Johan A. Grahnen, Ph.D.

Affiliations: 
Molecular Biology University of Wyoming, Laramie, WY, United States 
Area:
molecular evolution, comparative genomics, bioinformatics
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"Johan Grahnen"

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David A. Liberles grad student 2012 University of Wyoming
 (Modeling the influence of protein structure, function and biophysics on the evolution of protein-coding sequences at the genic and genomic levels.)
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Publications

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Liberles DA, Teichmann SA, Bahar I, et al. (2012) The interface of protein structure, protein biophysics, and molecular evolution. Protein Science : a Publication of the Protein Society. 21: 769-85
Grahnen JA, Liberles DA. (2012) CASS: Protein sequence simulation with explicit genotype-phenotype mapping Trends in Evolutionary Biology. 4: 47-49
Siltberg-Liberles J, Grahnen JA, Liberles DA. (2011) The evolution of protein structures and structural ensembles under functional constraint. Genes. 2: 748-62
Grahnen JA, Nandakumar P, Kubelka J, et al. (2011) Biophysical and structural considerations for protein sequence evolution. Bmc Evolutionary Biology. 11: 361
Konrad A, Teufel AI, Grahnen JA, et al. (2011) Toward a general model for the evolutionary dynamics of gene duplicates. Genome Biology and Evolution. 3: 1197-209
Grahnen JA, Kubelka J, Liberles DA. (2011) Fast side chain replacement in proteins using a coarse-grained approach for evaluating the effects of mutation during evolution. Journal of Molecular Evolution. 73: 23-33
Liberles DA, Tisdell MD, Grahnen JA. (2011) Binding constraints on the evolution of enzymes and signalling proteins: the important role of negative pleiotropy. Proceedings. Biological Sciences / the Royal Society. 278: 1930-5
Grahnen JA, Amunson KE, Kubelka J. (2010) DFT-based simulations of IR amide I' spectra for a small protein in solution. Comparison of explicit and empirical solvent models. The Journal of Physical Chemistry. B. 114: 13011-20
Parchman TL, Geist KS, Grahnen JA, et al. (2010) Transcriptome sequencing in an ecologically important tree species: assembly, annotation, and marker discovery. Bmc Genomics. 11: 180
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