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Eli Chapman, Ph.D. - Publications

Affiliations: 
2002 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
organic chemistry
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Stevens M, Howe C, Ray AM, Washburn A, Chitre S, Sivinski J, Park Y, Hoang QQ, Chapman E, Johnson SM. Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs. Bioorganic & Medicinal Chemistry. 28: 115710. PMID 33007545 DOI: 10.1016/J.Bmc.2020.115710  0.367
2019 Shi T, Zerio CJ, Sivinski J, Ambrose AJ, Moore KT, Buckley T, Kaneko L, Zhang M, Zhang DD, Chapman E. A one-step, atom economical synthesis of thieno[2,3-]pyrimidin-4-amine derivatives via a four-component reaction. European Journal of Organic Chemistry. 20: 3269-3272. PMID 31857792 DOI: 10.1002/Ejoc.201900414  0.303
2019 Gaffney DO, Jennings EQ, Anderson CC, Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M, Spiegel DA, Chapman E, Roede JR, Galligan JJ. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes. Cell Chemical Biology. PMID 31767537 DOI: 10.1016/J.Chembiol.2019.11.005  0.344
2019 Liu P, Tian W, Tao S, Tillotson J, Wijeratne EMK, Gunatilaka AAL, Zhang DD, Chapman E. Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation. Cell Chemical Biology. PMID 31402317 DOI: 10.1016/J.Chembiol.2019.07.011  0.323
2019 Shi T, Wijeratne EMK, Solano C, Ambrose AJ, Ross AB, Norwood CR, Orido CK, Grigoryan T, Tillotson J, Kang M, Luo G, Keegan BM, Hu W, Blagg BSJ, Zhang DD, ... ... Chapman E, et al. An isoform-selective PTP1B inhibitor derived from nitrogen-atom augmentation of radicicol. Biochemistry. PMID 31298844 DOI: 10.1021/Acs.Biochem.9B00499  0.334
2019 Ambrose AJ, Zerio CJ, Sivinski J, Schmidlin CJ, Shi T, Ross AB, Widrick KJ, Johnson SM, Zhang DD, Chapman E. A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorganic & Medicinal Chemistry Letters. PMID 31129054 DOI: 10.1016/J.Bmcl.2019.05.041  0.381
2019 Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM. Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorganic & Medicinal Chemistry Letters. PMID 31047750 DOI: 10.1016/J.Bmcl.2019.04.034  0.333
2019 Stevens M, Abdeen S, Salim N, Ray AM, Washburn A, Chitre S, Sivinski J, Park Y, Hoang QQ, Chapman E, Johnson SM. HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorganic & Medicinal Chemistry Letters. PMID 30852084 DOI: 10.1016/J.Bmcl.2019.02.028  0.344
2018 Kunkle T, Abdeen S, Salim N, Ray AM, Stevens M, Ambrose AJ, Victorino J, Park Y, Hoang QQ, Chapman E, Johnson SM. Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus. Journal of Medicinal Chemistry. PMID 30392371 DOI: 10.1021/Acs.Jmedchem.8B01293  0.353
2018 Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose A, Park Y, Schultz PG, Horwich AL, Hoang Q, Chapman E, Johnson SM. Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry. PMID 30060666 DOI: 10.1021/Acs.Jmedchem.8B00989  0.478
2018 Peters TL, Tillotson J, Yeomans AM, Wilmore S, Jiménez-Romero C, Amador LA, Amin AD, Li L, Pongtornpipat P, Zerio CJ, Paine-Murrieta G, Vega F, Packham G, Rodriguez AD, Chapman E, et al. Target-Based Screening Against eIF4A1 Reveals the Marine Natural Compound Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Anti-Tumor Activity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29844128 DOI: 10.1158/1078-0432.Ccr-17-3645  0.374
2018 Peters TL, Tillotson J, Li L, Chapman E, Schatz JH. Abstract B133: Identification of elatol as a novel eIF4A inhibitor and stress response activator Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B133  0.396
2017 Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorganic & Medicinal Chemistry Letters. PMID 28757063 DOI: 10.1016/J.Bmcl.2017.07.045  0.366
2017 Tillotson J, Zerio CJ, Harder B, Ambrose A, Jung KS, Kang M, Zhang DD, Chapman E. Arsenic compromises both p97 and proteasome functions. Chemical Research in Toxicology. PMID 28636814 DOI: 10.1021/Acs.Chemrestox.7B00158  0.308
2017 Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, Tillotson J, Chapman E, Zhang DD. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex. Molecular and Cellular Biology. PMID 28115426 DOI: 10.1128/Mcb.00660-16  0.343
2017 Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kanduluru AK, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ. Ritterostatin GN1N, a Cephalostatin-Ritterazine bis-Steroidal Pyrazine Hybrid, Selectively Targets GRP78. Chembiochem : a European Journal of Chemical Biology. PMID 28074539 DOI: 10.1002/Cbic.201600669  0.343
2016 de la Vega MR, Dodson M, Chapman E, Zhang DD. NRF2-targeted therapeutics: New targets and modes of NRF2 regulation. Current Opinion in Toxicology. 1: 62-70. PMID 29082352 DOI: 10.1016/J.Cotox.2016.10.005  0.335
2016 Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD. Brusatol overcomes chemoresistance through inhibition of protein translation. Molecular Carcinogenesis. PMID 28019675 DOI: 10.1002/Mc.22609  0.359
2016 Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorganic & Medicinal Chemistry Letters. PMID 27720295 DOI: 10.1016/J.Bmcl.2016.09.051  0.485
2016 Tillotson J, Bashyal BP, Kang M, Shi T, De La Cruz F, Gunatilaka AA, Chapman E. Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin. Organic & Biomolecular Chemistry. PMID 27223265 DOI: 10.1039/C6Ob00560H  0.358
2016 Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM. GroEL/ES inhibitors as potential antibiotics. Bioorganic & Medicinal Chemistry Letters. 26: 3127-34. PMID 27184767 DOI: 10.1016/J.Bmcl.2016.04.089  0.505
2016 Lee TC, Kang M, Kim CH, Schultz PG, Chapman E, Deniz AA. Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding. Chembiochem : a European Journal of Chemical Biology. 17: 981-4. PMID 27115850 DOI: 10.1002/Cbic.201500695  0.717
2016 Lee TC, Kang M, Kim CH, Schultz PG, Chapman E, Deniz AA. Cover Picture: Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding (ChemBioChem 11/2016) Chembiochem. 17: 969-969. DOI: 10.1002/Cbic.201600277  0.706
2015 Harder B, Jiang T, Wu T, Tao S, de la Vega MR, Tian W, Chapman E, Zhang DD. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochemical Society Transactions. 43: 680-6. PMID 26551712 DOI: 10.1042/Bst20150020  0.322
2015 Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem : a European Journal of Chemical Biology. 16: 2002-6. PMID 26267855 DOI: 10.1002/Cbic.201500229  0.35
2015 Jiang T, Harder B, Vega MR, Wong PK, Chapman E, Zhang DD. p62 links autophagy and Nrf2 signaling. Free Radical Biology & Medicine. PMID 26117325 DOI: 10.1016/J.Freeradbiomed.2015.06.014  0.324
2015 Tao S, Tillotson J, Wijeratne EM, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, La Clair JJ, Gunatilaka AA, Zhang DD, Chapman E. Withaferin A Analogs That Target the AAA+ Chaperone p97. Acs Chemical Biology. PMID 26006219 DOI: 10.1021/Acschembio.5B00367  0.353
2015 Chapman E, Maksim N, de la Cruz F, La Clair JJ. Inhibitors of the AAA+ chaperone p97. Molecules (Basel, Switzerland). 20: 3027-49. PMID 25685910 DOI: 10.3390/Molecules20023027  0.375
2014 Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem : a European Journal of Chemical Biology. 15: 2125-31. PMID 25125376 DOI: 10.1002/Cbic.201402258  0.363
2014 Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E. A biochemical screen for GroEL/GroES inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 786-9. PMID 24418775 DOI: 10.1016/J.Bmcl.2013.12.100  0.491
2014 Lee T, Kang M, Chapman E, Deniz AA. Single-Molecule and Ensemble Structural Study of the AAA+ Atpase P97 Biophysical Journal. 106: 49a. DOI: 10.1016/J.Bpj.2013.11.351  0.683
2013 Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD. USP15 negatively regulates Nrf2 through deubiquitination of Keap1. Molecular Cell. 51: 68-79. PMID 23727018 DOI: 10.1016/J.Molcel.2013.04.022  0.304
2013 Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. Journal of the American Chemical Society. 135: 5962-5. PMID 23550886 DOI: 10.1021/Ja400795M  0.54
2011 Charbon G, Wang J, Brustad E, Schultz PG, Horwich AL, Jacobs-Wagner C, Chapman E. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid. Bioorganic & Medicinal Chemistry Letters. 21: 6067-70. PMID 21890355 DOI: 10.1016/J.Bmcl.2011.08.057  0.458
2011 Charbon G, Brustad E, Scott KA, Wang J, Løbner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E. Subcellular protein localization by using a genetically encoded fluorescent amino acid. Chembiochem : a European Journal of Chemical Biology. 12: 1818-21. PMID 21681882 DOI: 10.1002/Cbic.201100282  0.455
2011 Chapman E, Fry AN, Kang M. The complexities of p97 function in health and disease. Molecular Biosystems. 7: 700-10. PMID 21152665 DOI: 10.1039/C0Mb00176G  0.333
2009 Chapman E, Farr GW, Furtak K, Horwich AL. A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL. Bioorganic & Medicinal Chemistry Letters. 19: 811-3. PMID 19110421 DOI: 10.1016/J.Bmcl.2008.12.015  0.366
2007 Horwich AL, Fenton WA, Chapman E, Farr GW. Two families of chaperonin: physiology and mechanism. Annual Review of Cell and Developmental Biology. 23: 115-45. PMID 17489689 DOI: 10.1146/Annurev.Cellbio.23.090506.123555  0.318
2004 Chapman E, Best MD, Hanson SR, Wong CH. Sulfotransferases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angewandte Chemie (International Ed. in English). 43: 3526-48. PMID 15293241 DOI: 10.1002/Anie.200300631  0.68
2004 Best MD, Brik A, Chapman E, Lee LV, Cheng WC, Wong CH. Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. Chembiochem : a European Journal of Chemical Biology. 5: 811-9. PMID 15174164 DOI: 10.1002/Cbic.200300841  0.684
2004 Chapman E, Best MD, Hanson SR, Wong C. Sulfotransferasen: Struktur, Mechanismus, biologische Aktivität, Inhibierung, Anwendung in Synthesen Angewandte Chemie. 116: 3610-3632. DOI: 10.1002/Ange.200300631  0.343
2003 Chapman E, Bryan MC, Wong CH. Mechanistic studies of beta-arylsulfotransferase IV. Proceedings of the National Academy of Sciences of the United States of America. 100: 910-5. PMID 12547913 DOI: 10.1073/Pnas.0337638100  0.696
2003 Wong CH, Bryan MC, Nyffeler PT, Liu H, Chapman E. Synthesis of carbohydrate-based antibiotics Pure and Applied Chemistry. 75: 179-186. DOI: 10.1351/Pac200375020179  0.653
2002 Chapman E, Ding S, Schultz PG, Wong CH. A potent and highly selective sulfotransferase inhibitor. Journal of the American Chemical Society. 124: 14524-5. PMID 12465948 DOI: 10.1021/Ja021086U  0.575
2002 Chapman E, Wong CH. A pH sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: a case study using kinases. Bioorganic & Medicinal Chemistry. 10: 551-5. PMID 11814841 DOI: 10.1016/S0968-0896(01)00306-6  0.449
2000 Burkart MD, Izumi M, Chapman E, Lin CH, Wong CH. Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides. The Journal of Organic Chemistry. 65: 5565-74. PMID 10970295 DOI: 10.1021/Jo000266O  0.579
1998 Thorson JS, Shin I, Chapman E, Stenberg G, Mannervik B, Schultz PG. Analysis of the role of the active site tyrosine in human glutathione transferase A1-1 by unnatural amino acid mutagenesis Journal of the American Chemical Society. 120: 451-452. DOI: 10.1021/Ja9731682  0.412
1997 Chapman E, Thorson JS, Schultz PG. Mutational analysis of backbone hydrogen bonds in staphylococcal nuclease [2] Journal of the American Chemical Society. 119: 7151-7152. DOI: 10.1021/Ja970826+  0.371
1995 Thorson JS, Chapman E, Schultz PG. Analysis of hydrogen bonding strengths in proteins using unnatural amino acids Journal of the American Chemical Society. 117: 9361-9362. DOI: 10.1021/Ja00141A032  0.417
1995 Thorson JS, Chapman E, Murphy EC, Schultz PG, Judice JK. Linear Free Energy Analysis of Hydrogen Bonding in Proteins Journal of the American Chemical Society. 117: 1157-1158. DOI: 10.1021/Ja00108A044  0.396
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