Alexander Hoffmann - Publications

Affiliations: 
Chemistry and Biochemistry University of California, San Diego, La Jolla, CA 
Area:
signaling, transcription, computational network; stress and immune responses, apoptosis, proliferation
Website:
http://www-chem.ucsd.edu/faculty/profiles/hoffmann_alexander.html

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Luecke S, Adelaja A, Guo X, Sen S, Spreafico R, Singh A, Liu Y, Taylor B, Diaz J, Cheng Q, Hoffmann A. Tonic TNF conditioning of macrophages safeguards stimulus-specific inflammatory responses. Embo Reports. e55986. PMID 37212045 DOI: 10.15252/embr.202255986  0.599
2023 Mitchell S, Tsui R, Tan ZC, Pack A, Hoffmann A. The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts. Science Signaling. 16: eabo2838. PMID 36917644 DOI: 10.1126/scisignal.abo2838  0.826
2021 Ando M, Magi S, Seki M, Suzuki Y, Kasukawa T, Lefaudeux D, Hoffmann A, Okada M. IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells. Npj Systems Biology and Applications. 7: 42. PMID 34853340 DOI: 10.1038/s41540-021-00204-7  0.364
2021 Son M, Wang AG, Tu HL, Metzig MO, Patel P, Husain K, Lin J, Murugan A, Hoffmann A, Tay S. NF-κB responds to absolute differences in cytokine concentrations. Science Signaling. 14. PMID 34211635  0.422
2021 Cheng QJ, Ohta S, Sheu KM, Spreafico R, Adelaja A, Taylor B, Hoffmann A. NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages. Science (New York, N.Y.). 372: 1349-1353. PMID 34140389 DOI: 10.1126/science.abc0269  0.628
2021 Adelaja A, Taylor B, Sheu KM, Liu Y, Luecke S, Hoffmann A. Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 54: 916-930.e7. PMID 33979588 DOI: 10.1016/j.immuni.2021.04.011  0.615
2020 Oliver Metzig M, Tang Y, Mitchell S, Taylor B, Foreman R, Wollman R, Hoffmann A. An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions. Molecular Systems Biology. 16: e9677. PMID 33314666 DOI: 10.15252/msb.20209677  0.708
2020 Lisiero DN, Cheng Z, Tejera MM, Neldner BT, Warrick JW, Wuerzberger-Davis SM, Hoffmann A, Suresh M, Miyamoto S. IκBα Nuclear Export Enables 4-1BB-Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 32817348 DOI: 10.4049/Jimmunol.2000039  0.3
2020 Ngo KA, Kishimoto K, Davis-Turak J, Pimplaskar A, Cheng Z, Spreafico R, Chen EY, Tam A, Ghosh G, Mitchell S, Hoffmann A. Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Reports. 30: 2758-2775.e6. PMID 32101750 DOI: 10.1016/J.Celrep.2020.01.108  0.658
2020 Sen S, Cheng Z, Sheu KM, Chen YH, Hoffmann A. Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression. Cell Systems. PMID 31972132 DOI: 10.1016/J.Cels.2019.12.004  0.425
2020 Kim YJ, Sheu KM, Tsoi J, Abril-Rodriguez G, Grasso C, Hoffmann A, Smale ST, Graeber TG, Puig-Saus C, Ribas A. Abstract 3155: Interferon-gamma-induced melanoma plasticity and response to PD-1 blockade therapy Cancer Research. 80: 3155-3155. DOI: 10.1158/1538-7445.Am2020-3155  0.581
2019 Sheu K, Luecke S, Hoffmann A. Stimulus-specificity in the Responses of Immune Sentinel Cells. Current Opinion in Systems Biology. 18: 53-61. PMID 32864512 DOI: 10.1016/J.Coisb.2019.10.011  0.307
2019 Adelaja A, Hoffmann A. Signaling Crosstalk Mechanisms That May Fine-Tune Pathogen-Responsive NFκB. Frontiers in Immunology. 10: 433. PMID 31312197 DOI: 10.3389/Fimmu.2019.00433  0.505
2019 Mitchell S, Mercado EL, Adelaja A, Ho JQ, Cheng QJ, Ghosh G, Hoffmann A. An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms. Frontiers in Immunology. 10: 1425. PMID 31293585 DOI: 10.3389/Fimmu.2019.01425  0.66
2019 Mitchell S, Hoffmann A. Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB. Proceedings of the National Academy of Sciences of the United States of America. PMID 31048505 DOI: 10.1073/Pnas.1816000116  0.654
2019 Cheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin RL, Hoffmann A. Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions. Scientific Reports. 9: 5288. PMID 30918279 DOI: 10.1038/S41598-019-40503-Y  0.371
2019 Roy K, Mitchell S, Liu Y, Ohta S, Lin YS, Metzig MO, Nutt SL, Hoffmann A. A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation. Immunity. PMID 30850343 DOI: 10.1016/J.Immuni.2019.02.004  0.627
2019 Davis-Turak J, Johnson TL, Hoffmann A. Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing. Nucleic Acids Research. PMID 30649426 DOI: 10.1093/Nar/Gkz013  0.308
2018 Yeom KH, Mitchell S, Linares AJ, Zheng S, Lin CH, Wang XJ, Hoffmann A, Black DL. Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse. Proceedings of the National Academy of Sciences of the United States of America. PMID 30401736 DOI: 10.1073/Pnas.1809609115  0.538
2018 Mitchell S, Hoffmann A. Identifying Noise Sources governing cell-to-cell variability. Current Opinion in Systems Biology. 8: 39-45. PMID 29623300 DOI: 10.1016/J.Coisb.2017.11.013  0.568
2018 Mitchell S, Roy K, Zangle TA, Hoffmann A. Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29514960 DOI: 10.1073/Pnas.1715639115  0.594
2018 Germain RN, Greenbaum BD, Hoffmann A, Miller-Jensen K, Mora T, Walczak AM, Segal E, Vogl T, Klompus S, Peled-Liviatan S, Weinberger A, Smale ST, Tsang JS. What Can Immunologists Learn from Systems Approaches Trends in Immunology. 39: 163-166. PMID 29477635 DOI: 10.1016/J.It.2018.01.002  0.502
2018 Roy K, Shokhirev MN, Mitchell S, Hoffmann A. Deriving Quantitative Cell Biological Information from Dye-Dilution Lymphocyte Proliferation Experiments. Methods in Molecular Biology (Clifton, N.J.). 1707: 81-94. PMID 29388101 DOI: 10.1007/978-1-4939-7474-0_6  0.711
2017 Mognol GP, Spreafico R, Wong V, Scott-Browne JP, Togher S, Hoffmann A, Hogan PG, Rao A, Trifari S. Exhaustion-associated regulatory regions in CD8(+) tumor-infiltrating T cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28283662 DOI: 10.1073/Pnas.1620498114  0.305
2017 Cheng CS, Behar MS, Suryawanshi GW, Feldman KE, Spreafico R, Hoffmann A. Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms. Cell Systems. PMID 28237795 DOI: 10.1016/J.Cels.2017.01.012  0.63
2017 Dembinski HE, Wismer K, Vargas JD, Suryawanshi GW, Kern N, Kroon G, Dyson HJ, Hoffmann A, Komives EA. Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant. Proceedings of the National Academy of Sciences of the United States of America. PMID 28167786 DOI: 10.1073/Pnas.1610192114  0.384
2016 Inoue K, Shinohara H, Behar M, Yumoto N, Tanaka G, Hoffmann A, Aihara K, Okada-Hatakeyama M. Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. Npj Systems Biology and Applications. 2: 16024. PMID 28725478 DOI: 10.1038/npjsba.2016.24  0.402
2016 Hoffmann A. Immune Response Signaling: Combinatorial and Dynamic Control. Trends in Immunology. PMID 27461000 DOI: 10.1016/J.It.2016.07.003  0.391
2016 Junkin M, Kaestli AJ, Cheng Z, Jordi C, Albayrak C, Hoffmann A, Tay S. High-Content Quantification of Single-Cell Immune Dynamics. Cell Reports. PMID 27050527 DOI: 10.1016/J.Celrep.2016.03.033  0.46
2016 Mitchell S, Vargas J, Hoffmann A. Signaling via the NFκB system. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26990581 DOI: 10.1002/Wsbm.1331  0.685
2016 Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, ... ... Hoffmann A, et al. The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. Nature Communications. 7: 10761. PMID 26899380 DOI: 10.1038/Ncomms10761  0.782
2016 Almaden JV, Liu YC, Yang E, Otero D, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A. B cell survival and development controlled by the coordination of NFκB family members RelB and cRel. Blood. PMID 26773039 DOI: 10.1182/Blood-2014-10-606988  0.447
2015 Fagerlund R, Behar M, Fortmann KT, Lin YE, Vargas JD, Hoffmann A. Anatomy of a negative feedback loop: the case of IκBα. Journal of the Royal Society, Interface / the Royal Society. 12. PMID 26311312 DOI: 10.1098/Rsif.2015.0262  0.799
2015 Fortmann KT, Lewis RD, Ngo KA, Fagerlund R, Hoffmann A. A Regulated, Ubiquitin-Independent Degron in IκBα. Journal of Molecular Biology. 427: 2748-56. PMID 26191773 DOI: 10.1016/J.Jmb.2015.07.008  0.783
2015 Cheng Z, Taylor B, Ourthiague DR, Hoffmann A. Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation. Science Signaling. 8: ra69. PMID 26175492 DOI: 10.1126/Scisignal.Aaa5208  0.694
2015 Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A. IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer. Nature Communications. 6: 7068. PMID 25946967 DOI: 10.1038/Ncomms8068  0.812
2015 Spreafico R, Mitchell S, Hoffmann A. Training the 21st Century Immunologist. Trends in Immunology. 36: 283-5. PMID 25911462 DOI: 10.1016/J.It.2015.04.001  0.547
2015 Ourthiague DR, Birnbaum H, Ortenlöf N, Vargas JD, Wollman R, Hoffmann A. Limited specificity of IRF3 and ISGF3 in the transcriptional innate-immune response to double-stranded RNA. Journal of Leukocyte Biology. 98: 119-28. PMID 25896227 DOI: 10.1189/Jlb.4A1014-483Rr  0.365
2015 Lee DJ, Du F, Chen SW, Nakasaki M, Rana I, Shih VF, Hoffmann A, Jamora C. Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment. The Journal of Investigative Dermatology. 135: 2012-20. PMID 25815426 DOI: 10.1038/Jid.2015.119  0.42
2015 Mitchell S, Tsui R, Hoffmann A. Studying NF-κB signaling with mathematical models. Methods in Molecular Biology (Clifton, N.J.). 1280: 647-61. PMID 25736777 DOI: 10.1007/978-1-4939-2422-6_38  0.8
2015 Shokhirev MN, Almaden J, Davis-Turak J, Birnbaum HA, Russell TM, Vargas JA, Hoffmann A. A multi-scale approach reveals that NF-κB cRel enforces a B-cell decision to divide. Molecular Systems Biology. 11: 783. PMID 25680807 DOI: 10.15252/Msb.20145554  0.681
2015 Davis-Turak JC, Allison K, Shokhirev MN, Ponomarenko P, Tsimring LS, Glass CK, Johnson TL, Hoffmann A. Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing. Nucleic Acids Research. 43: 699-707. PMID 25541195 DOI: 10.1093/Nar/Gku1338  0.631
2015 Jiang M, Österlund P, Fagerlund R, Rios DN, Hoffmann A, Poranen MM, Bamford DH, Julkunen I. MAP kinase p38α regulates type III interferon (IFN-λ1) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation. Journal of Leukocyte Biology. 97: 307-20. PMID 25473098 DOI: 10.1189/Jlb.2A0114-059Rr  0.406
2015 Shokhirev MN, Almaden J, Davis-Turak J, Birnbaum HA, Russell TM, Vargas JAD, Hoffmann A. A multi-scale approach reveals that NF-κB cRel enforces a B-cell decision to divide Molecular Systems Biology. 11. DOI: 10.15252/msb.20145554  0.626
2015 Liu Y, Hoffmann A. The NFkB System Regulates Flt3-Mediated Hematopoiesis Blood. 126: 3592-3592. DOI: 10.1182/Blood.V126.23.3592.3592  0.403
2014 Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, Tsimring L, Wollman R. Systems biology. Accurate information transmission through dynamic biochemical signaling networks. Science (New York, N.Y.). 346: 1370-3. PMID 25504722 DOI: 10.1126/Science.1254933  0.615
2014 Almaden JV, Tsui R, Liu YC, Birnbaum H, Shokhirev MN, Ngo KA, Davis-Turak JC, Otero D, Basak S, Rickert RC, Hoffmann A. A pathway switch directs BAFF signaling to distinct NFκB transcription factors in maturing and proliferating B cells. Cell Reports. 9: 2098-111. PMID 25497099 DOI: 10.1016/J.Celrep.2014.11.024  0.795
2014 Caldwell AB, Cheng Z, Vargas JD, Birnbaum HA, Hoffmann A. Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes & Development. 28: 2120-33. PMID 25274725 DOI: 10.1101/Gad.244749.114  0.749
2014 Shinohara H, Behar M, Inoue K, Hiroshima M, Yasuda T, Nagashima T, Kimura S, Sanjo H, Maeda S, Yumoto N, Ki S, Akira S, Sako Y, Hoffmann A, Kurosaki T, et al. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation. Science (New York, N.Y.). 344: 760-4. PMID 24833394 DOI: 10.1126/Science.1250020  0.48
2014 Alves BN, Tsui R, Almaden J, Shokhirev MN, Davis-Turak J, Fujimoto J, Birnbaum H, Ponomarenko J, Hoffmann A. IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. Journal of Immunology (Baltimore, Md. : 1950). 192: 3121-32. PMID 24591377 DOI: 10.4049/Jimmunol.1302351  0.807
2014 Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB. The Journal of Biological Chemistry. 289: 1866-75. PMID 24302727 DOI: 10.1074/Jbc.M113.505578  0.489
2013 Behar M, Barken D, Werner SL, Hoffmann A. The dynamics of signaling as a pharmacological target. Cell. 155: 448-61. PMID 24120141 DOI: 10.1016/J.Cell.2013.09.018  0.808
2013 Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE, Ghosh G. Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. Plos Biology. 11: e1001647. PMID 24019758 DOI: 10.1371/Journal.Pbio.1001647  0.443
2013 Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, ... ... Hoffmann A, et al. Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell. 24: 151-66. PMID 23850221 DOI: 10.1016/J.Ccr.2013.06.003  0.406
2013 Shokhirev MN, Hoffmann A. FlowMax: A Computational Tool for Maximum Likelihood Deconvolution of CFSE Time Courses. Plos One. 8: e67620. PMID 23826329 DOI: 10.1371/Journal.Pone.0067620  0.654
2013 Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module. Plos Computational Biology. 9: e1003112. PMID 23825938 DOI: 10.1371/Journal.Pcbi.1003112  0.744
2013 Behar M, Hoffmann A. Tunable signal processing through a kinase control cycle: the IKK signaling node. Biophysical Journal. 105: 231-41. PMID 23823243 DOI: 10.1016/J.Bpj.2013.05.013  0.483
2013 Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schröfelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. Plos Biology. 11: e1001581. PMID 23776406 DOI: 10.1371/Journal.Pbio.1001581  0.533
2013 Loriaux PM, Tesler G, Hoffmann A. Characterizing the relationship between steady state and response using analytical expressions for the steady states of mass action models. Plos Computational Biology. 9: e1002901. PMID 23509437 DOI: 10.1371/Journal.Pcbi.1002901  0.303
2013 Loriaux PM, Hoffmann A. A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways. Plos Computational Biology. 9: e1002932. PMID 23468615 DOI: 10.1371/Journal.Pcbi.1002932  0.434
2012 Tam AB, Mercado EL, Hoffmann A, Niwa M. ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. Plos One. 7: e45078. PMID 23110043 DOI: 10.1371/Journal.Pone.0045078  0.438
2012 Shih VF, Davis-Turak J, Macal M, Huang JQ, Ponomarenko J, Kearns JD, Yu T, Fagerlund R, Asagiri M, Zuniga EI, Hoffmann A. Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nature Immunology. 13: 1162-70. PMID 23086447 DOI: 10.1038/Ni.2446  0.751
2012 Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements. Cell Reports. 2: 824-39. PMID 23063365 DOI: 10.1016/J.Celrep.2012.08.042  0.387
2012 Schröfelbauer B, Polley S, Behar M, Ghosh G, Hoffmann A. NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. Molecular Cell. 47: 111-21. PMID 22633953 DOI: 10.1016/J.Molcel.2012.04.020  0.478
2012 Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 149: 630-41. PMID 22541433 DOI: 10.1016/J.Cell.2012.02.056  0.628
2012 Loriaux PM, Hoffmann A. A framework for modeling the relationship between cellular steady-state and stimulus-responsiveness. Methods in Cell Biology. 110: 81-109. PMID 22482946 DOI: 10.1016/B978-0-12-388403-9.00004-7  0.342
2012 Basak S, Behar M, Hoffmann A. Lessons from mathematically modeling the NF-κB pathway. Immunological Reviews. 246: 221-38. PMID 22435558 DOI: 10.1111/J.1600-065X.2011.01092.X  0.471
2012 Busino L, Millman SE, Scotto L, Kyratsous CA, Basrur V, O'Connor O, Hoffmann A, Elenitoba-Johnson KS, Pagano M. Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nature Cell Biology. 14: 375-85. PMID 22388891 DOI: 10.1038/Ncb2463  0.452
2012 Behar M, Hoffmann A. Signal Processing by the Control Cycle of the IKK Kinase in the NFκB Signaling Axis Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3624  0.475
2011 Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, ... Hoffmann A, et al. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. Plos Genetics. 7: e1002401. PMID 22174696 DOI: 10.1371/Journal.Pgen.1002401  0.719
2011 Murray SE, Polesso F, Rowe AM, Basak S, Koguchi Y, Toren KG, Hoffmann A, Parker DC. NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice. The Journal of Clinical Investigation. 121: 4775-86. PMID 22045568 DOI: 10.1172/Jci44943  0.377
2011 Schröfelbauer B, Hoffmann A. How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members? Immunological Reviews. 244: 29-43. PMID 22017429 DOI: 10.1111/J.1600-065X.2011.01060.X  0.445
2011 Ho JQ, Asagiri M, Hoffmann A, Ghosh G. NF-κB potentiates caspase independent hydrogen peroxide induced cell death. Plos One. 6: e16815. PMID 21347231 DOI: 10.1371/Journal.Pone.0016815  0.415
2011 Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Science Signaling. 4: ra11. PMID 21343618 DOI: 10.1126/Scisignal.2001501  0.661
2011 Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang TT, Wen R, Hoffmann A, Wang D, Miyamoto S. Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation. Immunity. 34: 188-200. PMID 21333553 DOI: 10.1016/J.Immuni.2011.01.014  0.719
2011 Shih VF, Tsui R, Caldwell A, Hoffmann A. A single NFκB system for both canonical and non-canonical signaling. Cell Research. 21: 86-102. PMID 21102550 DOI: 10.1038/Cr.2010.161  0.822
2011 Huxford T, Hoffmann A, Ghosh G. Understanding the logic of IκB:NF-κB regulation in structural terms. Current Topics in Microbiology and Immunology. 349: 1-24. PMID 20845107 DOI: 10.1007/82_2010_99  0.476
2011 Hoffmann A, VanHook AM. Science Signaling Podcast: 22 February 2011 Science Signaling. 4: pc3-pc3. DOI: 10.1126/Scisignal.2001898  0.478
2011 Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang TT, Wen R, Hoffmann A, Wang D, Miyamoto S. Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation Immunity. 34: 449. DOI: 10.1016/j.immuni.2011.03.001  0.695
2010 Hasty J, Hoffmann A, Golden S. Systems biology of cellular rhythms: from cacophony to symphony. Current Opinion in Genetics & Development. 20: 571-3. PMID 21036033 DOI: 10.1016/J.Gde.2010.10.003  0.384
2010 Behar M, Hoffmann A. Understanding the temporal codes of intra-cellular signals. Current Opinion in Genetics & Development. 20: 684-93. PMID 20956081 DOI: 10.1016/J.Gde.2010.09.007  0.406
2010 Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S. IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature. 466: 1115-9. PMID 20740013 DOI: 10.1038/Nature09283  0.689
2010 von Vietinghoff S, Asagiri M, Azar D, Hoffmann A, Ley K. Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 185: 670-8. PMID 20519647 DOI: 10.4049/Jimmunol.1000339  0.33
2010 Takeda N, O'Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, Asagiri M, Simon MC, Hoffmann A, Johnson RS. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes & Development. 24: 491-501. PMID 20194441 DOI: 10.1101/Gad.1881410  0.307
2010 O'Dea E, Hoffmann A. The regulatory logic of the NF-kappaB signaling system. Cold Spring Harbor Perspectives in Biology. 2: a000216. PMID 20182598 DOI: 10.1101/Cshperspect.A000216  0.526
2010 Longo DM, Hoffmann A, Tsimring LS, Hasty J. Coherent activation of a synthetic mammalian gene network. Systems and Synthetic Biology. 4: 15-23. PMID 19757189 DOI: 10.1007/S11693-009-9044-5  0.315
2009 O'Dea E, Hoffmann A. NF-κB signaling. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1: 107-15. PMID 20151024 DOI: 10.1002/Wsbm.30  0.516
2009 Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proceedings of the National Academy of Sciences of the United States of America. 106: 19328-33. PMID 19887633 DOI: 10.1073/Pnas.0908797106  0.445
2009 Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 138: 114-28. PMID 19596239 DOI: 10.1016/J.Cell.2009.04.020  0.711
2009 Savinova OV, Hoffmann A, Ghosh G. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Molecular Cell. 34: 591-602. PMID 19524538 DOI: 10.1016/J.Molcel.2009.04.033  0.402
2009 Shih VF, Kearns JD, Basak S, Savinova OV, Ghosh G, Hoffmann A. Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proceedings of the National Academy of Sciences of the United States of America. 106: 9619-24. PMID 19487661 DOI: 10.1073/Pnas.0812367106  0.763
2009 Kearns JD, Hoffmann A. Integrating computational and biochemical studies to explore mechanisms in NF-{kappa}B signaling. The Journal of Biological Chemistry. 284: 5439-43. PMID 18940809 DOI: 10.1074/Jbc.R800008200  0.713
2008 Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proceedings of the National Academy of Sciences of the United States of America. 105: 17463-8. PMID 18981423 DOI: 10.1073/Pnas.0808043105  0.323
2008 Werner SL, Kearns JD, Zadorozhnaya V, Lynch C, O'Dea E, Boldin MP, Ma A, Baltimore D, Hoffmann A. Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes & Development. 22: 2093-101. PMID 18676814 DOI: 10.1101/Gad.1680708  0.822
2008 Ch'en IL, Hedrick SM, Hoffmann A. NF-kappaB as a determinant of distinct cell death pathways. Methods in Enzymology. 446: 175-87. PMID 18603122 DOI: 10.1016/S0076-6879(08)01610-8  0.41
2008 O'Dea EL, Kearns JD, Hoffmann A. UV as an amplifier rather than inducer of NF-kappaB activity. Molecular Cell. 30: 632-41. PMID 18538661 DOI: 10.1016/J.Molcel.2008.03.017  0.751
2008 Basak S, Hoffmann A. Crosstalk via the NF-kappaB signaling system. Cytokine & Growth Factor Reviews. 19: 187-97. PMID 18515173 DOI: 10.1016/J.Cytogfr.2008.04.005  0.522
2008 Cheong R, Hoffmann A, Levchenko A. Understanding NF-kappaB signaling via mathematical modeling. Molecular Systems Biology. 4: 192. PMID 18463616 DOI: 10.1038/Msb.2008.30  0.531
2008 Cheng CS, Johnson TL, Hoffmann A. Epigenetic control: slow and global, nimble and local. Genes & Development. 22: 1110-4. PMID 18451102 DOI: 10.1101/Gad.1677008  0.627
2008 Kato T, Gotoh Y, Hoffmann A, Ono Y. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 13: 509-20. PMID 18429822 DOI: 10.1111/J.1365-2443.2008.01182.X  0.437
2008 Mathes E, O'Dea EL, Hoffmann A, Ghosh G. NF-kappaB dictates the degradation pathway of IkappaBalpha. The Embo Journal. 27: 1357-67. PMID 18401342 DOI: 10.1038/Emboj.2008.73  0.449
2008 Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G. Stabilization of RelB requires multidomain interactions with p100/p52. The Journal of Biological Chemistry. 283: 12324-32. PMID 18321863 DOI: 10.1074/Jbc.M707898200  0.675
2008 Basak S, Shih VF, Hoffmann A. Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system. Molecular and Cellular Biology. 28: 3139-50. PMID 18299388 DOI: 10.1128/Mcb.01469-07  0.525
2007 O'Dea EL, Barken D, Peralta RQ, Tran KT, Werner SL, Kearns JD, Levchenko A, Hoffmann A. A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Molecular Systems Biology. 3: 111. PMID 17486138 DOI: 10.1038/Msb4100148  0.825
2007 Hoffmann A, Xia Y, Verma IM. Inflammatory tales of liver cancer. Cancer Cell. 11: 99-101. PMID 17292819 DOI: 10.1016/J.Ccr.2007.01.008  0.561
2007 Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 128: 369-81. PMID 17254973 DOI: 10.1016/J.Cell.2006.12.033  0.839
2006 Hoffmann A, Natoli G, Ghosh G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 25: 6706-16. PMID 17072323 DOI: 10.1038/Sj.Onc.1209933  0.54
2006 Kearns JD, Basak S, Werner SL, Huang CS, Hoffmann A. IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. The Journal of Cell Biology. 173: 659-64. PMID 16735576 DOI: 10.1083/Jcb.200510155  0.837
2006 Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunological Reviews. 210: 171-86. PMID 16623771 DOI: 10.1111/J.0105-2896.2006.00375.X  0.624
2006 Cheong R, Bergmann A, Werner SL, Regal J, Hoffmann A, Levchenko A. Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. The Journal of Biological Chemistry. 281: 2945-50. PMID 16321974 DOI: 10.1074/Jbc.M510085200  0.739
2006 Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 107: 1048-55. PMID 16195333 DOI: 10.1182/Blood-2005-06-2452  0.41
2005 Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 23: 319-29. PMID 16169504 DOI: 10.1016/J.Immuni.2005.08.010  0.456
2005 Werner SL, Barken D, Hoffmann A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (New York, N.Y.). 309: 1857-61. PMID 16166517 DOI: 10.1126/Science.1113319  0.836
2005 Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes & Development. 19: 2138-51. PMID 16166378 DOI: 10.1101/Gad.1329805  0.603
2005 Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. Journal of Immunology (Baltimore, Md. : 1950). 175: 3469-73. PMID 16148088 DOI: 10.4049/Jimmunol.175.6.3469  0.398
2005 Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 122: 707-21. PMID 16143103 DOI: 10.1016/J.Cell.2005.06.029  0.605
2005 Shapira S, Harb OS, Margarit J, Matrajt M, Han J, Hoffmann A, Freedman B, May MJ, Roos DS, Hunter CA. Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii. Journal of Cell Science. 118: 3501-8. PMID 16079291 DOI: 10.1242/Jcs.02428  0.486
2005 Gapuzan ME, Schmah O, Pollock AD, Hoffmann A, Gilmore TD. Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene. 24: 6574-83. PMID 16027734 DOI: 10.1038/Sj.Onc.1208809  0.34
2005 Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. The Journal of Biological Chemistry. 280: 29256-62. PMID 15964844 DOI: 10.1074/Jbc.M502606200  0.426
2005 Barken D, Wang CJ, Kearns J, Cheong R, Hoffmann A, Levchenko A. Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (New York, N.Y.). 308: 52; author reply 52. PMID 15802586 DOI: 10.1126/Science.1107904  0.802
2004 Leung TH, Hoffmann A, Baltimore D. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell. 118: 453-64. PMID 15315758 DOI: 10.1016/J.Cell.2004.08.007  0.706
2004 Zarnegar B, He JQ, Oganesyan G, Hoffmann A, Baltimore D, Cheng G. Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proceedings of the National Academy of Sciences of the United States of America. 101: 8108-13. PMID 15148378 DOI: 10.1073/Pnas.0402629101  0.665
2003 Kato T, Delhase M, Hoffmann A, Karin M. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Molecular Cell. 12: 829-39. PMID 14580335 DOI: 10.1016/S1097-2765(03)00358-7  0.422
2003 Hoffmann A, Leung TH, Baltimore D. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. The Embo Journal. 22: 5530-9. PMID 14532125 DOI: 10.1093/Emboj/Cdg534  0.727
2002 Hoffmann A, Levchenko A, Scott ML, Baltimore D. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (New York, N.Y.). 298: 1241-5. PMID 12424381 DOI: 10.1126/Science.1071914  0.642
2002 Dadgostar H, Zarnegar B, Hoffmann A, Qin XF, Truong U, Rao G, Baltimore D, Cheng G. Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 1497-502. PMID 11830667 DOI: 10.1073/Pnas.032665099  0.67
2001 Dragneva Y, Anuradha CD, Valeva A, Hoffmann A, Bhakdi S, Husmann M. Subcytocidal Attack by Staphylococcal Alpha-Toxin Activates NF-κB and Induces Interleukin-8 Production Infection and Immunity. 69: 2630-2635. PMID 11254628 DOI: 10.1128/Iai.69.4.2630-2635.2001  0.397
2001 Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST. Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event. Nature Immunology. 2: 51-7. PMID 11135578 DOI: 10.1038/83168  0.651
2000 Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 97: 12705-10. PMID 11058167 DOI: 10.1073/Pnas.230436397  0.667
1998 Lin KI, DiDonato JA, Hoffmann A, Hardwick JM, Ratan RR. Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. The Journal of Cell Biology. 141: 1479-87. PMID 9647642 DOI: 10.1083/Jcb.141.7.1479  0.42
1998 Sachdev S, Hoffmann A, Hannink M. Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences. Molecular and Cellular Biology. 18: 2524-34. PMID 9566872 DOI: 10.1128/Mcb.18.5.2524  0.331
1997 Hoffmann A, Oelgeschläger T, Roeder RG. Considerations of transcriptional control mechanisms: do TFIID-core promoter complexes recapitulate nucleosome-like functions? Proceedings of the National Academy of Sciences of the United States of America. 94: 8928-35. PMID 9256411 DOI: 10.1073/Pnas.94.17.8928  0.563
1996 Segil N, Guermah M, Hoffmann A, Roeder RG, Heintz N. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Genes & Development. 10: 2389-400. PMID 8843192 DOI: 10.1101/Gad.10.19.2389  0.631
1996 Hoffmann A, Roeder RG. Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation. The Journal of Biological Chemistry. 271: 18194-202. PMID 8663456 DOI: 10.1074/Jbc.271.30.18194  0.504
1996 Hoffmann A, Chiang CM, Oelgeschläger T, Xie X, Burley SK, Nakatani Y, Roeder RG. A histone octamer-like structure within TFIID. Nature. 380: 356-9. PMID 8598932 DOI: 10.1038/380356A0  0.508
1996 Xie X, Kokubo T, Cohen SL, Mirza UA, Hoffmann A, Chait BT, Roeder RG, Nakatani Y, Burley SK. Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Nature. 380: 316-22. PMID 8598927 DOI: 10.1038/380316A0  0.435
1993 Chiang CM, Ge H, Wang Z, Hoffmann A, Roeder RG. Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III. The Embo Journal. 12: 2749-62. PMID 7687540 DOI: 10.1002/J.1460-2075.1993.Tb05936.X  0.492
1992 Takada R, Nakatani Y, Hoffmann A, Kokubo T, Hasegawa S, Roeder RG, Horikoshi M. Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau). Proceedings of the National Academy of Sciences of the United States of America. 89: 11809-13. PMID 1465404 DOI: 10.1073/Pnas.89.24.11809  0.492
1992 Nikolov DB, Hu SH, Lin J, Gasch A, Hoffmann A, Horikoshi M, Chua NH, Roeder RG, Burley SK. Crystal structure of TFIID TATA-box binding protein. Nature. 360: 40-6. PMID 1436073 DOI: 10.1038/360040A0  0.452
1991 Hoffmann A, Roeder RG. Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies. Nucleic Acids Research. 19: 6337-8. PMID 1956801 DOI: 10.1093/Nar/19.22.6337  0.427
1991 Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG. Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE. Nature. 354: 398-401. PMID 1956403 DOI: 10.1038/354398A0  0.485
1991 Tamura T, Sumita K, Fujino I, Aoyama A, Horikoshi M, Hoffmann A, Roeder RG, Muramatsu M, Mikoshiba K. Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Research. 19: 3861-5. PMID 1861978 DOI: 10.1093/Nar/19.14.3861  0.426
1990 Hoffmann A, Horikoshi M, Wang CK, Schroeder S, Weil PA, Roeder RG. Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID. Genes & Development. 4: 1141-8. PMID 2210373 DOI: 10.1101/Gad.4.7.1141  0.478
1990 Gasch A, Hoffmann A, Horikoshi M, Roeder RG, Chua NH. Arabidopsis thaliana contains two genes for TFIID. Nature. 346: 390-4. PMID 2197561 DOI: 10.1038/346390A0  0.514
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