Nicole M. Samuels, Ph.D.

2000

Bradford W. Gibson	grad student	2000	UCSF
(Sialylation of lipooligosaccharides in Haemophilus: Studies on cytidine 5'-monophosphate N -acetylneuraminic acid synthetase and sialyltransferase.)

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Tullius MV, Phillips NJ, Scheffler NK, et al. (2002) The lbgAB gene cluster of Haemophilus ducreyi encodes a beta-1,4-galactosyltransferase and an alpha-1,6-DD-heptosyltransferase involved in lipooligosaccharide biosynthesis. Infection and Immunity. 70: 2853-61
Jones PA, Samuels NM, Phillips NJ, et al. (2002) Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation. The Journal of Biological Chemistry. 277: 14598-611
Schilling B, Goon S, Samuels NM, et al. (2001) Biosynthesis of sialylated lipooligosaccharides in Haemophilus ducreyi is dependent on exogenous sialic acid and not mannosamine. Incorporation studies using N-acylmannosamine analogues, N-glycolylneuraminic acid, and 13C-labeled N-acetylneuraminic acid. Biochemistry. 40: 12666-77
Samuels NM, Gibson BW, Miller SM. (1999) Investigation of the kinetic mechanism of cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi with new insights on rate-limiting steps from product inhibition analysis. Biochemistry. 38: 6195-203