John D Hempel

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Protein structure, protein families
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"John Hempel"
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Holmes RS, Hempel J. (2011) Comparative studies of vertebrate aldehyde dehydrogenase 3: Sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene Chemico-Biological Interactions. 191: 113-121
Hempel J, Kraut A, Wymore T. (2009) Gamma glutamyl semialdehyde dehydrogenase: Simulations on native and mutant forms support the importance of outer shell lysines Chemico-Biological Interactions. 178: 75-78
Wymore T, Deerfield DW, Hempel J. (2007) Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations Biochemistry. 46: 9495-9506
Wymore T, Hempel J, Cho SS, et al. (2004) Molecular recognition of aldehydes by aldehyde dehydrogenase and mechanism of nucleophile activation. Proteins. 57: 758-71
Wymore T, Deerfield DW, Field MJ, et al. (2003) Initial catalytic events in class 3 aldehyde dehydrogenase: MM and QM/MM simulations. Chemico-Biological Interactions. 143: 75-84
Hempel J, Perozich J, Wymore T, et al. (2003) An algorithm for identification and ranking of family-specific residues, applied to the ALDH3 family. Chemico-Biological Interactions. 143: 23-28
Wymore T, Nicholas HB, Hempel J. (2001) Molecular dynamics simulation of class 3 aldehyde dehydrogenase. Chemico-Biological Interactions. 130: 201-207
Perozich J, Kuo I, Lindahl R, et al. (2001) Coenzyme specificity in aldehyde dehydrogenase Chemico-Biological Interactions. 130: 115-124
Hempel J, Lindahl R, Perozich J, et al. (2001) Beyond the catalytic core of ALDH: A web of important residues begins to emerge Chemico-Biological Interactions. 130: 39-46
Hempel J, Kuo I, Perozich J, et al. (2001) Aldehyde dehydrogenase: Maintaining critical active site geometry at motif 8 in the class 3 enzyme European Journal of Biochemistry. 268: 722-726
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