Kyle M. Brown, Ph.D.
Affiliations: | Harvard University, Cambridge, MA, United States |
Area:
evolutionary biology, molecular geneticsGoogle:
"Kyle Brown"Parents
Sign in to add mentor| Daniel L. Hartl | grad student | 2009 | Harvard | |
| (The evolutionary genetics of epistasis and pleiotropy.) | ||||
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Publications
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| Feng Y, Pinkerton AB, Hulea L, et al. (2015) SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Research |
| Kim H, Frederick DT, Levesque MP, et al. (2015) Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. Cell Reports. 11: 1458-73 |
| Costanzo MS, Brown KM, Hartl DL. (2011) Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum. Plos One. 6: e19636 |
| Brown KM, Costanzo MS, Xu W, et al. (2010) Compensatory mutations restore fitness during the evolution of dihydrofolate reductase. Molecular Biology and Evolution. 27: 2682-90 |
| Brown KM, Depristo MA, Weinreich DM, et al. (2009) Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways. Molecular Biology and Evolution. 26: 2455-62 |
| Lozovsky ER, Chookajorn T, Brown KM, et al. (2009) Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proceedings of the National Academy of Sciences of the United States of America. 106: 12025-30 |
| Brown KM, Landry CR, Hartl DL, et al. (2008) Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Molecular Ecology. 17: 2985-97 |