Dustin Duncan, PhD
Affiliations: | 2023- | Chemistry | Brock University, Saint Catharines, Ontario, Canada |
Area:
Drug DiscoveryGoogle:
"Dustin Duncan"Parents
Sign in to add mentor| Tim Storr | grad student | 2013-2016 | Simon Fraser (Chemistry Tree) |
| Karine Auclair | grad student | 2016-2021 | McGill (Chemistry Tree) |
| Robert A. Batey | post-doc | 2021- | University of Toronto (Chemistry Tree) |
| Leah E. Cowen | post-doc | 2021- | University of Toronto |
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Publications
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| Iyer KR, Li SC, Revie NM, et al. (2023) Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chemical Biology |
| Puumala E, Zaslaver O, Chen A, et al. (2022) The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis. Mbio. e0273022 |
| Kim SH, Steere L, Zhang YK, et al. (2022) Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. Acs Chemical Biology |
| Kaabel S, Therien JPD, Deschênes CE, et al. (2021) Enzymatic depolymerization of highly crystalline polyethylene terephthalate enabled in moist-solid reaction mixtures. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Duncan D, Lupien A, Behr MA, et al. (2021) Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate. Microbiology (Reading, England). 167 |
| Guan J, Spry C, Tjhin ET, et al. (2021) Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides. Journal of Medicinal Chemistry |
| Swain A, Bambouskova M, Kim H, et al. (2020) Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nature Metabolism. 2: 594-602 |
| Duncan D, Auclair K. (2019) The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation. Archives of Biochemistry and Biophysics. 108069 |
| Bambouskova M, Gorvel L, Lampropoulou V, et al. (2018) Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature |
| Hammerer F, Chang JH, Duncan D, et al. (2016) Small molecule restores itaconate sensitivity in Salmonella enterica: a potential new approach to treat bacterial infections. Chembiochem : a European Journal of Chemical Biology |