Alan C. Leonard - Publications

Affiliations: 
Florida Institute of Technology, Melbourne, FL, United States 
Area:
Molecular Biology, Genetics, Microbiology Biology

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Leonard AC. Recollections of a Helmstetter Disciple. Life (Basel, Switzerland). 13. PMID 37240759 DOI: 10.3390/life13051114  0.308
2021 Grimwade JE, Leonard AC. Blocking, Bending, and Binding: Regulation of Initiation of Chromosome Replication During the Cell Cycle by Transcriptional Modulators That Interact With Origin DNA. Frontiers in Microbiology. 12: 732270. PMID 34616385 DOI: 10.3389/fmicb.2021.732270  0.572
2019 Gao F, Leonard AC. Editorial: DNA Replication Origins in Microbial Genomes, Volume 2. Frontiers in Microbiology. 10: 2416. PMID 31708893 DOI: 10.3389/Fmicb.2019.02416  0.384
2019 Leonard AC, Rao P, Kadam RP, Grimwade JE. Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation. Frontiers in Microbiology. 10: 2009. PMID 31555240 DOI: 10.3389/Fmicb.2019.02009  0.599
2019 Grimwade JE, Leonard AC. Blocking the Trigger: Inhibition of the Initiation of Bacterial Chromosome Replication as an Antimicrobial Strategy. Antibiotics (Basel, Switzerland). 8. PMID 31390740 DOI: 10.3390/Antibiotics8030111  0.426
2018 Rao P, Rozgaja TA, Alqahtani A, Grimwade JE, Leonard AC. Low Affinity DnaA-ATP Recognition Sites in Make Non-equivalent and Growth Rate-Dependent Contributions to the Regulated Timing of Chromosome Replication. Frontiers in Microbiology. 9: 1673. PMID 30093890 DOI: 10.3389/Fmicb.2018.01673  0.601
2018 Grimwade JE, Rozgaja TA, Gupta R, Dyson K, Rao P, Leonard AC. Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication. Nucleic Acids Research. PMID 29800247 DOI: 10.1093/Nar/Gky457  0.631
2017 Grimwade JE, Leonard AC. Targeting the Bacterial Orisome in the Search for New Antibiotics. Frontiers in Microbiology. 8: 2352. PMID 29230207 DOI: 10.3389/Fmicb.2017.02352  0.445
2015 Leonard AC, Grimwade JE. The orisome: structure and function. Frontiers in Microbiology. 6: 545. PMID 26082765 DOI: 10.3389/Fmicb.2015.00545  0.583
2014 Kaur G, Vora MP, Czerwonka CA, Rozgaja TA, Grimwade JE, Leonard AC. Building the bacterial orisome: high-affinity DnaA recognition plays a role in setting the conformation of oriC DNA. Molecular Microbiology. 91: 1148-63. PMID 24443848 DOI: 10.1111/Mmi.12525  0.669
2014 Leonard AC, Grimwade JE. Chromosome Replication and Segregation Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.02351-5  0.344
2013 Leonard AC, Méchali M. DNA replication origins. Cold Spring Harbor Perspectives in Biology. 5: a010116. PMID 23838439 DOI: 10.1101/Cshperspect.A010116  0.511
2011 Rozgaja TA, Grimwade JE, Iqbal M, Czerwonka C, Vora M, Leonard AC. Two oppositely oriented arrays of low-affinity recognition sites in oriC guide progressive binding of DnaA during Escherichia coli pre-RC assembly. Molecular Microbiology. 82: 475-88. PMID 21895796 DOI: 10.1111/J.1365-2958.2011.07827.X  0.691
2011 Leonard AC, Grimwade JE. Regulation of DnaA assembly and activity: taking directions from the genome. Annual Review of Microbiology. 65: 19-35. PMID 21639790 DOI: 10.1146/Annurev-Micro-090110-102934  0.589
2010 Leonard AC, Grimwade JE. Initiation of DNA Replication. Ecosal Plus. 4. PMID 26443786 DOI: 10.1128/ecosalplus.4.4.1  0.446
2010 Leonard AC, Grimwade JE. Regulating DnaA complex assembly: it is time to fill the gaps. Current Opinion in Microbiology. 13: 766-72. PMID 21035377 DOI: 10.1016/J.Mib.2010.10.001  0.669
2009 Miller DT, Grimwade JE, Betteridge T, Rozgaja T, Torgue JJ, Leonard AC. Bacterial origin recognition complexes direct assembly of higher-order DnaA oligomeric structures. Proceedings of the National Academy of Sciences of the United States of America. 106: 18479-84. PMID 19833870 DOI: 10.1073/Pnas.0909472106  0.829
2009 Leonard AC, Grimwade JE. Initiating chromosome replication in E. coli: it makes sense to recycle. Genes & Development. 23: 1145-50. PMID 19451214 DOI: 10.1101/Gad.1809909  0.556
2007 Grimwade JE, Torgue JJ, McGarry KC, Rozgaja T, Enloe ST, Leonard AC. Mutational analysis reveals Escherichia coli oriC interacts with both DnaA-ATP and DnaA-ADP during pre-RC assembly. Molecular Microbiology. 66: 428-39. PMID 17850252 DOI: 10.1111/J.1365-2958.2007.05930.X  0.785
2007 Rozgaja T, Grimwade JE, Torgue JJ, Leonard AC. DnaA‐ATP‐specific binding sites in E. coli oriC are required for correct timing of initiation of DNA replication The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A658-C  0.659
2007 Miller DT, Grimwade J, Torgue J, Leonard A. ORC formation is required for proper bacterial origin function The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A658-B  0.693
2007 Leonard AC, Torgue JJ, Miller DT, Grimwade JE. Timing of E. coli pre‐RC assembly is determined by two different growth rate‐specific mechanisms The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A658  0.71
2006 Nievera C, Torgue JJ, Grimwade JE, Leonard AC. SeqA blocking of DnaA-oriC interactions ensures staged assembly of the E. coli pre-RC. Molecular Cell. 24: 581-92. PMID 17114060 DOI: 10.1016/J.Molcel.2006.09.016  0.727
2005 Leonard AC, Grimwade JE. Building a bacterial orisome: emergence of new regulatory features for replication origin unwinding. Molecular Microbiology. 55: 978-85. PMID 15686547 DOI: 10.1111/J.1365-2958.2004.04467.X  0.603
2004 Ryan VT, Grimwade JE, Camara JE, Crooke E, Leonard AC. Escherichia coli prereplication complex assembly is regulated by dynamic interplay among Fis, IHF and DnaA. Molecular Microbiology. 51: 1347-59. PMID 14982629 DOI: 10.1046/J.1365-2958.2003.03906.X  0.839
2004 McGarry KC, Ryan VT, Grimwade JE, Leonard AC. Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by initiator DnaA-ATP. Proceedings of the National Academy of Sciences of the United States of America. 101: 2811-6. PMID 14978287 DOI: 10.1073/Pnas.0400340101  0.761
2002 Ryan VT, Grimwade JE, Nievera CJ, Leonard AC. IHF and HU stimulate assembly of pre-replication complexes at Escherichia coli oriC by two different mechanisms. Molecular Microbiology. 46: 113-24. PMID 12366835 DOI: 10.1046/J.1365-2958.2002.03129.X  0.819
2000 Grimwade JE, Ryan VT, Leonard AC. IHF redistributes bound initiator protein, DnaA, on supercoiled oriC of Escherichia coli. Molecular Microbiology. 35: 835-44. PMID 10692160 DOI: 10.1046/J.1365-2958.2000.01755.X  0.802
1999 Cassler MR, Grimwade JE, McGarry KC, Mott RT, Leonard AC. Drunken-cell footprints: nuclease treatment of ethanol-permeabilized bacteria reveals an initiation-like nucleoprotein complex in stationary phase replication origins. Nucleic Acids Research. 27: 4570-6. PMID 10556312 DOI: 10.1093/Nar/27.23.4570  0.812
1997 Helmstetter CE, Thornton M, Zhou P, Bogan JA, Leonard AC, Grimwade JE. Replication and segregation of a miniF plasmid during the division cycle of Escherichia coli Journal of Bacteriology. 179: 1393-1399. PMID 9023227 DOI: 10.1128/Jb.179.4.1393-1399.1997  0.454
1995 Cassler MR, Grimwade JE, Leonard AC. Cell cycle-specific changes in nucleoprotein complexes at a chromosomal replication origin Embo Journal. 14: 5833-5841. PMID 8846776 DOI: 10.1002/J.1460-2075.1995.Tb00271.X  0.61
1993 Theisen PW, Grimwade JE, Leonard AC, Bogan JA, Helmstetter CE. Correlation of gene transcription with the time of initiation of chromosome replication in Escherichia coli Molecular Microbiology. 10: 575-584. PMID 7968535 DOI: 10.1111/J.1365-2958.1993.Tb00929.X  0.439
1992 Helmstetter CE, Leonard AC, Grimwade JE. Relationships between chromosome segregation, cell shape and temperature in Escherichia coli Journal of Theoretical Biology. 159: 261-266. PMID 1294848 DOI: 10.1016/S0022-5193(05)80705-2  0.367
1990 Helmstetter CE, Leonard AC. Involvement of cell shape in the replication and segregation of chromosomes in Escherichia coli Research in Microbiology. 141: 30-39. PMID 2194247 DOI: 10.1016/0923-2508(90)90095-8  0.337
1988 Leonard AC, Helmstetter CE. Replication patterns of multiple plasmids coexisting in Escherichia coli Journal of Bacteriology. 170: 1380-1383. PMID 3277954  0.301
1987 Helmstetter CE, Leonard AC. Mechanism for chromosome and minichromosome segregation in Escherichia coli Journal of Molecular Biology. 197: 195-204. PMID 3316668 DOI: 10.1016/0022-2836(87)90118-5  0.558
1987 Helmstetter CE, Leonard AC. Coordinate initiation of chromosome and minichromosome replication in Escherichia coli Journal of Bacteriology. 169: 3489-3494. PMID 3301802  0.322
1987 Pierucci O, Helmstetter CE, Rickert M, Weinberger M, Leonard AC. Overexpression of the dnaA gene in Escherichia coli B/r: Chromosome and minichromosome replication in the presence of rifampin Journal of Bacteriology. 169: 1871-1877. PMID 3032899 DOI: 10.1128/Jb.169.5.1871-1877.1987  0.429
1986 Leonard AC, Helmstetter CE. Cell cycle-specific replication of Escherichia coli minichromosomes Proceedings of the National Academy of Sciences of the United States of America. 83: 5101-5105. PMID 3523483 DOI: 10.1073/Pnas.83.14.5101  0.439
1986 Helmstetter CE, Krajewski CA, Leonard AC, Weinberger M. Discontinuity in DNA replication during expression of accumulated initiation potential in dnaA mutants of Escherichia coli Journal of Bacteriology. 165: 631-637. PMID 3511039 DOI: 10.1128/Jb.165.2.631-637.1986  0.476
1985 Leonard AC, Whitford WG, Helmstetter CE. Involvement of DNA superhelicity in minichromosome maintenance in Escherichia coli Journal of Bacteriology. 161: 687-695. PMID 2981821  0.367
Show low-probability matches.