Thomas E. Shenk
Affiliations: | Molecular Biology | Princeton University, Princeton, NJ |
Area:
Human cytomegalovirus replication and pathogenesisWebsite:
https://molbio.princeton.edu/people/thomas-e-shenkGoogle:
"Thomas Shenk"Bio:
http://www.nasonline.org/member-directory/members/40205.html
https://molbio.princeton.edu/research/labs/shenk-lab
https://scholar.princeton.edu/shenklab
DOI: 10.1016/0042-6822(73)90475-3
Thomas Shenk, the James A. Elkins Jr. Professor in the Life Sciences, was honored for “distinguished contributions to the field of virology.” Shenk studies the human cytomegalovirus -- how it originates, develops and spreads. He examines the biochemical activities of the genes of individual viruses, and he creates mutant viruses lacking specific genes and studies their growth. He also explores the molecular basis of the disease by studying large systems of genes. Shenk earned his Ph.D. from Rutgers University and worked as a postdoctoral fellow at Stanford University. He came to Princeton in 1984 after serving on the faculties of the University of Connecticut and the State University of New York-Stony Brook. A widely published author, he is a member of the National Academy of Sciences and the Institute of Medicine and a fellow of the American Academy of Arts and Sciences.
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Cross-listing: ID Tree
Parents
Sign in to add mentor| Victor Stollar | grad student | Rutgers, New Brunswick (Microtree) | |
| Paul Berg | post-doc | 1973-1975 | Stanford (Chemistry Tree) |
Children
Sign in to add trainee| Paul Soloway | grad student | (Neurotree) | |
| Tama Hasson | grad student | 1991 | Princeton (Chemistry Tree) |
| Ulrich Mueller | grad student | 1987-1991 | Princeton (Neurotree) |
| Catherine A. Blankenship | grad student | 2000 | Princeton |
| Katherine E. Gibson | grad student | 2000 | Princeton |
| Jill T. Bechtel | grad student | 2001 | Princeton (Microtree) |
| Jason L. Blanton | grad student | 2002 | Princeton (Microtree) |
| Edward P. Browne | grad student | 2003 | Princeton (Microtree) |
| Dimitri S. Laskoski | grad student | 2006 | Princeton |
| Joshua C. Oeltjen | grad student | 2006 | Princeton (Microtree) |
| Xuyan Feng | grad student | 2007 | Princeton |
| Dora Mitchell | grad student | 2008 | Princeton |
| Christian D. Cuevas | grad student | 2009 | Princeton |
| Sean T. Liu | grad student | 2010 | Princeton |
| Andrew W. Womack | grad student | 2011 | Princeton |
| Erin P. O'Keefe | grad student | 2012 | Princeton |
| Jesse Hwang | grad student | 2013 | Princeton |
| Sarah L. Grady | grad student | 2014 | Princeton |
| Yihao Fan | grad student | 2015 | Princeton |
| Leor S. Weinberger | post-doc | Princeton (Chemistry Tree) | |
| Nicholas C. Jones | post-doc | 1976-1977 | University of Connecticut School of Medicine (Chemistry Tree) |
| Richard J. Samulski | post-doc | 1984-1986 | Princeton (Neurotree) |
Publications
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| Roche KL, Remiszewski S, Todd MJ, et al. (2023) An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. The Journal of Clinical Investigation. 133 |
| Goodrum F, Lowen A, Lakdawala S, et al. (2023) Virology under the Microscope-a Call for Rational Discourse. Msphere. e0003423 |
| Goodrum F, Lowen A, Lakdawala S, et al. (2023) Virology under the Microscope-a Call for Rational Discourse. Mbio. e0018823 |
| Goodrum F, Lowen A, Lakdawala S, et al. (2023) Virology under the Microscope-a Call for Rational Discourse. Journal of Virology. e0008923 |
| Naseri-Nosar P, Nogalski MT, Shenk T. (2021) The aryl hydrocarbon receptor facilitates the human cytomegalovirus-mediated G1/S block to cell cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Chen S, Shenk T, Nogalski MT. (2019) P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells. Proceedings of the National Academy of Sciences of the United States of America. 116: 18971-18982 |
| Nogalski MT, Solovyov A, Kulkarni AS, et al. (2019) A tumor-specific endogenous repetitive element is induced by herpesviruses. Nature Communications. 10: 90 |
| Wu K, Oberstein A, Wang W, et al. (2018) Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts. Proceedings of the National Academy of Sciences of the United States of America |
| Oberstein A, Shenk T. (2017) Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype. Proceedings of the National Academy of Sciences of the United States of America |
| Ziehr B, Lenarcic E, Vincent HA, et al. (2015) Human cytomegalovirus TRS1 protein associates with the 7-methylguanosine mRNA cap and facilitates translation. Proteomics. 15: 1983-94 |