Dustin Duncan, PhD

2023- Chemistry Brock University, Saint Catharines, Ontario, Canada 
Drug Discovery
"Dustin Duncan"


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Tim Storr grad student 2013-2016 Simon Fraser (Chemistry Tree)
Karine Auclair grad student 2016-2021 McGill (Chemistry Tree)
Robert A. Batey post-doc 2021- University of Toronto (Chemistry Tree)
Leah E. Cowen post-doc 2021- University of Toronto
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Iyer KR, Li SC, Revie NM, et al. (2023) Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chemical Biology
Puumala E, Zaslaver O, Chen A, et al. (2022) The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis. Mbio. e0273022
Kim SH, Steere L, Zhang YK, et al. (2022) Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. Acs Chemical Biology
Kaabel S, Therien JPD, Deschênes CE, et al. (2021) Enzymatic depolymerization of highly crystalline polyethylene terephthalate enabled in moist-solid reaction mixtures. Proceedings of the National Academy of Sciences of the United States of America. 118
Duncan D, Lupien A, Behr MA, et al. (2021) Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate. Microbiology (Reading, England). 167
Guan J, Spry C, Tjhin ET, et al. (2021) Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides. Journal of Medicinal Chemistry
Swain A, Bambouskova M, Kim H, et al. (2020) Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nature Metabolism. 2: 594-602
Duncan D, Auclair K. (2019) The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation. Archives of Biochemistry and Biophysics. 108069
Bambouskova M, Gorvel L, Lampropoulou V, et al. (2018) Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature
Hammerer F, Chang JH, Duncan D, et al. (2016) Small molecule restores itaconate sensitivity in Salmonella enterica: a potential new approach to treat bacterial infections. Chembiochem : a European Journal of Chemical Biology
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