Kevin R. Lynch
Affiliations: | Pharmacology | University of Virginia, Charlottesville, VA |
Area:
receptor pharmacologyWebsite:
http://innovation.virginia.edu/advisory/profile/krl2zGoogle:
"Kevin R. Lynch"Mean distance: 4976.62
Children
Sign in to add trainee| Amy Lee | grad student | 1992-1998 | UVA (Neurotree) |
| Shelley B. Hooks | grad student | 2001 | UVA |
| Christopher E. Heise | grad student | 2002 | UVA |
| Sangderk Lee | grad student | 2006 | UVA |
| Carol M. Rivera-Lopez | grad student | 2008 | UVA |
| Ashley H. Snyder | grad student | 2008 | UVA |
| Perry C. Kennedy | grad student | 2011 | UVA |
| Amanda M. Gellett | grad student | 2012 | UVA |
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Publications
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| Burgio AL, Shrader CW, Kharel Y, et al. (2023) 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry |
| Pashikanti S, Foster DJ, Kharel Y, et al. (2022) Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. Acs Bio & Med Chem Au. 2: 469-489 |
| Fritzemeier R, Foster D, Peralta A, et al. (2022) Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry |
| Kharel Y, Huang T, Salamon A, et al. (2020) Mechanism of sphingosine 1-phosphate clearance from blood. The Biochemical Journal |
| Sibley CD, Morris EA, Kharel Y, et al. (2020) Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. Journal of Medicinal Chemistry |
| Kharel Y, Agah S, Huang T, et al. (2018) Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. Plos One. 13: e0192179 |
| Adamiak M, Chelvarajan L, Lynch KR, et al. (2017) Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. 8: 65588-65600 |
| Childress ES, Kharel Y, Brown AM, et al. (2017) Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and In Vivo Activity. Journal of Medicinal Chemistry |
| Lynch KR, Thorpe SB, Santos WL. (2016) Sphingosine kinase inhibitors: a review of patent literature (2006-2015). Expert Opinion On Therapeutic Patents |
| Houck JD, Dawson TK, Kennedy AJ, et al. (2016) Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92 |