| Year |
Citation |
Score |
| 2023 |
Walker RV, Yao Q, Xu H, Maranto A, Swaney KF, Ramachandran S, Li R, Cassina L, Polster BM, Outeda P, Boletta A, Watnick T, Qian F. Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis. Nature Communications. 14: 6513. PMID 37845212 DOI: 10.1038/s41467-023-42196-4 |
0.344 |
|
| 2021 |
Senum SR, Li YSM, Benson KA, Joli G, Olinger E, Lavu S, Madsen CD, Gregory AV, Neatu R, Kline TL, Audrézet MP, Outeda P, Nau CB, Meijer E, Ali H, ... ... Watnick TJ, et al. Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype. American Journal of Human Genetics. PMID 34890546 DOI: 10.1016/j.ajhg.2021.11.016 |
0.306 |
|
| 2020 |
Li W, Liang J, Outeda P, Turner S, Wakimoto BT, Watnick T. A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility. Plos Genetics. 16: e1009217. PMID 33378371 DOI: 10.1371/journal.pgen.1009217 |
0.348 |
|
| 2019 |
Wang K, Zelnick LR, Chen Y, Hoofnagle AN, Watnick T, Seliger S, Kestenbaum B. Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease. Clinical Journal of the American Society of Nephrology : Cjasn. PMID 31628117 DOI: 10.2215/Cjn.05610519 |
0.302 |
|
| 2018 |
Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schütze C, Wiedemann N, Artati A, Adamski J, Walz G, ... ... Watnick T, et al. The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. Plos Biology. 16: e2005651. PMID 30080851 DOI: 10.1371/Journal.Pbio.2005651 |
0.458 |
|
| 2018 |
Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, Pan D. A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes & Development. PMID 29891559 DOI: 10.1101/gad.315127.118 |
0.318 |
|
| 2018 |
Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, et al. A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Scientific Reports. 8: 2743. PMID 29426897 DOI: 10.1038/S41598-018-20856-6 |
0.367 |
|
| 2017 |
Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, ... Watnick T, et al. NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology. Scientific Reports. 7: 7733. PMID 28798345 DOI: 10.1038/S41598-017-08284-4 |
0.306 |
|
| 2017 |
Outeda P, Menezes L, Hartung EA, Bridges S, Zhou F, Zhu X, Xu H, Huang Q, Yao Q, Qian F, Germino GG, Watnick T. A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism. Kidney International. PMID 28729032 DOI: 10.1016/j.kint.2017.04.027 |
0.311 |
|
| 2017 |
Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, ... Watnick T, et al. Isolated polycystic liver disease genes define effectors of polycystin-1 function. The Journal of Clinical Investigation. PMID 28375157 DOI: 10.1172/Jci90129 |
0.344 |
|
| 2016 |
Porath B, Gainullin VG, Cornec-Le Gall E, Dillinger EK, Heyer CM, Hopp K, Edwards ME, Madsen CD, Mauritz SR, Banks CJ, Baheti S, Reddy B, Herrero JI, Bañales JM, Hogan MC, ... ... Watnick TJ, et al. Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease. American Journal of Human Genetics. 98: 1193-1207. PMID 27259053 DOI: 10.1016/J.Ajhg.2016.05.004 |
0.363 |
|
| 2016 |
Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L. The polycystin complex mediates Wnt/Ca(2+) signalling. Nature Cell Biology. PMID 27214281 DOI: 10.1038/Ncb3363 |
0.302 |
|
| 2016 |
Hofherr A, Wagner CJ, Watnick T, Köttgen M. Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition. Kidney International. PMID 26924047 DOI: 10.1016/j.kint.2015.11.015 |
0.336 |
|
| 2014 |
Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T. A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology : Jasn. 25: 81-91. PMID 24071006 DOI: 10.1681/Asn.2012050486 |
0.33 |
|
| 2012 |
Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T. A missense mutation in PKD1 attenuates the severity of renal disease. Kidney International. 81: 412-7. PMID 22031115 DOI: 10.1038/Ki.2011.370 |
0.361 |
|
| 2011 |
Köttgen M, Hofherr A, Li W, Chu K, Cook S, Montell C, Watnick T. Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels. Plos One. 6: e20031. PMID 21625494 DOI: 10.1371/Journal.Pone.0020031 |
0.516 |
|
| 2010 |
Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T. Pkd1 and Pkd2 are required for normal placental development. Plos One. 5. PMID 20862291 DOI: 10.1371/Journal.Pone.0012821 |
0.442 |
|
| 2009 |
Hartman TR, Liu D, Zilfou JT, Robb V, Morrison T, Watnick T, Henske EP. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway. Human Molecular Genetics. 18: 151-63. PMID 18845692 DOI: 10.1093/hmg/ddn325 |
0.327 |
|
| 2008 |
Köttgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, et al. TRPP2 and TRPV4 form a polymodal sensory channel complex. The Journal of Cell Biology. 182: 437-47. PMID 18695040 DOI: 10.1085/Jgp1323Oia2 |
0.399 |
|
| 2007 |
Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Human Molecular Genetics. 16: 1940-50. PMID 17575307 DOI: 10.1093/Hmg/Ddm141 |
0.344 |
|
| 2003 |
Watnick TJ, Jin Y, Matunis E, Kernan MJ, Montell C. A flagellar polycystin-2 homolog required for male fertility in Drosophila. Current Biology : Cb. 13: 2179-84. PMID 14680634 DOI: 10.1016/J.Cub.2003.12.002 |
0.561 |
|
| 2003 |
Watnick T, Germino G. From cilia to cyst. Nature Genetics. 34: 355-6. PMID 12923538 DOI: 10.1038/Ng0803-355 |
0.344 |
|
| 2002 |
Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG. Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proceedings of the National Academy of Sciences of the United States of America. 99: 16981-6. PMID 12482949 DOI: 10.1073/pnas.252484899 |
0.335 |
|
| 2001 |
Pei Y, Paterson AD, Wang KR, He N, Hefferton D, Watnick T, Germino GG, Parfrey P, Somlo S, St George-Hyslop P. Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease. American Journal of Human Genetics. 68: 355-63. PMID 11156533 DOI: 10.1086/318188 |
0.33 |
|
| 2000 |
Watnick T, He N, Wang K, Liang Y, Parfrey P, Hefferton D, St George-Hyslop P, Germino G, Pei Y. Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations. Nature Genetics. 25: 143-4. PMID 10835625 DOI: 10.1038/75981 |
0.385 |
|
| 1999 |
Watnick T, Phakdeekitcharoen B, Johnson A, Gandolph M, Wang M, Briefel G, Klinger KW, Kimberling W, Gabow P, Germino GG. Mutation detection of PKD1 identifies a novel mutation common to three families with aneurysms and/or very-early-onset disease. American Journal of Human Genetics. 65: 1561-71. PMID 10577909 DOI: 10.1086/302657 |
0.358 |
|
| 1999 |
Reynolds DM, Hayashi T, Cai Y, Veldhuisen B, Watnick TJ, Lens XM, Mochizuki T, Qian F, Maeda Y, Li L, Fossdal R, Coto E, Wu G, Breuning MH, Germino GG, et al. Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease. Journal of the American Society of Nephrology : Jasn. 10: 2342-51. PMID 10541293 |
0.338 |
|
| 1999 |
Qian F, Watnick TJ. Somatic mutation as mechanism for cyst formation in autosomal dominant polycystic kidney disease. Molecular Genetics and Metabolism. 68: 237-42. PMID 10527675 DOI: 10.1006/mgme.1999.2896 |
0.351 |
|
| 1999 |
Watnick T, Germino GG. Molecular basis of autosomal dominant polycystic kidney disease. Seminars in Nephrology. 19: 327-43. PMID 10435671 |
0.407 |
|
| 1999 |
Pei Y, Watnick T, He N, Wang K, Liang Y, Parfrey P, Germino G, St George-Hyslop P. Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology : Jasn. 10: 1524-9. PMID 10405208 |
0.343 |
|
| 1998 |
Watnick TJ, Torres VE, Gandolph MA, Qian F, Onuchic LF, Klinger KW, Landes G, Germino GG. Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease. Molecular Cell. 2: 247-51. PMID 9734362 |
0.384 |
|
| 1996 |
Qian F, Watnick TJ, Onuchic LF, Germino GG. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell. 87: 979-87. PMID 8978603 DOI: 10.1016/S0092-8674(00)81793-6 |
0.349 |
|
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