| Year |
Citation |
Score |
| 2018 |
Saito A, Okiyama N, Kubota N, Nakamura Y, Fujisawa Y, Watanabe R, Ishitsuka Y, Bleackley RC, Fujimoto M. Blockade of granzyme B remarkably improves mucocutaneous diseases with keratinocyte death in interface dermatitis. The Journal of Investigative Dermatology. PMID 29577918 DOI: 10.1016/j.jid.2018.03.1507 |
0.33 |
|
| 2013 |
Baginska J, Viry E, Berchem G, Poli A, Noman MZ, van Moer K, Medves S, Zimmer J, Oudin A, Niclou SP, Bleackley RC, Goping IS, Chouaib S, Janji B. Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia. Proceedings of the National Academy of Sciences of the United States of America. 110: 17450-5. PMID 24101526 DOI: 10.1073/pnas.1304790110 |
0.409 |
|
| 2013 |
Ewen CL, Kane KP, Bleackley RC. Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation. Molecular Immunology. 54: 309-18. PMID 23352961 DOI: 10.1016/j.molimm.2012.12.020 |
0.599 |
|
| 2012 |
Ewen CL, Kane KP, Bleackley RC. A quarter century of granzymes. Cell Death and Differentiation. 19: 28-35. PMID 22052191 DOI: 10.1038/Cdd.2011.153 |
0.412 |
|
| 2011 |
Marcet-Palacios M, Duggan BL, Shostak I, Barry M, Geskes T, Wilkins JA, Yanagiya A, Sonenberg N, Bleackley RC. Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3. Plos Pathogens. 7: e1002447. PMID 22194691 DOI: 10.1371/Journal.Ppat.1002447 |
0.436 |
|
| 2011 |
Haile Y, Simmen KC, Pasichnyk D, Touret N, Simmen T, Lu JQ, Bleackley RC, Giuliani F. Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 187: 4861-72. PMID 21964027 DOI: 10.4049/Jimmunol.1100943 |
0.303 |
|
| 2011 |
Sutendra G, Dromparis P, Bonnet S, Haromy A, McMurtry MS, Bleackley RC, Michelakis ED. Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension. Journal of Molecular Medicine (Berlin, Germany). 89: 771-83. PMID 21809123 DOI: 10.1007/s00109-011-0762-2 |
0.347 |
|
| 2011 |
Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nature Immunology. 12: 770-7. PMID 21685908 DOI: 10.1038/Ni.2050 |
0.434 |
|
| 2011 |
Mader JS, Ewen C, Hancock RE, Bleackley RC. The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in regulatory T cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 34: 229-35. PMID 21389875 DOI: 10.1097/CJI.0b013e318207ecdf |
0.523 |
|
| 2011 |
Mader JS, Marcet-Palacios M, Hancock RE, Bleackley RC. The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes. Experimental Cell Research. 317: 531-8. PMID 21134367 DOI: 10.1016/j.yexcr.2010.11.015 |
0.518 |
|
| 2009 |
Mader JS, Mookherjee N, Hancock RE, Bleackley RC. The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity. Molecular Cancer Research : McR. 7: 689-702. PMID 19435812 DOI: 10.1158/1541-7786.Mcr-08-0274 |
0.567 |
|
| 2008 |
Duggan BL, Cabilio NR, Dickie P, Witmer J, Goping IS, Underhill DA, Bleackley RC. A novel lineage-specific hypersensitive site is essential for position independent granzyme B expression in transgenic mice. Biochemical and Biophysical Research Communications. 368: 357-63. PMID 18222115 DOI: 10.1016/j.bbrc.2008.01.065 |
0.338 |
|
| 2008 |
Goping IS, Sawchuk T, Rieger A, Shostak I, Bleackley RC. Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise. Blood. 111: 2142-51. PMID 18096765 DOI: 10.1182/blood-2007-08-105221 |
0.579 |
|
| 2008 |
Marcet-Palacios M, Odemuyiwa SO, Coughlin JJ, Garofoli D, Ewen C, Davidson CE, Ghaffari M, Kane KP, Lacy P, Logan MR, Befus AD, Bleackley RC, Moqbel R. Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line. Biochemical and Biophysical Research Communications. 366: 617-23. PMID 18042464 DOI: 10.1016/J.Bbrc.2007.11.079 |
0.483 |
|
| 2006 |
Groenendyk J, Zuppini A, Shore G, Opas M, Bleackley RC, Michalak M. Caspase 12 in calnexin-deficient cells. Biochemistry. 45: 13219-26. PMID 17073443 DOI: 10.1021/Bi061428Z |
0.514 |
|
| 2006 |
Sipione S, Simmen KC, Lord SJ, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV, Bleackley RC. Identification of a novel human granzyme B inhibitor secreted by cultured sertoli cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 5051-8. PMID 17015688 DOI: 10.4049/Jimmunol.177.8.5051 |
0.416 |
|
| 2006 |
Qin HY, Mukherjee R, Lee-Chan E, Ewen C, Bleackley RC, Singh B. A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity. International Immunology. 18: 1001-15. PMID 16675487 DOI: 10.1093/intimm/dxl035 |
0.382 |
|
| 2006 |
Goping IS, Sawchuk T, Underhill DA, Bleackley RC. Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis. Journal of Cell Science. 119: 858-65. PMID 16495481 DOI: 10.1242/jcs.02791 |
0.494 |
|
| 2006 |
Ewen CL, Rong J, Kokaji AI, Bleackley RC, Kane KP. Evaluating antigen-specific cytotoxic T lymphocyte responses by a novel mouse granzyme B ELISPOT assay. Journal of Immunological Methods. 308: 156-66. PMID 16375915 DOI: 10.1016/j.jim.2005.10.009 |
0.34 |
|
| 2006 |
Veugelers K, Motyka B, Goping IS, Shostak I, Sawchuk T, Bleackley RC. Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate. Molecular Biology of the Cell. 17: 623-33. PMID 16280358 DOI: 10.1091/mbc.E05-07-0631 |
0.458 |
|
| 2005 |
Bleackley RC. A molecular view of cytotoxic T lymphocyte induced killing. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 83: 747-51. PMID 16333326 DOI: 10.1139/o05-146 |
0.546 |
|
| 2005 |
Sipione S, Ewen C, Shostak I, Michalak M, Bleackley RC. Impaired cytolytic activity in calreticulin-deficient CTLs. Journal of Immunology (Baltimore, Md. : 1950). 174: 3212-9. PMID 15749851 DOI: 10.4049/Jimmunol.174.6.3212 |
0.402 |
|
| 2005 |
Choy JC, Cruz RP, Kerjner A, Geisbrecht J, Sawchuk T, Fraser SA, Hudig D, Bleackley RC, Jirik FR, McManus BM, Granville DJ. Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 5: 494-9. PMID 15707403 DOI: 10.1111/J.1600-6143.2004.00710.X |
0.375 |
|
| 2004 |
Choy JC, Hung VH, Hunter AL, Cheung PK, Motyka B, Goping IS, Sawchuk T, Bleackley RC, Podor TJ, McManus BM, Granville DJ. Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 2245-50. PMID 15472125 DOI: 10.1161/01.Atv.0000147162.51930.B7 |
0.56 |
|
| 2004 |
Veugelers K, Motyka B, Frantz C, Shostak I, Sawchuk T, Bleackley RC. The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Blood. 103: 3845-53. PMID 14739229 DOI: 10.1182/blood-2003-06-2156 |
0.482 |
|
| 2003 |
Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunological Reviews. 193: 31-8. PMID 12752668 DOI: 10.1034/j.1600-065X.2003.00044.x |
0.68 |
|
| 2003 |
Ewen C, Kane KP, Shostak I, Griebel PJ, Bertram EM, Watts TH, Bleackley RC, McElhaney JE. A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B. Journal of Immunological Methods. 276: 89-101. PMID 12738362 DOI: 10.1016/S0022-1759(03)00073-5 |
0.431 |
|
| 2003 |
Roberts DL, Goping IS, Bleackley RC. Mitochondria at the heart of the cytotoxic attack. Biochemical and Biophysical Research Communications. 304: 513-8. PMID 12729586 DOI: 10.1016/S0006-291X(03)00624-7 |
0.624 |
|
| 2003 |
Goping IS, Barry M, Liston P, Sawchuk T, Constantinescu G, Michalak KM, Shostak I, Roberts DL, Hunter AM, Korneluk R, Bleackley RC. Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition. Immunity. 18: 355-65. PMID 12648453 DOI: 10.1016/S1074-7613(03)00032-3 |
0.625 |
|
| 2002 |
Everett H, Barry M, Sun X, Lee SF, Frantz C, Berthiaume LG, McFadden G, Bleackley RC. The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. The Journal of Experimental Medicine. 196: 1127-39. PMID 12417624 DOI: 10.1084/Jem.20011247 |
0.387 |
|
| 2002 |
Zuppini A, Groenendyk J, Cormack LA, Shore G, Opas M, Bleackley RC, Michalak M. Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis. Biochemistry. 41: 2850-8. PMID 11851433 DOI: 10.1021/Bi015967+ |
0.388 |
|
| 2001 |
Bleackley RC, Heibein JA. Enzymatic control of apoptosis. Natural Product Reports. 18: 431-40. PMID 11548051 DOI: 10.1039/A909080K |
0.752 |
|
| 2001 |
Pinkoski MJ, Waterhouse NJ, Heibein JA, Wolf BB, Kuwana T, Goldstein JC, Newmeyer DD, Bleackley RC, Green DR. Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway. The Journal of Biological Chemistry. 276: 12060-7. PMID 11278459 DOI: 10.1074/Jbc.M009038200 |
0.819 |
|
| 2000 |
Heibein JA, Goping IS, Barry M, Pinkoski MJ, Shore GC, Green DR, Bleackley RC. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. The Journal of Experimental Medicine. 192: 1391-402. PMID 11085742 DOI: 10.1084/Jem.192.10.1391 |
0.803 |
|
| 2000 |
Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J, Bleackley RC. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell. 103: 491-500. PMID 11081635 DOI: 10.1016/S0092-8674(00)00140-9 |
0.784 |
|
| 2000 |
Nakamura K, Bossy-Wetzel E, Burns K, Fadel MP, Lozyk M, Goping IS, Opas M, Bleackley RC, Green DR, Michalak M. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. The Journal of Cell Biology. 150: 731-40. PMID 10952999 DOI: 10.1083/Jcb.150.4.731 |
0.532 |
|
| 2000 |
Barry M, Heibein J, Pinkoski M, Bleackley RC. Quantitative measurement of apoptosis induced by cytotoxic T lymphocytes. Methods in Enzymology. 322: 40-6. PMID 10914003 DOI: 10.1016/S0076-6879(00)22006-5 |
0.781 |
|
| 2000 |
Barry M, Heibein JA, Pinkoski MJ, Lee SF, Moyer RW, Green DR, Bleackley RC. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Molecular and Cellular Biology. 20: 3781-94. PMID 10805722 DOI: 10.1128/Mcb.20.11.3781-3794.2000 |
0.823 |
|
| 2000 |
Everett H, Barry M, Lee SF, Sun X, Graham K, Stone J, Bleackley RC, McFadden G. M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes. The Journal of Experimental Medicine. 191: 1487-98. PMID 10790424 DOI: 10.1084/Jem.191.9.1487 |
0.378 |
|
| 2000 |
Hakimelahi S, Parker HR, Gilchrist AJ, Barry M, Li Z, Bleackley RC, Pasdar M. Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2. The Journal of Biological Chemistry. 275: 10905-11. PMID 10753888 DOI: 10.1074/Jbc.275.15.10905 |
0.405 |
|
| 2000 |
Pinkoski MJ, Heibein JA, Barry M, Bleackley RC. Nuclear translocation of granzyme B in target cell apoptosis. Cell Death and Differentiation. 7: 17-24. PMID 10713717 DOI: 10.1038/Sj.Cdd.4400604 |
0.798 |
|
| 1999 |
Heibein JA, Barry M, Motyka B, Bleackley RC. Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent. Journal of Immunology (Baltimore, Md. : 1950). 163: 4683-93. PMID 10528165 |
0.798 |
|
| 1999 |
Johnson BA, John VA, Henschler R, Hampson IN, Heyworth CM, Babichuk CK, Bleackley RC, Dexter TM, Cross MA. Upstream elements bestow T-cell and haemopoietic progenitor-specific activity on the granzyme B promoter. Gene. 234: 101-7. PMID 10393244 DOI: 10.1016/S0378-1119(99)00173-0 |
0.387 |
|
| 1998 |
Atkinson EA, Barry M, Darmon AJ, Shostak I, Turner PC, Moyer RW, Bleackley RC. Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B. The Journal of Biological Chemistry. 273: 21261-6. PMID 9694885 DOI: 10.1074/jbc.273.33.21261 |
0.592 |
|
| 1998 |
Pinkoski MJ, Hobman M, Heibein JA, Tomaselli K, Li F, Seth P, Froelich CJ, Bleackley RC. Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 92: 1044-54. PMID 9680374 DOI: 10.1182/Blood.V92.3.1044.415K12_1044_1054 |
0.791 |
|
| 1998 |
Darmon AJ, Bleackley RC. Proteases and cell-mediated cytotoxicity. Critical Reviews in Immunology. 18: 255-73. PMID 9637413 |
0.515 |
|
| 1997 |
Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley RC, Saxena S, Gietz RD, Greenberg AH. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. The Journal of Experimental Medicine. 186: 1975-83. PMID 9396766 DOI: 10.1084/jem.186.12.1975 |
0.467 |
|
| 1997 |
Sad S, Krishnan L, Bleackley RC, Kägi D, Hengartner H, Mosmann TR. Cytotoxicity and weak CD40 ligand expression of CD8+ type 2 cytotoxic T cells restricts their potential B cell helper activity. European Journal of Immunology. 27: 914-22. PMID 9130644 DOI: 10.1002/Eji.1830270417 |
0.401 |
|
| 1997 |
Bleackley RC. Mechanisms of cell-mediated cytotoxicity: proteases and antiproteases Proceedings of the Western Pharmacology Society. 40: 144-145. |
0.567 |
|
| 1996 |
Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. The Journal of Biological Chemistry. 271: 29073-9. PMID 8910561 DOI: 10.1074/Jbc.271.46.29073 |
0.597 |
|
| 1996 |
Macen JL, Garner RS, Musy PY, Brooks MA, Turner PC, Moyer RW, McFadden G, Bleackley RC. Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 9108-13. PMID 8799162 DOI: 10.1073/Pnas.93.17.9108 |
0.319 |
|
| 1996 |
Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC. Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation. The Journal of Biological Chemistry. 271: 21709-12. PMID 8702964 DOI: 10.1074/Jbc.271.36.21709 |
0.588 |
|
| 1996 |
Darmon AJ, Bleackley RC. An interleukin-1beta converting enzyme-like protease is a key component of Fas-mediated apoptosis. The Journal of Biological Chemistry. 271: 21699-702. PMID 8702962 DOI: 10.1074/jbc.271.36.21699 |
0.391 |
|
| 1996 |
Babichuk CK, Duggan BL, Bleackley RC. In vivo regulation of murine granzyme B gene transcription in activated primary T cells. The Journal of Biological Chemistry. 271: 16485-93. PMID 8663264 |
0.316 |
|
| 1996 |
Pinkoski MJ, Winkler U, Hudig D, Bleackley RC. Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein. The Journal of Biological Chemistry. 271: 10225-9. PMID 8626587 DOI: 10.1074/jbc.271.17.10225 |
0.482 |
|
| 1996 |
Atkinson EA, Ostergaard H, Kane K, Pinkoski MJ, Caputo A, Olszowy MW, Bleackley RC. A physical interaction between the cell death protein Fas and the tyrosine kinase p59fynT. The Journal of Biological Chemistry. 271: 5968-71. PMID 8626376 |
0.382 |
|
| 1995 |
Atkinson EA, Bleackley RC. Mechanisms of lysis by cytotoxic T cells. Critical Reviews in Immunology. 15: 359-84. PMID 8834456 |
0.473 |
|
| 1995 |
Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. The Journal of Biological Chemistry. 270: 10377-9. PMID 7737968 DOI: 10.1074/Jbc.270.18.10377 |
0.319 |
|
| 1995 |
Helgason CD, Atkinson EA, Pinkoski MJ, Bleackley RC. Proteinases are involved in both DNA fragmentation and membrane damage during CTL-mediated target cell killing. Experimental Cell Research. 218: 50-6. PMID 7737379 DOI: 10.1006/excr.1995.1129 |
0.367 |
|
| 1995 |
Darmon AJ, Nicholson DW, Bleackley RC. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature. 377: 446-8. PMID 7566124 DOI: 10.1038/377446a0 |
0.613 |
|
| 1994 |
Rabinovitch A, Suarez-Pinzon WL, Shi Y, Morgan AR, Bleackley RC. DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction. Diabetologia. 37: 733-8. PMID 7988773 DOI: 10.1007/Bf00404328 |
0.301 |
|
| 1994 |
Darmon AJ, Ehrman N, Caputo A, Fujinaga J, Bleackley RC. The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme. The Journal of Biological Chemistry. 269: 32043-6. PMID 7798197 |
0.361 |
|
| 1994 |
Garner R, Helgason CD, Atkinson EA, Pinkoski MJ, Ostergaard HL, Sorensen O, Fu A, Lapchak PH, Rabinovitch A, McElhaney JE, Berke G, Bleackley RC. Characterization of a granule-independent lytic mechanism used by CTL hybridomas Journal of Immunology. 153: 5413-5421. PMID 7527440 |
0.448 |
|
| 1993 |
Helgason CD, Shi L, Greenberg AH, Shi Y, Bromley P, Cotter TG, Green DR, Bleackley RC. DNA fragmentation induced by cytotoxic T lymphocytes can result in target cell death Experimental Cell Research. 206: 302-310. PMID 8500550 DOI: 10.1006/Excr.1993.1150 |
0.478 |
|
| 1993 |
Caputo A, Garner RS, Winkler U, Hudig D, Bleackley RC. Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide Journal of Biological Chemistry. 268: 17672-17675. PMID 8349649 |
0.352 |
|
| 1987 |
Redmond MJ, Letellier M, Parker JMR, Lobe C, Havele C, Paetkau V, Bleackley RC. A serine protease (CCP1) is sequestered in the cytoplasmic granules of cytotoxic T lymphocytes Journal of Immunology. 139: 3184-3188. PMID 2445811 |
0.309 |
|
| 1982 |
Bleackley RC, Havele C, Paetkau V. Cellular and molecular properties of an antigen-specific cytotoxic T lymphocyte line. Journal of Immunology (Baltimore, Md. : 1950). 128: 758-67. PMID 6172507 |
0.33 |
|
| Show low-probability matches. |