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Richard J. McKenney, Ph.D. - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Axonal transport, Neural development, Dynein
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Okada K, Iyer BR, Lammers LG, Gutierrez PA, Li W, Markus SM, McKenney RJ. Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein. Nature Communications. 14: 5833. PMID 37730751 DOI: 10.1038/s41467-023-41466-5  0.397
2023 Fan X, McKenney RJ. Control of motor landing and processivity by the CAP-Gly domain in the KIF13B tail. Nature Communications. 14: 4715. PMID 37543636 DOI: 10.1038/s41467-023-40425-4  0.491
2023 Rahi A, Chakraborty M, Agarwal S, Vosberg KM, Agarwal S, Wang AY, McKenney RJ, Varma D. The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit. The Journal of Cell Biology. 222. PMID 37265445 DOI: 10.1083/jcb.202208018  0.69
2023 Okada K, Iyer BR, Lammers LG, Gutierrez P, Li W, Markus SM, McKenney RJ. Conserved Roles for the Dynein Intermediate Chain and Ndel1 in Assembly and Activation of Dynein. Biorxiv : the Preprint Server For Biology. PMID 36711700 DOI: 10.1101/2023.01.13.523097  0.422
2022 Siahaan V, Tan R, Humhalova T, Libusova L, Lacey SE, Tan T, Dacy M, Ori-McKenney KM, McKenney RJ, Braun M, Lansky Z. Microtubule lattice spacing governs cohesive envelope formation of tau family proteins. Nature Chemical Biology. PMID 35996000 DOI: 10.1038/s41589-022-01096-2  0.337
2022 Chiba K, Ori-McKenney KM, Niwa S, McKenney RJ. Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity. Cell Reports. 39: 111016. PMID 35767955 DOI: 10.1016/j.celrep.2022.111016  0.387
2022 Chiba K, Ori-McKenney KM, Niwa S, McKenney RJ. Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity. Cell Reports. 39: 110900. PMID 35649356 DOI: 10.1016/j.celrep.2022.110900  0.522
2022 Afreen S, Rahi A, Landeros AG, Chakraborty M, McKenney RJ, Varma D. In Vitro and In Vivo Approaches to Study Kinetochore-Microtubule Attachments During Mitosis. Methods in Molecular Biology (Clifton, N.J.). 2415: 123-138. PMID 34972950 DOI: 10.1007/978-1-0716-1904-9_9  0.582
2021 Lam AJ, Rao L, Anazawa Y, Okada K, Chiba K, Dacy M, Niwa S, Gennerich A, Nowakowski DW, McKenney RJ. A highly conserved 3 helix within the kinesin motor domain is critical for kinesin function and human health. Science Advances. 7. PMID 33931448 DOI: 10.1126/sciadv.abf1002  0.448
2020 Markus SM, Marzo MG, McKenney RJ. New insights into the mechanism of dynein motor regulation by lissencephaly-1. Elife. 9. PMID 32692650 DOI: 10.7554/Elife.59737  0.501
2020 Doval F, Chiba K, McKenney RJ, Ori-McKenney KM, Vershinin MD. Temperature-dependent activity of kinesins is regulable. Biochemical and Biophysical Research Communications. PMID 32507595 DOI: 10.1016/J.Bbrc.2020.05.157  0.443
2020 McKenney RJ. LIS1 cracks open dynein. Nature Cell Biology. 22: 515-517. PMID 32341546 DOI: 10.1038/S41556-020-0500-5  0.585
2020 Monroy BY, Tan TC, Oclaman JM, Han JS, Simó S, Niwa S, Nowakowski DW, McKenney RJ, Ori-McKenney KM. A Combinatorial MAP Code Dictates Polarized Microtubule Transport. Developmental Cell. PMID 32109385 DOI: 10.1016/J.Devcel.2020.01.029  0.579
2020 Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, et al. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife. 9. PMID 31958056 DOI: 10.7554/Elife.51131  0.63
2020 Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, et al. Author response: The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding Elife. DOI: 10.7554/Elife.51131.Sa2  0.533
2019 McKenney RJ. The tail wags the motor. Nature Chemical Biology. PMID 31501591 DOI: 10.1038/S41589-019-0367-6  0.625
2019 Tan R, Lam AJ, Tan T, Han J, Nowakowski DW, Vershinin M, Simó S, Ori-McKenney KM, McKenney RJ. Microtubules gate tau condensation to spatially regulate microtubule functions. Nature Cell Biology. 21: 1078-1085. PMID 31481790 DOI: 10.1016/J.Bpj.2019.11.347  0.462
2019 Chiba K, Takahashi H, Chen M, Obinata H, Arai S, Hashimoto K, Oda T, McKenney RJ, Niwa S. Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors. Proceedings of the National Academy of Sciences of the United States of America. PMID 31455732 DOI: 10.1073/Pnas.1905690116  0.46
2019 Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. The Journal of Biological Chemistry. PMID 30992364 DOI: 10.1074/Jbc.Ra118.007004  0.432
2019 McKenney RJ. Decision letter: Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule Elife. DOI: 10.7554/Elife.47145.033  0.46
2018 Agarwal S, Smith KP, Zhou Y, Suzuki A, McKenney RJ, Varma D. Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism. The Journal of Cell Biology. PMID 30154187 DOI: 10.1083/Jcb.201705127  0.669
2018 Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Developmental Cell. 46: 518-524. PMID 30130532 DOI: 10.1016/J.Devcel.2018.08.004  0.493
2018 Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Developmental Cell. 46: 204-218.e7. PMID 30016622 DOI: 10.1016/J.Devcel.2018.06.013  0.443
2018 Amin MA, McKenney RJ, Varma D. Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis. The Journal of Biological Chemistry. 293: 10825. PMID 29980652 DOI: 10.1074/Jbc.Aac118.004421  0.662
2018 Tjioe M, Ryoo H, Ishitsuka Y, Ge P, Bookwalter C, Huynh W, McKenney RJ, Trybus KM, Selvin PR. Magnetic Cytoskeleton Affinity (MiCA) Purification of Microtubule Motors conjugated to Quantum Dots. Bioconjugate Chemistry. PMID 29932650 DOI: 10.1021/Acs.Bioconjchem.8B00264  0.55
2018 Amin MA, McKenney RJ, Varma D. Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis. The Journal of Biological Chemistry. PMID 29475948 DOI: 10.1074/Jbc.Ra117.001699  0.715
2018 Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC. Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Nature Structural & Molecular Biology. PMID 29416113 DOI: 10.1038/S41594-018-0027-7  0.573
2018 Tan R, Foster PJ, Needleman DJ, McKenney RJ. Cooperative Accumulation of Dynein-Dynactin at Microtubule Minus-Ends Drives Microtubule Network Reorganization. Developmental Cell. 44: 233-247.e4. PMID 29401420 DOI: 10.1016/J.Devcel.2017.12.023  0.593
2017 Gutierrez PA, Ackermann BE, Vershinin M, McKenney RJ. Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. The Journal of Biological Chemistry. PMID 28576829 DOI: 10.1074/Jbc.M117.790048  0.641
2016 Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. PMID 27112495 DOI: 10.1016/J.Neuron.2016.03.027  0.561
2016 McKenney RJ, Huynh W, Vale RD, Sirajuddin M. Tyrosination of α-tubulin controls the initiation of processive dynein-dynactin motility. The Embo Journal. PMID 26968983 DOI: 10.15252/Embj.201593071  0.682
2015 McKenney RJ, Huynh W, Siarjuddin M, Tanenbaum M, Bhabha G, Vale RD. Multiplex Regulation of Cytoplasmic Dynein Motility Biophysical Journal. 108: 9a. DOI: 10.1016/J.Bpj.2014.11.072  0.808
2014 McKenney RJ, Huynh W, Tanenbaum ME, Bhabha G, Vale RD. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science (New York, N.Y.). 345: 337-41. PMID 25035494 DOI: 10.1126/Science.1254198  0.803
2014 McKenney RJ, Tanenbaum ME, Bhabha G, Vale RD. BicD2 and Dynactin Convert a Non-Processive Cytoplasmic Dynein to an Ultra-Processive Directional Motor Biophysical Journal. 106: 353a. DOI: 10.1016/J.Bpj.2013.11.2009  0.801
2014 Vale R, Cheng H, Bhabha G, McKenney R, Tanenbaum M, Schroeder C. Mechanisms of Dynein-Driven Microtubule Sliding and Cargo Transport Biophysical Journal. 106: 10a. DOI: 10.1016/J.Bpj.2013.11.105  0.808
2013 Tanenbaum ME, Vale RD, McKenney RJ. Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife. 2: e00943. PMID 24015359 DOI: 10.7554/Elife.00943  0.817
2013 Tanenbaum ME, Vale RD, McKenney RJ. Author response: Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains Elife. DOI: 10.7554/Elife.00943.020  0.783
2012 Vallee RB, McKenney RJ, Ori-McKenney KM. Multiple modes of cytoplasmic dynein regulation. Nature Cell Biology. 14: 224-30. PMID 22373868 DOI: 10.1038/Ncb2420  0.687
2012 Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Gross SP. Detachment Kinetics of Single Kinesin and Dynein Biophysical Journal. 102: 370a. DOI: 10.1016/J.Bpj.2011.11.2021  0.452
2012 Ori-McKenney KM, McKenney RJ, Vallee RB. Studies of lissencephaly and neurodegenerative disease reveal novel aspects of cytoplasmic dynein regulation Dyneins. 440-453. DOI: 10.1016/B978-0-12-382004-4.10016-0  0.512
2011 Kunwar A, Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Mogilner A, Gross SP. Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport. Proceedings of the National Academy of Sciences of the United States of America. 108: 18960-5. PMID 22084076 DOI: 10.1073/Pnas.1107841108  0.539
2011 Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB. High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. The Journal of Cell Biology. 195: 193-201. PMID 22006948 DOI: 10.1083/Jcb.201104076  0.692
2011 McKenney RJ, Weil SJ, Scherer J, Vallee RB. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. The Journal of Biological Chemistry. 286: 39615-22. PMID 21911489 DOI: 10.1074/Jbc.M111.289017  0.728
2011 McKenney RJ, Vallee RB. Two decades of cytoplasmic dynein: From fast to forceful Handbook of Dynein. 27-41. DOI: 10.4032/9789814303347  0.483
2010 McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP. LIS1 and NudE induce a persistent dynein force-producing state. Cell. 141: 304-14. PMID 20403325 DOI: 10.1016/J.Cell.2010.02.035  0.723
2010 McKenney RJ, Vershinin M, Kunwar A, Kemal S, Vallee RB, Gross SP. LIS1 and Nude Permit Multiple Dynein Motors to Cooperate to Transport High Loads Biophysical Journal. 98: 726a-727a. DOI: 10.1016/J.Bpj.2009.12.3982  0.712
2009 Vershinin MD, McKenney RJ, Gross SP, Vallee R. LIS1 Converts Dynein to a Persistent-force State: A Molecular Model to Explain Lissencephaly Biophysical Journal. 96: 215a. DOI: 10.1016/J.Bpj.2008.12.1893  0.694
2007 Stehman SA, Chen Y, McKenney RJ, Vallee RB. NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. The Journal of Cell Biology. 178: 583-94. PMID 17682047 DOI: 10.1083/Jcb.200610112  0.764
2007 Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P, Vallee RB. Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathologica. 113: 591-9. PMID 17221205 DOI: 10.1007/S00401-006-0180-7  0.538
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