James B. Lok - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Parasitology Biology, Molecular Biology, Cell Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lok JB, Kliewer SA, Mangelsdorf DJ. The 'nuclear option' revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections. Molecular and Biochemical Parasitology. 250: 111490. PMID 35697206 DOI: 10.1016/j.molbiopara.2022.111490  0.308
2021 Wang Z, Cheong MC, Tsien J, Deng H, Qin T, Stoltzfus JD, Jaleta TG, Li X, Lok JB, Kliewer SA, Mangelsdorf DJ. Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in . Elife. 10. PMID 34874004 DOI: 10.7554/eLife.73535  0.752
2021 Cheong MC, Wang Z, Jaleta TG, Li X, Lok JB, Kliewer SA, Mangelsdorf DJ. Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite . Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33602820 DOI: 10.1073/pnas.2021864118  0.336
2021 McCrea AR, Edgerton EB, Oliver GT, O'Neill FM, Nolan TJ, Lok JB, Povelones M. A novel assay to isolate and quantify third-stage Dirofilaria immitis and Brugia malayi larvae emerging from individual Aedes aegypti. Parasites & Vectors. 14: 30. PMID 33413579 DOI: 10.1186/s13071-020-04529-w  0.344
2020 Edgerton EB, McCrea AR, Berry CT, Kwok JY, Thompson LK, Watson B, Fuller EM, Nolan TJ, Lok JB, Povelones M. Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015105 DOI: 10.1073/Pnas.1909369117  0.387
2019 Jaleta TG, Lok JB. Advances in the Molecular and Cellular Biology of spp. Current Tropical Medicine Reports. 6: 161-178. PMID 31929961 DOI: 10.1007/S40475-019-00186-X  0.318
2019 Doyle SR, Sankaranarayanan G, Allan F, Berger D, Jimenez Castro PD, Collins JB, Crellen T, Duque-Correa MA, Ellis P, Jaleta TG, Laing R, Maitland K, McCarthy C, Moundai T, Softley B, ... ... Lok J, et al. Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing. Frontiers in Genetics. 10: 826. PMID 31616465 DOI: 10.3389/Fgene.2019.00826  0.346
2019 Charuchaibovorn S, Sanprasert V, Sutthanont N, Hu Y, Abraham A, Ostroff GR, Aroian RV, Jaleta TG, Lok JB, Nuchprayoon S. Cry5B is active against in vitro. The American Journal of Tropical Medicine and Hygiene. PMID 31516117 DOI: 10.4269/Ajtmh.19-0083  0.431
2019 Lok JB. CRISPR/Cas9 Mutagenesis and Expression of Dominant Mutant Transgenes as Functional Genomic Approaches in Parasitic Nematodes. Frontiers in Genetics. 10: 656. PMID 31379923 DOI: 10.3389/Fgene.2019.00656  0.453
2019 Adams S, Pathak P, Shao H, Lok JB, Pires-daSilva A. Liposome-based transfection enhances RNAi and CRISPR-mediated mutagenesis in non-model nematode systems. Scientific Reports. 9: 483. PMID 30679624 DOI: 10.1038/S41598-018-37036-1  0.363
2019 Lok J. piggyBac: A vehicle for integrative DNA transformation of parasitic nematodes. Mobile Genetic Elements. 3: e24417. PMID 23914309 DOI: 10.4161/Mge.24417  0.381
2018 Lok JB. Functional Genomic Study in Strongyloides and Related Parasitic Nematodes by Transgenesis and CRISPR/Cas9 Mutagenesis. The Journal of Parasitology. PMID 30169120 DOI: 10.1645/18-134  0.352
2018 Arifin N, Yunus MH, Nolan TJ, Lok JB, Noordin R. Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis. The American Journal of Tropical Medicine and Hygiene. PMID 29436335 DOI: 10.4269/Ajtmh.17-0697  0.362
2017 Patton JB, Bonne-Année S, Deckman J, Hess JA, Torigian A, Nolan TJ, Wang Z, Kliewer SA, Durham AC, Lee JJ, Eberhard ML, Mangelsdorf DJ, Lok JB, Abraham D. Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203662 DOI: 10.1073/Pnas.1712235114  0.346
2017 Lei WQ, Lok JB, Yuan W, Zhang YZ, Stoltzfus JD, Gasser RB, He SY, Zhou H, Zhou R, Zhao JL, Hu M. Structural and developmental expression of Ss-riok-2, an RIO protein kinase encoding gene of Strongyloides stercoralis. Scientific Reports. 7: 8693. PMID 28821723 DOI: 10.1038/S41598-017-07991-2  0.77
2017 Jaleta TG, Zhou S, Bemm FM, Schär F, Khieu V, Muth S, Odermatt P, Lok JB, Streit A. Different but overlapping populations of Strongyloides stercoralis in dogs and humans-Dogs as a possible source for zoonotic strongyloidiasis. Plos Neglected Tropical Diseases. 11: e0005752. PMID 28793306 DOI: 10.1371/Journal.Pntd.0005752  0.355
2017 Yuan W, Zhou H, Lok JB, Lei W, He S, Gasser RB, Zhou R, Fang R, Zhou Y, Zhao J, Hu M. Functional genomic exploration reveals that Ss-RIOK-1 is essential for the development and survival of Strongyloides stercoralis larvae. International Journal For Parasitology. PMID 28780152 DOI: 10.1016/J.Ijpara.2017.06.005  0.49
2016 Lok JB. Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival. Current Clinical Microbiology Reports. 3: 186-197. PMID 28781934 DOI: 10.1007/s40588-016-0046-2  0.339
2016 Peng XQ, Tian GR, Ren GJ, Yu ZQ, Lok JB, Zhang LX, Wang XT, Song JK, Zhao GH. Infection rate of Giardia duodenalis, Cryptosporidium spp. and Enterocytozoon bieneusi in cashmere, dairy and meat goats in China. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. PMID 27017915 DOI: 10.1016/J.Meegid.2016.03.021  0.364
2016 Lok JB, Shao H, Massey HC, Li X. Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing. Parasitology. 1-16. PMID 27000743 DOI: 10.1017/S0031182016000391  0.46
2016 Lok JB. The Developmental Biology of Parasitic Nematodes. Plos Pathogens. 12: e1005328. PMID 26963933 DOI: 10.1371/Journal.Ppat.1005328  0.464
2016 Li FC, Gasser RB, Lok JB, Korhonen PK, He L, Di WD, Yin FY, Zhou R, Zhou YQ, Zhao JL, Hu M. Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1). Parasites & Vectors. 9: 65. PMID 26842781 DOI: 10.1186/S13071-016-1351-6  0.422
2016 Mohandas N, Hu M, Stroehlein AJ, Young ND, Sternberg PW, Lok JB, Gasser RB. Reconstruction of the insulin-like signalling pathway of Haemonchus contortus. Parasites & Vectors. 9: 64. PMID 26842675 DOI: 10.1186/S13071-016-1341-8  0.3
2016 Hunt VL, Tsai IJ, Coghlan A, Reid AJ, Holroyd N, Foth BJ, Tracey A, Cotton JA, Stanley EJ, Beasley H, Bennett HM, Brooks K, Harsha B, Kajitani R, Kulkarni A, ... ... Lok JB, et al. The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics. PMID 26829753 DOI: 10.1038/Ng.3495  0.77
2016 Albarqi MM, Stoltzfus JD, Pilgrim AA, Nolan TJ, Wang Z, Kliewer SA, Mangelsdorf DJ, Lok JB. Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid. Plos Pathogens. 12: e1005358. PMID 26727267 DOI: 10.1371/Journal.Ppat.1005358  0.745
2015 Viney ME, Lok JB. The biology of Strongyloides spp. Wormbook : the Online Review of C. Elegans Biology. 1-17. PMID 26183912 DOI: 10.1895/Wormbook.1.141.2  0.342
2015 Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA. The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes. Plos Genetics. 11: e1005027. PMID 25774872 DOI: 10.1371/Journal.Pgen.1005027  0.755
2014 Lok JB. and relatives: recent advances in general and molecular biology. Current Tropical Medicine Reports. 1: 194-206. PMID 29577012 DOI: 10.1007/S40475-014-0033-8  0.476
2014 Yuan W, Liu Y, Lok JB, Stoltzfus JD, Gasser RB, Lei W, Fang R, Zhao J, Hu M. Exploring features and function of Ss-riok-3, an enigmatic kinase gene from Strongyloides stercoralis. Parasites & Vectors. 7: 561. PMID 25477034 DOI: 10.1186/S13071-014-0561-Z  0.766
2014 Li FC, Gasser RB, Lok JB, Korhonen PK, Wang YF, Yin FY, He L, Zhou R, Zhao JL, Hu M. Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus. Parasites & Vectors. 7: 498. PMID 25388625 DOI: 10.1186/S13071-014-0498-2  0.465
2014 Castelletto ML, Gang SS, Okubo RP, Tselikova AA, Nolan TJ, Platzer EG, Lok JB, Hallem EA. Diverse host-seeking behaviors of skin-penetrating nematodes. Plos Pathogens. 10: e1004305. PMID 25121736 DOI: 10.1371/Journal.Ppat.1004305  0.771
2014 Yuan W, Lok JB, Stoltzfus JD, Gasser RB, Fang F, Lei WQ, Fang R, Zhou YQ, Zhao JL, Hu M. Toward understanding the functional role of Ss-RIOK-1, a RIO protein kinase-encoding gene of Strongyloides stercoralis. Plos Neglected Tropical Diseases. 8: e3062. PMID 25101874 DOI: 10.1371/Journal.Pntd.0003062  0.764
2014 Stoltzfus JD, Bart SM, Lok JB. cGMP and NHR signaling co-regulate expression of insulin-like peptides and developmental activation of infective larvae in Strongyloides stercoralis. Plos Pathogens. 10: e1004235. PMID 25010340 DOI: 10.1371/Journal.Ppat.1004235  0.768
2014 Li F, Lok JB, Gasser RB, Korhonen PK, Sandeman MR, Shi D, Zhou R, Li X, Zhou Y, Zhao J, Hu M. Hc-daf-2 encodes an insulin-like receptor kinase in the barber's pole worm, Haemonchus contortus, and restores partial dauer regulation. International Journal For Parasitology. 44: 485-96. PMID 24727120 DOI: 10.1016/J.Ijpara.2014.03.005  0.506
2014 Bonne-Année S, Kerepesi LA, Hess JA, Wesolowski J, Paumet F, Lok JB, Nolan TJ, Abraham D. Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis. Microbes and Infection / Institut Pasteur. 16: 502-11. PMID 24642003 DOI: 10.1016/J.Micinf.2014.02.012  0.331
2013 Bonne-Année S, Kerepesi LA, Hess JA, O'Connell AE, Lok JB, Nolan TJ, Abraham D. Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. Infection and Immunity. 81: 3346-55. PMID 23798541 DOI: 10.1128/Iai.00625-13  0.347
2013 Massey HC, Ranjit N, Stoltzfus JD, Lok JB. Strongyloides stercoralis daf-2 encodes a divergent ortholog of Caenorhabditis elegans DAF-2 International Journal For Parasitology. 43: 515-520. PMID 23500073 DOI: 10.1016/J.Ijpara.2013.01.008  0.765
2012 Stoltzfus JD, Minot S, Berriman M, Nolan TJ, Lok JB. RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways. Plos Neglected Tropical Diseases. 6: e1854. PMID 23145190 DOI: 10.1371/Journal.Pntd.0001854  0.796
2012 Huang SC, Freitas TC, Amiel E, Everts B, Pearce EL, Lok JB, Pearce EJ. Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni. Plos Pathogens. 8: e1002996. PMID 23133378 DOI: 10.1371/Journal.Ppat.1002996  0.338
2012 Shao H, Li X, Nolan TJ, Massey HC, Pearce EJ, Lok JB. Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines. Plos Pathogens. 8: e1002871. PMID 22912584 DOI: 10.1371/Journal.Ppat.1002871  0.332
2012 Stoltzfus JD, Massey HC, Nolan TJ, Griffith SD, Lok JB. Strongyloides stercoralis age-1: a potential regulator of infective larval development in a parasitic nematode. Plos One. 7: e38587. PMID 22701676 DOI: 10.1371/Journal.Pone.0038587  0.776
2012 Nolan TJ, Lok JB. Macrocyclic lactones in the treatment and control of parasitism in small companion animals. Current Pharmaceutical Biotechnology. 13: 1078-94. PMID 22039798 DOI: 10.2174/138920112800399167  0.359
2012 Lok JB. Nucleic acid transfection and transgenesis in parasitic nematodes. Parasitology. 139: 574-88. PMID 21880161 DOI: 10.1017/S0031182011001387  0.431
2011 Li X, Shao H, Junio A, Nolan TJ, Massey HC, Pearce EJ, Viney ME, Lok JB. Transgenesis in the parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitology. 179: 114-9. PMID 21723330 DOI: 10.1016/J.Molbiopara.2011.06.002  0.403
2011 Ramanathan R, Varma S, Ribeiro JM, Myers TG, Nolan TJ, Abraham D, Lok JB, Nutman TB. Microarray-based analysis of differential gene expression between infective and noninfective larvae of Strongyloides stercoralis. Plos Neglected Tropical Diseases. 5: e1039. PMID 21572524 DOI: 10.1371/Journal.Pntd.0001039  0.424
2011 Zhu H, Li J, Nolan TJ, Schad GA, Lok JB. Sensory neuroanatomy of Parastrongyloides trichosuri, a nematode parasite of mammals: Amphidial neurons of the first-stage larva. The Journal of Comparative Neurology. 519: 2493-507. PMID 21456026 DOI: 10.1002/Cne.22637  0.312
2011 O'Connell AE, Redding KM, Hess JA, Lok JB, Nolan TJ, Abraham D. Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment. Microbes and Infection / Institut Pasteur. 13: 536-44. PMID 21315175 DOI: 10.1016/J.Micinf.2011.01.016  0.317
2010 Hu M, Lok JB, Ranjit N, Massey HC, Sternberg PW, Gasser RB. Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida). International Journal For Parasitology. 40: 405-15. PMID 19796644 DOI: 10.1016/J.Ijpara.2009.09.005  0.529
2009 Stein LH, Redding KM, Lee JJ, Nolan TJ, Schad GA, Lok JB, Abraham D. Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis. Journal of Innate Immunity. 1: 618-30. PMID 20375616 DOI: 10.1159/000233235  0.388
2009 Lok JB. Transgenesis in parasitic nematodes: building a better array. Trends in Parasitology. 25: 345-7. PMID 19617000 DOI: 10.1016/J.Pt.2009.05.002  0.392
2009 Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ. Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proceedings of the National Academy of Sciences of the United States of America. 106: 9138-43. PMID 19497877 DOI: 10.1073/Pnas.0904064106  0.419
2009 Castelletto ML, Massey HC, Lok JB. Morphogenesis of strongyloides stercoralis infective larvae requires the DAF-16 ortholog FKTF-1 Plos Pathogens. 5. PMID 19360119 DOI: 10.1371/Journal.Ppat.1000370  0.79
2008 Lok JB, Artis D. Transgenesis and neuronal ablation in parasitic nematodes: Revolutionary new tools to dissect host-parasite interactions Parasite Immunology. 30: 203-214. PMID 18324923 DOI: 10.1111/J.1365-3024.2008.01006.X  0.311
2008 Junio AB, Li X, Massey HC, Nolan TJ, Todd Lamitina S, Sundaram MV, Lok JB. Strongyloides stercoralis: cell- and tissue-specific transgene expression and co-transformation with vector constructs incorporating a common multifunctional 3' UTR. Experimental Parasitology. 118: 253-65. PMID 17945217 DOI: 10.1016/J.Exppara.2007.08.018  0.356
2007 Nolan TJ, Zhu X, Ketschek A, Cole J, Grant W, Lok JB, Schad GA. The sugar glider (Petaurus breviceps): a laboratory host for the nematode Parastrongyloides trichosuri. The Journal of Parasitology. 93: 1084-9. PMID 18163342 DOI: 10.1645/Ge-1234R.1  0.418
2007 Lok JB. Strongyloides stercoralis: a model for translational research on parasitic nematode biology. Wormbook : the Online Review of C. Elegans Biology. 1-18. PMID 18050500 DOI: 10.1895/Wormbook.1.134.1  0.427
2007 Ashton FT, Zhu X, Boston R, Lok JB, Schad GA. Strongyloides stercoralis: Amphidial neuron pair ASJ triggers significant resumption of development by infective larvae under host-mimicking in vitro conditions. Experimental Parasitology. 115: 92-7. PMID 17067579 DOI: 10.1016/J.Exppara.2006.08.010  0.414
2006 Li X, Massey HC, Nolan TJ, Schad GA, Kraus K, Sundaram M, Lok JB. Successful transgenesis of the parasitic nematode Strongyloides stercoralis requires endogenous non-coding control elements. International Journal For Parasitology. 36: 671-9. PMID 16500658 DOI: 10.1016/J.Ijpara.2005.12.007  0.395
2006 Massey HC, Bhopale MK, Li X, Castelletto M, Lok JB. The fork head transcription factor FKTF-1b from Strongyloides stercoralis restores DAF-16 developmental function to mutant Caenorhabditis elegans International Journal For Parasitology. 36: 347-352. PMID 16442538 DOI: 10.1016/J.Ijpara.2005.11.007  0.766
2005 Massey HC, Castelletto ML, Bhopale VM, Schad GA, Lok JB. Sst-tgh-1 from Strongyloides stercoralis encodes a proposed ortholog of daf-7 in Caenorhabditis elegans. Molecular and Biochemical Parasitology. 142: 116-20. PMID 15907565 DOI: 10.1016/J.Molbiopara.2005.03.004  0.733
2003 Massey HC, Nishi M, Chaudhary K, Pakpour N, Lok JB. Structure and developmental expression of Strongyloides stercoralis fktf-1, a proposed ortholog of daf-16 in Caenorhabditis elegans International Journal For Parasitology. 33: 1537-1544. PMID 14572516 DOI: 10.1016/S0020-7519(03)00205-4  0.456
2001 Lok JB, Knight DH, Wang GT, Doscher ME, Nolan TJ, Hendrick MJ, Steber W, Heaney K. Activity of an injectable, sustained-release formulation of moxidectin administered prophylactically to mixed-breed dogs to prevent infection with Dirofilaria immitis. American Journal of Veterinary Research. 62: 1721-6. PMID 11703014 DOI: 10.2460/Ajvr.2001.62.1721  0.32
2001 Watts KJ, Reddy GR, Holmes RA, Lok JB, Knight DH, Smith G, Courtney CH. Seasonal prevalence of third-stage larvae of Dirofilaria immitis in mosquitoes from Florida and Louisiana Journal of Parasitology. 87: 322-329. PMID 11318562 DOI: 10.1645/0022-3395(2001)087[0322:Spotsl]2.0.Co;2  0.316
2001 Massey HC, Ball CC, Lok JB. PCR amplification of putative gpa-2 and gpa-3 orthologs from the (A+T)-rich genome of Strongyloides stercoralis. International Journal For Parasitology. 31: 377-83. PMID 11306115 DOI: 10.1016/S0020-7519(01)00117-5  0.473
1996 Mansfield LS, Niamatali S, Bhopale V, Volk S, Smith G, Lok JB, Genta RM, Schad GA. Strongyloides stercoralis: maintenance of exceedingly chronic infections. The American Journal of Tropical Medicine and Hygiene. 55: 617-24. PMID 9025687 DOI: 10.4269/Ajtmh.1996.55.617  0.38
1992 Abraham D, Eberhard ML, Lange AM, Yutanawiboonchai W, Perler FB, Lok JB. Identification of surrogate rodent hosts for larval Onchocerca lienalis and induction of protective immunity in a model system Journal of Parasitology. 78: 447-453. PMID 1597787 DOI: 10.2307/3283642  0.341
1983 Lok JB, Mika-Grieve M, Grieve RB. Cryopreservation of Dirofilaria Immitis Microfilariae and Third-Stage Larvae Journal of Helminthology. 57: 319-324. PMID 6668419 DOI: 10.1017/S0022149X00011019  0.347
1983 Grieve RB, Lok JB, Glickman LT. Epidemiology of canine heartworm infection Epidemiologic Reviews. 5: 220-246. PMID 6139288 DOI: 10.1093/Oxfordjournals.Epirev.A036260  0.35
1980 Lok JB, Cupp EW, Braide EI, Bernardo MJ. Aedes aegypti as a surrogate host for Onchocerca SPP American Journal of Tropical Medicine and Hygiene. 29: 382-388. PMID 7386718 DOI: 10.4269/Ajtmh.1980.29.382  0.311
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