Joseph W. Thornton

Affiliations: 
University of Oregon, Eugene, OR, United States 
Area:
protein evolution
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"Joseph Thornton"

Parents

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Rob DeSalle grad student American Museum of Natural History
Darcy B. Kelley grad student 2000 Columbia (Neurotree)
 (The evolution of molecular novelty: Mechanisms for generating and selecting new proteins and functions in the nuclear receptor superfamily.)
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Publications

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Eick GN, Bridgham JT, Anderson DP, et al. (2016) Robustness of reconstructed ancestral protein functions to statistical uncertainty. Molecular Biology and Evolution
Katsu Y, Cziko PA, Chandsawangbhuwana C, et al. (2016) A second estrogen receptor from Japanese lamprey (Lethenteron japonicum) does not have activities for estrogen binding and transcription. General and Comparative Endocrinology
Anderson DP, Whitney DS, Hanson-Smith V, et al. (2016) Correction: Evolution of an ancient protein function involved in organized multicellularity in animals. Elife. 5
Anderson DP, Whitney DS, Hanson-Smith V, et al. (2016) Evolution of an ancient protein function involved in organized multicellularity in animals. Elife. 5
Hudson WH, Kossmann BR, de Vera IM, et al. (2015) Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proceedings of the National Academy of Sciences of the United States of America
Anderson DW, McKeown AN, Thornton JW. (2015) Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites. Elife. 4
Hart KM, Harms MJ, Schmidt BH, et al. (2014) Thermodynamic system drift in protein evolution. Plos Biology. 12: e1001994
McKeown AN, Bridgham JT, Anderson DW, et al. (2014) Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell. 159: 58-68
Harms MJ, Thornton JW. (2014) Historical contingency and its biophysical basis in glucocorticoid receptor evolution. Nature. 512: 203-7
Bridgham JT, Keay J, Ortlund EA, et al. (2014) Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. Plos Genetics. 10: e1004058
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