Amol A. Padgaonkar, Ph.D.

Affiliations: 
2014 Molecular Biology and Genetics Temple University, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology, Oncology
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"Amol Padgaonkar"

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E Premkumar Reddy grad student 2014 Temple University
 (Discovery, biological and structural characterization of ON108600, a novel kinase inhibitor in triple negative breast cancer.)
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Publications

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Sato K, Padgaonkar AA, Baker SJ, et al. (2021) Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nature Communications. 12: 4671
Sato K, Padgaonkar A, Cosenza S, et al. (2020) Abstract P5-05-04: A novel inhibitor of cancer stem cells overcomes chemotherapy resistance of triple negative breast cancers Cancer Research
Padgaonkar A, Rechkoblit O, Vasquez-Del Carpio R, et al. (2018) Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia. Oncotarget. 9: 37753-37765
Padgaonkar A, Cosenza S, Pallela V, et al. (2015) Abstract 4453: The dual CK2/TNIK inhibitor, ON108600 targets cancer stem cells and induces apoptosis of paclitaxel resistant triple-negative breast cancer cells Cancer Research. 75: 4453-4453
Reddy MV, Akula B, Cosenza SC, et al. (2014) Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). Journal of Medicinal Chemistry. 57: 578-99
Roychowdhury A, Duraiswamy AJ, Maddi S, et al. (2014) Abstract 4537: Pharmacokinetics of PLK2 inhibitor GBO-006-1, developed as a novel first-in-class molecule to treat triple negative breast cancer Cancer Research. 74: 4537-4537
Godse P, Kumar P, Yewalkar N, et al. (2013) Discovery of P3971 an orally efficacious novel anticancer agent targeting HIF-1α and STAT3 pathways. Anti-Cancer Agents in Medicinal Chemistry. 13: 1460-6
Reddy MV, Mallireddigari MR, Pallela VR, et al. (2013) Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. Journal of Medicinal Chemistry. 56: 5562-86
Padgaonkar A, Rechkoblit O, Cosenza S, et al. (2013) Abstract 3239: Discovery and biological characterization of ON108600, a small molecule inhibitor of protein kinase CK2. Cancer Research. 73: 3239-3239
Manohar SM, Padgaonkar AA, Jalota-Badhwar A, et al. (2012) Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1α and induces G2/M arrest under hypoxia in prostate cancer cells. Prostate Cancer and Prostatic Diseases. 15: 15-27
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