| Year |
Citation |
Score |
| 2017 |
Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, et al. Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (ulixertinib). Molecular Cancer Therapeutics. PMID 28939558 DOI: 10.1158/1535-7163.Mct-17-0456 |
0.325 |
|
| 2015 |
Murphy-Benenato KE, Gingipalli L, Boriack-Sjodin PA, Martinez-Botella G, Carcanague D, Eyermann CJ, Gowravaram M, Harang J, Hale MR, Ioannidis G, Jahic H, Johnstone M, Kutschke A, Laganas VA, Loch JT, et al. Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development. Bioorganic & Medicinal Chemistry Letters. PMID 26463129 DOI: 10.1016/J.Bmcl.2015.09.075 |
0.325 |
|
| 2015 |
Germann U, Furey B, Roix J, Markland W, Hoover R, Aronov A, Hale M, Chen G, Martinez-Botella G, Alargova R, Fan B, Sorrell D, Meshaw K, Shapiro P, Wick MJ, et al. Abstract 4693: The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance Cancer Research. 75: 4693-4693. DOI: 10.1158/1538-7445.Am2015-4693 |
0.329 |
|
| 2015 |
Hale MR, Brassington C, Carcanague D, Embrey K, Eyermann CJ, Giacobbe RA, Gingipalli L, Gowravaram M, Harang J, Howard T, Ioannidis G, Jahic H, Kutschke A, Laganas VA, Loch J, et al. From fragments to leads: Novel bacterial NAD+-dependent DNA ligase inhibitors Tetrahedron Letters. 56: 3108-3112. DOI: 10.1016/J.Tetlet.2014.12.067 |
0.324 |
|
| 2014 |
Murphy-Benenato KE, Olivier N, Choy A, Ross PL, Miller MD, Thresher J, Gao N, Hale MR. Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. Acs Medicinal Chemistry Letters. 5: 1213-8. PMID 25408833 DOI: 10.1021/Ml500210X |
0.329 |
|
| 2014 |
Gao N, McLeod SM, Hajec L, Olivier NB, Lahiri SD, Bryan Prince D, Thresher J, Ross PL, Whiteaker JD, Doig P, Li AH, Hill PJ, Cornebise M, Reck F, Hale MR. Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain. Protein Expression and Purification. 104: 57-64. PMID 25240855 DOI: 10.1016/J.Pep.2014.09.006 |
0.323 |
|
| 2009 |
Aronov AM, Tang Q, Martinez-Botella G, Bemis GW, Cao J, Chen G, Ewing NP, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Markland W, et al. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. Journal of Medicinal Chemistry. 52: 6362-8. PMID 19827834 DOI: 10.1021/Jm900630Q |
0.348 |
|
| 2007 |
Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, et al. Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. Journal of Medicinal Chemistry. 50: 1280-7. PMID 17300186 DOI: 10.1021/Jm061381F |
0.325 |
|
| 2006 |
Miller JF, Andrews CW, Brieger M, Furfine ES, Hale MR, Hanlon MH, Hazen RJ, Kaldor I, McLean EW, Reynolds D, Sammond DM, Spaltenstein A, Tung R, Turner EM, Xu RX, et al. Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385. Bioorganic & Medicinal Chemistry Letters. 16: 1788-94. PMID 16458505 DOI: 10.1016/J.Bmcl.2006.01.035 |
0.32 |
|
| 1996 |
Conde-Frieboes K, Reynolds LJ, Lio YC, Hale MR, Wasserman HH, Dennis EA. Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A2 Journal of the American Chemical Society. 118: 5519-5525. DOI: 10.1021/Ja953553W |
0.409 |
|
| 1996 |
Young DGJ, Hale MR, Hoveyda AH. Highly diastereoselective hydrosilation reations. Spirocyclic siloxanes: Sources of Si-based Lewis acids Tetrahedron Letters. 37: 827-830. DOI: 10.1016/0040-4039(95)02332-1 |
0.428 |
|
| 1994 |
Hale MR, Hoveyda AH. Diastereoselective Heteroatom-Directed Conjugate Addition of Silylcuprate Reagents to Unsaturated Carbonyls. A Stereoselective Route to .beta.-Carbonyl Siloxanes1 The Journal of Organic Chemistry. 59: 4370-4374. DOI: 10.1021/Jo00095A007 |
0.437 |
|
| 1992 |
Hale MR, Hoveyda AH. Siloxanes: versatile templates for acyclic stereocontrol. Synthesis of the C27-C33 segment of rapamycin The Journal of Organic Chemistry. 57: 1643-1645. DOI: 10.1021/Jo00032A007 |
0.401 |
|
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