Nicole M. Robbins, Ph.D. - Publications

Affiliations: 
2013 University of Toronto, Toronto, ON, Canada 
Area:
Genetics, Molecular Biology, Pathology

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Puumala E, Fallah S, Robbins N, Cowen LE. Advancements and challenges in antifungal therapeutic development. Clinical Microbiology Reviews. e0014223. PMID 38294218 DOI: 10.1128/cmr.00142-23  0.599
2023 Case NT, Westman J, Hallett MT, Plumb J, Farheen A, Maxson ME, MacAlpine J, Liston SD, Hube B, Robbins N, Whitesell L, Grinstein S, Cowen LE. Respiration supports intraphagosomal filamentation and escape of from macrophages. Mbio. e0274523. PMID 38038475 DOI: 10.1128/mbio.02745-23  0.754
2023 MacAlpine J, Liu Z, Hossain S, Whitesell L, Robbins N, Cowen LE. DYRK-family kinases regulate morphogenesis and virulence through the Ras1/PKA pathway. Mbio. e0218323. PMID 38015416 DOI: 10.1128/mbio.02183-23  0.817
2023 Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE. Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence. Nature Communications. 14: 4528. PMID 37500616 DOI: 10.1038/s41467-023-40209-w  0.812
2023 Robbins N, Cowen LE. Roles of Hsp90 in Candida albicans morphogenesis and virulence. Current Opinion in Microbiology. 75: 102351. PMID 37399670 DOI: 10.1016/j.mib.2023.102351  0.667
2023 Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Ušaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota T, Yoshimura M, ... ... Robbins N, et al. Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chemical Biology. PMID 37369212 DOI: 10.1016/j.chembiol.2023.06.005  0.814
2023 Liu Z, MacAlpine J, Robbins N, Cowen LE. Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1. Msphere. e0009523. PMID 37039635 DOI: 10.1128/msphere.00095-23  0.812
2023 Robbins N, Ketela T, Kim SH, Cowen LE. Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathogen Candida albicans. Methods in Molecular Biology (Clifton, N.J.). 2658: 145-165. PMID 37024700 DOI: 10.1007/978-1-0716-3155-3_10  0.638
2023 Lee Y, Hossain S, MacAlpine J, Robbins N, Cowen LE. Functional genomic analysis of protein kinases reveals modulators of morphogenesis in diverse environments. Iscience. 26: 106145. PMID 36879823 DOI: 10.1016/j.isci.2023.106145  0.803
2023 Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE. Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans. Mbio. e0343422. PMID 36809010 DOI: 10.1128/mbio.03434-22  0.681
2022 Puumala E, Zaslaver O, Chen A, Duncan D, Fogal M, Shapiro RS, Mazhab-Jafari MT, Whitesell L, Montenegro-Burke JR, Robbins N, Cowen LE. The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis. Mbio. e0273022. PMID 36300931 DOI: 10.1128/mbio.02730-22  0.832
2022 Hossain S, Robbins N, Cowen LE. The GARP complex is required for filamentation in Candida albicans. Genetics. PMID 36226807 DOI: 10.1093/genetics/iyac152  0.641
2022 Robbins N, Cowen LE. Antifungal discovery. Current Opinion in Microbiology. 69: 102198. PMID 36037637 DOI: 10.1016/j.mib.2022.102198  0.616
2022 Revie NM, Iyer KR, Maxson ME, Zhang J, Yan S, Fernandes CM, Meyer KJ, Chen X, Skulska I, Fogal M, Sanchez H, Hossain S, Li S, Yashiroda Y, Hirano H, ... ... Robbins N, et al. Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation. Nature Communications. 13: 3634. PMID 35752611 DOI: 10.1038/s41467-022-31308-1  0.748
2022 Iyer KR, Kim SH, Robbins N, Cowen LE. Downregulation of Essential Genes in the Fungal Pathogen Candida auris. Methods in Molecular Biology (Clifton, N.J.). 2517: 111-126. PMID 35674949 DOI: 10.1007/978-1-0716-2417-3_9  0.67
2022 Lee Y, Liston SD, Lee D, Robbins N, Cowen LE. Functional analysis of the kinome reveals Hrr25 as a regulator of antifungal susceptibility. Iscience. 25: 104432. PMID 35663022 DOI: 10.1016/j.isci.2022.104432  0.83
2022 Robbins N, Cowen LE. Genomic Approaches to Antifungal Drug Target Identification and Validation. Annual Review of Microbiology. PMID 35650665 DOI: 10.1146/annurev-micro-041020-094524  0.645
2022 Du Bois AC, Xue A, Pham C, Revie NM, Meyer KJ, Yashiroda Y, Boone C, Nodwell JR, Stogios P, Savchenko A, Robbins N, Iyer KR, Cowen LE. High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11. Msphere. e0007522. PMID 35531664 DOI: 10.1128/msphere.00075-22  0.667
2022 Iyer KR, Robbins N, Cowen LE. The role of stress response pathways in antifungal tolerance and resistance. Iscience. 25: 103953. PMID 35281744 DOI: 10.1016/j.isci.2022.103953  0.669
2022 MacAlpine J, Robbins N, Cowen LE. Bacterial-Fungal Interactions and Their Impact on Microbial Pathogenesis. Molecular Ecology. PMID 35231147 DOI: 10.1111/mec.16411  0.798
2021 Robbins N, Cowen LE. Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata. Current Biology : Cb. 31: R1520-R1523. PMID 34875240 DOI: 10.1016/j.cub.2021.09.071  0.617
2021 Fu C, Beattie SR, Jezewski AJ, Robbins N, Whitesell L, Krysan DJ, Cowen LE. Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence. Genetics. PMID 34849848 DOI: 10.1093/genetics/iyab164  0.77
2021 Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, ... ... Robbins N, et al. Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets. Nature Communications. 12: 6497. PMID 34764269 DOI: 10.1038/s41467-021-26850-3  0.781
2021 MacAlpine J, Daniel-Ivad M, Liu Z, Yano J, Revie NM, Todd RT, Stogios PJ, Sanchez H, O'Meara TR, Tompkins TA, Savchenko A, Selmecki A, Veri AO, Andes DR, Fidel PL, ... Robbins N, et al. A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase. Nature Communications. 12: 6151. PMID 34686660 DOI: 10.1038/s41467-021-26390-w  0.803
2021 Hsu IS, Strome B, Lash E, Robbins N, Cowen LE, Moses AM. A functionally divergent intrinsically disordered region underlying the conservation of stochastic signaling. Plos Genetics. 17: e1009629. PMID 34506483 DOI: 10.1371/journal.pgen.1009629  0.536
2021 Case NT, Duah K, Larsen B, Wong CJ, Gingras AC, O'Meara TR, Robbins N, Veri AO, Whitesell L, Cowen LE. The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans. Cell Reports. 36: 109584. PMID 34433036 DOI: 10.1016/j.celrep.2021.109584  0.787
2021 Hossain S, Veri AO, Liu Z, Iyer KR, O'Meara TR, Robbins N, Cowen LE. Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans. Genetics. PMID 34143207 DOI: 10.1093/genetics/iyab095  0.765
2021 Iyer KR, Revie NM, Fu C, Robbins N, Cowen LE. Treatment strategies for cryptococcal infection: challenges, advances and future outlook. Nature Reviews. Microbiology. PMID 33558691 DOI: 10.1038/s41579-021-00511-0  0.759
2021 Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, et al. Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. Journal of Medicinal Chemistry. PMID 33444025 DOI: 10.1021/acs.jmedchem.0c01777  0.6
2020 Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, ... ... Robbins N, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3  0.676
2020 Iyer KR, Robbins N, Cowen LE. Flow Cytometric Measurement of Efflux in Candida Species. Current Protocols in Microbiology. 59: e121. PMID 33047867 DOI: 10.1002/cpmc.121  0.535
2020 Xue A, Robbins N, Cowen LE. Advances in fungal chemical genomics for the discovery of new antifungal agents. Annals of the New York Academy of Sciences. PMID 32860238 DOI: 10.1111/Nyas.14484  0.684
2020 Lee Y, Puumala E, Robbins N, Cowen LE. Antifungal Drug Resistance: Molecular Mechanisms in and Beyond. Chemical Reviews. PMID 32441527 DOI: 10.1021/Acs.Chemrev.0C00199  0.687
2020 Revie NM, Robbins N, Whitesell L, Frost JR, Appavoo SD, Yudin AK, Cowen LE. Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic Species. Msphere. 5. PMID 32269162 DOI: 10.1128/mSphere.00256-20  0.647
2020 Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11. PMID 32156828 DOI: 10.1128/Mbio.03329-19  0.682
2020 Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, et al. Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. Cell Chemical Biology. PMID 31924499 DOI: 10.1016/J.Chembiol.2019.12.008  0.828
2019 Huang D, LeBlanc E, Shekhar-Guturja T, Robbins N, Krysan D, Pizarro JC, Whitesell L, Cowen L, Brown LE. Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors. Journal of Medicinal Chemistry. PMID 31513387 DOI: 10.1021/Acs.Jmedchem.9B00826  0.67
2019 Kim SH, Iyer KR, Pardeshi L, Muñoz JF, Robbins N, Cuomo CA, Wong KH, Cowen LE. Erratum for Kim et al., "Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance". Mbio. 10. PMID 30890611 DOI: 10.1128/Mbio.00346-19  0.595
2019 Guan G, Tao L, Yue H, Liang W, Gong J, Bing J, Zheng Q, Veri AO, Fan S, Robbins N, Cowen LE, Huang G. Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway. Plos Biology. 17: e2006966. PMID 30865631 DOI: 10.1371/Journal.Pbio.2006966  0.615
2019 Kim SH, Iyer KR, Pardeshi L, Muñoz JF, Robbins N, Cuomo CA, Wong KH, Cowen LE. Genetic Analysis of Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance. Mbio. 10. PMID 30696744 DOI: 10.1128/Mbio.02529-18  0.702
2019 Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w  0.722
2019 Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N, et al. Functional divergence of a global regulatory complex governing fungal filamentation. Plos Genetics. 15: e1007901. PMID 30615616 DOI: 10.1371/Journal.Pgen.1007901  0.75
2018 Caplan T, Polvi EJ, Xie JL, Buckhalter S, Leach MD, Robbins N, Cowen LE. Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans. Cell Reports. 23: 2292-2298. PMID 29791841 DOI: 10.1016/J.Celrep.2018.04.084  0.691
2018 Veri AO, Robbins N, Cowen LE. Regulation of the heat shock transcription factor Hsf1 in fungi: implications for temperature-dependent virulence traits. Fems Yeast Research. 18. PMID 29788061 DOI: 10.1093/Femsyr/Foy041  0.657
2018 Mount HO, Revie NM, Todd RT, Anstett K, Collins C, Costanzo M, Boone C, Robbins N, Selmecki A, Cowen LE. Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs. Plos Genetics. 14: e1007319. PMID 29702647 DOI: 10.1371/Journal.Pgen.1007319  0.686
2018 Veri AO, Miao Z, Shapiro RS, Tebbji F, O'Meara TR, Kim SH, Colazo J, Tan K, Vyas VK, Whiteway M, Robbins N, Wong KH, Cowen LE. Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space. Plos Genetics. 14: e1007270. PMID 29590106 DOI: 10.1371/Journal.Pgen.1007270  0.802
2018 Revie NM, Iyer KR, Robbins N, Cowen LE. Antifungal drug resistance: evolution, mechanisms and impact. Current Opinion in Microbiology. 45: 70-76. PMID 29547801 DOI: 10.1016/J.Mib.2018.02.005  0.691
2017 Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, ... ... Robbins N, et al. The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation. Nature Communications. 8: 499. PMID 28894103 DOI: 10.1038/S41467-017-00547-Y  0.658
2017 Robbins N, Caplan T, Cowen LE. Molecular Evolution of Antifungal Drug Resistance. Annual Review of Microbiology. 71: 753-775. PMID 28886681 DOI: 10.1146/Annurev-Micro-030117-020345  0.666
2017 O'Meara TR, Robbins N, Cowen LE. The Hsp90 Chaperone Network Modulates Candida Virulence Traits. Trends in Microbiology. PMID 28549824 DOI: 10.1016/J.Tim.2017.05.003  0.772
2017 Xie JL, O'Meara TR, Polvi EJ, Robbins N, Cowen LE. Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A. Msphere. 2. PMID 28261668 DOI: 10.1128/mSphere.00056-17  0.81
2016 Lee JA, Robbins N, Xie JL, Ketela T, Cowen LE. Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation. Plos Genetics. 12: e1006452. PMID 27870871 DOI: 10.1371/Journal.Pgen.1006452  0.675
2016 Li X, Robbins N, O'Meara TR, Cowen LE. Extensive Functional Redundancy in the Regulation of Candida albicans Drug Resistance and Morphogenesis by Lysine Deacetylases Hos2, Hda1, Rpd3, and Rpd31. Molecular Microbiology. PMID 27868254 DOI: 10.1111/Mmi.13578  0.787
2016 Xie JL, Grahl N, Sless T, Leach MD, Kim SH, Hogan DA, Robbins N, Cowen LE. Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues. Plos Genetics. 12: e1006405. PMID 27788136 DOI: 10.1371/Journal.Pgen.1006405  0.682
2016 Robbins N, Wright GD, Cowen LE. Antifungal Drugs: The Current Armamentarium and Development of New Agents. Microbiology Spectrum. 4. PMID 27763259 DOI: 10.1128/Microbiolspec.Funk-0002-2016  0.657
2016 Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD. Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function. Cell Chemical Biology. PMID 27746129 DOI: 10.1016/J.Chembiol.2016.08.015  0.4
2016 Polvi EJ, Averette AF, Lee SC, Kim T, Bahn YS, Veri AO, Robbins N, Heitman J, Cowen LE. Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis. Plos Genetics. 12: e1006350. PMID 27695031 DOI: 10.1371/Journal.Pgen.1006350  0.715
2016 Spitzer M, Robbins N, Wright GD. Combinatorial Strategies For Combating Invasive Fungal Infections. Virulence. 0. PMID 27268286 DOI: 10.1080/21505594.2016.1196300  0.446
2015 Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD. An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. Cell Reports. PMID 26549450 DOI: 10.1016/J.Celrep.2015.10.018  0.482
2012 Robbins N, Leach MD, Cowen LE. Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance. Cell Reports. 2: 878-88. PMID 23041319 DOI: 10.1016/J.Celrep.2012.08.035  0.666
2011 Robbins N, Uppuluri P, Nett J, Rajendran R, Ramage G, Lopez-Ribot JL, Andes D, Cowen LE. Hsp90 governs dispersion and drug resistance of fungal biofilms. Plos Pathogens. 7: e1002257. PMID 21931556 DOI: 10.1371/Journal.Ppat.1002257  0.691
2011 Shapiro RS, Robbins N, Cowen LE. Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiology and Molecular Biology Reviews : Mmbr. 75: 213-67. PMID 21646428 DOI: 10.1128/Mmbr.00045-10  0.78
2010 Robbins N, Collins C, Morhayim J, Cowen LE. Metabolic control of antifungal drug resistance. Fungal Genetics and Biology : Fg & B. 47: 81-93. PMID 19595784 DOI: 10.1016/J.Fgb.2009.07.004  0.671
2009 Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE. Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. Plos Pathogens. 5: e1000532. PMID 19649312 DOI: 10.1371/Journal.Ppat.1000532  0.756
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