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Larry Tobacman - Publications

Affiliations: 
Anatomy and Cell Biology University of Illinois at Chicago, Chicago, IL, United States 
Area:
Neuroscience Biology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Tobacman LS, Cammarato A. Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin. The Journal of General Physiology. 153. PMID 33492345 DOI: 10.1085/jgp.202012815  0.375
2020 Tobacman LS. Troponin Revealed: Uncovering the Structure of the Thin Filament On-Off Switch in Striated Muscle. Biophysical Journal. 120: 1-9. PMID 33221250 DOI: 10.1016/j.bpj.2020.11.014  0.57
2020 Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690703 DOI: 10.1073/Pnas.2001692117  0.474
2014 Mun JY, Previs MJ, Yu HY, Gulick J, Tobacman LS, Beck Previs S, Robbins J, Warshaw DM, Craig R. Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 111: 2170-5. PMID 24477690 DOI: 10.1073/Pnas.1316001111  0.488
2012 Kowlessur D, Tobacman LS. Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy. The Journal of Biological Chemistry. 287: 42299-311. PMID 23066014 DOI: 10.1074/jbc.M112.423459  0.348
2011 Li XE, Tobacman LS, Mun JY, Craig R, Fischer S, Lehman W. Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. Biophysical Journal. 100: 1005-13. PMID 21320445 DOI: 10.1016/J.Bpj.2010.12.3697  0.31
2010 Ali LF, Cohen JM, Tobacman LS. Push and pull of tropomyosin's opposite effects on myosin attachment to actin. A chimeric tropomyosin host-guest study. Biochemistry. 49: 10873-80. PMID 21114337 DOI: 10.1021/bi101632f  0.488
2010 Sousa D, Cammarato A, Jang K, Graceffa P, Tobacman LS, Li XE, Lehman W. Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophysical Journal. 99: 862-8. PMID 20682264 DOI: 10.1016/J.Bpj.2010.05.004  0.376
2010 Mouannes JJ, Kobayashi T, Leek D, Tobacman L. Studies of the Mid Region of Tropomyosin Using an Incorporated Tryptophan Analogue Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1894  0.487
2009 Lehman W, Galińska-Rakoczy A, Hatch V, Tobacman LS, Craig R. Structural basis for the activation of muscle contraction by troponin and tropomyosin. Journal of Molecular Biology. 388: 673-81. PMID 19341744 DOI: 10.1016/J.Jmb.2009.03.060  0.543
2009 Siththanandan VB, Tobacman LS, Van Gorder N, Homsher E. Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils Pflugers Archiv European Journal of Physiology. 458: 761-776. PMID 19255776 DOI: 10.1007/s00424-009-0653-3  0.313
2009 Kowlessur D, Tobacman L. Dynamic Studies Of Truncated Troponin Complex Usin Hdx Biophysical Journal. 96: 2-9. DOI: 10.1016/J.Bpj.2008.12.1125  0.444
2008 Tobacman LS. Cooperative binding of tropomyosin to actin. Advances in Experimental Medicine and Biology. 644: 85-94. PMID 19209815 DOI: 10.1007/978-0-387-85766-4_7  0.388
2008 Galińska-Rakoczy A, Engel P, Xu C, Jung H, Craig R, Tobacman LS, Lehman W. Structural basis for the regulation of muscle contraction by troponin and tropomyosin. Journal of Molecular Biology. 379: 929-35. PMID 18514658 DOI: 10.1016/j.jmb.2008.04.062  0.542
2006 Lu X, Tobacman LS, Kawai M. Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant. Biophysical Journal. 91: 4230-40. PMID 16980359 DOI: 10.1529/biophysj.106.084608  0.346
2006 Poole KJ, Lorenz M, Evans G, Rosenbaum G, Pirani A, Craig R, Tobacman LS, Lehman W, Holmes KC. A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle. Journal of Structural Biology. 155: 273-84. PMID 16793285 DOI: 10.1016/J.Jsb.2006.02.020  0.437
2006 Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. An atomic model of the thin filament in the relaxed and Ca2+-activated states. Journal of Molecular Biology. 357: 707-17. PMID 16469331 DOI: 10.1016/J.Jmb.2005.12.050  0.511
2005 Brown JH, Zhou Z, Reshetnikova L, Robinson H, Yammani RD, Tobacman LS, Cohen C. Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proceedings of the National Academy of Sciences of the United States of America. 102: 18878-83. PMID 16365313 DOI: 10.1073/Pnas.0509269102  0.39
2005 Pirani A, Xu C, Hatch V, Craig R, Tobacman LS, Lehman W. Single particle analysis of relaxed and activated muscle thin filaments. Journal of Molecular Biology. 346: 761-72. PMID 15713461 DOI: 10.1016/J.Jmb.2004.12.013  0.389
2005 Gong H, Hatch V, Ali L, Lehman W, Craig R, Tobacman LS. Mini-thin filaments regulated by troponin-tropomyosin. Proceedings of the National Academy of Sciences of the United States of America. 102: 656-61. PMID 15644437 DOI: 10.1073/Pnas.0407225102  0.515
2004 Cammarato A, Hatch V, Saide J, Craig R, Sparrow JC, Tobacman LS, Lehman W. Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants. Biophysical Journal. 86: 1618-24. PMID 14990488 DOI: 10.1016/S0006-3495(04)74229-0  0.439
2003 Lu X, Tobacman LS, Kawai M. Effects of tropomyosin internal deletion Delta23Tm on isometric tension and the cross-bridge kinetics in bovine myocardium. The Journal of Physiology. 553: 457-71. PMID 14500764 DOI: 10.1113/jphysiol.2003.053694  0.475
2003 Heller MJ, Nili M, Homsher E, Tobacman LS. Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility. The Journal of Biological Chemistry. 278: 41742-8. PMID 12900417 DOI: 10.1074/jbc.M303408200  0.302
2003 Homsher E, Nili M, Chen IY, Tobacman LS. Regulatory proteins alter nucleotide binding to acto-myosin of sliding filaments in motility assays. Biophysical Journal. 85: 1046-52. PMID 12885651 DOI: 10.1016/S0006-3495(03)74543-3  0.397
2003 Pavlov D, Gerson JH, Yu T, Tobacman LS, Homsher E, Reisler E. The regulation of subtilisin-cleaved actin by tropomyosin/troponin. The Journal of Biological Chemistry. 278: 5517-22. PMID 12468534 DOI: 10.1074/Jbc.M210889200  0.471
2002 Li Y, Mui S, Brown JH, Strand J, Reshetnikova L, Tobacman LS, Cohen C. The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site. Proceedings of the National Academy of Sciences of the United States of America. 99: 7378-83. PMID 12032291 DOI: 10.1073/Pnas.102179999  0.336
2002 Tobacman LS, Nihli M, Butters C, Heller M, Hatch V, Craig R, Lehman W, Homsher E. The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity. The Journal of Biological Chemistry. 277: 27636-42. PMID 12011043 DOI: 10.1074/Jbc.M201768200  0.484
2001 Strand J, Nili M, Homsher E, Tobacman LS. Modulation of Myosin Function by Isoform-specific Properties of Saccharomyces cerevisiae and Muscle Tropomyosins Journal of Biological Chemistry. 276: 34832-34839. PMID 11457840 DOI: 10.1074/jbc.M104750200  0.502
2001 Lehman W, Rosol M, Tobacman LS, Craig R. Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction Journal of Molecular Biology. 307: 739-744. PMID 11273697 DOI: 10.1006/Jmbi.2001.4514  0.523
2001 Burhop J, Rosol M, Craig R, Tobacman LS, Lehman W. Effects of a Cardiomyopathy-causing Troponin T Mutation on Thin Filament Function and Structure Journal of Biological Chemistry. 276: 20788-20794. PMID 11262409 DOI: 10.1074/Jbc.M101110200  0.454
2001 Morris CA, Tobacman LS, Homsher E. Modulation of Contractile Activation in Skeletal Muscle by a Calcium-insensitive Troponin C Mutant Journal of Biological Chemistry. 276: 20245-20251. PMID 11262388 DOI: 10.1074/jbc.M007371200  0.332
2000 Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. Journal of Molecular Biology. 302: 593-606. PMID 10986121 DOI: 10.1006/Jmbi.2000.4080  0.522
2000 Tobacman LS, Butters CA. A new model of cooperative myosin-thin filament binding Journal of Biological Chemistry. 275: 27587-27593. PMID 10864931 DOI: 10.1074/jbc.M003648200  0.51
2000 Korman VL, Hatch V, Dixon KY, Craig R, Lehman W, Tobacman LS. An actin subdomain 2 mutation that impairs thin filament regulation by troponin and tropomyosin. The Journal of Biological Chemistry. 275: 22470-8. PMID 10801864 DOI: 10.1074/Jbc.M002939200  0.543
2000 Homsher E, Lee DM, Morris C, Pavlov D, Tobacman LS. Regulation of force and unloaded sliding speed in single thin filaments: Effects of regulatory proteins and calcium Journal of Physiology. 524: 233-243. PMID 10747195 DOI: 10.1111/J.1469-7793.2000.00233.X  0.449
2000 Rosol M, Lehman W, Craig R, Landis C, Butters C, Tobacman LS. Three-dimensional reconstruction of thin filaments containing mutant tropomyosin. Biophysical Journal. 78: 908-17. PMID 10653803 DOI: 10.1016/S0006-3495(00)76648-3  0.492
1999 Xu C, Craig R, Tobacman L, Horowitz R, Lehman W. Tropomyosin positions in regulated thin filaments revealed by cryoelectron microscopy. Biophysical Journal. 77: 985-92. PMID 10423443 DOI: 10.1016/S0006-3495(99)76949-3  0.462
1999 Hinkle A, Goranson A, Butters CA, Tobacman LS. Roles for the troponin tail domain in thin filament assembly and regulation: A deletional study of cardiac troponin T Journal of Biological Chemistry. 274: 7157-7164. PMID 10066775 DOI: 10.1074/jbc.274.11.7157  0.577
1997 Butters CA, Tobacman JB, Tobacman LS. Cooperative effect of calcium binding to adjacent troponin molecules on the thin filament-myosin subfragment 1 MgATPase rate. The Journal of Biological Chemistry. 272: 13196-202. PMID 9148936 DOI: 10.1074/Jbc.272.20.13196  0.477
1996 Tobacman LS. Thin filament-mediated regulation of cardiac contraction Annual Review of Physiology. 58: 447-481. PMID 8815803  0.486
1996 Homsher E, Kim B, Bobkova A, Tobacman LS. Calcium regulation of thin filament movement in an in vitro motility assay Biophysical Journal. 70: 1881-1892. PMID 8785348  0.376
1996 Huynh Q, Butters CA, Leiden JM, Tobacman LS. Effects of cardiac thin filament Ca2+: statistical mechanical analysis of a troponin C site II mutant. Biophysical Journal. 70: 1447-55. PMID 8785301 DOI: 10.1016/S0006-3495(96)79704-7  0.489
1996 Lin D, Bobkova A, Homsher E, Tobacman LS. Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy Journal of Clinical Investigation. 97: 2842-2848. PMID 8675696  0.33
1996 Cassell M, Tobacman LS. Opposite effects of myosin subfragment 1 on binding of cardiac troponin and tropomyosin to the thin filament. The Journal of Biological Chemistry. 271: 12867-72. PMID 8662810 DOI: 10.1074/jbc.271.22.12867  0.383
1995 Fisher D, Wang G, Tobacman LS. NH2-terminal truncation of skeletal muscle troponin T does not alter the Ca2+ sensitivity of thin filament assembly Journal of Biological Chemistry. 270: 25455-25460. PMID 7592713  0.472
1994 Dahiya R, Butters CA, Tobacman LS. Equilibrium linkage analysis of cardiac thin filament assembly: Implications for the regulation of muscle contraction Journal of Biological Chemistry. 269: 29457-29461. PMID 7961927  0.523
1992 Hill LE, Mehegan JP, Butters CA, Tobacman LS. Analysis of troponin-tropomyosin binding to actin. Troponin does not promote interactions between tropomyosin molecules. The Journal of Biological Chemistry. 267: 16106-13. PMID 1644797  0.343
1991 Mehegan JP, Tobacman LS. Cooperative interactions between troponin molecules bound to the cardiac thin filament Journal of Biological Chemistry. 266: 966-972. PMID 1985974  0.478
1990 Tobacman LS, Sawyer D. Calcium binds cooperatively to the regulatory sites of the cardiac thin filament Journal of Biological Chemistry. 265: 931-939. PMID 2136850  0.474
1988 Tobacman LS. Structure-function studies of the amino-terminal region of bovine cardiac troponin T Journal of Biological Chemistry. 263: 2668-2672. PMID 2963817  0.452
1987 Tobacman LS, Lee R. Isolation and functional comparison of bovine cardiac troponin T isoforms Journal of Biological Chemistry. 262: 4059-4064. PMID 2951382  0.415
1987 Tobacman LS. Activation of actin-cardiac myosin subfragment 1 MgATPase rate by Ca2+ shows cooperativity intrinsic to the thin filament Biochemistry. 26: 492-497. PMID 2950924  0.492
1986 Tobacman LS, Adelstein RS. Mechanism of regulation of cardiac actin-myosin subfragment 1 by troponin-tropomyosin Biochemistry. 25: 798-802. PMID 2938620 DOI: 10.1021/Bi00352A010  0.492
1983 Tobacman LS, Korn ED. The kinetics of actin nucleation and polymerization Journal of Biological Chemistry. 258: 3207-3214. PMID 6826559  0.311
1982 Tobacman LS, Korn ED. The regulation of actin polymerization and the inhibition of monomeric actin ATPase activity by Acanthamoeba profilin Journal of Biological Chemistry. 257: 4166-4170. PMID 6461652  0.35
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