, Koretzky GA. Signaling Via the T Cell Receptor Science Signaling. 2003: cm7-cm7. DOI: 10.1126/Stke.2003.194.Cm7  0.303
2001 Nichols KE, Koretzky GA, June CH. SAP: Natural inhibitor or grand SLAM of T cell activation? Nature Immunology. 2: 665-666. PMID 11477397 DOI: 10.1038/90595  0.369
2000 Tangye SG, Phillips JH, Lanier LL, Nichols KE. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. Journal of Immunology (Baltimore, Md. : 1950). 165: 2932-6. PMID 10975798 DOI: 10.4049/Jimmunol.165.6.2932  0.339
1998 Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proceedings of the National Academy of Sciences of the United States of America. 95: 13765-70. PMID 9811875 DOI: 10.1073/Pnas.95.23.13765  0.346
1986 Ball ED, Nichols KE, Pettengill OS, Sorenson GD, Fanger MW. Lysis of small cell carcinoma of the lung tumor cell lines by gamma interferon-activated allogeneic peripheral blood mononuclear cells: abrogation of killing by pretreatment of tumor cells with gamma interferon Cancer Immunology Immunotherapy. 22: 211-216. PMID 3015408 DOI: 10.1007/Bf00200035  0.324
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