Laura M Richards, Ph.D.

2015-2021 Medical Biophysics University of Toronto, Toronto, ON, Canada 
"Laura Richards"


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Trevor Pugh grad student 2015-2021
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Qazi MA, Salim SK, Brown KR, et al. (2022) Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma. Cell Reports. 40: 111420
Hamed AA, Kunz DJ, El-Hamamy I, et al. (2022) A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nature Communications. 13: 4178
Richards LM, Whitley OKN, MacLeod G, et al. (2021) Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity. Nature Cancer. 2: 157-173
Croucher DC, Richards LM, Tsofack SP, et al. (2021) Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression. Nature Communications. 12: 6322
Pryszlak M, Wiggans M, Chen X, et al. (2021) The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports. 34: 108903
Sachamitr P, Ho JC, Ciamponi FE, et al. (2021) PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature Communications. 12: 979
Restall IJ, Cseh O, Richards LM, et al. (2020) Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway. Cancer Research
Manoranjan B, Venugopal C, Bakhshinyan D, et al. (2020) Wnt activation as a therapeutic strategy in medulloblastoma. Nature Communications. 11: 4323
Mohanraj S, Díaz-Mejía JJ, Pham MD, et al. (2020) CReSCENT: CanceR Single Cell ExpressioN Toolkit. Nucleic Acids Research
Lan X, Jörg DJ, Cavalli FMG, et al. (2017) Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature
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