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Jeffrey R. Holt - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
sensory hair cells
Website:
https://sites.google.com/site/holtgeleoclab/people
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95 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith HE, Halford J, Shen C, Murthy SE, Ulbrich MH, Sotomayor M, Fu TM, Holt JR. TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron. PMID 37543036 DOI: 10.1016/j.neuron.2023.07.006  0.624
2023 Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Rivera RA, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, et al. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. Biorxiv : the Preprint Server For Biology. PMID 37398045 DOI: 10.1101/2023.05.26.542533  0.655
2023 Mathiesen BK, Miyakoshi LM, Cederroth CR, Tserga E, Versteegh C, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B. Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice. Science Translational Medicine. 15: eabq3916. PMID 37379370 DOI: 10.1126/scitranslmed.abq3916  0.301
2022 Marcovich I, Baer NK, Shubina-Oleinik O, Eclov R, Beard CW, Holt JR. Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11. Biomolecules. 12. PMID 35883470 DOI: 10.3390/biom12070914  0.376
2022 van Beelen ESA, van der Valk WH, Verhagen TO, de Groot JCMJ, Madison MA, Shadmanfar W, Hensen EF, Jansen JC, van Benthem PPG, Holt JR, Locher H. Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors. Biomolecules. 12. PMID 35740941 DOI: 10.3390/biom12060816  0.344
2021 Lee J, Kosuke Kawai K, Holt JR, Geleoc G. Sensory transduction is required for normal development and maturation ofcochlear inner hair cell synapses. Elife. 10. PMID 34734805 DOI: 10.7554/eLife.69433  0.832
2020 Taiber S, Cohen R, Yizhar-Barnea O, Sprinzak D, Holt JR, Avraham KB. Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness. Embo Molecular Medicine. e13259. PMID 33350593 DOI: 10.15252/emmm.202013259  0.384
2020 Zheng W, Holt JR. The Mechanosensory Transduction Machinery in Inner Ear Hair Cells. Annual Review of Biophysics. PMID 33285080 DOI: 10.1146/annurev-biophys-062420-081842  0.375
2020 Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR. Single and dual vector gene therapy with AAV9-PHP.B rescues hearing in Tmc1 mutant mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33212302 DOI: 10.1016/j.ymthe.2020.11.016  0.385
2020 Holt JR, Raphael Y. Introduction to the Hearing Research special issue on inner ear gene therapy. Hearing Research. 108010. PMID 32624335 DOI: 10.1016/J.Heares.2020.108010  0.332
2020 Yeh WH, Shubina-Oleinik O, Levy JM, Pan B, Newby GA, Wornow M, Burt R, Chen JC, Holt JR, Liu DR. In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness. Science Translational Medicine. 12. PMID 32493795 DOI: 10.1126/Scitranslmed.Aay9101  0.516
2020 Lee J, Nist-Lund C, Solanes P, Goldberg H, Wu J, Pan B, Schneider BL, Holt JR. Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B. Hearing Research. 107882. PMID 31980281 DOI: 10.1016/J.Heares.2020.107882  0.46
2020 Marcovich I, Holt JR. Evolution and function of Tmc genes in mammalian hearing Current Opinion in Physiology. 18: 11-19. DOI: 10.1016/J.Cophys.2020.06.011  0.468
2019 Meng X, Murali S, Cheng Y, Lu J, Hight AE, Kanumuri VV, Brown MC, Holt JR, Lee DJ, Edge ASB. Increasing the Expression Level of ChR2 Enhances the Optogenetic Excitability of Cochlear Neurons. Journal of Neurophysiology. PMID 31533018 DOI: 10.1152/Jn.00828.2018  0.35
2019 György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nature Medicine. PMID 31270503 DOI: 10.1038/S41591-019-0500-9  0.809
2019 Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nature Communications. 10: 734. PMID 30737404 DOI: 10.1038/s41467-019-08716-x  0.772
2019 Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nature Communications. 10: 236. PMID 30670701 DOI: 10.1038/s41467-018-08264-w  0.829
2019 Holt JR, Geleoc GS. Split otoferlins reunited. Embo Molecular Medicine. 11. PMID 30573543 DOI: 10.15252/emmm.201809995  0.798
2019 Pan B, Akyuz N, Liu X, Asai Y, Nist-Lund C, Kurima K, Derfler B, György B, Limapichat W, Walujkar S, Wimalasena L, Sotomayor M, Corey D, Holt JR. Cysteine Substitution Reveals the Pore-Forming Region of TMC1 in Hair Cell Sensory Transduction Channels Biophysical Journal. 116: 460a. DOI: 10.1016/J.Bpj.2018.11.2486  0.822
2018 Corey DP, Akyuz N, Holt JR. Function and Dysfunction of TMC Channels in Inner Ear Hair Cells. Cold Spring Harbor Perspectives in Medicine. PMID 30291150 DOI: 10.1101/Cshperspect.A033506  0.835
2018 Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 99: 736-753.e6. PMID 30138589 DOI: 10.1016/J.Neuron.2018.07.033  0.825
2018 Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG. Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1. Scientific Reports. 8: 12124. PMID 30108254 DOI: 10.1038/S41598-018-28958-X  0.573
2018 Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald TS, Géléoc GS, Holt JR, Griffith AJ. Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. Scientific Reports. 8: 12125. PMID 30108230 DOI: 10.1038/S41598-018-29709-8  0.843
2018 Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A. Regenerating hair cells in human vestibular sensory epithelia. Elife. 7. PMID 30019672 DOI: 10.7554/Elife.34817  0.505
2018 Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A. Author response: Regenerating hair cells in vestibular sensory epithelia from humans Elife. DOI: 10.7554/Elife.34817.016  0.435
2017 Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, ... ... Holt JR, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. PMID 29258297 DOI: 10.1038/Nature25164  0.417
2017 Ahmed H, Shubina-Oleinik O, Holt JR. Emerging Gene Therapies for Genetic Hearing Loss. Journal of the Association For Research in Otolaryngology : Jaro. PMID 28815315 DOI: 10.1007/s10162-017-0634-8  0.359
2017 Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nature Biotechnology. PMID 28459451 DOI: 10.1038/nbt.3840  0.747
2017 Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS. Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nature Biotechnology. PMID 28165476 DOI: 10.1038/Nbt.3801  0.798
2017 Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nature Biotechnology. PMID 28165475 DOI: 10.1038/Nbt.3781  0.805
2016 Corey DP, Holt JR. Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10921-10926. PMID 27798174 DOI: 10.1523/JNEUROSCI.1148-16.2016  0.737
2016 Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJ. RNA Interference Prevents Autosomal-Dominant Hearing Loss. American Journal of Human Genetics. PMID 27236922 DOI: 10.1016/J.Ajhg.2016.03.028  0.399
2016 Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR. Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells. Nature Communications. 7: 11508. PMID 27215798 DOI: 10.1038/ncomms11508  0.776
2016 Akyuz N, Holt JR. Plug-N-Play: Mechanotransduction Goes Modular. Neuron. 89: 1128-30. PMID 26985721 DOI: 10.1016/J.Neuron.2016.02.041  0.795
2016 Imtiaz A, Maqsood A, Rehman AU, Morell RJ, Holt JR, Friedman TB, Naz S. Recessive mutations of TMC1 associated with moderate to severe hearing loss. Neurogenetics. PMID 26879195 DOI: 10.1007/s10048-016-0477-1  0.416
2016 Landegger L, Pang B, Wassmer S, Gluck S, Galvin A, Stankovic KM, Holt JR, Vandenberghe LH. 269. Novel Synthetic AAV Efficiently Transduces Neurosensory Hair Cells in the Cochlea Molecular Therapy. 24: S107. DOI: 10.1016/S1525-0016(16)33078-7  0.497
2015 Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B. TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Reports. 12: 1606-17. PMID 26321635 DOI: 10.1016/J.Celrep.2015.07.058  0.533
2015 Pan B, Holt JR. The molecules that mediate sensory transduction in the mammalian inner ear. Current Opinion in Neurobiology. 34: 165-71. PMID 26218316 DOI: 10.1016/j.conb.2015.06.013  0.409
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice. Science Translational Medicine. 7: 295ra108. PMID 26157030 DOI: 10.1126/Scitranslmed.Aab1996  0.814
2015 Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR. Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation. PflüGers Archiv : European Journal of Physiology. 467: 85-94. PMID 25074487 DOI: 10.1007/s00424-014-1582-3  0.575
2015 Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab1996  0.767
2015 Liu X, Pan B, Asai Y, Kurima K, Griffith AJ, Holt JR. Probing the Structure and Function of TMC1 in Sensory Hair Cells using Mutagenesis and Cysteine Modification Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2770  0.548
2014 Géléoc GS, Holt JR. Sound strategies for hearing restoration. Science (New York, N.Y.). 344: 1241062. PMID 24812404 DOI: 10.1126/Science.1241062  0.455
2014 Horwitz GC, Risner-Janiczek JR, Holt JR. Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons. The Journal of General Physiology. 143: 481-97. PMID 24638995 DOI: 10.1085/Jgp.201311126  0.809
2014 Holt JR, Pan B, Koussa MA, Asai Y. TMC function in hair cell transduction. Hearing Research. 311: 17-24. PMID 24423408 DOI: 10.1016/J.Heares.2014.01.001  0.827
2014 Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J. Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Human Molecular Genetics. 23: 2374-90. PMID 24334608 DOI: 10.1093/Hmg/Ddt629  0.825
2014 Holt JR. TMC Function in Hair Cell Mechanotransduction Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.2386  0.574
2013 Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV. A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2: e01341. PMID 24327562 DOI: 10.7554/Elife.01341  0.467
2013 Kim YH, Holt JR. Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear. The Journal of General Physiology. 142: 207-23. PMID 23980193 DOI: 10.1085/jgp.201311019  0.649
2013 Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR. TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron. 79: 504-15. PMID 23871232 DOI: 10.1016/J.Neuron.2013.06.019  0.839
2013 Yu W, Appler JM, Kim Y, Nishitani AM, Holt JR, Goodrich LV. Author response: A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing Elife. DOI: 10.7554/Elife.01341.020  0.467
2012 Holt JR, Vandenberghe LH. Gene therapy for deaf mice goes viral. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1836-7. PMID 23023054 DOI: 10.1038/Mt.2012.196  0.464
2012 Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9485-98. PMID 22787034 DOI: 10.1523/Jneurosci.0311-12.2012  0.819
2012 Levin ME, Holt JR. The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear. Journal of Neurophysiology. 108: 175-86. PMID 22496522 DOI: 10.1152/jn.00098.2012  0.689
2011 Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della Santina CC, Holt JR, Griffith AJ. Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. The Journal of Clinical Investigation. 121: 4796-809. PMID 22105175 DOI: 10.1172/Jci60405  0.607
2011 Horwitz GC, Risner-Janiczek JR, Jones SM, Holt JR. HCN channels expressed in the inner ear are necessary for normal balance function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16814-25. PMID 22090507 DOI: 10.1523/Jneurosci.3064-11.2011  0.834
2011 Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12241-50. PMID 21865467 DOI: 10.1523/Jneurosci.6531-10.2011  0.499
2011 Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, Srisailapathy CR, Oostrik J, Admiraal RJ, Neely HR, Latoche JR, Smith RJ, Northup JK, Kremer H, Holt JR, et al. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nature Communications. 2: 201. PMID 21326233 DOI: 10.1038/Ncomms1200  0.431
2010 Lelli A, Kazmierczak P, Kawashima Y, Müller U, Holt JR. Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11259-69. PMID 20739546 DOI: 10.1523/JNEUROSCI.1949-10.2010  0.509
2010 Horwitz GC, Lelli A, Géléoc GS, Holt JR. HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear. Plos One. 5: e8627. PMID 20062532 DOI: 10.1371/Journal.Pone.0008627  0.847
2010 Asai Y, Holt JR, Géléoc GS. A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. Journal of the Association For Research in Otolaryngology : Jaro. 11: 27-37. PMID 19834762 DOI: 10.1007/S10162-009-0193-8  0.498
2010 Stauffer EA, Lelli A, Holt JR. Hair Cell Transduction and Adaptation: Physiology and Molecular Mechanisms The Senses: a Comprehensive Reference. 3: 263-292. DOI: 10.1016/B978-012370880-9.00024-4  0.633
2010 Géléoc GSG, Holt JR. Hair Cells: Sensory Transduction Encyclopedia of Neuroscience. 1015-1020. DOI: 10.1016/B978-008045046-9.00255-2  0.393
2009 Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. Bmc Neuroscience. 10: 122. PMID 19778451 DOI: 10.1186/1471-2202-10-122  0.789
2009 Lelli A, Asai Y, Forge A, Holt JR, Géléoc GS. Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. Journal of Neurophysiology. 101: 2961-73. PMID 19339464 DOI: 10.1152/Jn.00136.2009  0.472
2009 Schwander M, Xiong W, Tokita J, Lelli A, Elledge HM, Kazmierczak P, Sczaniecka A, Kolatkar A, Wiltshire T, Kuhn P, Holt JR, Kachar B, Tarantino L, Müller U. A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 5252-7. PMID 19270079 DOI: 10.1073/Pnas.0900691106  0.468
2009 Collado MS, Holt JR. Can neurosphere production help restore inner ear transduction? Proceedings of the National Academy of Sciences of the United States of America. 106: 8-9. PMID 19118205 DOI: 10.1073/Pnas.0811804106  0.529
2008 Kesser BW, Hashisaki GT, Holt JR. Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapy. The Laryngoscope. 118: 821-31. PMID 18300702 DOI: 10.1097/MLG.0b013e318164d0aa  0.4
2007 Stauffer EA, Holt JR. Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system. Journal of Neurophysiology. 98: 3360-9. PMID 17942617 DOI: 10.1152/jn.00914.2007  0.749
2007 Holt JR, Stauffer EA, Abraham D, Géléoc GS. Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8940-51. PMID 17699675 DOI: 10.1523/Jneurosci.2085-07.2007  0.742
2007 Kesser BW, Hashisaki GT, Fletcher K, Eppard H, Holt JR. An in vitro model system to study gene therapy in the human inner ear. Gene Therapy. 14: 1121-31. PMID 17568767 DOI: 10.1038/sj.gt.3302980  0.445
2007 Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. Journal of the Association For Research in Otolaryngology : Jaro. 8: 18-31. PMID 17171473 DOI: 10.1007/S10162-006-0058-3  0.465
2006 Risner JR, Holt JR. Heterogeneous potassium conductances contribute to the diverse firing properties of postnatal mouse vestibular ganglion neurons. Journal of Neurophysiology. 96: 2364-76. PMID 16855108 DOI: 10.1152/jn.00523.2006  0.783
2006 McGee J, Goodyear RJ, McMillan DR, Stauffer EA, Holt JR, Locke KG, Birch DG, Legan PK, White PC, Walsh EJ, Richardson GP. The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6543-53. PMID 16775142 DOI: 10.1523/Jneurosci.0693-06.2006  0.709
2006 Senften M, Schwander M, Kazmierczak P, Lillo C, Shin JB, Hasson T, Géléoc GS, Gillespie PG, Williams D, Holt JR, Müller U. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2060-71. PMID 16481439 DOI: 10.1523/Jneurosci.4251-05.2006  0.838
2005 Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG. Fast adaptation in vestibular hair cells requires myosin-1c activity. Neuron. 47: 541-53. PMID 16102537 DOI: 10.1016/J.Neuron.2005.07.024  0.7
2004 Géléoc GS, Risner JR, Holt JR. Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11148-59. PMID 15590931 DOI: 10.1523/Jneurosci.2662-04.2004  0.83
2004 Corey DP, García-Añoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Géléoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 432: 723-30. PMID 15483558 DOI: 10.1038/Nature03066  0.781
2003 Géléoc GS, Holt JR. Developmental acquisition of sensory transduction in hair cells of the mouse inner ear. Nature Neuroscience. 6: 1019-20. PMID 12973354 DOI: 10.1038/Nn1120  0.473
2003 Colclasure JC, Holt JR. Transduction and adaptation in sensory hair cells of the mammalian vestibular system. Gravitational and Space Biology Bulletin : Publication of the American Society For Gravitational and Space Biology. 16: 61-70. PMID 12959133  0.417
2003 Géléoc GS, Holt JR. Auditory amplification: outer hair cells pres the issue. Trends in Neurosciences. 26: 115-7. PMID 12591210 DOI: 10.1016/S0166-2236(03)00030-4  0.451
2002 Dumont RA, Zhao YD, Holt JR, Bähler M, Gillespie PG. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Journal of the Association For Research in Otolaryngology : Jaro. 3: 375-89. PMID 12486594 DOI: 10.1007/S101620020049  0.482
2002 Holt JR. Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiology & Neuro-Otology. 7: 157-60. PMID 12053137 DOI: 10.1159/000058302  0.412
2002 Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 108: 371-81. PMID 11853671 DOI: 10.1016/S0092-8674(02)00629-3  0.665
2001 Gillespie PG, Albanesi JP, Bahler M, Bement WM, Berg JS, Burgess DR, Burnside B, Cheney RE, Corey DP, Coudrier E, de Lanerolle P, Hammer JA, Hasson T, Holt JR, Hudspeth AJ, et al. Myosin-I nomenclature. The Journal of Cell Biology. 155: 703-4. PMID 11724811 DOI: 10.1083/Jcb.200110032  0.644
2000 Holt JR, Corey DP. Two mechanisms for transducer adaptation in vertebrate hair cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 11730-5. PMID 11050202 DOI: 10.1073/pnas.97.22.11730  0.669
2000 Oghalai JS, Holt JR, Nakagawa T, Jung TM, Coker NJ, Jenkins HA, Eatock RA, Brownell WE. Harvesting human hair cells. The Annals of Otology, Rhinology, and Laryngology. 109: 9-16. PMID 10651405 DOI: 10.1177/000348940010900102  0.821
1999 Holt JR, Vollrath MA, Eatock RA. Stimulus processing by type II hair cells in the mouse utricle. Annals of the New York Academy of Sciences. 871: 15-26. PMID 10372060 DOI: 10.1111/j.1749-6632.1999.tb09172.x  0.806
1999 Holt JR, Johns DC, Wang S, Chen ZY, Dunn RJ, Marban E, Corey DP. Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. Journal of Neurophysiology. 81: 1881-8. PMID 10200223 DOI: 10.1152/Jn.1999.81.4.1881  0.705
1999 Holt JR, Corey DP. Ion channel defects in hereditary hearing loss. Neuron. 22: 217-9. PMID 10069328 DOI: 10.1016/S0896-6273(00)81083-1  0.643
1998 Oghalai JS, Holt JR, Nakagawa T, Jung TM, Coker NJ, Jenkins HA, Eatock RA, Brownell WE. Ionic currents and electromotility in inner ear hair cells from humans. Journal of Neurophysiology. 79: 2235-9. PMID 9535985 DOI: 10.1152/Jn.1998.79.4.2235  0.827
1998 Rüsch A, Holt JR, Eatock RA, Vollrath MA. The frequency dependence of receptor potentials in hair cells of the mouse utricle Primary Sensory Neuron. 2: 233-241. DOI: 10.1163/092996398750132133  0.791
1997 Holt JR, Corey DP, Eatock RA. Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8739-48. PMID 9348343 DOI: 10.1523/Jneurosci.17-22-08739.1997  0.804
1995 Denk W, Holt JR, Shepherd GM, Corey DP. Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links. Neuron. 15: 1311-21. PMID 8845155 DOI: 10.1016/0896-6273(95)90010-1  0.715
1995 Holt JR, Eatock RA. Inwardly rectifying currents of saccular hair cells from the leopard frog. Journal of Neurophysiology. 73: 1484-502. PMID 7543944 DOI: 10.1152/Jn.1995.73.4.1484  0.782
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