| Year |
Citation |
Score |
| 2024 |
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology. PMID 38233584 DOI: 10.1038/s41589-023-01537-6 |
0.515 |
|
| 2024 |
Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife. 12. PMID 38189455 DOI: 10.7554/eLife.89489 |
0.568 |
|
| 2023 |
Joseph RE, Wales TE, Jayne S, Britton RG, Fulton DB, Engen JR, Dyer MJS, Andreotti AH. Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. Biorxiv : the Preprint Server For Biology. PMID 38187560 DOI: 10.1101/2023.12.18.572223 |
0.53 |
|
| 2023 |
Lin DY, Kueffer LE, Juneja P, Wales T, Engen JR, Andreotti AH. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Biorxiv : the Preprint Server For Biology. PMID 37786675 DOI: 10.1101/2023.06.02.543453 |
0.569 |
|
| 2023 |
A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, et al. Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α. Molecular Cell. 83: 1903-1920.e12. PMID 37267907 DOI: 10.1016/j.molcel.2023.05.008 |
0.501 |
|
| 2022 |
Peterle D, DePice D, Wales TE, Engen JR. Increase the flow rate and improve hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. 1689: 463742. PMID 36586285 DOI: 10.1016/j.chroma.2022.463742 |
0.478 |
|
| 2022 |
Du S, Alvarado JJ, Wales TE, Moroco JA, Engen JR, Smithgall TE. ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure (London, England : 1993). PMID 36115344 DOI: 10.1016/j.str.2022.08.008 |
0.577 |
|
| 2022 |
Peterle D, Wales TE, Engen JR. Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical Chemistry. PMID 35796687 DOI: 10.1021/acs.analchem.2c01446 |
0.539 |
|
| 2022 |
Prew MS, Camara CM, Botzanowski T, Moroco JA, Bloch NB, Levy HR, Seo HS, Dhe-Paganon S, Bird GH, Herce HD, Gygi MA, Escudero S, Wales TE, Engen JR, Walensky LD. Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nature Communications. 13: 3669. PMID 35760926 DOI: 10.1038/s41467-022-31466-2 |
0.523 |
|
| 2021 |
Joseph RE, Lowe J, Fulton DB, Engen JR, Wales TE, Andreotti AH. The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. Journal of Molecular Biology. 434: 167422. PMID 34954235 DOI: 10.1016/j.jmb.2021.167422 |
0.534 |
|
| 2021 |
Ji Z, Li H, Peterle D, Paulo JA, Ficarro SB, Wales TE, Marto JA, Gygi SP, Engen JR, Rapoport TA. Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Molecular Cell. PMID 34951965 DOI: 10.1016/j.molcel.2021.11.033 |
0.541 |
|
| 2021 |
Peterle D, Klimtchuk ES, Wales TE, Georgescauld F, Connors LH, Engen JR, Gursky O. A conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation. Journal of Molecular Biology. 167310. PMID 34678302 DOI: 10.1016/j.jmb.2021.167310 |
0.542 |
|
| 2021 |
Bloch NB, Wales TE, Prew MS, Levy HR, Engen JR, Walensky LD. The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932. PMID 34389733 DOI: 10.1038/s41467-021-25200-7 |
0.561 |
|
| 2020 |
Joseph RE, Amatya N, Fulton DB, Engen JR, Wales TE, Andreotti A. Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. Elife. 9. PMID 33226337 DOI: 10.7554/eLife.60470 |
0.568 |
|
| 2020 |
Engen JR, Botzanowski T, Peterle D, Georgescauld F, Wales TE. Developments in Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry. PMID 33112590 DOI: 10.1021/acs.analchem.0c04281 |
0.495 |
|
| 2020 |
Staudt RP, Alvarado JJ, Emert-Sedlak LA, Shi H, Shu ST, Wales TE, Engen JR, Smithgall TE. Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry. PMID 32862141 DOI: 10.1074/Jbc.Rev120.012317 |
0.554 |
|
| 2020 |
Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nature Chemical Biology. PMID 32807965 DOI: 10.1038/S41589-020-0625-7 |
0.562 |
|
| 2020 |
Vetter CJ, Thorn DC, Wheeler SG, Mundorff C, Halverson K, Wales TE, Shinde U, Engen JR, David LL, Carver JA, Lampi KJ. Cumulative deamidations of the major lens protein γS-crystallin increase its aggregation during unfolding and oxidation. Protein Science : a Publication of the Protein Society. PMID 32697405 DOI: 10.1002/Pro.3915 |
0.557 |
|
| 2020 |
Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nature Structural & Molecular Biology. PMID 32661419 DOI: 10.1038/S41594-020-0458-9 |
0.579 |
|
| 2020 |
Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, et al. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell. PMID 32533918 DOI: 10.1016/J.Molcel.2020.05.029 |
0.568 |
|
| 2020 |
Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/J.Chembiol.2020.04.004 |
0.602 |
|
| 2020 |
Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993). PMID 32359398 DOI: 10.1016/J.Str.2020.04.011 |
0.552 |
|
| 2020 |
Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. Acs Chemical Biology. PMID 32348108 DOI: 10.1021/Acschembio.0C00308 |
0.523 |
|
| 2020 |
Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Reports. 30: 3229-3239.e6. PMID 32160532 DOI: 10.1016/J.Celrep.2020.02.057 |
0.593 |
|
| 2020 |
Fleischhacker AS, Gunawan AL, Kochert BA, Liu L, Wales TE, Borowy MC, Engen JR, Ragsdale SW. The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation. The Journal of Biological Chemistry. PMID 32152224 DOI: 10.1074/Jbc.Ra120.012803 |
0.58 |
|
| 2020 |
Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A. Journal of Molecular Biology. PMID 32035904 DOI: 10.1016/J.Jmb.2020.01.029 |
0.59 |
|
| 2020 |
Eggertson MJ, Fadgen K, Engen JR, Wales TE. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data. Methods in Molecular Biology (Clifton, N.J.). 2051: 407-435. PMID 31552640 DOI: 10.1007/978-1-4939-9744-2_18 |
0.507 |
|
| 2019 |
Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH. Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591208 DOI: 10.1073/Pnas.1907566116 |
0.617 |
|
| 2019 |
Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nature Biotechnology. PMID 31427820 DOI: 10.1038/S41587-019-0222-Z |
0.528 |
|
| 2019 |
Bera AK, Lu J, Wales TE, Gondi S, Gurbani D, Nelson A, Engen JR, Westover KD. Structural basis of the atypical activation mechanism of KRAS V14I. The Journal of Biological Chemistry. PMID 31341022 DOI: 10.1074/Jbc.Ra119.009131 |
0.585 |
|
| 2019 |
Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, ... ... Wales TE, et al. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nature Methods. 16: 595-602. PMID 31249422 DOI: 10.1038/S41592-019-0459-Y |
0.552 |
|
| 2019 |
Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science (New York, N.Y.). PMID 31249135 DOI: 10.1126/science.aax1033 |
0.566 |
|
| 2019 |
Georgescauld F, Wales TE, Engen JR. Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding. Expert Review of Proteomics. 1-13. PMID 31215268 DOI: 10.1080/14789450.2019.1633920 |
0.618 |
|
| 2019 |
Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, ... ... Wales TE, et al. Tissue-specific oncogenic activity of K-RasA146T. Cancer Discovery. PMID 30952657 DOI: 10.1158/2159-8290.Cd-18-1220 |
0.529 |
|
| 2019 |
Kochert BA, Fleischhacker AS, Wales TE, Becker DF, Engen JR, Ragsdale SW. Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions. The Journal of Biological Chemistry. PMID 30944174 DOI: 10.1074/Jbc.Ra119.008592 |
0.6 |
|
| 2019 |
Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F. Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange. Biochemistry. PMID 30785730 DOI: 10.1021/Acs.Biochem.8B01308 |
0.597 |
|
| 2018 |
Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nature Structural & Molecular Biology. PMID 29967539 DOI: 10.1038/S41594-018-0085-X |
0.588 |
|
| 2018 |
de Wispelaere M, Lian W, Potisopon S, Li PC, Jang J, Ficarro SB, Clark MJ, Zhu X, Kaplan JB, Pitts JD, Wales TE, Wang J, Engen JR, Marto JA, Gray NS, et al. Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chemical Biology. PMID 29937406 DOI: 10.1016/J.Chembiol.2018.05.011 |
0.557 |
|
| 2018 |
Kochert BA, Iacob RE, Wales TE, Makriyannis A, Engen JR. Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes. Methods in Molecular Biology (Clifton, N.J.). 1764: 153-171. PMID 29605914 DOI: 10.1007/978-1-4939-7759-8_10 |
0.604 |
|
| 2018 |
Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, et al. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Molecular Cell. 69: 729-743.e7. PMID 29499131 DOI: 10.1016/J.Molcel.2018.02.005 |
0.555 |
|
| 2017 |
Moroco JA, Alvarado JJ, Staudt RP, Shic H, Wales TE, Smithgall TE, Engen JR. Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding. Journal of Molecular Biology. PMID 29258818 DOI: 10.1016/J.Jmb.2017.12.008 |
0.643 |
|
| 2017 |
Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH. Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts. Structure (London, England : 1993). PMID 28867612 DOI: 10.1016/J.Str.2017.07.014 |
0.635 |
|
| 2017 |
Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic BAX. Nature Chemical Biology. PMID 28692068 DOI: 10.1038/Nchembio.2433 |
0.577 |
|
| 2017 |
Wales TE, Fadgen KE, Eggertson MJ, Engen JR. Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. PMID 28596009 DOI: 10.1016/J.Chroma.2017.05.067 |
0.566 |
|
| 2016 |
Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-2. PMID 28042708 DOI: 10.1080/13506129.2016.1269737 |
0.555 |
|
| 2016 |
Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology. PMID 27159560 DOI: 10.1038/Nsmb.3223 |
0.588 |
|
| 2016 |
Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR. Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants. Journal of the American Society For Mass Spectrometry. PMID 27032648 DOI: 10.1007/S13361-016-1365-5 |
0.624 |
|
| 2016 |
Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH. Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases. Plos Computational Biology. 12: e1004826. PMID 27010561 DOI: 10.1371/Journal.Pcbi.1004826 |
0.623 |
|
| 2016 |
Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK. Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. Journal of the American Society For Mass Spectrometry. PMID 26810432 DOI: 10.1007/S13361-015-1330-8 |
0.559 |
|
| 2016 |
Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE. Dynamics of the Tec-family Tyrosine Kinase SH3 domains. Protein Science : a Publication of the Protein Society. PMID 26808198 DOI: 10.1002/Pro.2887 |
0.637 |
|
| 2016 |
Lee S, Wales TE, Gallagher C, Cohen DT, Escudero S, Luccarelli J, Huhn AJ, Cohen NA, Bird GH, Engen JR, Walensky LD. Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 Cancer Research. 76: 3553-3553. DOI: 10.1158/1538-7445.Am2016-3553 |
0.595 |
|
| 2015 |
Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? Journal of Molecular Biology. PMID 26562506 DOI: 10.1016/J.Jmb.2015.10.029 |
0.621 |
|
| 2015 |
Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR. Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor. Biochemistry. 54: 6382-91. PMID 26440750 DOI: 10.1021/Acs.Biochem.5B00875 |
0.612 |
|
| 2015 |
Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR. Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer. Analytical Chemistry. PMID 26133569 DOI: 10.1021/Acs.Analchem.5B01725 |
0.593 |
|
| 2015 |
Engen JR, Wales TE. Analytical Aspects of Hydrogen Exchange Mass Spectrometry. Annual Review of Analytical Chemistry (Palo Alto, Calif.). PMID 26048552 DOI: 10.1146/Annurev-Anchem-062011-143113 |
0.564 |
|
| 2015 |
Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Molecular Cell. 57: 873-86. PMID 25684204 DOI: 10.1016/J.Molcel.2015.01.014 |
0.585 |
|
| 2014 |
Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH. A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. Journal of Molecular Biology. 426: 3656-69. PMID 25193673 DOI: 10.1016/J.Jmb.2014.08.018 |
0.598 |
|
| 2014 |
Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE. Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. Plos One. 9: e105629. PMID 25144189 DOI: 10.1371/Journal.Pone.0105629 |
0.624 |
|
| 2013 |
Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA. Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties. Analytical Chemistry. 85: 11185-8. PMID 24215480 DOI: 10.1021/Ac403173P |
0.579 |
|
| 2013 |
Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Science Signaling. 6: ra76. PMID 23982207 DOI: 10.1126/Scisignal.2004298 |
0.586 |
|
| 2013 |
Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry. 52: 5016-26. PMID 23795559 DOI: 10.1021/Bi400430K |
0.621 |
|
| 2013 |
Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. Journal of Molecular Biology. 425: 3192-204. PMID 23747483 DOI: 10.1016/J.Jmb.2013.05.025 |
0.574 |
|
| 2013 |
Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O. Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI). The Journal of Biological Chemistry. 288: 19845-60. PMID 23720744 DOI: 10.1074/Jbc.M113.460170 |
0.61 |
|
| 2013 |
Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE. Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. International Reviews in Physical Chemistry. 32: 96-127. PMID 23682200 DOI: 10.1080/0144235X.2012.751175 |
0.631 |
|
| 2013 |
Wales TE, Eggertson MJ, Engen JR. Considerations in the analysis of hydrogen exchange mass spectrometry data. Methods in Molecular Biology (Clifton, N.J.). 1007: 263-88. PMID 23666730 DOI: 10.1007/978-1-62703-392-3_11 |
0.555 |
|
| 2013 |
Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Science : a Publication of the Protein Society. 22: 774-87. PMID 23553709 DOI: 10.1002/Pro.2257 |
0.593 |
|
| 2013 |
Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. The Journal of Biological Chemistry. 288: 6116-29. PMID 23303187 DOI: 10.1074/Jbc.M112.431312 |
0.618 |
|
| 2013 |
Panjarian SB, Iacob R, Shugui C, Wales T, Engen JR, Smithgall TE. Abstract 2221: Enhanced SH3:linker interaction allosterically sensitizes Abl kinases to small molecule inhibitors. Cancer Research. 73: 2221-2221. DOI: 10.1158/1538-7445.Am2013-2221 |
0.636 |
|
| 2012 |
Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A. Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). Acs Chemical Neuroscience. 3: 393-9. PMID 22860208 DOI: 10.1021/Cn3000263 |
0.581 |
|
| 2012 |
Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. Bmc Chemical Biology. 12: 1. PMID 22420777 DOI: 10.1186/1472-6769-12-1 |
0.611 |
|
| 2012 |
Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993). 20: 340-9. PMID 22325781 DOI: 10.1016/J.Str.2011.12.011 |
0.581 |
|
| 2012 |
Panjarian SB, Chen S, Iacob R, Wales T, Engen JR, Smithgall TE. Abstract 5599: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction Cancer Research. 72: 5599-5599. DOI: 10.1158/1538-7445.Am2012-5599 |
0.634 |
|
| 2011 |
Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (London, England : 1993). 19: 546-54. PMID 21481777 DOI: 10.1016/J.Str.2011.01.016 |
0.576 |
|
| 2011 |
Panjarian SB, Chen S, Iacob R, Wales TE, Engen JR, Smithgall TE. Abstract B75: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B75 |
0.638 |
|
| 2010 |
Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ. Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. Journal of Molecular Biology. 398: 40-53. PMID 20206636 DOI: 10.1016/J.Jmb.2010.02.040 |
0.586 |
|
| 2008 |
Wales TE, Fadgen KE, Gerhardt GC, Engen JR. High-speed and high-resolution UPLC separation at zero degrees Celsius. Analytical Chemistry. 80: 6815-20. PMID 18672890 DOI: 10.1021/Ac8008862 |
0.573 |
|
| 2008 |
Engen JR, Wales TE, Hochrein JM, Meyn MA, Banu Ozkan S, Bahar I, Smithgall TE. Structure and dynamic regulation of Src-family kinases. Cellular and Molecular Life Sciences : Cmls. 65: 3058-73. PMID 18563293 DOI: 10.1007/S00018-008-8122-2 |
0.584 |
|
| 2007 |
Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE. Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. Journal of Molecular Biology. 374: 121-9. PMID 17920628 DOI: 10.1016/J.Jmb.2007.09.009 |
0.6 |
|
| 2006 |
Weis DD, Wales TE, Engen JR, Hotchko M, Ten Eyck LF. Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. Journal of the American Society For Mass Spectrometry. 17: 1498-509. PMID 16875839 DOI: 10.1016/J.Jasms.2006.05.014 |
0.586 |
|
| 2006 |
Hochrein JM, Wales TE, Lerner EC, Schiavone AP, Smithgall TE, Engen JR. Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry. 45: 7733-9. PMID 16784224 DOI: 10.1021/Bi060438X |
0.58 |
|
| 2006 |
Wales TE, Engen JR. Partial unfolding of diverse SH3 domains on a wide timescale. Journal of Molecular Biology. 357: 1592-604. PMID 16487539 DOI: 10.1016/J.Jmb.2006.01.075 |
0.611 |
|
| 2006 |
Wang M, Wales TE, Fitzgerald MC. Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. Proceedings of the National Academy of Sciences of the United States of America. 103: 2600-4. PMID 16473949 DOI: 10.1073/Pnas.0508121103 |
0.547 |
|
| 2006 |
Wales TE, Engen JR. Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrometry Reviews. 25: 158-70. PMID 16208684 DOI: 10.1002/Mas.20064 |
0.613 |
|
| 2004 |
Wales TE, Richardson JS, Fitzgerald MC. Facile chemical synthesis and equilibrium unfolding properties of CopG. Protein Science : a Publication of the Protein Society. 13: 1918-26. PMID 15169951 DOI: 10.1110/Ps.04671804 |
0.513 |
|
| 2003 |
Powell KD, Wang MZ, Silinski P, Ma L, Wales TE, Dai SY, Warner AH, Yang X, Fitzgerald MC. The accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic stability of proteins Analytica Chimica Acta. 496: 225-232. DOI: 10.1016/S0003-2670(03)01002-X |
0.75 |
|
| 2002 |
Powell KD, Wales TE, Fitzgerald MC. Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. Protein Science : a Publication of the Protein Society. 11: 841-51. PMID 11910027 DOI: 10.1110/Ps.3820102 |
0.681 |
|
| 2001 |
Wales TE, Fitzgerald MC. The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant. Journal of the American Chemical Society. 123: 7709-10. PMID 11480998 DOI: 10.1021/Ja010775N |
0.497 |
|
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