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Kristen J. Brennand, Ph.D. - Publications

Affiliations: 
2002-2007 Molecular and Cellular Biology Harvard University, Cambridge, MA, United States 
 2007-2012 Laboratory of Genetics Salk Institute for Biological Studies, La Jolla, CA, United States 
 2012-2020 Genetics, Neuroscience, Psychatry Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2021- Psychiatry and Genetics Yale University, New Haven, CT 
Area:
Psychiatric genomics, human induced pluripotent stem cells, CRISPR
Website:
http://labs.neuroscience.mssm.edu/project/brennand-lab/
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124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Schrode N, Seah C, Deans PJM, Hoffman G, Brennand KJ. Analysis framework and experimental design for evaluating synergy-driving gene expression. Nature Protocols. PMID 33432232 DOI: 10.1038/s41596-020-00436-7  0.775
2020 Wang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang YS, ... ... Brennand KJ, et al. Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease. Neuron. PMID 33238137 DOI: 10.1016/j.neuron.2020.11.002  0.794
2020 Townsley KG, Brennand KJ, Huckins LM. Massively parallel techniques for cataloguing the regulome of the human brain. Nature Neuroscience. PMID 33199899 DOI: 10.1038/s41593-020-00740-1  0.385
2020 Powell SK, O'Shea C, Brennand KJ, Akbarian S. Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological Psychiatry. PMID 33131715 DOI: 10.1016/j.biopsych.2020.06.033  0.629
2020 Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Iskhakova M, Fernando MB, Deans PJM, Powell SK, Javidfar B, Murphy A, Peter C, Møeller R, Garcia MF, Kimura M, ... ... Brennand KJ, et al. Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology. PMID 32995783 DOI: 10.1101/2020.09.20.300574  0.797
2020 Matos MR, Ho SM, Schrode N, Brennand KJ. Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics. Molecular and Cellular Neurosciences. 103532. PMID 32712198 DOI: 10.1016/J.Mcn.2020.103532  0.828
2020 Powell SK, O'Shea CP, Shannon SR, Akbarian S, Brennand KJ. Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. Advances in Neurobiology. 25: 155-206. PMID 32578147 DOI: 10.1007/978-3-030-45493-7_6  0.675
2020 Breen MS, Browne A, Hoffman GE, Stathopoulos S, Brennand K, Buxbaum JD, Drapeau E. Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism. Molecular Autism. 11: 53. PMID 32560742 DOI: 10.1186/S13229-020-00355-0  0.41
2020 Han L, Zhao X, Benton ML, Perumal T, Collins RL, Hoffman GE, Johnson JS, Sloofman L, Wang HZ, Stone MR, Brennand KJ, Brand H, Sieberts SK, Marenco S, et al. Functional annotation of rare structural variation in the human brain. Nature Communications. 11: 2990. PMID 32533064 DOI: 10.1038/S41467-020-16736-1  0.406
2020 Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, ... ... Brennand KJ, et al. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 9. PMID 32516938 DOI: 10.3390/Cells9061406  0.815
2020 Issler O, van der Zee YY, Ramakrishnan A, Wang J, Tan C, Loh YE, Purushothaman I, Walker DM, Lorsch ZS, Hamilton PJ, Peña CJ, Flaherty E, Hartley BJ, Torres-Berrío A, Parise EM, ... ... Brennand KJ, et al. Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression. Neuron. PMID 32304628 DOI: 10.1016/J.Neuron.2020.03.023  0.731
2020 Fernando MB, Ahfeldt T, Brennand KJ. Modeling the complex genetic architectures of brain disease. Nature Genetics. PMID 32203467 DOI: 10.1038/S41588-020-0596-3  0.796
2020 Sey NYA, Hu B, Mah W, Fauni H, McAfee JC, Rajarajan P, Brennand KJ, Akbarian S, Won H. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nature Neuroscience. PMID 32152537 DOI: 10.1038/S41593-020-0603-0  0.814
2020 Barretto N, Zhang H, Powell SK, Fernando MB, Zhang S, Flaherty EK, Ho SM, Slesinger PA, Duan J, Brennand KJ. ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs. Journal of Neuroscience Methods. 334: 108548. PMID 32065989 DOI: 10.1016/J.Jneumeth.2019.108548  0.81
2020 Rehbach K, Fernando MB, Brennand KJ. Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 40: 1176-1185. PMID 32024766 DOI: 10.1523/Jneurosci.0518-19.2019  0.806
2020 Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell'Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, et al. A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Molecular Psychiatry. PMID 31988434 DOI: 10.1038/S41380-020-0653-4  0.433
2020 Powell S, Yu A, Katz C, Brennand KJ. Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental Disorders Psychiatric News. 55. DOI: 10.1176/appi.pn.2020.7b14  0.301
2020 Dobrindt K, Zhang H, Das D, Abdollahi S, Prorok T, Ghosh S, Weintraub S, Genovese G, Powell SK, Lund A, Akbarian S, Eggan K, McCarroll S, Duan J, Avramopoulos D, ... Brennand KJ, et al. Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia Complex Psychiatry. 6: 68-82. DOI: 10.1159/000512716  0.41
2020 Farrelly L, Zhang S, Flaherty E, Topol A, Schrode N, Bastle R, Bhanu N, Garcia B, Li H, Brennand K, Maze I. T9. EPIGENETIC PROFILING IN SCHIZOPHRENIA DERIVED HUMAN INDUCED PLURIPOTENT STEM CELLS (HIPSCS) AND NEURONS Schizophrenia Bulletin. 46: S234-S234. DOI: 10.1093/Schbul/Sbaa029.569  0.795
2020 Breen M, Bierer LM, Bader HN, Makotkine I, Flory J, Meaney MJ, Brennand K, Yehuda R. Differential Transcriptional Responses to Glucocorticoid Activation in Cultured Blood Immune Cells and Neurons: A Novel Approach to PTSD Biomarker Development Biological Psychiatry. 87. DOI: 10.1016/J.Biopsych.2020.02.151  0.378
2019 Flaherty E, Zhu S, Barretto N, Cheng E, Deans PJM, Fernando MB, Schrode N, Francoeur N, Antoine A, Alganem K, Halpern M, Deikus G, Shah H, Fitzgerald M, Ladran I, ... ... Brennand KJ, et al. Neuronal impact of patient-specific aberrant NRXN1α splicing. Nature Genetics. 51: 1679-1690. PMID 31784728 DOI: 10.1038/S41588-019-0539-Z  0.813
2019 Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, ... ... Brennand KJ, et al. Synergistic effects of common schizophrenia risk variants. Nature Genetics. PMID 31548722 DOI: 10.1038/S41588-019-0497-5  0.821
2019 Halpern M, Brennand KJ, Gregory J. Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs. Neurobiology of Disease. 132: 104562. PMID 31381978 DOI: 10.1016/J.Nbd.2019.104562  0.427
2019 Rajarajan P, Flaherty E, Akbarian S, Brennand KJ. CRISPR-based functional evaluation of schizophrenia risk variants. Schizophrenia Research. PMID 31277978 DOI: 10.1016/J.Schres.2019.06.017  0.818
2019 Rajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Current Opinion in Neurobiology. 59: 112-119. PMID 31255842 DOI: 10.1016/J.Conb.2019.05.007  0.809
2019 Nudell V, Wei H, Nievergelt C, Maihofer AX, Shilling P, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Covault JM, Frye MA, Gage F, Gershon E, McInnis MG, et al. Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. Molecular Neuropsychiatry. 5: 115-124. PMID 31192224 DOI: 10.1159/000497354  0.362
2019 Brennand KJ. Leveraging Human Induced Pluripotent Stem Cell-Based Models Provides Biological Context to Genome-wide Association Study Findings. Biological Psychiatry. 85: 532-533. PMID 30871689 DOI: 10.1016/J.Biopsych.2019.01.021  0.442
2019 Eggenberger J, Blanco-Melo D, Panis M, Brennand KJ, tenOever BR. Type I interferon response impairs differentiation potential of pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30606801 DOI: 10.1073/Pnas.1812449116  0.398
2019 Brennand K. 9. Modelling The Impact Of Rare And Common Variants In Schizophrenia Using Stem Cells Schizophrenia Bulletin. 45. DOI: 10.1093/Schbul/Sbz022.032  0.426
2019 Absherty E, Zhu S, Cheng E, Antoine A, Halpern M, Deikus G, Gochman P, Rapoport J, Hoffman G, Tsankova N, Crary J, Sebra R, Fang G, Brennand K. 21ABERRANT NRXN1α SPLICING ARISING FROM 2P16.3 HETEROZYGOUS DELETIONS IMPACTS NEURONAL FUNCTION European Neuropsychopharmacology. 29: S1077-S1078. DOI: 10.1016/J.Euroneuro.2018.08.028  0.375
2019 Brennand K, Hoffman G, Schrode N, Flaherty E, Ho S. MODELING THE IMPACT OF RARE AND COMMON VARIANTS ON PREDISPOSITION TO SCHIZOPHRENIA USING STEM CELLS European Neuropsychopharmacology. 29: S1061. DOI: 10.1016/J.Euroneuro.2018.07.083  0.805
2019 Hoffman G, Hartley B, Flaherty E, Ladran I, Gochman P, Ruderfer D, Rapoport J, Sklar P, Brennand K. Transcriptional Signatures Of Childhood Onset Schizophrenia In Hipsc-Derived Npcs And Neurons Are Concordant With Signatures From Post Mortem Adult Brains European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.404  0.801
2019 Buxbaum J, Brennand K, Browne A, Drapeau E, Brenner K, Noggle S, Yehuda R. Large-Scale Reprogramming and Neuronal Differentiation In Complex Psychiatric Disorders European Neuropsychopharmacology. 29: S765-S766. DOI: 10.1016/J.Euroneuro.2017.06.124  0.485
2019 Weick J, Zimmerman A, Amoah S, Rodriguez B, DellOrco M, Hafez A, Chander P, Alural B, Hartley B, Lalonde J, Chen J, Webster M, Perlis R, Haggarty S, Brennand K, et al. F163. A Psychiatric Disease-Related Circular RNA Controls Neuronal Function and Cognition Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.700  0.34
2018 Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, ... ... Brennand KJ, et al. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science (New York, N.Y.). 362. PMID 30545851 DOI: 10.1126/Science.Aat4311  0.801
2018 McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, et al. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30487653 DOI: 10.1038/S41386-018-0273-8  0.465
2018 Readhead B, Hartley BJ, Eastwood BJ, Collier DA, Evans D, Farias R, He C, Hoffman G, Sklar P, Dudley JT, Schadt EE, Savić R, Brennand KJ. Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia. Nature Communications. 9: 4926. PMID 30451900 DOI: 10.1038/S41467-018-07326-3  0.322
2018 Readhead B, Hartley BJ, Eastwood BJ, Collier DA, Evans D, Farias R, He C, Hoffman G, Sklar P, Dudley JT, Schadt EE, Savić R, Brennand KJ. Expression-based drug screening of neural progenitor cells from individuals with schizophrenia. Nature Communications. 9: 4412. PMID 30356048 DOI: 10.1038/S41467-018-06515-4  0.432
2018 Grochowski CM, Gu S, Yuan B, Tcw J, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB. Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes. Human Mutation. PMID 29696747 DOI: 10.1002/Humu.23537  0.33
2018 Guennewig B, Bitar M, Obiorah I, Hanks J, O'Brien EA, Kaczorowski DC, Hurd YL, Roussos P, Brennand KJ, Barry G. THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Translational Psychiatry. 8: 89. PMID 29691375 DOI: 10.1038/S41398-018-0137-3  0.539
2018 LaMarca EA, Powell SK, Akbarian S, Brennand KJ. Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells. Frontiers in Pediatrics. 6: 82. PMID 29666786 DOI: 10.3389/Fped.2018.00082  0.658
2018 Hoffman GE, Schrode N, Flaherty E, Brennand KJ. New considerations for hiPSC-based models of neuropsychiatric disorders. Molecular Psychiatry. PMID 29483625 DOI: 10.1038/S41380-018-0029-1  0.821
2018 Hoffman GE, Brennand KJ. Mapping regulatory variants in hiPSC models. Nature Genetics. 50: 1-2. PMID 29273803 DOI: 10.1038/S41588-017-0017-4  0.477
2018 Hoffman G, Hartley B, Ruderfer D, Rapoport J, Sklar P, Brennand K. 20.4 MODELING THE CONTRIBUTION OF COMMON VARIANTS TO SCHIZOPHRENIA RISK Schizophrenia Bulletin. 44: S34-S34. DOI: 10.1093/Schbul/Sby014.083  0.618
2018 Brennand K. 20. THE APPLICATION OF STEM CELL MODELS TO VALIDATE RARE AND COMMON VARIANTS CONTRIBUTING TO SCHIZOPHRENIA Schizophrenia Bulletin. 44: S32-S33. DOI: 10.1093/Schbul/Sby014.079  0.548
2018 Brennand K. 105. Modeling the Contribution of Common Variants to Schizophrenia Risk Biological Psychiatry. 83: S43. DOI: 10.1016/J.Biopsych.2018.02.123  0.359
2017 Stachowiak EK, Benson CA, Narla ST, Dimitri A, Chuye LEB, Dhiman S, Harikrishnan K, Elahi S, Freedman D, Brennand KJ, Sarder P, Stachowiak MK. Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1. Translational Psychiatry. 7: 6. PMID 30446636 DOI: 10.1038/S41398-017-0054-X  0.481
2017 Gonzalez DM, Gregory J, Brennand KJ. The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. Frontiers in Cell and Developmental Biology. 5: 117. PMID 29312938 DOI: 10.3389/Fcell.2017.00117  0.498
2017 Brennand KJ. Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells. Stem Cell Investigation. 4: 91. PMID 29270417 DOI: 10.21037/Sci.2017.10.05  0.539
2017 Hoffman GE, Hartley BJ, Flaherty E, Ladran I, Gochman P, Ruderfer DM, Stahl EA, Rapoport J, Sklar P, Brennand KJ. Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains. Nature Communications. 8: 2225. PMID 29263384 DOI: 10.1038/S41467-017-02330-5  0.801
2017 Obiorah IV, Muhammad H, Stafford K, Flaherty EK, Brennand KJ. THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons. Molecular Neuropsychiatry. 3: 73-84. PMID 29230395 DOI: 10.1159/000477762  0.776
2017 Prytkova I, Brennand KJ. Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells. Frontiers in Cellular Neuroscience. 11: 360. PMID 29217999 DOI: 10.3389/fncel.2017.00360  0.438
2017 Flaherty E, Deranieh RM, Artimovich E, Lee IS, Siegel AJ, Levy DL, Nestor MW, Brennand KJ. Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity. Npj Schizophrenia. 3: 35. PMID 28975140 DOI: 10.1038/s41537-017-0033-5  0.788
2017 Flaherty E, Deranieh RM, Artimovich E, Lee IS, Siegel AJ, Levy DL, Nestor MW, Brennand KJ. Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity. Npj Schizophrenia. 3: 35. PMID 28970473 DOI: 10.1038/s41537-017-0033-5  0.788
2017 Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, ... ... Brennand KJ, et al. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Reports. 20: 2525. PMID 28877483 DOI: 10.1016/J.Celrep.2017.08.073  0.486
2017 Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28757165 DOI: 10.1016/J.Stemcr.2017.06.018  0.766
2017 Ho SM, Hartley BJ, Flaherty E, Rajarajan P, Abdelaal R, Obiorah I, Barretto N, Muhammad H, Phatnani HP, Akbarian S, Brennand KJ. Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. Stem Cell Reports. PMID 28757163 DOI: 10.1016/J.Stemcr.2017.06.012  0.817
2017 Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE, Evans T, Studer L, Chen S. High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell Stem Cell. PMID 28736217 DOI: 10.1016/J.Stem.2017.06.017  0.343
2017 Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, ... ... Brennand KJ, et al. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature Genetics. PMID 28671686 DOI: 10.1038/Ng.3906  0.813
2017 Powell SK, Gregory J, Akbarian S, Brennand KJ. Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease. Molecular and Cellular Neurosciences. PMID 28549865 DOI: 10.1016/J.Mcn.2017.05.007  0.428
2017 Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nature Communications. 8: 15157. PMID 28462912 DOI: 10.1038/Ncomms15157  0.48
2017 Tcw J, Carvalho CM, Yuan B, Gu S, Altheimer AN, McCarthy S, Malhotra D, Sebat J, Siegel AJ, Rudolph U, Lupski JR, Levy DL, Brennand KJ. Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis. Stem Cell Reports. PMID 28216146 DOI: 10.1016/J.Stemcr.2017.01.010  0.416
2017 Mitchell AC, Javidfar B, Pothula V, Ibi D, Shen EY, Peter CJ, Bicks LK, Fehr T, Jiang Y, Brennand KJ, Neve RL, Gonzalez-Maeso J, Akbarian S. MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Molecular Psychiatry. PMID 28115742 DOI: 10.1038/Mp.2016.254  0.485
2017 Gönenç A, Douvaras P, Siegel A, Olson D, Rudolph U, Fossati V, Brennand K, Levy D. SA93. Deletion of CNTNAP2 and White Matter Changes in Schizophrenia Schizophrenia Bulletin. 43: S146-S146. DOI: 10.1093/Schbul/Sbx023.091  0.454
2017 Kelsoe J, McCarthy M, Nievergelt C, Shilling P, Nurnberger J, Gershon E, Coryell W, McInnis M, Berrettini W, Odegaard K, Calabrese J, Zandi P, Alda M, Frye M, Craig D, ... ... Brennand K, et al. 705. Using iPS Derived Neurons and GWAS Together to Identify Genes for Lithium Response Biological Psychiatry. 81: S285-S286. DOI: 10.1016/J.Biopsych.2017.02.772  0.759
2017 Akbarian S, Rajaran P, Brennand K. 692. From Nucleosome to Nucleus: 3D Genome Mappings in Mouse Models of Psychiatric Disease, and in Human Postmortem Brain Biological Psychiatry. 81. DOI: 10.1016/J.Biopsych.2017.02.759  0.348
2016 Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, ... ... Brennand KJ, et al. Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Molecular Psychiatry. PMID 27752082 DOI: 10.1038/mp.2016.163  0.776
2016 Hartley BJ, Brennand KJ. Neural organoids for disease phenotyping, drug screening and developmental biology studies. Neurochemistry International. PMID 27744003 DOI: 10.1016/J.Neuint.2016.10.004  0.419
2016 Roussos P, Guennewig B, Kaczorowski DC, Barry G, Brennand KJ. Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons. Jama Psychiatry. PMID 27732689 DOI: 10.1001/Jamapsychiatry.2016.2575  0.472
2016 Rajarajan P, Gil SE, Brennand KJ, Akbarian S. Spatial genome organization and cognition. Nature Reviews. Neuroscience. PMID 27708356 DOI: 10.1038/Nrn.2016.124  0.787
2016 Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, ... ... Brennand KJ, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nature Neuroscience. PMID 27668389 DOI: 10.1038/Nn.4399  0.427
2016 Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, ... ... Brennand KJ, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine. PMID 27571349 DOI: 10.1038/Nm.4184  0.607
2016 Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria KC, Beltrao-Braga PC, Trujillo CA, Mendes AP, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand KJ, et al. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Molecular Psychiatry. PMID 27378147 DOI: 10.1038/Mp.2016.95  0.829
2016 Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, et al. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. Bmc Psychiatry. 16: 129. PMID 27150464 DOI: 10.1186/S12888-016-0732-X  0.748
2016 Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, ... ... Brennand KJ, et al. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Reports. PMID 27117414 DOI: 10.1016/J.Celrep.2016.03.090  0.435
2016 Brennand K. Can prenatal infection contribute to psychiatric disease in offspring Science Translational Medicine. 8. DOI: 10.1126/Scitranslmed.Aaf3846  0.404
2016 Brennand K. Is Huntington’s disease a neurodevelopmental disorder? Science Translational Medicine. 8. DOI: 10.1126/Scitranslmed.Aad9760  0.334
2016 Tcw J, Wang M, Bertelsen S, Zhang B, Brennand K, Goate AM. P1-021: Exploring Cell Autonomous and Non-Cell Autonomous Effects of APOE Genotype in IPSC-Derived Astrocytes and Neurons Alzheimer's & Dementia. 12: P407-P407. DOI: 10.1016/J.Jalz.2016.06.768  0.422
2016 Hartley BJ, Hadas Y, Brennand KJ. hiPSC Models Relevant to Schizophrenia Handbook of Behavioral Neuroscience. 23: 391-406. DOI: 10.1016/B978-0-12-800981-9.00023-7  0.515
2015 Lee IS, Carvalho CM, Douvaras P, Ho SM, Hartley BJ, Zuccherato LW, Ladran IG, Siegel AJ, McCarthy S, Malhotra D, Sebat J, Rapoport J, Fossati V, Lupski JR, Levy DL, ... Brennand KJ, et al. Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells. Npj Schizophrenia. 1. PMID 26985448  0.803
2015 Ho SM, Hartley BJ, Tcw J, Beaumont M, Stafford K, Slesinger PA, Brennand KJ. Rapid Ngn2-induction of Excitatory Neurons from hiPSC-Derived Neural Progenitor Cells. Methods (San Diego, Calif.). PMID 26626326 DOI: 10.1016/J.Ymeth.2015.11.019  0.837
2015 Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, et al. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. PMID 26610635 DOI: 10.1016/J.Stemcr.2015.10.011  0.774
2015 Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, ... ... Brennand KJ, et al. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. PMID 26605530 DOI: 10.1038/Nature16182  0.778
2015 Flaherty EK, Brennand KJ. Using hiPSCs to Model Neuropsychiatric Copy Number Variations (CNVs) has Potential to Reveal Underlying Disease Mechanisms. Brain Research. PMID 26581337 DOI: 10.1016/J.Brainres.2015.11.009  0.776
2015 Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, ... ... Brennand KJ, et al. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. PMID 26524527 DOI: 10.1038/Nature15526  0.785
2015 Topol A, English JA, Flaherty E, Rajarajan P, Hartley BJ, Gupta S, Desland F, Zhu S, Goff T, Friedman L, Rapoport J, Felsenfeld D, Cagney G, Mackay-Sim A, Savas JN, ... ... Brennand KJ, et al. Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients. Translational Psychiatry. 5: e662. PMID 26485546 DOI: 10.1038/Tp.2015.118  0.812
2015 Ho SM, Topol A, Brennand KJ. From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease. Biomarker Insights. 10: 31-41. PMID 26045654 DOI: 10.4137/Bmi.S20066  0.82
2015 Kocerha J, Dwivedi Y, Brennand KJ. Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease. Molecular Psychiatry. 20: 677-84. PMID 25824307 DOI: 10.1038/Mp.2015.30  0.411
2015 Topol A, Tran NN, Brennand KJ. A guide to generating and using hiPSC derived NPCs for the study of neurological diseases. Journal of Visualized Experiments : Jove. e52495. PMID 25742222 DOI: 10.3791/52495  0.503
2015 Topol A, Zhu S, Tran N, Simone A, Fang G, Brennand KJ. Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients. Biological Psychiatry. PMID 25708228 DOI: 10.1016/J.Biopsych.2014.12.028  0.443
2015 Hartley BJ, Tran N, Ladran I, Reggio K, Brennand KJ. Dopaminergic differentiation of schizophrenia hiPSCs. Molecular Psychiatry. 20: 549-50. PMID 25623947 DOI: 10.1038/Mp.2014.194  0.355
2015 Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont KG, Kim HJ, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao SH, Mrksich M, Rakic P, et al. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry. 20: 361-8. PMID 24686136 DOI: 10.1038/Mp.2014.22  0.645
2015 Brennand K. A new recipe for serotonergic neurons Science Translational Medicine. 7. DOI: 10.1126/Scitranslmed.Aad5908  0.42
2015 Brennand K. Insights into the pharmacology of depression Science Translational Medicine. 7. DOI: 10.1126/Scitranslmed.Aad3628  0.359
2015 Brennand K. Detecting mutant huntingtin protein in HD patients Science Translational Medicine. 7. DOI: 10.1126/Scitranslmed.Aac8559  0.307
2015 Brennand K. Stem cells in gels Science Translational Medicine. 7. DOI: 10.1126/Scitranslmed.Aac5089  0.353
2014 Schadt EE, Buchanan S, Brennand KJ, Merchant KM. Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Frontiers in Pharmacology. 5: 252. PMID 25520658 DOI: 10.3389/Fphar.2014.00252  0.462
2014 Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, ... ... Brennand KJ, et al. A role for noncoding variation in schizophrenia. Cell Reports. 9: 1417-29. PMID 25453756 DOI: 10.1016/J.Celrep.2014.10.015  0.665
2014 Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 3: 531-8. PMID 25358781 DOI: 10.1016/J.Stemcr.2014.08.001  0.596
2014 Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 82: 560-72. PMID 24726381 DOI: 10.1016/J.Neuron.2014.03.002  0.567
2014 Yu DX, Di Giorgio FP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmick JM, Silberman P, Silberman G, Jappelli R, Gage FH. Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2: 295-310. PMID 24672753 DOI: 10.1016/J.Stemcr.2014.01.009  0.695
2014 Brennand KJ, Landek-Salgado MA, Sawa A. Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells. Biological Psychiatry. 75: 936-44. PMID 24331955 DOI: 10.1016/J.Biopsych.2013.10.025  0.473
2014 Brennand K. Modeling predisposition to schizophrenia using hiPSCs Schizophrenia Research. 160: 11-12. DOI: 10.1016/J.Schres.2014.09.077  0.328
2013 Brennand KJ. Inducing cellular aging: enabling neurodegeneration-in-a-dish. Cell Stem Cell. 13: 635-6. PMID 24315433 DOI: 10.1016/J.Stem.2013.11.017  0.485
2013 McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. Mosaic copy number variation in human neurons. Science (New York, N.Y.). 342: 632-7. PMID 24179226 DOI: 10.1126/Science.1243472  0.73
2013 Ladran I, Tran N, Topol A, Brennand KJ. Neural stem and progenitor cells in health and disease. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 5: 701-15. PMID 24068527 DOI: 10.1002/Wsbm.1239  0.467
2013 Tran NN, Ladran IG, Brennand KJ. Modeling schizophrenia using induced pluripotent stem cell-derived and fibroblast-induced neurons. Schizophrenia Bulletin. 39: 4-10. PMID 23172000 DOI: 10.1093/Schbul/Sbs127  0.542
2013 Brennand K, Gage F. Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells Patterning and Cell Type Specification in the Developing Cns and Pns. 111-129. DOI: 10.1016/B978-0-12-397265-1.00046-0  0.445
2012 Brennand KJ, Simone A, Tran N, Gage FH. Modeling psychiatric disorders at the cellular and network levels. Molecular Psychiatry. 17: 1239-53. PMID 22472874 DOI: 10.1038/Mp.2012.20  0.622
2012 Brennand KJ, Gage FH. Modeling psychiatric disorders through reprogramming. Disease Models & Mechanisms. 5: 26-32. PMID 21954066 DOI: 10.1242/Dmm.008268  0.6
2011 Brennand KJ, Gage FH. Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. Stem Cells (Dayton, Ohio). 29: 1915-22. PMID 22009633 DOI: 10.1002/Stem.762  0.671
2011 Marchetto MC, Brennand KJ, Boyer LF, Gage FH. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Human Molecular Genetics. 20: R109-15. PMID 21828073 DOI: 10.1093/Hmg/Ddr336  0.582
2011 Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells (Dayton, Ohio). 29: 1158-64. PMID 21544903 DOI: 10.1002/Stem.657  0.494
2011 Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. Modelling schizophrenia using human induced pluripotent stem cells. Nature. 473: 221-5. PMID 21490598 DOI: 10.1038/Nature09915  0.699
2011 Rigamonti A, Brennand K, Lau F, Cowan CA. Rapid cellular turnover in adipose tissue. Plos One. 6: e17637. PMID 21407813 DOI: 10.1371/Journal.Pone.0017637  0.59
2011 Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proceedings of the National Academy of Sciences of the United States of America. 108: 3005-10. PMID 21278334 DOI: 10.1073/Pnas.1007753108  0.609
2011 Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. Erratum: Modelling schizophrenia using human induced pluripotent stem cells Nature. 479: 556-556. DOI: 10.1038/Nature10603  0.369
2010 Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage FH, Izpisua-Belmonte JC. High-efficient generation of induced pluripotent stem cells from human astrocytes. Plos One. 5: e15526. PMID 21170306 DOI: 10.1371/Journal.Pone.0015526  0.549
2009 Brennand K, Melton D. Slow and steady is the key to β-cell replication Journal of Cellular and Molecular Medicine. 13: 472-487. PMID 19379145 DOI: 10.1111/J.1582-4934.2008.00635.X  0.516
2008 Szotek PP, Chang HL, Brennand K, Fujino A, Pieretti-Vanmarcke R, Lo Celso C, Dombkowski D, Preffer F, Cohen KS, Teixeira J, Donahoe PK. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proceedings of the National Academy of Sciences of the United States of America. 105: 12469-73. PMID 18711140 DOI: 10.1073/Pnas.0805012105  0.389
2008 Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells Current Biology. 18: 890-894. PMID 18501604 DOI: 10.1016/J.Cub.2008.05.010  0.409
2008 Szotek PP, Chang HL, Brennand K, Fujino A, Pieretti-Vanmarcke R, Celso CL, Dombkowski D, Preffer F, Cohen KS, Teixeira J, Donahoe PK. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 34, (12469-12473) DOI: 10.1073/pnas.0805012105) Proceedings of the National Academy of Sciences of the United States of America. 105. DOI: 10.1073/Pnas.0809025105  0.328
2007 Brennand K, Huangfu D, Melton D. All beta cells contribute equally to islet growth and maintenance. Plos Biology. 5: e163. PMID 17535113 DOI: 10.1371/Journal.Pbio.0050163  0.705
2007 Brennand K, Huangfu D, Melton D. Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance Plos Biology. 5: e240. DOI: 10.1371/Journal.Pbio.0050240  0.679
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