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Hang Yin - Publications

Affiliations: 
Ottawa Health Research Institute, Ottawa, Ontario, Canada 
Area:
Satellite Stem Cells
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Small-Molecule Modulators of Toll-like Receptors. Accounts of Chemical Research. PMID 32233400 DOI: 10.1021/Acs.Accounts.9B00631  0.317
2020 Jiang S, Tanji H, Yin K, Zhang S, Sakaniwa K, Huang J, Yang Y, Li J, Ohto U, Shimizu T, Yin HH. Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface. Journal of Medicinal Chemistry. PMID 32233366 DOI: 10.1021/Acs.Jmedchem.9B02128  0.329
2019 Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity. PMID 31542403 DOI: 10.1016/J.Bbi.2019.09.013  0.317
2019 Zhang Y, Jin X, Liang J, Guo Y, Sun G, Zeng X, Yin H. Extracellular vesicles derived from ODN-stimulated macrophages transfer and activate Cdc42 in recipient cells and thereby increase cellular permissiveness to EV uptake. Science Advances. 5: eaav1564. PMID 31355328 DOI: 10.1126/Sciadv.Aav1564  0.313
2018 Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H. Small-Molecule TLR8 Antagonists via Structure-Based Rational Design. Cell Chemical Biology. PMID 30100350 DOI: 10.1016/J.Chembiol.2018.07.004  0.323
2017 Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U, Shimizu T, Yin H. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nature Chemical Biology. PMID 29155428 DOI: 10.1038/Nchembio.2518  0.334
2017 Bhattacharyya S, Midwood KS, Yin H, Varga J. Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma. Advances in Wound Care. 6: 356-369. PMID 29062592 DOI: 10.1089/Wound.2017.0732  0.319
2017 Kargas V, Marzinek JK, Holdbrook DA, Yin H, Ford RC, Bond PJ. A Polar SxxS Motif Drives Assembly of the Transmembrane Domains of Toll-Like Receptor 4. Biochimica Et Biophysica Acta. PMID 28739292 DOI: 10.1016/J.Bbamem.2017.07.010  0.32
2017 Zhang L, Dewan V, Yin HH. Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. Journal of Medicinal Chemistry. PMID 28537730 DOI: 10.1021/Acs.Jmedchem.7B00419  0.306
2017 Zeng X, Wu P, Yao C, Liang J, Zhang ST, Yin HH. Small molecule and peptide recognition of protein transmembrane domains. Biochemistry. PMID 28353343 DOI: 10.1021/Acs.Biochem.6B00909  0.324
2017 Tamura R, Yin H. Rationally Designed Peptide Probes for Extracellular Vesicles. Advances in Clinical Chemistry. 79: 25-41. PMID 28212713 DOI: 10.1016/Bs.Acc.2016.09.001  0.311
2016 Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Reports. 17: 1128-1140. PMID 27760316 DOI: 10.1016/J.Celrep.2016.09.076  0.32
2016 Yin H, Flynn AD. Drugging Membrane Protein Interactions. Annual Review of Biomedical Engineering. PMID 26863923 DOI: 10.1146/Annurev-Bioeng-092115-025322  0.306
2015 Yan L, Liang J, Yao C, Wu P, Zeng X, Cheng K, Yin H. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. Chemmedchem. PMID 26634412 DOI: 10.1002/Cmdc.201500471  0.346
2015 Li J, Csakai A, Jin J, Zhang F, Yin H. Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation. Chemmedchem. PMID 26136385 DOI: 10.1002/Cmdc.201500188  0.337
2015 Lin H, Chen M, Kundaje A, Valouev A, Yin H, Liu N, Neuenkirchen N, Zhong M, Snyder M. Reassessment of Piwi binding to the genome and Piwi impact on RNA polymerase II distribution. Developmental Cell. 32: 772-4. PMID 25805139 DOI: 10.1016/J.Devcel.2015.03.004  0.549
2015 Gao M, Cheng K, Yin H. Targeting protein-protein interfaces using macrocyclic peptides. Biopolymers. PMID 25664609 DOI: 10.1002/Bip.22625  0.301
2015 D'Atri LP, Etulain J, Rivadeneyra L, Lapponi MJ, Centurion M, Cheng K, Yin H, Schattner M. Expression and functionality of Toll-like receptor 3 in the megakaryocytic lineage. Journal of Thrombosis and Haemostasis : Jth. 13: 839-50. PMID 25594115 DOI: 10.1111/Jth.12842  0.308
2015 Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nature Communications. 6: 5717. PMID 25564762 DOI: 10.1038/Ncomms6717  0.327
2015 Jahani-Asl A, Yin H, Soleimani V, Chang N, Sincennes M, Luchman HA, Sidharth P, Scott A, Lorimer I, Perkins T, Ligon K, Weiss S, Rudnicki M, Bonni A. CSIG-06EGFRvIII REQUIRES OSMR AS A CO-RECEPTOR TO DRIVE GLIOBLASTOMA PATHOGENESIS Neuro-Oncology. 17: v67.2-v67. DOI: 10.1093/Neuonc/Nov210.06  0.301
2015 Kargas VE, Holdbrook DA, Godfroy JI, Yin H, Ford RC, Bond PJ. Sending Innate Immune Signals Across the Membrane: A Multiscale Simulation Approach to Toll-Like Receptor Assembly Biophysical Journal. 108: 99. DOI: 10.1016/J.Bpj.2014.11.567  0.323
2015 Berglund NA, Febbraio MA, Ford RC, Godfroy JI, Holdbrook DA, Kargas VE, Khalid S, Lancaster GI, Yin H, Bond PJ. Establishing the Structural Rules for Ligand Recognition, Signaling and Assembly in Innate Immune Receptors Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.562  0.32
2014 Gao M, London N, Cheng K, Tamura R, Jin J, Schueler-Furman O, Yin H. Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response. Tetrahedron. 70: 7664-7668. PMID 25400297 DOI: 10.1016/J.Tet.2014.07.026  0.307
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, Yin H, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/J.Neuroscience.2014.09.020  0.305
2014 Morton LA, Tamura R, de Jesus AJ, Espinoza A, Yin H. Biophysical investigations with MARCKS-ED: dissecting the molecular mechanism of its curvature sensing behaviors. Biochimica Et Biophysica Acta. 1838: 3137-44. PMID 25195712 DOI: 10.1016/J.Bbamem.2014.08.027  0.304
2014 Yin H, Lin H. Chromatin immunoprecipitation assay of Piwi in Drosophila. Methods in Molecular Biology (Clifton, N.J.). 1093: 1-11. PMID 24178552 DOI: 10.1007/978-1-62703-694-8_1  0.59
2013 Lluis MW, Yin H. Engineering and utilization of reporter cell lines for cell-based assays of transmembrane receptors. Methods in Molecular Biology (Clifton, N.J.). 1063: 211-25. PMID 23975780 DOI: 10.1007/978-1-62703-583-5_12  0.304
2013 Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2713-22. PMID 23568774 DOI: 10.1096/Fj.12-222992  0.322
2013 Li J, Wang X, Zhang F, Yin H. Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases. Pharmacology & Therapeutics. 138: 441-51. PMID 23531543 DOI: 10.1016/J.Pharmthera.2013.03.003  0.313
2013 Wang X, Smith C, Yin H. Targeting Toll-like receptors with small molecule agents. Chemical Society Reviews. 42: 4859-66. PMID 23503527 DOI: 10.1039/C3Cs60039D  0.313
2013 Huang XA, Yin H, Sweeney S, Raha D, Snyder M, Lin H. A major epigenetic programming mechanism guided by piRNAs. Developmental Cell. 24: 502-16. PMID 23434410 DOI: 10.1016/J.Devcel.2013.01.023  0.562
2013 Price FD, Yin H, Jones A, van Ijcken W, Grosveld F, Rudnicki MA. Canonical Wnt signaling induces a primitive endoderm metastable state in mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 31: 752-64. PMID 23307624 DOI: 10.1002/Stem.1321  0.3
2013 Bentzinger CF, Wang YX, von Maltzahn J, Soleimani VD, Yin H, Rudnicki MA. Fibronectin regulates Wnt7a signaling and satellite cell expansion. Cell Stem Cell. 12: 75-87. PMID 23290138 DOI: 10.1016/J.Stem.2012.09.015  0.312
2012 Wang X, Fiorini Z, Smith C, Zhang Y, Li J, Watkins LR, Yin H. Repositioning antimicrobial agent pentamidine as a disruptor of the lateral interactions of transmembrane domain 5 of EBV latent membrane protein 1. Plos One. 7: e47703. PMID 23094078 DOI: 10.1371/Journal.Pone.0047703  0.317
2012 Zhang S, Cheng K, Wang X, Yin H. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorganic & Medicinal Chemistry. 20: 6073-9. PMID 22985959 DOI: 10.1016/J.Bmc.2012.08.022  0.311
2012 Cheng K, Wang X, Zhang S, Yin H. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angewandte Chemie (International Ed. in English). 51: 12246-9. PMID 22969053 DOI: 10.1002/Anie.201204910  0.312
2012 Wang X, Saludes JP, Zhao TX, Csakai A, Fiorini Z, Chavez SA, Li J, Lee GI, Varga K, Yin H. Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Biochimica Et Biophysica Acta. 1818: 2282-9. PMID 22609737 DOI: 10.1016/J.Bbamem.2012.05.013  0.312
2011 Yin H, Sweeney S, Raha D, Snyder M, Lin H. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. Plos Genetics. 7: e1002380. PMID 22194694 DOI: 10.1371/Journal.Pgen.1002380  0.574
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. Chembiochem : a European Journal of Chemical Biology. 12: 1827-31. PMID 21678541 DOI: 10.1002/Cbic.201100211  0.303
2011 Joce C, Wiener A, Yin H. Transmembrane domain oligomerization propensity determined by ToxR assay. Journal of Visualized Experiments. PMID 21654625 DOI: 10.3791/2721  0.32
2011 Chavez SA, Martinko AJ, Lau C, Pham MN, Cheng K, Bevan DE, Mollnes TE, Yin H. Development of β-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics. Journal of Medicinal Chemistry. 54: 4659-69. PMID 21591694 DOI: 10.1021/Jm2003365  0.31
2011 Sammond DW, Joce C, Takeshita R, McQuate SE, Ghosh N, Martin JM, Yin H. Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1. Biopolymers. 95: 772-84. PMID 21560118 DOI: 10.1002/Bip.21672  0.32
2011 Cheng K, Wang X, Yin H. Small-molecule inhibitors of the TLR3/dsRNA complex. Journal of the American Chemical Society. 133: 3764-7. PMID 21355588 DOI: 10.1021/Ja111312H  0.335
2011 Gangaraju VK, Yin H, Weiner MM, Wang J, Huang XA, Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nature Genetics. 43: 153-8. PMID 21186352 DOI: 10.1038/Ng.743  0.587
2011 Yin H. Abstract LB-242: Dissecting Cell Signaling Mediated by Multi-spanning Transmembrane Domain Association Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-242  0.308
2010 Bevan DE, Martinko AJ, Loram LC, Stahl JA, Taylor FR, Joshee S, Watkins LR, Yin H. Selection, Preparation, and Evaluation of Small- Molecule Inhibitors of Toll-Like Receptor 4. Acs Medicinal Chemistry Letters. 1: 194-198. PMID 20824192 DOI: 10.1021/Ml100041F  0.334
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/J.Neuroscience.2010.03.067  0.317
2009 Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H. A peptide antagonist of the TLR4-MD2 interaction. Chembiochem : a European Journal of Chemical Biology. 10: 645-9. PMID 19184989 DOI: 10.1002/Cbic.200800769  0.31
2009 Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi-Miyagawa S, Nakano T, Lin H. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. The Journal of Biological Chemistry. 284: 6507-19. PMID 19114715 DOI: 10.1074/Jbc.M809104200  0.754
2008 Lin H, Yin H. A novel epigenetic mechanism in Drosophila somatic cells mediated by Piwi and piRNAs. Cold Spring Harbor Symposia On Quantitative Biology. 73: 273-81. PMID 19270080 DOI: 10.1101/Sqb.2008.73.056  0.604
2008 Slivka PF, Wong J, Caputo GA, Yin H. Peptide probes for protein transmembrane domains. Acs Chemical Biology. 3: 402-11. PMID 18533658 DOI: 10.1021/Cb800049W  0.314
2008 Lin H, Yin H, Beyret E, Findley S, Deng W. The role of the piRNA pathway in stem cell self-renewal Developmental Biology. 319: 479. DOI: 10.1016/J.Ydbio.2008.05.048  0.737
2007 Yin H, Lin H. An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature. 450: 304-8. PMID 17952056 DOI: 10.1038/Nature06263  0.575
2007 Brower-Toland B, Findley SD, Jiang L, Liu L, Yin H, Dus M, Zhou P, Elgin SC, Lin H. Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes & Development. 21: 2300-11. PMID 17875665 DOI: 10.1101/Gad.1564307  0.59
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