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Bruce D Walker, M.D - Publications

Affiliations: 
Ragon Ragon Institute of MGH, MIT and Harvard 
Area:
HIV, T Cell Biology, Immunology
Website:
https://www.hhmi.org/scientists/bruce-d-walker
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425 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Viard M, O'hUigin C, Yuki Y, Bashirova AA, Collins DR, Urbach JM, Wolinsky S, Buchbinder S, Kirk GD, Goedert JJ, Michael NL, Haas DW, Deeks SG, Walker BD, Yu X, et al. Impact of HLA class I functional divergence on HIV control. Science (New York, N.Y.). 383: 319-325. PMID 38236978 DOI: 10.1126/science.adk0777  0.492
2023 Zonozi R, Walters LC, Shulkin A, Naranbhai V, Nithagon P, Sauvage G, Kaeske C, Cosgrove K, Nathan A, Tano-Menka R, Gayton AC, Getz MA, Senjobe F, Worrall D, Iafrate AJ, ... ... Walker BD, et al. T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19. Science Translational Medicine. 15: eadh4529. PMID 38019932 DOI: 10.1126/scitranslmed.adh4529  0.421
2023 McLaren PJ, Porreca I, Iaconis G, Mok HP, Mukhopadhyay S, Karakoc E, Cristinelli S, Pomilla C, Bartha I, Thorball CW, Tough RH, Angelino P, Kiar CS, Carstensen T, Fatumo S, ... Walker BD, et al. Africa-specific human genetic variation near CHD1L associates with HIV-1 load. Nature. PMID 37532928 DOI: 10.1038/s41586-023-06370-4  0.387
2023 Li X, Singh NK, Collins DR, Ng R, Zhang A, Lamothe-Molina PA, Shahinian P, Xu S, Tan K, Piechocka-Trocha A, Urbach JM, Weber JK, Gaiha GD, Takou Mbah OC, Huynh T, ... ... Walker BD, et al. Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide. Nature Communications. 14: 2929. PMID 37217466 DOI: 10.1038/s41467-023-38573-8  0.705
2023 Collins DR, Hitschfel J, Urbach JM, Mylvaganam GH, Ly NL, Arshad U, Racenet ZJ, Yanez AG, Diefenbach TJ, Walker BD. Cytolytic CD8 T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes. Science Immunology. 8: eade5872. PMID 37205767 DOI: 10.1126/sciimmunol.ade5872  0.505
2023 Adriano Vieira V, Lim N, Singh A, Leitman E, D'Souza RR, Adland E, Muenchhoff M, Roider J, Marín Lopez MÁ, Carabelli J, Giandhari J, Groll A, Jooste P, Prado JG, Thobakgale C, ... ... Walker BD, et al. Paediatric HIV slow-progression is associated with early CD8+ T-cell PD-1 expression and a stem-like phenotype. Jci Insight. PMID 36602861 DOI: 10.1172/jci.insight.156049  0.386
2023 Sun W, Gao C, Hartana CA, Osborn MR, Einkauf KB, Lian X, Bone B, Bonheur N, Chun TW, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Phenotypic signatures of immune selection in HIV-1 reservoir cells. Nature. PMID 36599977 DOI: 10.1038/s41586-022-05538-8  0.454
2022 Mandizvo T, Gumede N, Ndlovu B, Ndlovu S, Mann JK, Chopera DR, Singh L, Dong KL, Walker BD, Ndhlovu ZM, Lavine CL, Seaman MS, Gounder K, Ndung'u T. Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection. Journal of Virology. 96: e0127022. PMID 36453881 DOI: 10.1128/jvi.01270-22  0.343
2022 Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP, Walker BD, Seaman MS, et al. A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Science Advances. 8: eabp8155. PMID 35960796 DOI: 10.1126/sciadv.abp8155  0.308
2022 Baiyegunhi OO, Mann J, Khaba T, Nkosi T, Mbatha A, Ogunshola F, Chasara C, Ismail N, Ngubane T, Jajbhay I, Pansegrouw J, Dong KL, Walker BD, Ndung'u T, Ndhlovu ZM. CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. Nature Communications. 13: 4041. PMID 35831418 DOI: 10.1038/s41467-022-31692-8  0.429
2022 Gaebler C, Nogueira L, Stoffel E, Oliveira TY, Breton G, Millard KG, Turroja M, Butler A, Ramos V, Seaman MS, Reeves JD, Petroupoulos CJ, Shimeliovich I, Gazumyan A, Jiang CS, ... ... Walker BD, et al. Prolonged viral suppression with anti-HIV-1 antibody therapy. Nature. PMID 35418681 DOI: 10.1038/s41586-022-04597-1  0.327
2022 Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, ... ... Walker BD, et al. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Cell. 185: 1259. PMID 35364034 DOI: 10.1016/j.cell.2022.03.022  0.308
2022 Lorin V, Fernández I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Péhau-Arnaudet G, Hrebík D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, et al. Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller. The Journal of Experimental Medicine. 219. PMID 35230385 DOI: 10.1084/jem.20212045  0.389
2022 Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, ... ... Walker BD, et al. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Cell. PMID 35202566 DOI: 10.1016/j.cell.2022.01.029  0.421
2022 Zhang A, Piechocka-Trocha A, Li X, Walker BD. A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Expression System. Cells. 11. PMID 35159122 DOI: 10.3390/cells11030312  0.407
2022 Sari H, Galbusera R, Bonnier G, Lin Y, Alshelh Z, Torrado-Carvajal A, Mukerji SS, Ratai EM, Gandhi RT, Chu JT, Akeju O, Orhurhu V, Salvatore AN, Sherman J, Kwon DS, ... Walker B, et al. Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers. Neurology(R) Neuroimmunology & Neuroinflammation. 9. PMID 35140142 DOI: 10.1212/NXI.0000000000001144  0.338
2022 Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Denis KJS, Lam EC, Garcia-Beltran WF, Balazs AB, ... Walker BD, et al. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all prior infected and vaccinated individuals. Medrxiv : the Preprint Server For Health Sciences. PMID 35018386 DOI: 10.1101/2022.01.04.21268586  0.401
2022 Ogunshola FJ, Smidt W, Naidoo AF, Nkosi TP, Ngubane T, Khaba PT, Baiyegunhi OO, Mahlobo B, Rasehlo S, Ngema N, Jajbhay I, Dong KL, Ramsuran V, Pansegrouw J, Ndung'u T, ... Walker B, et al. Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection. Blood Advances. PMID 34991160 DOI: 10.1182/bloodadvances.2021006001  0.475
2021 Lian X, Gao C, Sun X, Jiang C, Einkauf KB, Seiger KW, Chevalier JM, Yuki Y, Martin M, Hoh R, Peluso MJ, Carrington M, Ruiz-Mateos E, Deeks SG, Rosenberg ES, Walker BD, et al. Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers. Science Translational Medicine. 13: eabl4097. PMID 34910552 DOI: 10.1126/scitranslmed.abl4097  0.314
2021 Adriano Vieira V, Adland E, Malone DFG, Martin MP, Groll A, Ansari MA, Garcia-Guerrero MC, Puertas MC, Muenchhoff M, Guash CF, Brander C, Martinez-Picado J, Bamford A, Tudor-Williams G, Ndung'u T, Walker BD, et al. An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults. Plos Pathogens. 17: e1010090. PMID 34793581 DOI: 10.1371/journal.ppat.1010090  0.48
2021 Omondi FH, Sudderuddin H, Shahid A, Kinloch NN, Jones BR, Miller RL, Tsai O, MacMillan D, Trocha A, Brockman MA, Brumme CJ, Joy JB, Liang R, Walker BD, Brumme ZL. HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy. Mbio. e0249021. PMID 34781741 DOI: 10.1128/mBio.02490-21  0.336
2021 Turk G, Seiger K, Lian X, Sun W, Parsons EM, Gao C, Rassadkina Y, Polo ML, Czernikier A, Ghiglione Y, Vellicce A, Varriale J, Lai J, Yuki Y, Martin M, ... Walker BD, et al. A Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation. Annals of Internal Medicine. PMID 34781719 DOI: 10.7326/L21-0297  0.322
2021 Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, ... Walker BD, et al. Functional impairment of HIV-specific CD8 T cells precedes aborted spontaneous control of viremia. Immunity. PMID 34496223 DOI: 10.1016/j.immuni.2021.08.007  0.477
2021 Nathan A, Rossin EJ, Kaseke C, Park RJ, Khatri A, Koundakjian D, Urbach JM, Singh NK, Bashirova A, Tano-Menka R, Senjobe F, Waring MT, Piechocka-Trocha A, Garcia-Beltran WF, Iafrate AJ, ... ... Walker BD, et al. Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses. Cell. PMID 34265281 DOI: 10.1016/j.cell.2021.06.029  0.662
2021 Kaseke C, Park RJ, Singh NK, Koundakjian D, Bashirova A, Garcia Beltran WF, Takou Mbah OC, Ma J, Senjobe F, Urbach JM, Nathan A, Rossin EJ, Tano-Menka R, Khatri A, Piechocka-Trocha A, ... Walker BD, et al. HLA class-I-peptide stability mediates CD8 T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV. Cell Reports. 36: 109378. PMID 34260940 DOI: 10.1016/j.celrep.2021.109378  0.673
2021 Singh R, Ramsuran V, Naranbhai V, Yende-Zuma N, Garrett N, Mlisana K, Dong KL, Walker BD, Abdool Karim SS, Carrington M, Ndung'u T. Epigenetic Regulation of Expression Levels and the Effect on HIV-1 Pathogenesis. Frontiers in Immunology. 12: 669241. PMID 34025670 DOI: 10.3389/fimmu.2021.669241  0.346
2021 McCann CD, van Dorp CH, Danesh A, Ward AR, Dilling TR, Mota TM, Zale E, Stevenson EM, Patel S, Brumme CJ, Dong W, Jones DS, Andresen TL, Walker BD, Brumme ZL, et al. A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies. The Journal of Experimental Medicine. 218. PMID 33988715 DOI: 10.1084/jem.20201908  0.484
2021 Clayton KL, Mylvaganam G, Villasmil-Ocando A, Stuart H, Maus MV, Rashidian M, Ploegh HL, Walker BD. HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses. Cell Host & Microbe. PMID 33571449 DOI: 10.1016/j.chom.2021.01.006  0.451
2021 Garcia-Bates TM, Palma ML, Anderko RR, Hsu DC, Ananworanich J, Korber BT, Gaiha GD, Phanuphak N, Thomas R, Tovanabutra S, Walker BD, Mellors JW, Piazza PA, Kroon E, Riddler SA, et al. Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes. Ebiomedicine. 63: 103175. PMID 33450518 DOI: 10.1016/j.ebiom.2020.103175  0.472
2020 Kazer SW, Walker BD, Shalek AK. Evolution and Diversity of Immune Responses during Acute HIV Infection. Immunity. 53: 908-924. PMID 33207216 DOI: 10.1016/j.immuni.2020.10.015  0.343
2020 Bashirova AA, Viard M, Naranbhai V, Grifoni A, Garcia-Beltran W, Akdag M, Yuki Y, Gao X, O'hUigin C, Raghavan M, Wolinsky S, Bream JH, Duggal P, Martinson J, Michael NL, ... ... Walker B, et al. HLA tapasin independence: broader peptide repertoire and HIV control. Proceedings of the National Academy of Sciences of the United States of America. PMID 33097667 DOI: 10.1073/pnas.2013554117  0.41
2020 Painter MM, Zimmerman GE, Merlino MS, Robertson AW, Terry VH, Ren X, McLeod MR, Gomez-Rodriguez L, Garcia KA, Leonard JA, Leopold KE, Neevel AJ, Lubow J, Olson E, Piechocka-Trocha A, ... Walker BD, et al. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32900948 DOI: 10.1073/Pnas.2008615117  0.51
2020 Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, ... ... Walker BD, et al. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. Cell. PMID 32877699 DOI: 10.1016/J.Cell.2020.08.025  0.649
2020 Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, ... Walker BD, et al. Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature. PMID 32848246 DOI: 10.1038/S41586-020-2651-8  0.325
2020 Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, ... ... Walker BD, et al. The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19. Ssrn. 3652322. PMID 32742244 DOI: 10.2139/ssrn.3652322  0.635
2020 Ndlovu B, Gounder K, Muema D, Raju N, Hermanus T, Mthethwa Q, Robertson K, Walker BD, Georgiev IS, Morris L, Moore PL, Ndung'u T. Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection. Virology. 546: 1-12. PMID 32275203 DOI: 10.1016/J.Virol.2020.03.003  0.371
2020 Kazer SW, Aicher TP, Muema DM, Carroll SL, Ordovas-Montanes J, Miao VN, Tu AA, Ziegler CGK, Nyquist SK, Wong EB, Ismail N, Dong M, Moodley A, Berger B, Love JC, ... Walker BD, et al. Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection. Nature Medicine. PMID 32251406 DOI: 10.1038/S41591-020-0799-2  0.354
2020 Muema DM, Akilimali NA, Ndumnego OC, Rasehlo SS, Durgiah R, Ojwach DBA, Ismail N, Dong M, Moodley A, Dong KL, Ndhlovu ZM, Mabuka JM, Walker BD, Mann JK, Ndung'u T. Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection. Bmc Medicine. 18: 81. PMID 32209092 DOI: 10.1186/S12916-020-01529-6  0.37
2020 Collins DR, Gaiha GD, Walker BD. CD8 T cells in HIV control, cure and prevention. Nature Reviews. Immunology. PMID 32051540 DOI: 10.1038/s41577-020-0274-9  0.475
2020 Martin-Gayo E, Gao C, Chen HR, Ouyang Z, Kim D, Kolb KE, Shalek AK, Walker BD, Lichterfeld M, Yu XG. Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies. Cell Reports. 30: 984-996.e4. PMID 31995767 DOI: 10.1016/J.Celrep.2019.12.087  0.456
2019 Jin SW, Alsahafi N, Kuang XT, Swann SA, Toyoda M, Göttlinger H, Walker BD, Ueno T, Finzi A, Brumme ZL, Brockman MA. Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. Cell Reports. 29: 1449-1457.e5. PMID 31693887 DOI: 10.1016/J.Celrep.2019.10.007  0.441
2019 Mylvaganam G, Yanez AG, Maus M, Walker BD. Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology. Frontiers in Immunology. 10: 2109. PMID 31552045 DOI: 10.3389/Fimmu.2019.02109  0.493
2019 Lee GQ, Reddy K, Einkauf KB, Gounder K, Chevalier JM, Dong KL, Walker BD, Yu XG, Ndung'u T, Lichterfeld M. HIV-1 DNA sequence diversity and evolution during acute subtype C infection. Nature Communications. 10: 2737. PMID 31227699 DOI: 10.1038/s41467-019-10659-2  0.347
2019 Kulkarni S, Lied A, Kulkarni V, Rucevic M, Martin MP, Walker-Sperling V, Anderson SK, Ewy R, Singh S, Nguyen H, McLaren PJ, Viard M, Naranbhai V, Zou C, Lin Z, ... ... Walker B, et al. CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. Nature Immunology. PMID 31209403 DOI: 10.1038/S41590-019-0406-1  0.409
2019 Ndhlovu ZM, Kazer SW, Nkosi T, Ogunshola F, Muema DM, Anmole G, Swann SA, Moodley A, Dong K, Reddy T, Brockman MA, Shalek AK, Ndung'u T, Walker BD. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Science Translational Medicine. 11. PMID 31118290 DOI: 10.1126/Scitranslmed.Aau0528  0.496
2019 Gaiha GD, Rossin EJ, Urbach J, Landeros C, Collins DR, Nwonu C, Muzhingi I, Anahtar MN, Waring OM, Piechocka-Trocha A, Waring M, Worrall DP, Ghebremichael MS, Newman RM, Power KA, ... Walker BD, et al. Structural topology defines protective CD8 T cell epitopes in the HIV proteome. Science (New York, N.Y.). 364: 480-484. PMID 31048489 DOI: 10.1126/Science.Aav5095  0.517
2019 Gonzalo-Gil E, Rapuano PB, Ikediobi U, Leibowitz R, Mehta S, Coskun AK, Porterfield JZ, Lampkin TD, Marconi VC, Rimland D, Walker BD, Deeks S, Sutton RE. Transcriptional down-regulation of in a subset of HIV+ controllers and their family members. Elife. 8. PMID 30964004 DOI: 10.7554/eLife.44360  0.392
2019 Monel B, McKeon A, Lamothe-Molina P, Jani P, Boucau J, Pacheco Y, Jones RB, Le Gall S, Walker BD. HIV Controllers Exhibit Effective CD8 T Cell Recognition of HIV-1-Infected Non-activated CD4 T Cells. Cell Reports. 27: 142-153.e4. PMID 30943397 DOI: 10.1016/j.celrep.2019.03.016  0.5
2019 Mori M, Leitman E, Walker B, Ndung’u T, Carrington M, Goulder P. Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa The Journal of Infectious Diseases. 219: 1456-1463. PMID 30520960 DOI: 10.1093/Infdis/Jiy692  0.535
2018 Chowdhury FZ, Ouyang Z, Buzon M, Walker BD, Lichterfeld M, Yu XG. Metabolic pathway activation distinguish transcriptional signatures of CD8+ T cells from HIV-1 elite controllers. Aids (London, England). PMID 30289807 DOI: 10.1097/QAD.0000000000002007  0.392
2018 Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, ... Walker BD, et al. Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement. Science Immunology. 3. PMID 30120121 DOI: 10.1126/Sciimmunol.Aat7796  0.326
2018 Baiyegunhi O, Ndlovu B, Ogunshola F, Ismail N, Walker BD, Ndung'u T, Ndhlovu ZM. Frequencies of circulating Th1-biased T follicular helper cells in acute HIV-1 infection correlate with the development of HIV-specific antibody responses and lower set point viral load. Journal of Virology. PMID 29793949 DOI: 10.1128/Jvi.00659-18  0.436
2018 Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8 T lymphocyte-mediated killing drives activation of the immune system. Nature Immunology. 19: 475-486. PMID 29670239 DOI: 10.1038/S41590-018-0085-3  0.473
2018 Chung A, Makuba JM, Ndlovu B, Licht A, Robinson H, Ramlakhan Y, Ghebremichael M, Reddy T, Goulder P, Walker B, Ndung'u T, Alter G. Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity. Aids (London, England). PMID 29620716 DOI: 10.1097/Qad.0000000000001812  0.357
2018 Alter G, Dowell KG, Brown EP, Suscovich TJ, Mikhailova A, Mahan AE, Walker BD, Nimmerjahn F, Bailey-Kellogg C, Ackerman ME. High-resolution definition of humoral immune response correlates of effective immunity against HIV. Molecular Systems Biology. 14: e7881. PMID 29581149 DOI: 10.15252/Msb.20177881  0.329
2018 Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Hedestam GBK, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, et al. Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site. Jci Insight. 3. PMID 29515029 DOI: 10.1172/Jci.Insight.97018  0.365
2018 Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, Gao X, Thomas R, Brumme ZL, Carlson JM, Wolinsky SM, Goedert JJ, Walker BD, Segal FP, Deeks SG, et al. Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. The Journal of Clinical Investigation. PMID 29461980 DOI: 10.1172/JCI98463  0.488
2018 Joglekar AV, Liu Z, Weber JK, Ouyang Y, Jeppson JD, Noh WJ, Lamothe-Molina PA, Chen H, Kang SG, Bethune MT, Zhou R, Walker BD, Baltimore D. T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. Proceedings of the National Academy of Sciences of the United States of America. PMID 29437954 DOI: 10.1073/Pnas.1718659115  0.533
2018 Martin-Gayo E, Cole MB, Kolb KE, Ouyang Z, Cronin J, Kazer SW, Ordovas-Montanes J, Lichterfeld M, Walker BD, Yosef N, Shalek AK, Yu XG. A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers. Genome Biology. 19: 10. PMID 29378643 DOI: 10.1186/S13059-017-1385-X  0.366
2018 Huang SH, Ren Y, Thomas AS, Chan D, Mueller S, Ward AR, Patel S, Bollard CM, Cruz CR, Karandish S, Truong R, Macedo AB, Bosque A, Kovacs C, Benko E, ... Walker BD, et al. Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells. The Journal of Clinical Investigation. PMID 29355843 DOI: 10.1172/Jci97555  0.444
2018 Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, ... Walker BD, et al. Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells. Science (New York, N.Y.). 359: 86-90. PMID 29302013 DOI: 10.1126/Science.Aam8825  0.519
2017 Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F, Radkowski M, Kowalska JD, Paraskevis D, Hatzakis A, Valenzuela-Ponce H, Pfafferott K, Williams I, Pellegrino P, Borrow P, ... ... Walker B, et al. DIFFERENTIAL IMMUNODOMINANCE HIERARCHY OF CD8+ T CELL RESPONSES IN HLA-B*27:05 AND B*27:02-MEDIATED CONTROL OF HIV-1 INFECTION. Journal of Virology. PMID 29167337 DOI: 10.1128/JVI.01685-17  0.576
2017 Leitman EM, Palmer CD, Buus S, Chen F, Riddell L, Sims S, Klenerman P, Sáez-Cirión A, Walker BD, Hess PR, Altfeld M, Matthews PC, Goulder PJR. Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities. Plos One. 12: e0184496. PMID 29020090 DOI: 10.1371/journal.pone.0184496  0.542
2017 Leitman EM, Thobakgale CF, Adland E, Ansari MA, Raghwani J, Prendergast AJ, Tudor-Williams G, Kiepiela P, Hemelaar J, Brener J, Tsai MH, Mori M, Riddell L, Luzzi G, Jooste P, ... Walker BD, et al. Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape. The Journal of Experimental Medicine. PMID 28983013 DOI: 10.1084/Jem.20162123  0.361
2017 Mabuka JM, Dugast AS, Muema DM, Reddy T, Ramlakhan Y, Euler Z, Ismail N, Moodley A, Dong KL, Morris L, Walker BD, Alter G, Ndung'u T. Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies. Frontiers in Immunology. 8: 1104. PMID 28943879 DOI: 10.3389/Fimmu.2017.01104  0.33
2017 Thomas AS, Jones KL, Gandhi RT, McMahon DK, Cyktor JC, Chan D, Huang SH, Truong R, Bosque A, Macedo AB, Kovacs C, Benko E, Eron JJ, Bosch RJ, Lalama CM, ... Walker BD, et al. mT-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy. Plos Pathogens. 13: e1006629. PMID 28931091 DOI: 10.1371/Journal.Ppat.1006629  0.506
2017 Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, et al. HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION. Journal of Virology. PMID 28878089 DOI: 10.1128/Jvi.00544-17  0.535
2017 Clayton KL, Garcia JV, Clements JE, Walker BD. HIV Infection of Macrophages: Implications for Pathogenesis and Cure. Pathogens & Immunity. 2: 179-192. PMID 28752134 DOI: 10.20411/pai.v2i2.204  0.38
2017 Lee GQ, Orlova-Fink N, Einkauf K, Chowdhury FZ, Sun X, Harrington S, Kuo HH, Hua S, Chen HR, Ouyang Z, Reddy K, Dong K, Ndung'u T, Walker BD, Rosenberg ES, et al. Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. The Journal of Clinical Investigation. PMID 28628034 DOI: 10.1172/JCI93289  0.438
2017 Li X, Lamothe PA, Walker BD, Wang JH. Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation. Cellular & Molecular Immunology. PMID 28552904 DOI: 10.1038/Cmi.2017.24  0.391
2017 Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich T, Pereyra F, Walker BD, Lauffenburger D, Kwon D, Keele BF, Alter G. Virus-driven inflammation is associated with the development of bNAbs in spontaneous controllers of HIV. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 28158448 DOI: 10.1093/Cid/Cix057  0.396
2017 Martin-Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb KE, Schulze Zur Wiesch J, Cubas R, Porichis F, Shalek AK, van Lunzen J, Haddad EK, Walker BD, Kaufmann DE, Lichterfeld M, et al. Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. Jci Insight. 2: e89574. PMID 28138558 DOI: 10.1172/Jci.Insight.89574  0.329
2017 Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, ... Walker BD, et al. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Science Translational Medicine. 9. PMID 28100831 DOI: 10.1126/Scitranslmed.Aal2144  0.414
2017 Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, ... Walker BD, et al. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. PMID 28087240 DOI: 10.1016/J.Immuni.2016.12.013  0.38
2017 Laher F, Ranasinghe S, Porichis F, Mewalal N, Pretorius K, Ismail N, Buus S, Stryhn A, Carrington M, Walker BD, Ndung'u T, Ndhlovu ZM. HIV controllers exhibit enhanced frequencies of MHC class II tetramer+ Gag-specific CD4+ T cells in chronic clade C HIV-1 infection. Journal of Virology. PMID 28077659 DOI: 10.1128/Jvi.02477-16  0.551
2017 Flerin NC, Chen H, Glover TD, Lamothe PA, Zheng JH, Fang JW, Ndhlovu ZM, Newell EW, Davis MM, Walker BD, Goldstein H. TCR Clonotype-specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T Cell Clones is Not Mediated by TCR Alone. Journal of Virology. PMID 28077649 DOI: 10.1128/Jvi.02412-16  0.521
2016 Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, ... Walker BD, et al. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nature Genetics. PMID 27992415 DOI: 10.1038/Ng.3741  0.399
2016 Palmer CD, Romero-Tejeda M, Scully EP, Lockhart A, Seaman MS, Goldenthal A, Piechocka-Trocha A, Walker BD, Chibnik LB, Jost S, Porichis F. Increased frequencies of CD8(+)CD57(+) T cells are associated with antibody neutralization breadth against HIV in viraemic controllers. Journal of the International Aids Society. 19: 21136. PMID 27938646 DOI: 10.7448/IAS.19.1.21136  0.482
2016 Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ. Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 117: 44-53. PMID 27936416 DOI: 10.1016/J.Biomaterials.2016.11.048  0.337
2016 Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, ... Walker BD, et al. Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Immunity. 45: 917-930. PMID 27760342 DOI: 10.1016/J.Immuni.2016.09.015  0.518
2016 Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, ... Walker BD, et al. Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. Science Translational Medicine. 8: 358ra125. PMID 27683550 DOI: 10.1126/scitranslmed.aag1048  0.442
2016 Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? Pathogens & Immunity. 1: 154-164. PMID 27668293 DOI: 10.20411/pai.v1i1.133  0.326
2016 Gaiha GD, Walker BD. CD8(+) T Cells and cART: A Dynamic Duo? Immunity. 45: 466-8. PMID 27653598 DOI: 10.1016/j.immuni.2016.09.003  0.371
2016 Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JH. Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection. Protein & Cell. PMID 27638468 DOI: 10.1007/S13238-016-0309-Y  0.444
2016 Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado GG, Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals. Cell Host & Microbe. PMID 27545045 DOI: 10.1016/J.Chom.2016.07.015  0.461
2016 Sips M, Liu Q, Draghi M, Ghebremichael M, Berger CT, Suscovich TJ, Sun Y, Walker BD, Carrington M, Altfeld M, Brouckaert P, De Jager PL, Alter G. HLA-C levels impact natural killer cell subset distribution and function. Human Immunology. PMID 27521484 DOI: 10.1016/J.Humimm.2016.08.004  0.42
2016 Rucevic M, Kourjian G, Boucau J, Blatnik R, Garcia Bertran W, Berberich MJ, Walker BD, Riemer AB, Le Gall S. MHC-bound HIV Peptides Identified from Various Cell Types Reveal Common Nested Peptides and Novel T Cell Responses. Journal of Virology. PMID 27440904 DOI: 10.1128/JVI.00599-16  0.466
2016 Shasha D, Karel D, Angiuli O, Greenblatt A, Ghebremichael M, Yu X, Porichis F, Walker BD. Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors. Journal of Leukocyte Biology. PMID 27406996 DOI: 10.1189/jlb.4A0915-422R  0.409
2016 Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, ... Walker BD, et al. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature. PMID 27338952 DOI: 10.1038/Nature18929  0.345
2016 Barton JP, Goonetilleke N, Butler TC, Walker BD, McMichael AJ, Chakraborty AK. Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable. Nature Communications. 7: 11660. PMID 27212475 DOI: 10.1038/Ncomms11660  0.353
2016 Koofhethile CK, Ndhlovu ZM, Thobakgale-Tshabalala C, Prado JG, Ismail N, Mncube Z, Mkhize L, van der Stok M, Yende N, Walker BD, Goulder PJ, Ndung'u T. CD8+ T cell breadth and ex vivo virus inhibition capacity distinguish between viremic controllers with and without protective HLA class I alleles. Journal of Virology. PMID 27194762 DOI: 10.1128/Jvi.00276-16  0.555
2016 Apps R, Del Prete GQ, Chatterjee P, Lara A, Brumme ZL, Brockman MA, Neil S, Pickering S, Schneider DK, Piechocka-Trocha A, Walker BD, Thomas R, Shaw GM, Hahn BH, Keele BF, et al. HIV-1 Vpu Mediates HLA-C Downregulation. Cell Host & Microbe. 19: 686-95. PMID 27173934 DOI: 10.1016/J.Chom.2016.04.005  0.512
2016 Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, ... Walker BD, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. Plos Pathogens. 12: e1005545. PMID 27082643 DOI: 10.1371/Journal.Ppat.1005545  0.455
2016 Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, ... Walker BD, et al. Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. PMID 27007847 DOI: 10.1038/Nature17642  0.309
2016 Gunn BM, Schneider JR, Shansab M, Bastian AR, Fahrbach KM, Smith AD, Mahan AE, Karim MM, Licht AF, Zvonar I, Tedesco J, Anderson MR, Chapel A, Suscovich TJ, Malaspina DC, ... Walker BD, et al. Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16. Mucosal Immunology. PMID 26960182 DOI: 10.1038/Mi.2016.8  0.371
2016 Leitman EM, Hurst J, Mori M, Kublin J, Ndung'u T, Walker BD, Carlson J, Gray GE, Matthews PC, Frahm N, Goulder PJ. Lower Viral Loads and Slower CD4 Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02. The Journal of Infectious Diseases. PMID 26951820 DOI: 10.1093/infdis/jiw093  0.562
2016 Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS, McGuire HM, Bothwell M, Vagefi PA, Scully E, ... Walker BD, et al. CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26908875 DOI: 10.1073/Pnas.1520112113  0.421
2016 Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Ndhlovu Z, Yadon MC, Nhamoyebonde S, Muenchhoff M, Simoni Y, Andersson F, Kuhn W, Garrett N, Burgers WA, Kamya P, ... Walker BD, et al. Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity. PMID 26850658 DOI: 10.1016/J.Immuni.2016.01.006  0.352
2016 Mahiti M, Toyoda M, Jia X, Kuang XT, Mwimanzi F, Mwimanzi P, Walker BD, Xiong Y, Brumme ZL, Brockman MA, Ueno T. Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences. Mbio. 7. PMID 26787826 DOI: 10.1128/Mbio.01516-15  0.572
2016 Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G. Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control. Plos Pathogens. 12: e1005315. PMID 26745376 DOI: 10.1371/Journal.Ppat.1005315  0.36
2016 Jones RB, Walker BD. HIV-specific CD8+ T cells and HIV eradication. The Journal of Clinical Investigation. 1-9. PMID 26731469 DOI: 10.1172/JCI80566  0.477
2015 Byrne EH, Anahtar MN, Cohen KE, Moodley A, Padavattan N, Ismail N, Bowman BA, Olson GS, Mabhula A, Leslie A, Ndung'u T, Walker BD, Ghebremichael MS, Dong KL, Kwon DS. Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study. The Lancet. Infectious Diseases. PMID 26723758 DOI: 10.1016/S1473-3099(15)00429-6  0.322
2015 Alsahafi N, Ding S, Richard J, Markle T, Brassard N, Walker B, Lewis GK, Kaufmann DE, Brockman MA, Finzi A. Nef proteins from HIV-1 elite controllers are inefficient at preventing ADCC. Journal of Virology. PMID 26719277 DOI: 10.1128/Jvi.02973-15  0.447
2015 Ranasinghe S, Soghoian DZ, Lindqvist M, Ghebremichael M, Donaghey F, Carrington M, Seaman MS, Kaufmann DE, Walker BD, Porichis F. HIV-1 antibody neutralization breadth is associated with enhanced HIV-specific CD4+ T cell responses. Journal of Virology. PMID 26656715 DOI: 10.1128/JVI.02278-15  0.494
2015 Heesters BA, Lindqvist M, Vagefi PA, Scully EP, Schildberg FA, Altfeld M, Walker BD, Kaufmann DE, Carroll MC. Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes. Plos Pathogens. 11: e1005285. PMID 26623655 DOI: 10.1371/journal.ppat.1005285  0.449
2015 Hölzemer A, Thobakgale CF, Jimenez Cruz CA, Garcia-Beltran WF, Carlson JM, van Teijlingen NH, Mann JK, Jaggernath M, Kang SG, Körner C, Chung AW, Schafer JL, Evans DT, Alter G, Walker BD, et al. Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa. Plos Medicine. 12: e1001900. PMID 26575988 DOI: 10.1371/Journal.Pmed.1001900  0.43
2015 Kinloch NN, MacMillan DR, Le AQ, Cotton LA, Bangsberg DR, Buchbinder S, Carrington M, Fuchs J, Harrigan PR, Koblin B, Kushel M, Markowitz M, Mayer K, Milloy MJ, Schechter MT, ... ... Walker BD, et al. Population-level Immune-mediated Adaptation in HIV-1 Polymerase during the North American Epidemic. Journal of Virology. PMID 26559841 DOI: 10.1128/JVI.02353-15  0.45
2015 McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, ... ... Walker BD, et al. Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553974 DOI: 10.1073/Pnas.1514867112  0.388
2015 Freund NT, Horwitz JA, Nogueira L, Sievers SA, Scharf L, Scheid JF, Gazumyan A, Liu C, Velinzon K, Goldenthal A, Sanders RW, Moore JP, Bjorkman PJ, Seaman MS, Walker BD, et al. A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. Plos Pathogens. 11: e1005238. PMID 26516768 DOI: 10.1371/Journal.Ppat.1005238  0.324
2015 Gandhi RT, Kwon DS, Macklin EA, Shopis JR, McLean AP, McBrine N, Theresa Flynn AN, Peter L, Sbrolla A, Kaufmann DE, Porichis F, Walker BD, Bhardwaj N, Barouch DH, Kavanagh DG. Immunization of HIV-1-infected Persons with Autologous Dendritic Cells Transfected with mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 26379068 DOI: 10.1097/Qai.0000000000000852  0.392
2015 Ndhlovu ZM, Kamya P, Mewalal N, Kløverpris HN, Nkosi T, Pretorius K, Laher F, Ogunshola F, Chopera D, Shekhar K, Ghebremichael M, Ismail N, Moodley A, Malik A, Leslie A, ... ... Walker BD, et al. Magnitude and Kinetics of CD8(+) T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity. 43: 591-604. PMID 26362266 DOI: 10.1016/J.Immuni.2015.08.012  0.486
2015 Ndhlovu ZM, Stampouloglou E, Cesa K, Mavrothalassitis O, Alvino DM, Li JZ, Wilton S, Karel D, Piechocka-Trocha A, Chen H, Pereyra F, Walker BD. The breadth of expandable memory CD8+ T cells inversely correlates with residual viral loads in HIV elite controllers. Journal of Virology. PMID 26269189 DOI: 10.1128/Jvi.01527-15  0.408
2015 Toyoda M, Ogata Y, Mahiti M, Maeda Y, Kuang XT, Miura T, Jessen H, Walker BD, Brockman MA, Brumme ZL, Ueno T. Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors. Journal of Virology. 89: 9639-52. PMID 26178998 DOI: 10.1128/Jvi.01548-15  0.391
2015 Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, et al. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nature Communications. 6: 7562. PMID 26108174 DOI: 10.1038/Ncomms8562  0.305
2015 Adland E, Paioni P, Thobakgale C, Laker L, Mori L, Muenchhoff M, Csala A, Clapson M, Flynn J, Novelli V, Hurst J, Naidoo V, Shapiro R, Huang KH, Frater J, ... ... Walker BD, et al. Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection. Plos Pathogens. 11: e1004954. PMID 26076345 DOI: 10.1371/journal.ppat.1004954  0.434
2015 Martin-Gayo E, Buzon MJ, Ouyang Z, Hickman T, Cronin J, Pimenova D, Walker BD, Lichterfeld M, Yu XG. Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers. Plos Pathogens. 11: e1004930. PMID 26067651 DOI: 10.1371/journal.ppat.1004930  0.474
2015 Vigano S, Negron J, Ouyang Z, Rosenberg ES, Walker BD, Lichterfeld M, Yu XG. Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties. Journal of Virology. 89: 7829-40. PMID 25995260 DOI: 10.1128/JVI.00789-15  0.469
2015 Kløverpris HN, McGregor R, McLaren JE, Ladell K, Harndahl M, Stryhn A, Carlson JM, Koofhethile C, Gerritsen B, Ke?mir C, Chen F, Riddell L, Luzzi G, Leslie A, Walker BD, et al. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 5329-45. PMID 25911754 DOI: 10.4049/jimmunol.1400854  0.541
2015 Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, ... ... Walker BD, et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 522: 487-91. PMID 25855300 DOI: 10.1038/Nature14411  0.38
2015 Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, Mueller B, Haller C, Walker BD, Kirchhoff F, Brumme ZL, Ueno T, Fackler OT. Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. Plos One. 10: e0120434. PMID 25793728 DOI: 10.1371/Journal.Pone.0120434  0.452
2015 Gounder K, Padayachi N, Mann JK, Radebe M, Mokgoro M, van der Stok M, Mkhize L, Mncube Z, Jaggernath M, Reddy T, Walker BD, Ndung'u T. High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection. Plos One. 10: e0119886. PMID 25781986 DOI: 10.1371/journal.pone.0119886  0.434
2015 Kikuchi T, Iwabu Y, Tada T, Kawana-Tachikawa A, Koga M, Hosoya N, Nomura S, Brumme ZL, Jessen H, Pereyra F, Trocha A, Walker BD, Iwamoto A, Tokunaga K, Miura T. Anti-APOBEC3G activity of HIV-1 Vif protein is attenuated in elite controllers. Journal of Virology. 89: 4992-5001. PMID 25717111 DOI: 10.1128/JVI.03464-14  0.41
2015 Cohn LB, Silva IT, Oliveira TY, Rosales RA, Parrish EH, Learn GH, Hahn BH, Czartoski JL, McElrath MJ, Lehmann C, Klein F, Caskey M, Walker BD, Siliciano JD, Siliciano RF, et al. HIV-1 integration landscape during latent and active infection. Cell. 160: 420-32. PMID 25635456 DOI: 10.1016/J.Cell.2015.01.020  0.457
2015 Radebe M, Gounder K, Mokgoro M, Ndhlovu ZM, Mncube Z, Mkhize L, van der Stok M, Jaggernath M, Walker BD, Ndung'u T. Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection. Aids (London, England). 29: 23-33. PMID 25387316 DOI: 10.1097/Qad.0000000000000508  0.471
2014 Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, ... ... Walker BD, et al. Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity. 41: 1001-12. PMID 25526311 DOI: 10.1016/J.Immuni.2014.12.011  0.45
2014 Payne R, Muenchhoff M, Mann J, Roberts HE, Matthews P, Adland E, Hempenstall A, Huang KH, Brockman M, Brumme Z, Sinclair M, Miura T, Frater J, Essex M, Shapiro R, ... Walker BD, et al. Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence. Proceedings of the National Academy of Sciences of the United States of America. 111: E5393-400. PMID 25453107 DOI: 10.1073/Pnas.1413339111  0.447
2014 Mann JK, Chopera D, Omarjee S, Kuang XT, Le AQ, Anmole G, Danroth R, Mwimanzi P, Reddy T, Carlson J, Radebe M, Goulder PJ, Walker BD, Abdool Karim S, Novitsky V, et al. Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure. Virology. 468: 214-25. PMID 25193656 DOI: 10.1016/J.Virol.2014.08.009  0.491
2014 Pereyra F, Heckerman D, Carlson JM, Kadie C, Soghoian DZ, Karel D, Goldenthal A, Davis OB, DeZiel CE, Lin T, Peng J, Piechocka A, Carrington M, Walker BD. HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes. Journal of Virology. 88: 12937-48. PMID 25165115 DOI: 10.1128/Jvi.01004-14  0.504
2014 Jones RB, O'Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. Plos Pathogens. 10: e1004287. PMID 25122219 DOI: 10.1371/Journal.Ppat.1004287  0.47
2014 Kuang XT, Li X, Anmole G, Mwimanzi P, Shahid A, Le AQ, Chong L, Qian H, Miura T, Markle T, Baraki B, Connick E, Daar ES, Jessen H, Kelleher AD, ... ... Walker BD, et al. Impaired Nef function is associated with early control of HIV-1 viremia. Journal of Virology. 88: 10200-13. PMID 24965469 DOI: 10.1128/Jvi.01334-14  0.457
2014 Buzon MJ, Martin-Gayo E, Pereyra F, Ouyang Z, Sun H, Li JZ, Piovoso M, Shaw A, Dalmau J, Zangger N, Martinez-Picado J, Zurakowski R, Yu XG, Telenti A, Walker BD, et al. Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells. Journal of Virology. 88: 10056-65. PMID 24965451 DOI: 10.1128/Jvi.01046-14  0.407
2014 Leng J, Ho HP, Buzon MJ, Pereyra F, Walker BD, Yu XG, Chang EJ, Lichterfeld M. A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers. Cell Host & Microbe. 15: 717-28. PMID 24922574 DOI: 10.1016/j.chom.2014.05.011  0.383
2014 Cotton LA, Kuang XT, Le AQ, Carlson JM, Chan B, Chopera DR, Brumme CJ, Markle TJ, Martin E, Shahid A, Anmole G, Mwimanzi P, Nassab P, Penney KA, Rahman MA, ... ... Walker BD, et al. Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic. Plos Genetics. 10: e1004295. PMID 24762668 DOI: 10.1371/Journal.Pgen.1004295  0.399
2014 Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MM. HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. The Journal of Infectious Diseases. 210: 899-903. PMID 24664171 DOI: 10.1093/infdis/jiu188  0.455
2014 Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, Gao X, Burke PS, Taylor CJ, Rogich J, Wolinsky S, Bream JH, Duggal P, Hussain S, Martinson J, Weintrob A, ... ... Walker BD, et al. LILRB2 interaction with HLA class I correlates with control of HIV-1 infection. Plos Genetics. 10: e1004196. PMID 24603468 DOI: 10.1371/Journal.Pgen.1004196  0.524
2014 Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JC. Profiling human antibody responses by integrated single-cell analysis. Vaccine. 32: 2866-73. PMID 24602776 DOI: 10.1016/J.Vaccine.2014.02.020  0.376
2014 Kay MA, Walker BD. Engineering cellular resistance to HIV. The New England Journal of Medicine. 370: 968-9. PMID 24597871 DOI: 10.1056/Nejme1400593  0.417
2014 Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, Irvine DJ. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. Plos One. 9: e87873. PMID 24551068 DOI: 10.1371/Journal.Pone.0087873  0.455
2014 Xia Z, Chen H, Kang SG, Huynh T, Fang JW, Lamothe PA, Walker BD, Zhou R. The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function. Scientific Reports. 4: 4087. PMID 24522437 DOI: 10.1038/srep04087  0.398
2014 Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, et al. HIV-1 persistence in CD4+ T cells with stem cell-like properties. Nature Medicine. 20: 139-42. PMID 24412925 DOI: 10.1038/Nm.3445  0.416
2014 Kløverpris HN, Adland E, Koyanagi M, Stryhn A, Harndahl M, Matthews PC, Shapiro R, Walker BD, Ndung'u T, Brander C, Takiguchi M, Buus S, Goulder P. HIV subtype influences HLA-B*07:02-associated HIV disease outcome. Aids Research and Human Retroviruses. 30: 468-75. PMID 24010680 DOI: 10.1089/AID.2013.0197  0.54
2013 Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO. Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. Plos One. 8: e83474. PMID 24391773 DOI: 10.1371/Journal.Pone.0083474  0.434
2013 Kulkarni S, Qi Y, O'hUigin C, Pereyra F, Ramsuran V, McLaren P, Fellay J, Nelson G, Chen H, Liao W, Bass S, Apps R, Gao X, Yuki Y, Lied A, ... ... Walker BD, et al. Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease. Proceedings of the National Academy of Sciences of the United States of America. 110: 20705-10. PMID 24248364 DOI: 10.1073/pnas.1312237110  0.357
2013 Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS, Addo MM, Rychert J, Routy JP, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Carrington M, Walker BD, et al. Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. Retrovirology. 10: 139. PMID 24245727 DOI: 10.1186/1742-4690-10-139  0.452
2013 Kløverpris HN, Jackson A, Handley A, Hayes P, Gilmour J, Riddell L, Chen F, Atkins M, Boffito M, Walker BD, Ackland J, Sullivan M, Goulder P. Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals. Plos One. 8: e74389. PMID 24124451 DOI: 10.1371/journal.pone.0074389  0.488
2013 Jackson A, Kløverpris HN, Boffito M, Handley A, Atkins M, Hayes P, Gilmour J, Riddel L, Chen F, Bailey-Tippets M, Walker B, Ackland J, Sullivan M, Goulder P. A randomised, placebo-controlled, first-in-human study of a novel clade C therapeutic peptide vaccine administered ex vivo to autologous white blood cells in HIV infected individuals. Plos One. 8: e73765. PMID 24069230 DOI: 10.1371/Journal.Pone.0073765  0.342
2013 Mann JK, Byakwaga H, Kuang XT, Le AQ, Brumme CJ, Mwimanzi P, Omarjee S, Martin E, Lee GQ, Baraki B, Danroth R, McCloskey R, Muzoora C, Bangsberg DR, Hunt PW, ... ... Walker BD, et al. Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. Retrovirology. 10: 100. PMID 24041011 DOI: 10.1186/1742-4690-10-100  0.459
2013 Adland E, Carlson JM, Paioni P, Kløverpris H, Shapiro R, Ogwu A, Riddell L, Luzzi G, Chen F, Balachandran T, Heckerman D, Stryhn A, Edwards A, Ndung'u T, Walker BD, et al. Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. Plos One. 8: e73117. PMID 24023819 DOI: 10.1371/journal.pone.0073117  0.597
2013 McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, ... ... Walker BD, et al. Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. Plos Pathogens. 9: e1003515. PMID 23935489 DOI: 10.1371/Journal.Ppat.1003515  0.341
2013 Kløverpris HN, Stryhn A, Harndahl M, Payne R, Towers GJ, Chen F, Riddell L, Walker BD, Ndung'u T, Leslie A, Buus S, Goulder P. HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01. Journal of Virology. 87: 10889-94. PMID 23864640 DOI: 10.1128/JVI.01122-13  0.525
2013 Shasha D, Walker BD. Lessons to be Learned from Natural Control of HIV - Future Directions, Therapeutic, and Preventive Implications. Frontiers in Immunology. 4: 162. PMID 23805139 DOI: 10.3389/fimmu.2013.00162  0.473
2013 Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nature Reviews. Immunology. 13: 487-98. PMID 23797064 DOI: 10.1038/nri3478  0.402
2013 Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, et al. Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control. Nature Medicine. 19: 930-3. PMID 23793098 DOI: 10.1038/Nm.3229  0.561
2013 Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, et al. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 191: 540-4. PMID 23772031 DOI: 10.4049/Jimmunol.1203161  0.388
2013 Koff WC, Russell ND, Walport M, Feinberg MB, Shiver JW, Karim SA, Walker BD, McGlynn MG, Nweneka CV, Nabel GJ. Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines. Vaccine. 31: B204-8. PMID 23598483 DOI: 10.1016/J.Vaccine.2012.10.115  0.382
2013 Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, ... ... Walker B, et al. Influence of HLA-C expression level on HIV control. Science (New York, N.Y.). 340: 87-91. PMID 23559252 DOI: 10.1126/Science.1232685  0.404
2013 Kløverpris HN, Stryhn A, Harndahl M, Carlson JM, Leslie AJ, Chen F, Riddell L, Mulenga J, Walker BD, Ndung'u T, Buus S, Goulder P. HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective. Aids (London, England). 27: 1717-23. PMID 23525031 DOI: 10.1097/QAD.0b013e32836146cd  0.501
2013 Ferguson AL, Mann JK, Omarjee S, Ndung'u T, Walker BD, Chakraborty AK. Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design. Immunity. 38: 606-17. PMID 23521886 DOI: 10.1016/J.Immuni.2012.11.022  0.327
2013 Mwimanzi P, Markle TJ, Ogata Y, Martin E, Tokunaga M, Mahiti M, Kuang XT, Walker BD, Brockman MA, Brumme ZL, Ueno T. Dynamic range of Nef functions in chronic HIV-1 infection. Virology. 439: 74-80. PMID 23490051 DOI: 10.1016/J.Virol.2013.02.005  0.355
2013 Mwimanzi P, Markle TJ, Martin E, Ogata Y, Kuang XT, Tokunaga M, Mahiti M, Pereyra F, Miura T, Walker BD, Brumme ZL, Brockman MA, Ueno T. Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology. 10: 1. PMID 23289738 DOI: 10.1186/1742-4690-10-1  0.408
2013 Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, ... ... Walker BD, et al. High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. Blood. 121: 801-11. PMID 23233659 DOI: 10.1182/Blood-2012-06-436295  0.469
2012 Matthews PC, Listgarten J, Carlson JM, Payne R, Huang KH, Frater J, Goedhals D, Steyn D, van Vuuren C, Paioni P, Jooste P, Ogwu A, Shapiro R, Mncube Z, Ndung'u T, ... Walker BD, et al. Co-operative additive effects between HLA alleles in control of HIV-1. Plos One. 7: e47799. PMID 23094091 DOI: 10.1371/journal.pone.0047799  0.453
2012 Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, et al. A Blueprint for HIV Vaccine Discovery. Cell Host & Microbe. 12: 396-407. PMID 23084910 DOI: 10.1016/J.Chom.2012.09.008  0.387
2012 Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Reports. 2: 807-16. PMID 23041316 DOI: 10.1016/J.Celrep.2012.09.008  0.373
2012 Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, et al. Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness. Journal of Virology. 86: 13423-33. PMID 23015721 DOI: 10.1128/Jvi.02171-12  0.382
2012 Walker B, McMichael A. The T-cell response to HIV. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23002014 DOI: 10.1101/Cshperspect.A007054  0.486
2012 Goulder PJ, Walker BD. HIV and HLA class I: an evolving relationship. Immunity. 37: 426-40. PMID 22999948 DOI: 10.1016/j.immuni.2012.09.005  0.489
2012 Matthews PC, Koyanagi M, Kløverpris HN, Harndahl M, Stryhn A, Akahoshi T, Gatanaga H, Oka S, Juarez Molina C, Valenzuela Ponce H, Avila Rios S, Cole D, Carlson J, Payne RP, Ogwu A, ... ... Walker B, et al. Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope. Journal of Virology. 86: 12643-54. PMID 22973023 DOI: 10.1128/Jvi.01381-12  0.582
2012 Kløverpris HN, Harndahl M, Leslie AJ, Carlson JM, Ismail N, van der Stok M, Huang KH, Chen F, Riddell L, Steyn D, Goedhals D, van Vuuren C, Frater J, Walker BD, Carrington M, et al. HIV control through a single nucleotide on the HLA-B locus. Journal of Virology. 86: 11493-500. PMID 22896606 DOI: 10.1128/JVI.01020-12  0.51
2012 Angin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM. Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. Aids (London, England). 26: 2112-5. PMID 22874519 DOI: 10.1097/Qad.0B013E328358Cc75  0.525
2012 Klein F, Gaebler C, Mouquet H, Sather DN, Lehmann C, Scheid JF, Kraft Z, Liu Y, Pietzsch J, Hurley A, Poignard P, Feizi T, Morris L, Walker BD, Fätkenheuer G, et al. Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein. The Journal of Experimental Medicine. 209: 1469-79. PMID 22826297 DOI: 10.1084/Jem.20120423  0.4
2012 Walker B. "Elite controllers" provide clues to keeping HIV infection in check. Interview by Tracy Hampton. Jama. 308: 328-9. PMID 22820769 DOI: 10.1001/jama.2012.8463  0.335
2012 Walker BD. Secrets of the HIV controllers: A rare group of HIV-positive individuals need no medicine to keep the virus in check. Their good fortune could point the way to more powerful treatments--and perhaps a vaccine. Scientific American. 307: 44-51. PMID 22779271  0.323
2012 McElrath MJ, Walker BD. Is an HIV vaccine possible? Journal of Acquired Immune Deficiency Syndromes (1999). 60: S41-3. PMID 22772390 DOI: 10.1097/QAI.0b013e31825b7118  0.436
2012 Stephenson KE, Li H, Walker BD, Michael NL, Barouch DH. Gag-specific cellular immunity determines in vitro viral inhibition and in vivo virologic control following simian immunodeficiency virus challenges of vaccinated rhesus monkeys. Journal of Virology. 86: 9583-9. PMID 22761379 DOI: 10.1128/JVI.00996-12  0.379
2012 McLaren PJ, Ripke S, Pelak K, Weintrob AC, Patsopoulos NA, Jia X, Erlich RL, Lennon NJ, Kadie CM, Heckerman D, Gupta N, Haas DW, Deeks SG, Pereyra F, Walker BD, et al. Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. Human Molecular Genetics. 21: 4334-47. PMID 22718199 DOI: 10.1093/Hmg/Dds226  0.48
2012 Mitchell JE, Chetty S, Govender P, Pillay M, Jaggernath M, Kasmar A, Ndung'u T, Klenerman P, Walker BD, Kasprowicz VO. Prospective monitoring reveals dynamic levels of T cell immunity to Mycobacterium tuberculosis in HIV infected individuals. Plos One. 7: e37920. PMID 22685549 DOI: 10.1371/journal.pone.0037920  0.317
2012 Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, ... ... Walker BD, et al. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nature Immunology. 13: 691-700. PMID 22683743 DOI: 10.1038/Ni.2342  0.565
2012 Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, et al. Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals. Journal of Immunology (Baltimore, Md. : 1950). 188: 5924-34. PMID 22586036 DOI: 10.4049/Jimmunol.1200219  0.443
2012 Ndhlovu ZM, Proudfoot J, Cesa K, Alvino DM, McMullen A, Vine S, Stampouloglou E, Piechocka-Trocha A, Walker BD, Pereyra F. Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. Journal of Virology. 86: 6959-69. PMID 22514340 DOI: 10.1128/Jvi.00531-12  0.475
2012 Brockman MA, Chopera DR, Olvera A, Brumme CJ, Sela J, Markle TJ, Martin E, Carlson JM, Le AQ, McGovern R, Cheung PK, Kelleher AD, Jessen H, Markowitz M, Rosenberg E, ... ... Walker BD, et al. Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity. Journal of Virology. 86: 6913-23. PMID 22496233 DOI: 10.1128/Jvi.07133-11  0.449
2012 Thobakgale CF, Fadda L, Lane K, Toth I, Pereyra F, Bazner S, Ndung'u T, Walker BD, Rosenberg ES, Alter G, Carrington M, Allen TM, Altfeld M. Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. Journal of Virology. 86: 6986-93. PMID 22496218 DOI: 10.1128/Jvi.00569-12  0.458
2012 Li JZ, Brumme CJ, Lederman MM, Brumme ZL, Wang H, Spritzler J, Carrington M, Medvik K, Walker BD, Schooley RT, Kuritzkes DR. Characteristics and outcomes of initial virologic suppressors during analytic treatment interruption in a therapeutic HIV-1 gag vaccine trial. Plos One. 7: e34134. PMID 22479542 DOI: 10.1371/Journal.Pone.0034134  0.342
2012 Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, Law K, Hongo TC, Pyo A, Piechocka-Trocha A, Toth I, Pereyra F, Ghebremichael M, Rodig SJ, Milner DA, ... ... Walker BD, et al. Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. The Journal of Infectious Diseases. 205: 1495-500. PMID 22427677 DOI: 10.1093/infdis/jis236  0.42
2012 Henn MR, Boutwell CL, Charlebois P, Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S, Zody MC, Erlich RL, Green LM, Berical A, Wang Y, ... ... Walker BD, et al. Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. Plos Pathogens. 8: e1002529. PMID 22412369 DOI: 10.1371/Journal.Ppat.1002529  0.421
2012 Carlson JM, Listgarten J, Pfeifer N, Tan V, Kadie C, Walker BD, Ndung'u T, Shapiro R, Frater J, Brumme ZL, Goulder PJ, Heckerman D. Widespread impact of HLA restriction on immune control and escape pathways of HIV-1. Journal of Virology. 86: 5230-43. PMID 22379086 DOI: 10.1128/JVI.06728-11  0.481
2012 Soghoian DZ, Jessen H, Flanders M, Sierra-Davidson K, Cutler S, Pertel T, Ranasinghe S, Lindqvist M, Davis I, Lane K, Rychert J, Rosenberg ES, Piechocka-Trocha A, Brass AL, Brenchley JM, ... Walker BD, et al. HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome. Science Translational Medicine. 4: 123ra25. PMID 22378925 DOI: 10.1126/scitranslmed.3003165  0.482
2012 Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proceedings of the National Academy of Sciences of the United States of America. 109: 3885-90. PMID 22355106 DOI: 10.1073/Pnas.1111205109  0.433
2012 Julg B, Poole D, Ghebremichael M, Castilla C, Altfeld M, Sunpath H, Murphy RA, Walker BD. Factors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa. Plos One. 7: e31161. PMID 22348047 DOI: 10.1371/journal.pone.0031161  0.355
2012 Jia M, Hong K, Chen J, Ruan Y, Wang Z, Su B, Ren G, Zhang X, Liu Z, Zhao Q, Li D, Peng H, Altfeld M, Walker BD, Yu XG, et al. Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China. Cell Research. 22: 903-14. PMID 22290423 DOI: 10.1038/cr.2012.19  0.495
2012 Carrington M, Walker BD. Immunogenetics of spontaneous control of HIV. Annual Review of Medicine. 63: 131-45. PMID 22248321 DOI: 10.1146/annurev-med-062909-130018  0.37
2012 Mothe B, Llano A, Ibarrondo J, Zamarreño J, Schiaulini M, Miranda C, Ruiz-Riol M, Berger CT, Herrero MJ, Palou E, Plana M, Rolland M, Khatri A, Heckerman D, Pereyra F, ... Walker BD, et al. CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control. Plos One. 7: e29717. PMID 22238642 DOI: 10.1371/Journal.Pone.0029717  0.489
2012 Angin M, Streeck H, Wen F, King M, Pereyra F, Altfeld M, Walker BD, Addo MM. Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses. Aids Research and Human Retroviruses. 28: 749-51. PMID 22214208 DOI: 10.1089/AID.2011.0353  0.427
2012 Chang JJ, Lacas A, Lindsay RJ, Doyle EH, Axten KL, Pereyra F, Rosenberg ES, Walker BD, Allen TM, Altfeld M. Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection. Aids (London, England). 26: 533-41. PMID 22210629 DOI: 10.1097/Qad.0B013E32834F3167  0.388
2012 Wright JK, Brumme ZL, Julg B, van der Stok M, Mncube Z, Gao X, Carlson JM, Goulder PJ, Walker BD, Brockman MA, Ndung'u T. Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. Journal of Virology. 86: 1273-6. PMID 22090116 DOI: 10.1128/Jvi.06533-11  0.484
2012 Kloverpris HN, Stryhn A, Harndahl M, van der Stok M, Payne RP, Matthews PC, Chen F, Riddell L, Walker BD, Ndung'u T, Buus S, Goulder P. HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control. Journal of Virology. 86: 919-29. PMID 22090105 DOI: 10.1128/JVI.06150-11  0.564
2012 Ranasinghe S, Flanders M, Cutler S, Soghoian DZ, Ghebremichael M, Davis I, Lindqvist M, Pereyra F, Walker BD, Heckerman D, Streeck H. HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome. Journal of Virology. 86: 277-83. PMID 22031937 DOI: 10.1128/JVI.05577-11  0.53
2011 Mothe B, Llano A, Ibarrondo J, Daniels M, Miranda C, Zamarreño J, Bach V, Zuniga R, Pérez-Álvarez S, Berger CT, Puertas MC, Martinez-Picado J, Rolland M, Farfan M, Szinger JJ, ... ... Walker BD, et al. Definition of the viral targets of protective HIV-1-specific T cell responses. Journal of Translational Medicine. 9: 208. PMID 22152067 DOI: 10.1186/1479-5876-9-208  0.499
2011 Walker BD, Ahmed R, Plotkin S. Moving ahead an HIV vaccine: use both arms to beat HIV. Nature Medicine. 17: 1194-5. PMID 21988996 DOI: 10.1038/Nm.2529  0.425
2011 Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JC. A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis. The Journal of Clinical Investigation. 121: 4322-31. PMID 21965332 DOI: 10.1172/Jci58653  0.461
2011 Buranapraditkun S, Hempel U, Pitakpolrat P, Allgaier RL, Thantivorasit P, Lorenzen SI, Sirivichayakul S, Hildebrand WH, Altfeld M, Brander C, Walker BD, Phanuphak P, Hansasuta P, Rowland-Jones SL, Allen TM, et al. A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais. Plos One. 6: e23603. PMID 21887282 DOI: 10.1371/Journal.Pone.0023603  0.505
2011 Kasprowicz VO, Mitchell JE, Chetty S, Govender P, Huang KH, Fletcher HA, Webster DP, Brown S, Kasmar A, Millington K, Day CL, Mkhwanazi N, McClurg C, Chonco F, Lalvani A, ... Walker BD, et al. A molecular assay for sensitive detection of pathogen-specific T-cells. Plos One. 6: e20606. PMID 21853018 DOI: 10.1371/journal.pone.0020606  0.328
2011 Radebe M, Nair K, Chonco F, Bishop K, Wright JK, van der Stok M, Bassett IV, Mncube Z, Altfeld M, Walker BD, Ndung'u T. Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection. The Journal of Infectious Diseases. 204: 768-76. PMID 21844303 DOI: 10.1093/infdis/jir394  0.457
2011 Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, Pietzsch J, Fenyo D, Abadir A, Velinzon K, Hurley A, Myung S, Boulad F, Poignard P, Burton DR, ... ... Walker BD, et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science (New York, N.Y.). 333: 1633-7. PMID 21764753 DOI: 10.1126/Science.1207227  0.331
2011 Berger CT, Frahm N, Price DA, Mothe B, Ghebremichael M, Hartman KL, Henry LM, Brenchley JM, Ruff LE, Venturi V, Pereyra F, Sidney J, Sette A, Douek DC, Walker BD, et al. High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control. Journal of Virology. 85: 9334-45. PMID 21752903 DOI: 10.1128/JVI.00460-11  0.532
2011 Dahirel V, Shekhar K, Pereyra F, Miura T, Artyomov M, Talsania S, Allen TM, Altfeld M, Carrington M, Irvine DJ, Walker BD, Chakraborty AK. Coordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 108: 11530-5. PMID 21690407 DOI: 10.1073/Pnas.1105315108  0.304
2011 Ndhlovu ZM, Piechocka-Trocha A, Vine S, McMullen A, Koofhethile KC, Goulder PJ, Ndung'u T, Barouch DH, Walker BD. Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 6914-24. PMID 21576505 DOI: 10.4049/Jimmunol.1004231  0.515
2011 Huang KH, Goedhals D, Carlson JM, Brockman MA, Mishra S, Brumme ZL, Hickling S, Tang CS, Miura T, Seebregts C, Heckerman D, Ndung'u T, Walker B, Klenerman P, Steyn D, et al. Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations. Plos One. 6: e19018. PMID 21544209 DOI: 10.1371/Journal.Pone.0019018  0.474
2011 Novitsky V, Ndung'u T, Wang R, Bussmann H, Chonco F, Makhema J, De Gruttola V, Walker BD, Essex M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. Aids (London, England). 25: 1515-22. PMID 21505307 DOI: 10.1097/QAD.0b013e3283471eb2  0.312
2011 Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, et al. Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature. 472: 495-8. PMID 21499264 DOI: 10.1038/Nature09914  0.382
2011 Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, ... ... Walker BD, et al. CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. The Journal of Clinical Investigation. 121: 1549-60. PMID 21403397 DOI: 10.1172/Jci44539  0.425
2011 Streeck H, Kwon DS, Pyo A, Flanders M, Chevalier MF, Law K, Jülg B, Trocha K, Jolin JS, Anahtar MN, Lian J, Toth I, Brumme Z, Chang JJ, Caron T, ... ... Walker BD, et al. Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions. Blood. 117: 5112-22. PMID 21403126 DOI: 10.1182/blood-2010-12-321588  0.459
2011 Li JZ, Brumme ZL, Brumme CJ, Wang H, Spritzler J, Robertson MN, Lederman MM, Carrington M, Walker BD, Schooley RT, Kuritzkes DR. Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial. The Journal of Infectious Diseases. 203: 976-83. PMID 21402549 DOI: 10.1093/Infdis/Jiq143  0.404
2011 Hersperger AR, Martin JN, Shin LY, Sheth PM, Kovacs CM, Cosma GL, Makedonas G, Pereyra F, Walker BD, Kaul R, Deeks SG, Betts MR. Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression. Blood. 117: 3799-808. PMID 21289310 DOI: 10.1182/Blood-2010-12-322727  0.486
2011 Wright JK, Novitsky V, Brockman MA, Brumme ZL, Brumme CJ, Carlson JM, Heckerman D, Wang B, Losina E, Leshwedi M, van der Stok M, Maphumulo L, Mkhwanazi N, Chonco F, Goulder PJ, ... ... Walker BD, et al. Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C. Journal of Virology. 85: 3996-4006. PMID 21289112 DOI: 10.1128/Jvi.02520-10  0.437
2011 Addo MM, Altfeld M, Brainard DM, Rathod A, Piechocka-Trocha A, Fideli U, Mulenga J, Shutes E, Alvino DM, Hunter E, Allen SA, Walker BD. Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals. The Journal of Infectious Diseases. 203: 258-62. PMID 21288826 DOI: 10.1093/Infdis/Jiq028  0.478
2011 Thobakgale CF, Streeck H, Mkhwanazi N, Mncube Z, Maphumulo L, Chonco F, Prendergast A, Tudor-Williams G, Walker BD, Goulder PJ, Altfeld M, Ndung'u T. Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection. Aids Research and Human Retroviruses. 27: 1005-12. PMID 21288139 DOI: 10.1089/AID.2010.0227  0.449
2011 Julg B, Moodley ES, Qi Y, Ramduth D, Reddy S, Mncube Z, Gao X, Goulder PJ, Detels R, Ndung'u T, Walker BD, Carrington M. Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. The Journal of Infectious Diseases. 203: 803-9. PMID 21257739 DOI: 10.1093/Infdis/Jiq122  0.543
2011 Brumme ZL, Li C, Miura T, Sela J, Rosato PC, Brumme CJ, Markle TJ, Martin E, Block BL, Trocha A, Kadie CM, Allen TM, Pereyra F, Heckerman D, Walker BD, et al. Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers. Journal of Acquired Immune Deficiency Syndromes (1999). 56: 100-8. PMID 21124229 DOI: 10.1097/Qai.0B013E3181Fe9450  0.407
2011 Chevalier MF, Jülg B, Pyo A, Flanders M, Ranasinghe S, Soghoian DZ, Kwon DS, Rychert J, Lian J, Muller MI, Cutler S, McAndrew E, Jessen H, Pereyra F, Rosenberg ES, ... ... Walker BD, et al. HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function. Journal of Virology. 85: 733-41. PMID 21047960 DOI: 10.1128/JVI.02030-10  0.435
2011 Singh R, Gaiha G, Werner L, McKim K, Mlisana K, Luban J, Walker BD, Karim SS, Brass AL, Ndung'u T. Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. Journal of Virology. 85: 208-16. PMID 20980524 DOI: 10.1128/Jvi.01810-10  0.364
2011 Mureithi MW, Cohen K, Moodley R, Poole D, Mncube Z, Kasmar A, Moody DB, Goulder PJ, Walker BD, Altfeld M, Ndung'u T. Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection. Aids Research and Human Retroviruses. 27: 501-9. PMID 20942750 DOI: 10.1089/AID.2010.0237  0.484
2011 Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, et al. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 140: 686-696.e1. PMID 20875418 DOI: 10.1053/J.Gastro.2010.09.042  0.367
2010 Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (New York, N.Y.). 330: 1551-7. PMID 21051598 DOI: 10.1126/Science.1195271  0.451
2010 Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, ... ... Walker BD, et al. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nature Medicine. 16: 1147-51. PMID 20890291 DOI: 10.1038/Nm.2232  0.39
2010 Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, et al. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 467: 591-5. PMID 20882016 DOI: 10.1038/Nature09385  0.359
2010 Rolland M, Carlson JM, Manocheewa S, Swain JV, Lanxon-Cookson E, Deng W, Rousseau CM, Raugi DN, Learn GH, Maust BS, Coovadia H, Ndung'u T, Goulder PJ, Walker BD, Brander C, et al. Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics. Plos One. 5. PMID 20824187 DOI: 10.1371/Journal.Pone.0012463  0.382
2010 Brockman MA, Brumme ZL, Brumme CJ, Miura T, Sela J, Rosato PC, Kadie CM, Carlson JM, Markle TJ, Streeck H, Kelleher AD, Markowitz M, Jessen H, Rosenberg E, Altfeld M, ... ... Walker BD, et al. Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. Journal of Virology. 84: 11937-49. PMID 20810731 DOI: 10.1128/Jvi.01086-10  0.462
2010 Honeyborne I, Codoñer FM, Leslie A, Tudor-Williams G, Luzzi G, Ndung'u T, Walker BD, Goulder PJ, Prado JG. HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation. Journal of Virology. 84: 11279-88. PMID 20739527 DOI: 10.1128/JVI.01144-10  0.551
2010 Wright JK, Brumme ZL, Carlson JM, Heckerman D, Kadie CM, Brumme CJ, Wang B, Losina E, Miura T, Chonco F, van der Stok M, Mncube Z, Bishop K, Goulder PJ, Walker BD, et al. Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters. Journal of Virology. 84: 10820-31. PMID 20702636 DOI: 10.1128/Jvi.01084-10  0.51
2010 Leslie A, Matthews PC, Listgarten J, Carlson JM, Kadie C, Ndung'u T, Brander C, Coovadia H, Walker BD, Heckerman D, Goulder PJ. Additive contribution of HLA class I alleles in the immune control of HIV-1 infection. Journal of Virology. 84: 9879-88. PMID 20660184 DOI: 10.1128/JVI.00320-10  0.488
2010 Mkhwanazi N, Thobakgale CF, van der Stok M, Reddy S, Mncube Z, Chonco F, Walker BD, Altfeld M, Goulder PJ, Ndung'u T. Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality. Virology. 405: 483-91. PMID 20638093 DOI: 10.1016/j.virol.2010.06.002  0.514
2010 Huang J, Burke PS, Cung TD, Pereyra F, Toth I, Walker BD, Borges L, Lichterfeld M, Yu XG. Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. Journal of Virology. 84: 9463-71. PMID 20631139 DOI: 10.1128/JVI.01009-10  0.434
2010 Williams K, Seiss K, Beamon J, Pereyra F, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells. Aids (London, England). 24: 1964-6. PMID 20588158 DOI: 10.1097/QAD.0b013e32833c7170  0.479
2010 Hersperger AR, Pereyra F, Nason M, Demers K, Sheth P, Shin LY, Kovacs CM, Rodriguez B, Sieg SF, Teixeira-Johnson L, Gudonis D, Goepfert PA, Lederman MM, Frank I, Makedonas G, ... ... Walker BD, et al. Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. Plos Pathogens. 6: e1000917. PMID 20523897 DOI: 10.1371/Journal.Ppat.1000917  0.513
2010 Miura T, Brumme ZL, Brockman MA, Rosato P, Sela J, Brumme CJ, Pereyra F, Kaufmann DE, Trocha A, Block BL, Daar ES, Connick E, Jessen H, Kelleher AD, Rosenberg E, ... ... Walker BD, et al. Impaired replication capacity of acute/early viruses in persons who become HIV controllers. Journal of Virology. 84: 7581-91. PMID 20504921 DOI: 10.1128/Jvi.00286-10  0.39
2010 Kosmrlj A, Read EL, Qi Y, Allen TM, Altfeld M, Deeks SG, Pereyra F, Carrington M, Walker BD, Chakraborty AK. Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature. 465: 350-4. PMID 20445539 DOI: 10.1038/Nature08997  0.612
2010 Wong AH, Williams K, Reddy S, Wilson D, Giddy J, Alter G, Ghebremichael M, Carrington MN, Ndung'u T, Walker BD, Altfeld M, Carr WH. Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults. Aids Research and Human Retroviruses. 26: 459-69. PMID 20380481 DOI: 10.1089/Aid.2009.0176  0.422
2010 Banerjee K, Klasse PJ, Sanders RW, Pereyra F, Michael E, Lu M, Walker BD, Moore JP. IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines. Aids Research and Human Retroviruses. 26: 445-58. PMID 20377426 DOI: 10.1089/aid.2009.0223  0.322
2010 Virgin HW, Walker BD. Immunology and the elusive AIDS vaccine. Nature. 464: 224-31. PMID 20220841 DOI: 10.1038/nature08898  0.332
2010 Miura T, Ngumbela K, Ramduth D, Pereyra F, Walker B. HIV controllers. Iavi Report : Newsletter On International Aids Vaccine Research. 11: 1, 7-10. PMID 20213861  0.318
2010 Spentzou A, Bergin P, Gill D, Cheeseman H, Ashraf A, Kaltsidis H, Cashin-Cox M, Anjarwalla I, Steel A, Higgs C, Pozniak A, Piechocka-Trocha A, Wong J, Anzala O, Karita E, ... ... Walker B, et al. Viral inhibition assay: a CD8 T cell neutralization assay for use in clinical trials of HIV-1 vaccine candidates. The Journal of Infectious Diseases. 201: 720-9. PMID 20132004 DOI: 10.1086/650492  0.489
2010 Bansal A, Carlson J, Yan J, Akinsiku OT, Schaefer M, Sabbaj S, Bet A, Levy DN, Heath S, Tang J, Kaslow RA, Walker BD, Ndung'u T, Goulder PJ, Heckerman D, et al. CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription. The Journal of Experimental Medicine. 207: 51-9. PMID 20065064 DOI: 10.1084/Jem.20092060  0.467
2010 Ferreira MA, Mangino M, Brumme CJ, Zhao ZZ, Medland SE, Wright MJ, Nyholt DR, Gordon S, Campbell M, McEvoy BP, Henders A, Evans DM, Lanchbury JS, Pereyra F, ... Walker BD, et al. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. American Journal of Human Genetics. 86: 88-92. PMID 20045101 DOI: 10.1016/J.Ajhg.2009.12.008  0.341
2010 Prado JG, Prendergast A, Thobakgale C, Molina C, Tudor-Williams G, Ndung'u T, Walker BD, Goulder P. Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate. Journal of Virology. 84: 492-502. PMID 19828603 DOI: 10.1128/JVI.01743-09  0.369
2009 Thomas R, Apps R, Qi Y, Gao X, Male V, O'hUigin C, O'Connor G, Ge D, Fellay J, Martin JN, Margolick J, Goedert JJ, Buchbinder S, Kirk GD, Martin MP, ... ... Walker BD, et al. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nature Genetics. 41: 1290-4. PMID 19935663 DOI: 10.1038/Ng.486  0.423
2009 Singh A, Page T, Moore PL, Allgaier RL, Hiramen K, Coovadia HM, Walker BD, Morris L, Ndung'u T. Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates. Virology. 393: 56-67. PMID 19695656 DOI: 10.1016/j.virol.2009.07.021  0.328
2009 Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, ... ... Walker BD, et al. HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. Plos One. 4: e6687. PMID 19690614 DOI: 10.1371/Journal.Pone.0006687  0.459
2009 Brumme Z, Wang B, Nair K, Brumme C, de Pierres C, Reddy S, Julg B, Moodley E, Thobakgale C, Lu Z, van der Stok M, Bishop K, Mncube Z, Chonco F, Yuki Y, ... ... Walker B, et al. Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 49: 956-64. PMID 19663693 DOI: 10.1086/605503  0.45
2009 Pereyra F, Palmer S, Miura T, Block BL, Wiegand A, Rothchild AC, Baker B, Rosenberg R, Cutrell E, Seaman MS, Coffin JM, Walker BD. Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters. The Journal of Infectious Diseases. 200: 984-90. PMID 19656066 DOI: 10.1086/605446  0.322
2009 Thobakgale CF, Prendergast A, Crawford H, Mkhwanazi N, Ramduth D, Reddy S, Molina C, Mncube Z, Leslie A, Prado J, Chonco F, Mphatshwe W, Tudor-Williams G, Jeena P, Blanckenberg N, ... ... Walker BD, et al. Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection. Journal of Virology. 83: 10234-44. PMID 19605475 DOI: 10.1128/JVI.00921-09  0.49
2009 Liu Q, Sun Y, Rihn S, Nolting A, Tsoukas PN, Jost S, Cohen K, Walker B, Alter G. Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. Journal of Virology. 83: 8705-12. PMID 19553339 DOI: 10.1128/Jvi.02666-08  0.385
2009 Lazaro E, Godfrey SB, Stamegna P, Ogbechie T, Kerrigan C, Zhang M, Walker BD, Gall SL. Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition Journal of Infectious Diseases. 200: 236-243. PMID 19505257 DOI: 10.1086/599837  0.457
2009 Brumme ZL, Walker BD. Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification. The Journal of Experimental Medicine. 206: 1215-8. PMID 19487418 DOI: 10.1084/jem.20091094  0.414
2009 Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, ... Walker BD, et al. Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. Journal of Virology. 83: 7641-8. PMID 19458000 DOI: 10.1128/Jvi.00182-09  0.471
2009 Julg B, Reddy S, van der Stok M, Kulkarni S, Qi Y, Bass S, Gold B, Nalls MA, Nelson GW, Walker BD, Carrington M, Ndung'u T. Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population. Cell Host & Microbe. 5: 413-5; author reply . PMID 19454341 DOI: 10.1016/j.chom.2009.04.009  0.334
2009 Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, Carrington M, Cohen MS, de Bakker PI, Goldstein DB, Shianna KV, Haynes BF, Letvin NL, McMichael AJ, Michael NL, et al. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host & Microbe. 5: 408-10; author reply. PMID 19454339 DOI: 10.1016/J.Chom.2009.04.011  0.317
2009 Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, Hart WK, Shin HS, Brooks SF, Knight HL, Eichbaum Q, Yang YG, Sykes M, Walker BD, Freeman GJ, Pillai S, et al. Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. Journal of Virology. 83: 7305-21. PMID 19420076 DOI: 10.1128/Jvi.02207-08  0.445
2009 Kaufmann DE, Walker BD. PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention. Journal of Immunology (Baltimore, Md. : 1950). 182: 5891-7. PMID 19414738 DOI: 10.4049/jimmunol.0803771  0.432
2009 Kaufmann DE, Walker BD. Programmed death-1 as a factor in immune exhaustion and activation in HIV infection. Current Opinion in Hiv and Aids. 3: 362-7. PMID 19372991 DOI: 10.1097/COH.0b013e3282f9ae8b  0.37
2009 Kaufmann DE, Walker BD. Treatment interruption to boost specific HIV immunity in acute infection. Current Opinion in Hiv and Aids. 2: 21-5. PMID 19372861 DOI: 10.1097/COH.0b013e3280119275  0.321
2009 Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 114: 346-56. PMID 19365081 DOI: 10.1182/Blood-2008-12-191296  0.319
2009 Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES, Kaufmann DE, Streeck H, Coovadia HM, Kiepiela P, Goulder PJ, ... Walker BD, et al. Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection. Plos One. 4: e5013. PMID 19352428 DOI: 10.1371/journal.pone.0005013  0.5
2009 Rousseau CM, Lockhart DW, Listgarten J, Maley SN, Kadie C, Learn GH, Nickle DC, Heckerman DE, Deng W, Brander C, Ndung'u T, Coovadia H, Goulder PJ, Korber BT, Walker BD, et al. Rare HLA drive additional HIV evolution compared to more frequent alleles. Aids Research and Human Retroviruses. 25: 297-303. PMID 19327049 DOI: 10.1089/Aid.2008.0208  0.415
2009 Crawford H, Lumm W, Leslie A, Schaefer M, Boeras D, Prado JG, Tang J, Farmer P, Ndung'u T, Lakhi S, Gilmour J, Goepfert P, Walker BD, Kaslow R, Mulenga J, et al. Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients. The Journal of Experimental Medicine. 206: 909-21. PMID 19307327 DOI: 10.1084/Jem.20081984  0.517
2009 Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, ... Walker BD, et al. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature. 458: 636-40. PMID 19287373 DOI: 10.1038/Nature07930  0.409
2009 Streeck H, Frahm N, Walker BD. The role of IFN-gamma Elispot assay in HIV vaccine research. Nature Protocols. 4: 461-9. PMID 19282851 DOI: 10.1038/nprot.2009.7  0.409
2009 Matthews PC, Leslie AJ, Katzourakis A, Crawford H, Payne R, Prendergast A, Power K, Kelleher AD, Klenerman P, Carlson J, Heckerman D, Ndung'u T, Walker BD, Allen TM, Pybus OG, et al. HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering. Journal of Virology. 83: 4605-15. PMID 19244334 DOI: 10.1128/Jvi.02017-08  0.465
2009 Kawashima Y, Pfafferott K, Frater J, Matthews P, Payne R, Addo M, Gatanaga H, Fujiwara M, Hachiya A, Koizumi H, Kuse N, Oka S, Duda A, Prendergast A, Crawford H, ... ... Walker BD, et al. Adaptation of HIV-1 to human leukocyte antigen class I. Nature. 458: 641-5. PMID 19242411 DOI: 10.1038/Nature07746  0.597
2009 Apuzzo LG, Vaida F, Gallant JE, Ernstrom KB, Little SJ, Routy JP, Collier AC, Conway B, Markowitz MH, Hecht FM, Walker BD, Connick E, Margolick JB. Tolerability and efficacy of PI versus NNRTI-based regimens in subjects receiving HAART during acute or early HIV infection. Journal of Acquired Immune Deficiency Syndromes (1999). 50: 267-75. PMID 19194317 DOI: 10.1097/Qai.0B013E3181963Ae6  0.314
2009 Lubong Sabado R, Kavanagh DG, Kaufmann DE, Fru K, Babcock E, Rosenberg E, Walker B, Lifson J, Bhardwaj N, Larsson M. In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection. Plos One. 4: e4256. PMID 19165342 DOI: 10.1371/Journal.Pone.0004256  0.484
2009 Chen H, Piechocka-Trocha A, Miura T, Brockman MA, Julg BD, Baker BM, Rothchild AC, Block BL, Schneidewind A, Koibuchi T, Pereyra F, Allen TM, Walker BD. Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes. Journal of Virology. 83: 3138-49. PMID 19158248 DOI: 10.1128/Jvi.02073-08  0.668
2009 Miura T, Brumme CJ, Brockman MA, Brumme ZL, Pereyra F, Block BL, Trocha A, John M, Mallal S, Harrigan PR, Walker BD. HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers. Journal of Virology. 83: 3407-12. PMID 19153230 DOI: 10.1128/Jvi.02459-08  0.461
2009 Miura T, Brockman MA, Schneidewind A, Lobritz M, Pereyra F, Rathod A, Block BL, Brumme ZL, Brumme CJ, Baker B, Rothchild AC, Li B, Trocha A, Cutrell E, Frahm N, ... ... Walker BD, et al. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. Journal of Virology. 83: 2743-55. PMID 19116253 DOI: 10.1128/Jvi.02265-08  0.469
2009 Scheid JF, Mouquet H, Feldhahn N, Walker BD, Pereyra F, Cutrell E, Seaman MS, Mascola JR, Wyatt RT, Wardemann H, Nussenzweig MC. A method for identification of HIV gp140 binding memory B cells in human blood. Journal of Immunological Methods. 343: 65-7. PMID 19100741 DOI: 10.1016/J.Jim.2008.11.012  0.317
2009 Streeck H, Jessen H, Kuecherer C, Li B, Jessen AB, Dupke S, Baumgarten A, Stahmer I, van Lunzen J, Altfeld M, Walker BD, Allen TM. Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. Aids (London, England). 23: 259-62. PMID 19098497 DOI: 10.1097/Qad.0B013E328315A78B  0.363
2009 Wang YE, Li B, Carlson JM, Streeck H, Gladden AD, Goodman R, Schneidewind A, Power KA, Toth I, Frahm N, Alter G, Brander C, Carrington M, Walker BD, Altfeld M, et al. Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. Journal of Virology. 83: 1845-55. PMID 19036810 DOI: 10.1128/Jvi.01061-08  0.441
2009 Mahalanabis M, Jayaraman P, Miura T, Pereyra F, Chester EM, Richardson B, Walker B, Haigwood NL. Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllers. Journal of Virology. 83: 662-72. PMID 18987151 DOI: 10.1128/Jvi.01328-08  0.304
2009 Miura T, Brockman MA, Brumme ZL, Brumme CJ, Pereyra F, Trocha A, Block BL, Schneidewind A, Allen TM, Heckerman D, Walker BD. HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1. Journal of Virology. 83: 140-9. PMID 18971283 DOI: 10.1128/Jvi.01471-08  0.45
2008 Carlson JM, Brumme ZL, Rousseau CM, Brumme CJ, Matthews P, Kadie C, Mullins JI, Walker BD, Harrigan PR, Goulder PJ, Heckerman D. Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. Plos Computational Biology. 4: e1000225. PMID 19023406 DOI: 10.1371/Journal.Pcbi.1000225  0.459
2008 Huang S, Dunkley-Thompson J, Tang Y, Macklin EA, Steel-Duncan J, Singh-Minott I, Ryland EG, Smikle M, Walker BD, Christie CD, Feeney ME. Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment. Journal of Immunology (Baltimore, Md. : 1950). 181: 8103-11. PMID 19018003 DOI: 10.4049/jimmunol.181.11.8103  0.451
2008 Lichterfeld M, Mou D, Cung TD, Williams KL, Waring MT, Huang J, Pereyra F, Trocha A, Freeman GJ, Rosenberg ES, Walker BD, Yu XG. Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood. 112: 3679-87. PMID 18728248 DOI: 10.1182/blood-2008-01-135442  0.478
2008 Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, et al. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 1859-68. PMID 18641323 DOI: 10.4049/Jimmunol.181.3.1859  0.311
2008 Brumme ZL, Brumme CJ, Carlson J, Streeck H, John M, Eichbaum Q, Block BL, Baker B, Kadie C, Markowitz M, Jessen H, Kelleher AD, Rosenberg E, Kaldor J, Yuki Y, ... ... Walker BD, et al. Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection. Journal of Virology. 82: 9216-27. PMID 18614631 DOI: 10.1128/Jvi.01041-08  0.518
2008 Matthews PC, Prendergast A, Leslie A, Crawford H, Payne R, Rousseau C, Rolland M, Honeyborne I, Carlson J, Kadie C, Brander C, Bishop K, Mlotshwa N, Mullins JI, Coovadia H, ... ... Walker BD, et al. Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. Journal of Virology. 82: 8548-59. PMID 18596105 DOI: 10.1128/Jvi.00580-08  0.485
2008 Autran B, Murphy RL, Costagliola D, Tubiana R, Clotet B, Gatell J, Staszewski S, Wincker N, Assoumou L, El-Habib R, Calvez V, Walker B, Katlama C. Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452). Aids. 22: 1313-1322. PMID 18580611 DOI: 10.1097/Qad.0B013E3282Fdce94  0.401
2008 Brumme ZL, Tao I, Szeto S, Brumme CJ, Carlson JM, Chan D, Kadie C, Frahm N, Brander C, Walker B, Heckerman D, Harrigan PR. Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection. Aids (London, England). 22: 1277-86. PMID 18580606 DOI: 10.1097/Qad.0B013E3283021A8C  0.506
2008 Alter G, Rihn S, Streeck H, Teigen N, Piechocka-Trocha A, Moss K, Cohen K, Meier A, Pereyra F, Walker B, Altfeld M. Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection. Journal of Virology. 82: 9668-77. PMID 18579582 DOI: 10.1128/Jvi.00341-08  0.465
2008 Miura T, Brockman MA, Brumme CJ, Brumme ZL, Carlson JM, Pereyra F, Trocha A, Addo MM, Block BL, Rothchild AC, Baker BM, Flynn T, Schneidewind A, Li B, Wang YE, ... ... Walker BD, et al. Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. Journal of Virology. 82: 8422-30. PMID 18562530 DOI: 10.1128/Jvi.00535-08  0.558
2008 Zhuang Y, Sun Y, Zhai S, Huang D, Zhao S, Wang S, Kang W, Li X, Walker BD, Altfeld M, Yu XG. Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection. Current Hiv Research. 6: 239-45. PMID 18473787 DOI: 10.2174/157016208784324921  0.418
2008 Walker BD, Burton DR. Toward an AIDS vaccine. Science (New York, N.Y.). 320: 760-4. PMID 18467582 DOI: 10.1126/science.1152622  0.342
2008 Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, Meier A, Brumme CJ, Rosenberg ES, Alter G, Allen TM, Walker BD, Altfeld M. Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. Plos Medicine. 5: e100. PMID 18462013 DOI: 10.1371/Journal.Pmed.0050100  0.513
2008 Rousseau CM, Daniels MG, Carlson JM, Kadie C, Crawford H, Prendergast A, Matthews P, Payne R, Rolland M, Raugi DN, Maust BS, Learn GH, Nickle DC, Coovadia H, Ndung'u T, ... ... Walker BD, et al. HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load. Journal of Virology. 82: 6434-46. PMID 18434400 DOI: 10.1128/Jvi.02455-07  0.452
2008 Day CL, Mkhwanazi N, Reddy S, Mncube Z, van der Stok M, Klenerman P, Walker BD. Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. The Journal of Infectious Diseases. 197: 990-9. PMID 18419535 DOI: 10.1086/529048  0.353
2008 Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, ... ... Walker BD, et al. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. Journal of Virology. 82: 5594-605. PMID 18385228 DOI: 10.1128/Jvi.02356-07  0.319
2008 Frahm N, Nickle DC, Linde CH, Cohen DE, Zuñiga R, Lucchetti A, Roach T, Walker BD, Allen TM, Korber BT, Mullins JI, Brander C. Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity. Aids (London, England). 22: 447-56. PMID 18301057 DOI: 10.1097/Qad.0B013E3282F42412  0.419
2008 Ramduth D, Thobakgale CF, Mkhwanazi NP, De Pierres C, Reddy S, van der Stok M, Mncube Z, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Coovadia HM, ... ... Walker BD, et al. Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants. Aids Research and Human Retroviruses. 24: 265-70. PMID 18284325 DOI: 10.1089/aid.2007.0096  0.312
2008 Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, Baker B, Trocha A, Rosenberg R, Mackey E, Ueda P, Lu Z, Cohen D, Wrin T, Petropoulos CJ, ... ... Walker BD, et al. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. The Journal of Infectious Diseases. 197: 563-71. PMID 18275276 DOI: 10.1086/526786  0.376
2008 Kasprowicz V, Ward SM, Turner A, Grammatikos A, Nolan BE, Lewis-Ximenez L, Sharp C, Woodruff J, Fleming VM, Sims S, Walker BD, Sewell AK, Lauer GM, Klenerman P. Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. The Journal of Clinical Investigation. 118: 1143-53. PMID 18246203 DOI: 10.1172/JCI33082  0.327
2008 Northfield JW, Kasprowicz V, Lucas M, Kersting N, Bengsch B, Bengsh B, Kim A, Phillips RE, Walker BD, Thimme R, Lauer G, Klenerman P. CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation. Hepatology (Baltimore, Md.). 47: 396-406. PMID 18219672 DOI: 10.1002/hep.22040  0.362
2008 Joseph A, Zheng JH, Follenzi A, Dilorenzo T, Sango K, Hyman J, Chen K, Piechocka-Trocha A, Brander C, Hooijberg E, Vignali DA, Walker BD, Goldstein H. Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity. Journal of Virology. 82: 3078-89. PMID 18184707 DOI: 10.1128/Jvi.01812-07  0.476
2008 Rolland M, Heckerman D, Deng W, Rousseau CM, Coovadia H, Bishop K, Goulder PJ, Walker BD, Brander C, Mullins JI. Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads. Plos One. 3: e1424. PMID 18183304 DOI: 10.1371/Journal.Pone.0001424  0.501
2007 Lichterfeld M, Kavanagh DG, Williams KL, Moza B, Mui SK, Miura T, Sivamurthy R, Allgaier R, Pereyra F, Trocha A, Feeney M, Gandhi RT, Rosenberg ES, Altfeld M, Allen TM, ... ... Walker BD, et al. A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. The Journal of Experimental Medicine. 204: 2813-24. PMID 18025130 DOI: 10.1084/Jem.20061865  0.514
2007 Frahm N, Kaufmann DE, Yusim K, Muldoon M, Kesmir C, Linde CH, Fischer W, Allen TM, Li B, McMahon BH, Faircloth KL, Hewitt HS, Mackey EW, Miura T, Khatri A, ... ... Walker BD, et al. Increased sequence diversity coverage improves detection of HIV-specific T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 179: 6638-50. PMID 17982054 DOI: 10.4049/Jimmunol.179.10.6638  0.438
2007 Le Gall S, Stamegna P, Walker BD. Portable flanking sequences modulate CTL epitope processing. The Journal of Clinical Investigation. 117: 3563-75. PMID 17975674 DOI: 10.1172/JCI32047  0.498
2007 Dolan MJ, Kulkarni H, Camargo JF, He W, Smith A, Anaya JM, Miura T, Hecht FM, Mamtani M, Pereyra F, Marconi V, Mangano A, Sen L, Bologna R, Clark RA, ... ... Walker BD, et al. CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nature Immunology. 8: 1324-36. PMID 17952079 DOI: 10.1038/ni1521  0.399
2007 Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, ... ... Walker BD, et al. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nature Immunology. 8: 1246-54. PMID 17906628 DOI: 10.1038/Ni1515  0.494
2007 Deeks SG, Walker BD. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity. 27: 406-16. PMID 17892849 DOI: 10.1016/J.IMMUNI.2007.08.010  0.35
2007 Thobakgale CF, Ramduth D, Reddy S, Mkhwanazi N, de Pierres C, Moodley E, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Kindra G, Bobat R, ... ... Walker BD, et al. Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants. Journal of Virology. 81: 12775-84. PMID 17881456 DOI: 10.1128/JVI.00624-07  0.364
2007 Yu XG, Lichterfeld M, Williams KL, Martinez-Picado J, Walker BD. Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain. Journal of Virology. 81: 12666-9. PMID 17804503 DOI: 10.1128/JVI.01450-07  0.506
2007 Rolland M, Nickle DC, Deng W, Frahm N, Brander C, Learn GH, Heckerman D, Jojic N, Jojic V, Walker BD, Mullins JI. Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins. Plos One. 2: e823. PMID 17786195 DOI: 10.1371/Journal.Pone.0000823  0.426
2007 Brockman MA, Schneidewind A, Lahaie M, Schmidt A, Miura T, Desouza I, Ryvkin F, Derdeyn CA, Allen S, Hunter E, Mulenga J, Goepfert PA, Walker BD, Allen TM. Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. Journal of Virology. 81: 12608-18. PMID 17728232 DOI: 10.1128/Jvi.01369-07  0.504
2007 Chen J, Hong K, Jia M, Liu H, Zhang Y, Liu S, Zhang X, Zhao H, Peng H, Ma P, Xing H, Ruan Y, Williams KL, Yu XG, Altfeld M, ... Walker BD, et al. Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B'/C Recombinant (CRF07_BC). Retrovirology. 4: 62. PMID 17727734 DOI: 10.1186/1742-4690-4-62  0.485
2007 Walker BD. Elite control of HIV Infection: implications for vaccines and treatment. Topics in Hiv Medicine : a Publication of the International Aids Society, Usa. 15: 134-6. PMID 17720999  0.39
2007 Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, ... ... Walker BD, et al. Extensive HLA class I allele promiscuity among viral CTL epitopes. European Journal of Immunology. 37: 2419-33. PMID 17705138 DOI: 10.1002/Eji.200737365  0.41
2007 Hoxie JA, Miller V, Walker B. Tuberculosis and HIV coinfection: genesis of the supplement and sponsors' contribution. The Journal of Infectious Diseases. 196: S4. PMID 17624824 DOI: 10.1086/518666  0.308
2007 Brumme ZL, Brumme CJ, Heckerman D, Korber BT, Daniels M, Carlson J, Kadie C, Bhattacharya T, Chui C, Szinger J, Mo T, Hogg RS, Montaner JS, Frahm N, Brander C, ... Walker BD, et al. Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. Plos Pathogens. 3: e94. PMID 17616974 DOI: 10.1371/Journal.Ppat.0030094  0.494
2007 Brainard DM, Tager AM, Misdraji J, Frahm N, Lichterfeld M, Draenert R, Brander C, Walker BD, Luster AD. Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction. Journal of Virology. 81: 8439-50. PMID 17553894 DOI: 10.1128/JVI.00199-07  0.467
2007 Mphatswe W, Blanckenberg N, Tudor-Williams G, Prendergast A, Thobakgale C, Mkhwanazi N, McCarthy N, Walker BD, Kiepiela P, Goulder P. High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis. Aids (London, England). 21: 1253-61. PMID 17545701 DOI: 10.1097/QAD.0b013e3281a3bec2  0.308
2007 Sabado RL, Babcock E, Kavanagh DG, Tjomsland V, Walker BD, Lifson JD, Bhardwaj N, Larsson M. Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1. European Journal of Immunology. 37: 1752-63. PMID 17534864 DOI: 10.1002/Eji.200636981  0.502
2007 Crawford H, Prado JG, Leslie A, Hué S, Honeyborne I, Reddy S, van der Stok M, Mncube Z, Brander C, Rousseau C, Mullins JI, Kaslow R, Goepfert P, Allen S, Hunter E, ... ... Walker BD, et al. Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. Journal of Virology. 81: 8346-51. PMID 17507468 DOI: 10.1128/Jvi.00465-07  0.403
2007 Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, ... ... Walker BD, et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nature Genetics. 39: 733-40. PMID 17496894 DOI: 10.1038/Ng2035  0.495
2007 Streeck H, Lichterfeld M, Alter G, Meier A, Teigen N, Yassine-Diab B, Sidhu HK, Little S, Kelleher A, Routy JP, Rosenberg ES, Sekaly RP, Walker BD, Altfeld M. Recognition of a defined region within p24 GAG by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles Journal of Virology. 81: 7725-7731. PMID 17494064 DOI: 10.1128/Jvi.00708-07  0.582
2007 Walker BD. HIV controllers: an untapped source of clues to overcoming HIV infection. Research Initiative, Treatment Action : Rita. 12: 21-2. PMID 17489119  0.338
2007 Streeck H, Schweighardt B, Jessen H, Allgaier RL, Wrin T, Stawiski EW, Jessen AB, Allen TM, Walker BD, Altfeld M. Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression. Aids (London, England). 21: 889-91. PMID 17415054 DOI: 10.1097/Qad.0B013E3280F77439  0.424
2007 Addo MM, Draenert R, Rathod A, Verrill CL, Davis BT, Gandhi RT, Robbins GK, Basgoz NO, Stone DR, Cohen DE, Johnston MN, Flynn T, Wurcel AG, Rosenberg ES, Altfeld M, ... Walker BD, et al. Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection Plos One. 2. PMID 17389912 DOI: 10.1371/journal.pone.0000321  0.484
2007 Gasser O, Bihl FK, Wolbers M, Loggi E, Steffen I, Hirsch HH, Günthard HF, Walker BD, Brander C, Battegay M, Hess C. HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts. Plos Medicine. 4: e96. PMID 17388662 DOI: 10.1371/journal.pmed.0040096  0.429
2007 Bhattacharya T, Daniels M, Heckerman D, Foley B, Frahm N, Kadie C, Carlson J, Yusim K, McMahon B, Gaschen B, Mallal S, Mullins JI, Nickle DC, Herbeck J, Rousseau C, ... ... Walker B, et al. Founder effects in the assessment of HIV polymorphisms and HLA allele associations. Science (New York, N.Y.). 315: 1583-6. PMID 17363674 DOI: 10.1126/Science.1131528  0.407
2007 Zhao S, Zhai S, Zhuang Y, Wang S, Huang D, Kang W, Li X, Yu XG, Walker BD, Altfeld MA, Sun Y. Inter-clade cross-reactivity of HIV-1-specific T cell responses in human immunodeficiency virus type 1 infection in China. Current Hiv Research. 5: 251-9. PMID 17346138 DOI: 10.2174/157016207780076995  0.463
2007 Lichterfeld M, Yu XG, Mui SK, Williams KL, Trocha A, Brockman MA, Allgaier RL, Waring MT, Koibuchi T, Johnston MN, Cohen D, Allen TM, Rosenberg ES, Walker BD, Altfeld M. Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection. Journal of Virology. 81: 4199-214. PMID 17287271 DOI: 10.1128/Jvi.01388-06  0.481
2007 Wang S, Sun Y, Zhai S, Zhuang Y, Zhao S, Kang W, Li X, Huang D, Yu XG, Walker BD, Altfeld MA. Identification of HLA-A11-restricted HIV-1-specific cytotoxic T-lymphocyte epitopes in China. Current Hiv Research. 5: 119-28. PMID 17266563 DOI: 10.2174/157016207779316404  0.453
2007 Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R, Reddy S, Bishop K, Moodley E, Nair K, van der Stok M, McCarthy N, Rousseau CM, Addo M, Mullins JI, ... ... Walker BD, et al. Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes. Journal of Virology. 81: 3667-72. PMID 17251285 DOI: 10.1128/Jvi.02689-06  0.568
2007 Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD, Hahn BH, Korber BT. Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants. Nature Medicine. 13: 100-6. PMID 17187074 DOI: 10.1038/Nm1461  0.36
2007 Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N, Bishop K, van der Stok M, Nair K, Khan N, Crawford H, ... ... Walker BD, et al. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nature Medicine. 13: 46-53. PMID 17173051 DOI: 10.1038/Nm1520  0.515
2007 Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, ... ... Walker BD, et al. Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. Journal of Virology. 81: 1619-31. PMID 17121793 DOI: 10.1128/Jvi.01580-06  0.531
2007 Day CL, Kiepiela P, Leslie AJ, van der Stok M, Nair K, Ismail N, Honeyborne I, Crawford H, Coovadia HM, Goulder PJ, Walker BD, Klenerman P. Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection. Journal of Virology. 81: 434-8. PMID 17050606 DOI: 10.1128/JVI.01754-06  0.457
2006 Altfeld M, Kalife ET, Qi Y, Streeck H, Lichterfeld M, Johnston MN, Burgett N, Swartz ME, Yang A, Alter G, Yu XG, Meier A, Rockstroh JK, Allen TM, Jessen H, ... ... Walker BD, et al. HLA alleles associated with delayed progression to AIDS contribute strongly to the initial CD8+ T cell response against HIV-1 Plos Medicine. 3: 1851-1864. PMID 17076553 DOI: 10.1371/Journal.Pmed.0030403  0.567
2006 Zaunders JJ, Ip S, Munier ML, Kaufmann DE, Suzuki K, Brereton C, Sasson SC, Seddiki N, Koelsch K, Landay A, Grey P, Finlayson R, Kaldor J, Rosenberg ES, Walker BD, et al. Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection. Journal of Virology. 80: 10162-72. PMID 17005693 DOI: 10.1128/JVI.00249-06  0.426
2006 Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rousseau CM, Rosseau CM, Mullins JI, Tudor-Williams G, ... ... Walker BD, et al. Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. Journal of Immunology (Baltimore, Md. : 1950). 177: 4699-708. PMID 16982909 DOI: 10.4049/Jimmunol.177.7.4699  0.477
2006 Streeck H, Jessen H, Alter G, Teigen N, Waring MT, Jessen A, Stahmer I, Lunzen Jv, Lichterfeld M, Gao X, Allen TM, Carrington M, Walker BD, Rockstroh JK, Altfeld M. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. The Journal of Infectious Diseases. 194: 734-739. PMID 16941338 DOI: 10.1086/503811  0.442
2006 Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, ... ... Walker BD, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 443: 350-4. PMID 16921384 DOI: 10.1038/Nature05115  0.423
2006 Wang S, Zhuang Y, Zhai S, Zhao S, Kang W, Li X, Yu XG, Walker BD, Altfeld MA, Sun Y. Association between HIV Type 1-specific T cell responses and CD4+ T cell counts or CD4+:CD8+ T cell ratios in HIV Type 1 subtype B infection in China. Aids Research and Human Retroviruses. 22: 780-7. PMID 16910834 DOI: 10.1089/AID.2006.22.780  0.514
2006 Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD. HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. Virology. 353: 366-73. PMID 16860834 DOI: 10.1016/J.Virol.2006.06.017  0.457
2006 Brander C, Frahm N, Walker BD. The challenges of host and viral diversity in HIV vaccine design. Current Opinion in Immunology. 18: 430-7. PMID 16777397 DOI: 10.1016/J.COI.2006.05.012  0.378
2006 Lichterfeld M, Williams KL, Mui SK, Shah SS, Mothe BR, Sette A, Kim A, Johnston MN, Burgett N, Frahm N, Cohen D, Brander C, Rosenberg ES, Walker BD, Altfeld M, et al. T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily International Immunology. 18: 1179-1188. PMID 16772368 DOI: 10.1093/intimm/dxl052  0.374
2006 Martinez-Hackert E, Anikeeva N, Kalams SA, Walker BD, Hendrickson WA, Sykulev Y. Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes Journal of Biological Chemistry. 281: 20205-20212. PMID 16702212 DOI: 10.1074/Jbc.M601934200  0.414
2006 Rousseau CM, Birditt BA, McKay AR, Stoddard JN, Lee TC, McLaughlin S, Moore SW, Shindo N, Learn GH, Korber BT, Brander C, Goulder PJ, Kiepiela P, Walker BD, Mullins JI. Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. Journal of Virological Methods. 136: 118-25. PMID 16701907 DOI: 10.1016/J.Jviromet.2006.04.009  0.302
2006 Honeyborne I, Rathod A, Buchli R, Ramduth D, Moodley E, Rathnavalu P, Chetty S, Day C, Brander C, Hildebrand W, Walker BD, Kiepiela P, Goulder PJ. Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa. Journal of Immunology (Baltimore, Md. : 1950). 176: 4699-705. PMID 16585563 DOI: 10.4049/Jimmunol.176.8.4699  0.409
2006 Bihl F, Frahm N, Di Giammarino L, Sidney J, John M, Yusim K, Woodberry T, Sango K, Hewitt HS, Henry L, Linde CH, Chisholm JV, Zaman TM, Pae E, Mallal S, ... Walker BD, et al. Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses. Journal of Immunology (Baltimore, Md. : 1950). 176: 4094-101. PMID 16547245  0.477
2006 Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, Chetty S, Thobakgale C, Honeyborne I, Crawford H, Matthews P, Pillay T, Rousseau C, Mullins JI, Brander C, Walker BD, et al. Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. Journal of Virology. 80: 3617-23. PMID 16537629 DOI: 10.1128/Jvi.80.7.3617-3623.2006  0.441
2006 Draenert R, Allen TM, Liu Y, Wrin T, Chappey C, Verrill CL, Sirera G, Eldridge RL, Lahaie MP, Ruiz L, Clotet B, Petropoulos CJ, Walker BD, Martinez-Picado J. Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus. The Journal of Experimental Medicine. 203: 529-39. PMID 16533886 DOI: 10.1084/Jem.20052116  0.403
2006 Kassutto S, Maghsoudi K, Johnston MN, Robbins GK, Burgett NC, Sax PE, Cohen D, Pae E, Davis B, Zachary K, Basgoz N, D'agata EM, DeGruttola V, Walker BD, Rosenberg ES. Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infection. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 42: 1024-31. PMID 16511771 DOI: 10.1086/500410  0.359
2006 Zuñiga R, Lucchetti A, Galvan P, Sanchez S, Sanchez C, Hernandez A, Sanchez H, Frahm N, Linde CH, Hewitt HS, Hildebrand W, Altfeld M, Allen TM, Walker BD, Korber BT, et al. Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. Journal of Virology. 80: 3122-5. PMID 16501126 DOI: 10.1128/Jvi.80.6.3122-3125.2006  0.49
2006 Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, ... ... Walker BD, et al. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nature Immunology. 7: 173-8. PMID 16369537 DOI: 10.1038/Ni1281  0.447
2006 Meyer-Olson D, Brady KW, Bartman MT, O'Sullivan KM, Simons BC, Conrad JA, Duncan CB, Lorey S, Siddique A, Draenert R, Addo M, Altfeld M, Rosenberg E, Allen TM, Walker BD, et al. Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire. Blood. 107: 2373-83. PMID 16322475 DOI: 10.1182/Blood-2005-04-1636  0.521
2006 Kavanagh DG, Kaufmann DE, Sunderji S, Frahm N, Le Gall S, Boczkowski D, Rosenberg ES, Stone DR, Johnston MN, Wagner BS, Zaman MT, Brander C, Gilboa E, Walker BD, Bhardwaj N. Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef. Blood. 107: 1963-9. PMID 16249391 DOI: 10.1182/Blood-2005-04-1513  0.46
2006 Norris PJ, Stone JD, Anikeeva N, Heitman JW, Wilson IC, Hirschkorn DF, Clark MJ, Moffett HF, Cameron TO, Sykulev Y, Stern LJ, Walker BD. Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope. Molecular Immunology. 43: 1349-57. PMID 16216327 DOI: 10.1016/J.Molimm.2005.09.004  0.434
2006 Brockman MA, Tanzi GO, Walker BD, Allen TM. Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry. Journal of Virological Methods. 131: 134-42. PMID 16182382 DOI: 10.1016/J.Jviromet.2005.08.003  0.337
2005 Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, ... ... Walker BD, et al. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. Journal of Virology. 79: 13239-49. PMID 16227247 DOI: 10.1128/Jvi.79.21.13239-13249.2005  0.441
2005 Ramduth D, Chetty P, Mngquandaniso NC, Nene N, Harlow JD, Honeyborne I, Ntumba N, Gappoo S, Henry C, Jeena P, Addo MM, Altfeld M, Brander C, Day C, Coovadia H, ... ... Walker B, et al. Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses. The Journal of Infectious Diseases. 192: 1588-96. PMID 16206073 DOI: 10.1086/496894  0.425
2005 Woodberry T, Suscovich TJ, Henry LM, Davis JK, Frahm N, Walker BD, Scadden DT, Wang F, Brander C. Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection. The Journal of Infectious Diseases. 192: 1513-24. PMID 16206065 DOI: 10.1086/491741  0.356
2005 Lauer GM, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Zur Wiesch JS, Paranhos-Baccala G, Sheridan I, Casson DR, Reiser M, Gandhi RT, Li B, Allen TM, Chung RT, ... ... Walker BD, et al. Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy Journal of Virology. 79: 12979-12988. PMID 16189000 DOI: 10.1128/Jvi.79.20.12979-12988.2005  0.336
2005 Allen TM, Yu XG, Kalife ET, Reyor LL, Lichterfeld M, John M, Cheng M, Allgaier RL, Mui S, Frahm N, Alter G, Brown NV, Johnston MN, Rosenberg ES, Mallal SA, ... ... Walker BD, et al. De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. Journal of Virology. 79: 12952-60. PMID 16188997 DOI: 10.1128/Jvi.79.20.12952-12960.2005  0.5
2005 Yu XG, Lichterfeld M, Perkins B, Kalife E, Mui S, Chen J, Cheng M, Kang W, Alter G, Brander C, Walker BD, Altfeld M. High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. Aids (London, England). 19: 1449-56. PMID 16135897 DOI: 10.1097/01.Aids.0000183126.32077.C8  0.495
2005 Frahm N, Adams S, Kiepiela P, Linde CH, Hewitt HS, Lichterfeld M, Sango K, Brown NV, Pae E, Wurcel AG, Altfeld M, Feeney ME, Allen TM, Roach T, St John MA, ... ... Walker BD, et al. HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. Journal of Virology. 79: 10218-25. PMID 16051815 DOI: 10.1128/Jvi.79.16.10218-10225.2005  0.526
2005 Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, Davis JK, Osmond D, Lee TH, Kedes DH, Khatri A, Lee J, Walker BD, Scadden DT, Brander C. Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. The Journal of Infectious Diseases. 192: 622-9. PMID 16028131 DOI: 10.1086/432103  0.348
2005 Rodriguez WR, Christodoulides N, Floriano PN, Graham S, Mohanty S, Dixon M, Hsiang M, Peter T, Zavahir S, Thior I, Romanovicz D, Bernard B, Goodey AP, Walker BD, McDevitt JT. A microchip CD4 counting method for HIV monitoring in resource-poor settings Plos Medicine. 2: 0663-0672. PMID 16013921 DOI: 10.1371/Journal.Pmed.0020182  0.311
2005 Koibuchi T, Allen TM, Lichterfeld M, Mui SK, O'Sullivan KM, Trocha A, Kalams SA, Johnson RP, Walker BD. Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection. Journal of Virology. 79: 8171-8181. PMID 15956562 DOI: 10.1128/Jvi.79.13.8171-8181.2005  0.421
2005 Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, Yu XG, Verrill C, Allen T, Moore C, Mallal S, Burchett S, McIntosh K, Pelton SI, St John MA, ... ... Walker BD, et al. HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. Journal of Immunology (Baltimore, Md. : 1950). 174: 7524-30. PMID 15944251 DOI: 10.4049/Jimmunol.174.12.7524  0.337
2005 Zaunders JJ, Munier ML, Kaufmann DE, Ip S, Grey P, Smith D, Ramacciotti T, Quan D, Finlayson R, Kaldor J, Rosenberg ES, Walker BD, Cooper DA, Kelleher AD. Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection. Blood. 106: 1660-7. PMID 15905189 DOI: 10.1182/BLOOD-2005-01-0206  0.464
2005 Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, ... ... Walker BD, et al. The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. Journal of Virology. 79: 5000-5. PMID 15795285 DOI: 10.1128/Jvi.79.8.5000-5005.2005  0.47
2005 Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, ... ... Walker B, et al. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. The Journal of Experimental Medicine. 201: 891-902. PMID 15781581 DOI: 10.1084/Jem.20041455  0.476
2005 Lebedeva T, Anikeeva N, Kalams SA, Walker BD, Gaidarov I, Keen JH, Sykulev Y. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes. Immunology. 113: 460-71. PMID 15554924 DOI: 10.1111/j.1365-2567.2004.01985.x  0.365
2005 Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BD. The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. Blood. 105: 1170-8. PMID 15459014 DOI: 10.1182/blood-2004-06-2336  0.392
2004 Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, ... ... Walker BD, et al. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 432: 769-75. PMID 15592417 DOI: 10.1038/Nature03113  0.607
2004 Kaufmann DE, Lichterfeld M, Altfeld M, Addo MM, Johnston MN, Lee PK, Wagner BS, Kalife ET, Strick D, Rosenberg ES, Walker BD. Limited durability of viral control following treated acute HIV infection. Plos Medicine. 1: e36. PMID 15526059 DOI: 10.1371/journal.pmed.0010036  0.318
2004 Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld M. Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4 + T cells Journal of Experimental Medicine. 200: 701-712. PMID 15381726 DOI: 10.1084/Jem.20041270  0.506
2004 Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, Dusheiko G, Allen TM, Chung RT, Walker BD, Klenerman P. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology. 127: 924-936. PMID 15362047 DOI: 10.1053/J.Gastro.2004.06.015  0.351
2004 Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander C. Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leukemia & Lymphoma. 45: 1223-38. PMID 15360006 DOI: 10.1080/10428190310001643358  0.379
2004 Zavala-Ruiz Z, Strug I, Walker BD, Norris PJ, Stern LJ. A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition. Proceedings of the National Academy of Sciences of the United States of America. 101: 13279-84. PMID 15331779 DOI: 10.1073/Pnas.0403371101  0.365
2004 Hess C, Means TK, Autissier P, Woodberry T, Altfeld M, Addo MM, Frahm N, Brander C, Walker BD, Luster AD. IL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood. 104: 3463-71. PMID 15292066 DOI: 10.1182/Blood-2004-03-1067  0.444
2004 SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander C. Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II. Journal of Immunology (Baltimore, Md. : 1950). 173: 1987-93. PMID 15265933 DOI: 10.4049/Jimmunol.173.3.1987  0.493
2004 Lichterfeld M, Yu XG, Cohen D, Addo MM, Malenfant J, Perkins B, Pae E, Johnston MN, Strick D, Allen TM, Rosenberg ES, Korber B, Walker BD, Altfeld M. HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. Aids (London, England). 18: 1383-92. PMID 15199314 DOI: 10.1097/01.Aids.0000131329.51633.A3  0.478
2004 Allen TM, Altfeld M, Yu XG, O'Sullivan KM, Lichterfeld M, Le Gall S, John M, Mothe BR, Lee PK, Kalife ET, Cohen DE, Freedberg KA, Strick DA, Johnston MN, Sette A, ... ... Walker BD, et al. Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. Journal of Virology. 78: 7069-78. PMID 15194783 DOI: 10.1128/Jvi.78.13.7069-7078.2004  0.442
2004 Yu XG, Addo MM, Perkins BA, Wej F, Rathod A, Geer SC, Parta M, Cohen D, Stone DR, Russell CJ, Tanzi G, Mei S, Wurcel AG, Frahm N, Lichterfeld M, ... ... Walker BD, et al. Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians. Aids Research and Human Retroviruses. 20: 557-64. PMID 15186531 DOI: 10.1089/088922204323087813  0.506
2004 Rodriguez WR, Addo MM, Rathod A, Fitzpatrick CA, Yu XG, Perkins B, Rosenberg ES, Altfeld M, Walker BD. CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects. Journal of Translational Medicine. 2: 15. PMID 15154967 DOI: 10.1186/1479-5876-2-15  0.474
2004 Norris PJ, Moffett HF, Brander C, Allen TM, O'Sullivan KM, Cosimi LA, Kaufmann DE, Walker BD, Rosenberg ES. Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells. Aids Research and Human Retroviruses. 20: 315-25. PMID 15117455 DOI: 10.1089/088922204322996554  0.515
2004 Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky MC. Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. Journal of Virology. 78: 5184-93. PMID 15113900 DOI: 10.1128/Jvi.78.10.5184-5193.2004  0.479
2004 Kaufmann DE, Bailey PM, Sidney J, Wagner B, Norris PJ, Johnston MN, Cosimi LA, Addo MM, Lichterfeld M, Altfeld M, Frahm N, Brander C, Sette A, Walker BD, Rosenberg ES. Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. Journal of Virology. 78: 4463-77. PMID 15078927 DOI: 10.1128/JVI.78.9.4463-4477.2004  0.518
2004 Deeks SG, Walker BD. The immune response to AIDS virus infection: good, bad, or both? The Journal of Clinical Investigation. 113: 808-10. PMID 15067312 DOI: 10.1172/jci21318  0.478
2004 Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, ... ... Walker BD, et al. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. The Journal of Experimental Medicine. 199: 905-15. PMID 15067030 DOI: 10.1084/Jem.20031982  0.497
2004 Draenert R, Brander C, Yu XG, Altfeld M, Verrill CL, Feeney ME, Walker BD, Goulder PJ. Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels. Aids (London, England). 18: 871-6. PMID 15060434 DOI: 10.1097/00002030-200404090-00004  0.384
2004 Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld M. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood. 104: 487-94. PMID 15059848 DOI: 10.1182/Blood-2003-12-4341  0.438
2004 Hess C, Altfeld M, Thomas SY, Addo MM, Rosenberg ES, Allen TM, Draenert R, Eldrige RL, van Lunzen J, Stellbrink HJ, Walker BD, Luster AD. HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet (London, England). 363: 863-6. PMID 15031033 DOI: 10.1016/S0140-6736(04)15735-8  0.45
2004 Lucas M, Vargas-Cuero AL, Lauer GM, Barnes E, Willberg CB, Semmo N, Walker BD, Phillips R, Klenerman P. Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 172: 1744-53. PMID 14734757 DOI: 10.4049/jimmunol.172.3.1744  0.35
2004 Brander C, Walker BD. Gradual adaptation of HIV to human host populations: good or bad news? Nature Medicine. 9: 1359-62. PMID 14595431 DOI: 10.1038/nm941  0.32
2003 Altfeld M, Addo MM, Rosenberg ES, Hecht FM, Lee PK, Vogel M, Yu XG, Draenert R, Johnston MN, Strick D, Allen TM, Feeney ME, Kahn JO, Sekaly RP, Levy JA, ... ... Walker BD, et al. Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. Aids (London, England). 17: 2581-91. PMID 14685052 DOI: 10.1097/00002030-200312050-00005  0.477
2003 Delgado JC, Leung JY, Baena A, Clavijo OP, Vittinghoff E, Buchbinder S, Wolinsky S, Addo M, Walker BD, Yunis EJ, Goldfeld AE. The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. Immunogenetics. 55: 497-501. PMID 14517700 DOI: 10.1007/S00251-003-0604-7  0.387
2003 Yang OO, Sarkis PT, Trocha A, Kalams SA, Johnson RP, Walker BD. Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL. Journal of Immunology (Baltimore, Md. : 1950). 171: 3718-24. PMID 14500671 DOI: 10.4049/Jimmunol.171.7.3718  0.459
2003 Day CL, Seth NP, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. The Journal of Clinical Investigation. 112: 831-42. PMID 12975468 DOI: 10.1172/Jci18509  0.404
2003 Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections Nature Medicine. 9: 861-866. PMID 12835706 DOI: 10.1038/nm0703-861  0.432
2003 Robbins GK, Addo MM, Troung H, Rathod A, Habeeb K, Davis B, Heller H, Basgoz N, Walker BD, Rosenberg ES. Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization. Aids (London, England). 17: 1121-6. PMID 12819512 DOI: 10.1097/00002030-200305230-00002  0.439
2003 Altfeld M, Addo MM, Shankarappa R, Lee PK, Allen TM, Yu XG, Rathod A, Harlow J, O'Sullivan K, Johnston MN, Goulder PJ, Mullins JI, Rosenberg ES, Brander C, Korber B, ... Walker BD, et al. Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. Journal of Virology. 77: 7330-40. PMID 12805431 DOI: 10.1128/Jvi.77.13.7330-7340.2003  0.502
2003 Autran B, Debré P, Walker B, Katlama C. Therapeutic vaccines against HIV need international partnerships. Nature Reviews Immunology. 3: 503-509. PMID 12776210 DOI: 10.1038/Nri1107  0.361
2003 Yang OO, Sarkis PT, Ali A, Harlow JD, Brander C, Kalams SA, Walker BD. Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. The Journal of Experimental Medicine. 197: 1365-75. PMID 12743169 DOI: 10.1084/Jem.20022138  0.388
2003 Draenert R, Altfeld M, Brander C, Basgoz N, Corcoran C, Wurcel AG, Stone DR, Kalams SA, Trocha A, Addo MM, Goulder PJR, Walker BD. Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses Journal of Immunological Methods. 275: 19-29. PMID 12667667 DOI: 10.1016/S0022-1759(02)00541-0  0.388
2003 Montefiori DC, Altfeld M, Lee PK, Bilska M, Zhou J, Johnston MN, Gao F, Walker BD, Rosenberg ES. Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual Journal of Immunology. 170: 3906-3914. PMID 12646660 DOI: 10.4049/jimmunol.170.7.3906  0.421
2003 Severino ME, Sarkis PT, Walker BD, Yang OO. Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection. Virology. 306: 371-5. PMID 12642109 DOI: 10.1016/S0042-6822(02)00055-7  0.49
2003 Bobbitt KR, Addo MM, Altfeld M, Filzen T, Onafuwa AA, Walker BD, Collins KL. Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing. Immunity. 18: 289-99. PMID 12594955 DOI: 10.1016/S1074-7613(03)00031-1  0.428
2003 Bhardwaj N, Walker BD. Immunotherapy for AIDS virus infections: Cautious optimism for cell-based vaccine Nature Medicine. 9: 13-14. PMID 12514710 DOI: 10.1038/Nm0103-13  0.352
2003 Geiben-Lynn R, Kursar M, Brown NV, Addo MM, Shau H, Lieberman J, Luster AD, Walker BD. HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. Journal of Biological Chemistry. 278: 1569-1574. PMID 12421812 DOI: 10.1074/Jbc.M209964200  0.495
2002 Altfeld M, Allen TM, Yu XG, Johnston MN, Agrawal D, Korber BT, Montefiori DC, O'Connor DH, Davis BT, Lee PK, Maier EL, Harlow J, Goulder PJ, Brander C, Rosenberg ES, ... Walker BD, et al. HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature. 420: 434-9. PMID 12459786 DOI: 10.1038/Nature01200  0.492
2002 Allen TM, Kelleher AD, Zaunders J, Walker BD. STI and beyond: the prospects of boosting anti-HIV immune responses. Trends in Immunology. 23: 456-460. PMID 12200068 DOI: 10.1016/S1471-4906(02)02297-4  0.304
2002 Geiben-Lynn R, Brown N, Walker BD, Luster AD. Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor. The Journal of Biological Chemistry. 277: 42352-7. PMID 12192009 DOI: 10.1074/jbc.M207079200  0.443
2002 Yu XG, Addo MM, Rosenberg ES, Rodriguez WR, Lee PK, Fitzpatrick CA, Johnston MN, Strick D, Goulder PJ, Walker BD, Altfeld M. Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection. Journal of Virology. 76: 8690-701. PMID 12163589 DOI: 10.1128/JVI.76.17.8690-8701.2002  0.55
2002 Gandhi RT, Walker BD. Promises and pitfalls in the reconstitution of immunity in patients who have HIV-1 infection. Current Opinion in Immunology. 14: 487-94. PMID 12088684 DOI: 10.1016/S0952-7915(02)00359-X  0.38
2002 Barnes E, Lauer G, Walker B, Klenerman P. T cell failure in hepatitis C virus infection. Viral Immunology. 15: 285-293. PMID 12081013 DOI: 10.1089/08828240260066233  0.344
2002 Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, Reiser M, Kim AY, Lucas M, Klenerman P, Walker BD. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. Journal of Virology. 76: 6104-13. PMID 12021343 DOI: 10.1128/JVI.76.12.6104-6113.2002  0.336
2002 Addo MM, Altfeld M, Rathod A, Yu M, Yu XG, Goulder PJ, Rosenberg ES, Walker BD. HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. Aids (London, England). 16: 1071-3. PMID 11953475 DOI: 10.1097/00002030-200205030-00015  0.477
2002 Yang OO, Garcia-Zepeda EA, Walker BD, Luster AD. Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. The Journal of Infectious Diseases. 185: 1174-8. PMID 11930329 DOI: 10.1086/339678  0.336
2002 Altfeld M, van Lunzen J, Frahm N, Yu XG, Schneider C, Eldridge RL, Feeney ME, Meyer-Olson D, Stellbrink HJ, Walker BD. Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection. The Journal of Clinical Investigation. 109: 837-43. PMID 11901192 DOI: 10.1172/JCI14789  0.459
2002 Lauer GM, Nguyen TN, Day CL, Robbins GK, Flynn T, McGowan K, Rosenberg ES, Lucas M, Klenerman P, Chung RT, Walker BD. Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses. Journal of Virology. 76: 2817-26. PMID 11861849 DOI: 10.1128/JVI.76.6.2817-2826.2002  0.335
2002 Yu XG, Shang H, Addo MM, Eldridge RL, Phillips MN, Feeney ME, Strick D, Brander C, Goulder PJ, Rosenberg ES, Walker BD, Altfeld M. Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. Aids (London, England). 16: 321-8. PMID 11834942 DOI: 10.1097/00002030-200202150-00002  0.321
2002 Gandhi RT, Walker BD. Immunologic control of HIV-1. Annual Review of Medicine. 53: 149-72. PMID 11818468 DOI: 10.1146/ANNUREV.MED.53.082901.104011  0.448
2002 Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BD. Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. Journal of Virology. 76: 1626-31. PMID 11799157 DOI: 10.1128/Jvi.76.4.1626-1631.2002  0.489
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