W. Ford Doolittle, PhD - Publications

Affiliations: 
Biochemistry and Molecular Biology Dalhousie University, Halifax, Nova Scotia, Canada 
Area:
genome evolution

219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Booth A, Mariscal C, Doolittle WF. The Modern Synthesis in the Light of Microbial Genomics. Annual Review of Microbiology. PMID 27482743 DOI: 10.1146/annurev-micro-102215-095456  1
2015 Eme L, Doolittle WF. Archaea. Current Biology : Cb. 25: R851-5. PMID 26439345 DOI: 10.1016/j.cub.2015.05.025  1
2015 Mariscal C, Doolittle WF. Eukaryotes first: how could that be? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370: 20140322. PMID 26323754 DOI: 10.1098/rstb.2014.0322  1
2015 Booth A, Doolittle WF. Reply to Lane and Martin: Being and becoming eukaryotes. Proceedings of the National Academy of Sciences of the United States of America. 112: E4824. PMID 26283404 DOI: 10.1073/pnas.1513285112  1
2015 Keeling PJ, McCutcheon JP, Doolittle WF. Symbiosis becoming permanent: Survival of the luckiest. Proceedings of the National Academy of Sciences of the United States of America. 112: 10101-3. PMID 26283342 DOI: 10.1073/pnas.1513346112  1
2015 Brunet TD, Doolittle WF. Multilevel Selection Theory and the Evolutionary Functions of Transposable Elements. Genome Biology and Evolution. 7: 2445-57. PMID 26253318 DOI: 10.1093/gbe/evv152  1
2015 Booth A, Doolittle WF. Eukaryogenesis, how special really? Proceedings of the National Academy of Sciences of the United States of America. PMID 25883267 DOI: 10.1073/pnas.1421376112  1
2015 Eme L, Doolittle WF. Microbial diversity: a bonanza of phyla. Current Biology : Cb. 25: R227-30. PMID 25784040 DOI: 10.1016/j.cub.2014.12.044  1
2015 Doolittle WF. Rethinking the tree of life: Even though lateral gene transfers tend to undermine this beloved metaphor, the underlying theory of evolution is very much intact Microbe. 10: 319-323.  1
2014 Hillesland KL, Lim S, Flowers JJ, Turkarslan S, Pinel N, Zane GM, Elliott N, Qin Y, Wu L, Baliga NS, Zhou J, Wall JD, Stahl DA. Erosion of functional independence early in the evolution of a microbial mutualism. Proceedings of the National Academy of Sciences of the United States of America. 111: 14822-7. PMID 25267659 DOI: 10.1073/pnas.1407986111  1
2014 Brunet TD, Doolittle WF. Getting "function" right. Proceedings of the National Academy of Sciences of the United States of America. 111: E3365. PMID 25107292 DOI: 10.1073/pnas.1409762111  1
2014 Doolittle WF. The trouble with (group II) introns. Proceedings of the National Academy of Sciences of the United States of America. 111: 6536-7. PMID 24757059 DOI: 10.1073/pnas.1405174111  1
2013 Doolittle WF. The spliceosomal catalytic core arose in the RNA world… or did it? Genome Biology. 14: 141. PMID 24330866 DOI: 10.1186/gb4145  1
2013 Doolittle WF, Fraser P, Gerstein MB, Graveley BR, Henikoff S, Huttenhower C, Oshlack A, Ponting CP, Rinn JL, Schatz MC, Ule J, Weigel D, Weinstock GM. Sixty years of genome biology. Genome Biology. 14: 113. PMID 23651518 DOI: 10.1186/gb-2013-14-4-113  1
2013 Doolittle WF. Carl R. Woese (1928–2012). Current Biology : Cb. 23: R183-5. PMID 23596635  1
2013 Doolittle WF. Is junk DNA bunk? A critique of ENCODE. Proceedings of the National Academy of Sciences of the United States of America. 110: 5294-300. PMID 23479647 DOI: 10.1073/pnas.1221376110  1
2013 Doolittle WF. Microbial neopleomorphism Biology and Philosophy. 28: 351-378. DOI: 10.1007/s10539-012-9358-7  1
2013 Doolittle WF, Zhaxybayeva O. What is a prokaryote? The Prokaryotes: Prokaryotic Biology and Symbiotic Associations. 21-37. DOI: 10.1007/978-3-642-30194-0_114  1
2013 Doolittle WF, Zhaxybayeva O. What is a prokaryote? The Prokaryotes: Prokaryotic Biology and Symbiotic Associations. 21-37. DOI: 10.1007/978-3-642-30194-0_114  1
2012 Zhaxybayeva O, Swithers KS, Foght J, Green AG, Bruce D, Detter C, Han S, Teshima H, Han J, Woyke T, Pitluck S, Nolan M, Ivanova N, Pati A, Land ML, ... ... Doolittle WF, et al. Genome sequence of the mesophilic Thermotogales bacterium Mesotoga prima MesG1.Ag.4.2 reveals the largest Thermotogales genome to date. Genome Biology and Evolution. 4: 700-8. PMID 22798451 DOI: 10.1093/gbe/evs059  1
2012 Doolittle WF. Population genomics: how bacterial species form and why they don't exist. Current Biology : Cb. 22: R451-3. PMID 22677288 DOI: 10.1016/j.cub.2012.04.034  1
2012 Nesbø CL, Bradnan DM, Adebusuyi A, Dlutek M, Petrus AK, Foght J, Doolittle WF, Noll KM. Mesotoga prima gen. nov., sp. nov., the first described mesophilic species of the Thermotogales. Extremophiles : Life Under Extreme Conditions. 16: 387-93. PMID 22411358 DOI: 10.1007/s00792-012-0437-0  1
2012 Doolittle WF. Evolutionary biology: A ratchet for protein complexity. Nature. 481: 270-1. PMID 22230958 DOI: 10.1038/nature10816  1
2011 Lukeš J, Archibald JM, Keeling PJ, Doolittle WF, Gray MW. How a neutral evolutionary ratchet can build cellular complexity. Iubmb Life. 63: 528-37. PMID 21698757 DOI: 10.1002/iub.489  1
2011 Doolittle WF, Lukeš J, Archibald JM, Keeling PJ, Gray MW. Comment on "Does constructive neutral evolution play an important role in the origin of cellular complexity?" DOI 10.1002/bies.201100010. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 33: 427-9. PMID 21538416 DOI: 10.1002/bies.201100039  1
2011 Zhaxybayeva O, Doolittle WF. Lateral gene transfer. Current Biology : Cb. 21: R242-6. PMID 21481756 DOI: 10.1016/j.cub.2011.01.045  1
2011 Koenig JE, Bourne DG, Curtis B, Dlutek M, Stokes HW, Doolittle WF, Boucher Y. Coral-mucus-associated Vibrio integrons in the Great Barrier Reef: genomic hotspots for environmental adaptation. The Isme Journal. 5: 962-72. PMID 21270840 DOI: 10.1038/ismej.2010.193  1
2010 Gray MW, Lukes J, Archibald JM, Keeling PJ, Doolittle WF. Cell biology. Irremediable complexity? Science (New York, N.Y.). 330: 920-1. PMID 21071654 DOI: 10.1126/science.1198594  1
2010 Nesbø CL, Kumaraswamy R, Dlutek M, Doolittle WF, Foght J. Searching for mesophilic Thermotogales bacteria: "mesotogas" in the wild. Applied and Environmental Microbiology. 76: 4896-900. PMID 20495053 DOI: 10.1128/AEM.02846-09  1
2010 Doolittle WF, Zhaxybayeva O. Metagenomics and the units of biological organization Bioscience. 60: 102-112. DOI: 10.1525/bio.2010.60.2.5  1
2010 Doolittle WF, Zhaxybayeva O. Metagenomics and the units of biological organization Bioscience. 60: 102-112. DOI: 10.1525/bio.2010.60.2.5  1
2010 Doolittle WF. The attempt on the life of the Tree of Life: Science, philosophy and politics Biology and Philosophy. 25: 455-473. DOI: 10.1007/s10539-010-9210-x  1
2009 Zhaxybayeva O, Doolittle WF, Papke RT, Gogarten JP. Intertwined evolutionary histories of marine Synechococcus and Prochlorococcus marinus. Genome Biology and Evolution. 1: 325-39. PMID 20333202 DOI: 10.1093/gbe/evp032  1
2009 Doolittle WF. Eradicating typological thinking in prokaryotic systematics and evolution. Cold Spring Harbor Symposia On Quantitative Biology. 74: 197-204. PMID 19667014 DOI: 10.1101/sqb.2009.74.002  1
2009 Dipippo JL, Nesbø CL, Dahle H, Doolittle WF, Birkland NK, Noll KM. Kosmotoga olearia gen. nov., sp. nov., a thermophilic, anaerobic heterotroph isolated from an oil production fluid. International Journal of Systematic and Evolutionary Microbiology. 59: 2991-3000. PMID 19643902 DOI: 10.1099/ijs.0.008045-0  1
2009 Jezbera J, Sharma AK, Brandt U, Doolittle WF, Hahn MW. 'Candidatus Planktophila limnetica', an actinobacterium representing one of the most numerically important taxa in freshwater bacterioplankton. International Journal of Systematic and Evolutionary Microbiology. 59: 2864-9. PMID 19628588 DOI: 10.1099/ijs.0.010199-0  1
2009 Doolittle WF, Zhaxybayeva O. On the origin of prokaryotic species. Genome Research. 19: 744-56. PMID 19411599 DOI: 10.1101/gr.086645.108  1
2009 Koenig JE, Sharp C, Dlutek M, Curtis B, Joss M, Boucher Y, Doolittle WF. Integron gene cassettes and degradation of compounds associated with industrial waste: the case of the Sydney tar ponds. Plos One. 4: e5276. PMID 19390587 DOI: 10.1371/journal.pone.0005276  1
2009 Joss MJ, Koenig JE, Labbate M, Polz MF, Gillings MR, Stokes HW, Doolittle WF, Boucher Y. ACID: annotation of cassette and integron data. Bmc Bioinformatics. 10: 118. PMID 19383137 DOI: 10.1186/1471-2105-10-118  1
2009 Zhaxybayeva O, Swithers KS, Lapierre P, Fournier GP, Bickhart DM, DeBoy RT, Nelson KE, Nesbø CL, Doolittle WF, Gogarten JP, Noll KM. On the chimeric nature, thermophilic origin, and phylogenetic placement of the Thermotogales. Proceedings of the National Academy of Sciences of the United States of America. 106: 5865-70. PMID 19307556 DOI: 10.1073/pnas.0901260106  1
2009 Sharma AK, Sommerfeld K, Bullerjahn GS, Matteson AR, Wilhelm SW, Jezbera J, Brandt U, Doolittle WF, Hahn MW. Actinorhodopsin genes discovered in diverse freshwater habitats and among cultivated freshwater Actinobacteria. The Isme Journal. 3: 726-37. PMID 19242530 DOI: 10.1038/ismej.2009.13  1
2009 Nesbø CL, Bapteste E, Curtis B, Dahle H, Lopez P, Macleod D, Dlutek M, Bowman S, Zhaxybayeva O, Birkeland NK, Doolittle WF. The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea. Journal of Bacteriology. 191: 1974-8. PMID 19124572 DOI: 10.1128/JB.01448-08  1
2008 Beiko RG, Doolittle WF, Charlebois RL. The impact of reticulate evolution on genome phylogeny. Systematic Biology. 57: 844-56. PMID 19085328 DOI: 10.1080/10635150802559265  1
2008 Doolittle WF. Microbial evolution: stalking the wild bacterial species. Current Biology : Cb. 18: R565-7. PMID 18606128 DOI: 10.1016/j.cub.2008.05.029  1
2008 Sharma AK, Zhaxybayeva O, Papke RT, Doolittle WF. Actinorhodopsins: proteorhodopsin-like gene sequences found predominantly in non-marine environments. Environmental Microbiology. 10: 1039-56. PMID 18218036 DOI: 10.1111/j.1462-2920.2007.01525.x  1
2008 Koenig JE, Boucher Y, Charlebois RL, Nesbø C, Zhaxybayeva O, Bapteste E, Spencer M, Joss MJ, Stokes HW, Doolittle WF. Integron-associated gene cassettes in Halifax Harbour: assessment of a mobile gene pool in marine sediments. Environmental Microbiology. 10: 1024-38. PMID 18190517 DOI: 10.1111/j.1462-2920.2007.01524.x  1
2008 Bapteste E, Susko E, Leigh J, Ruiz-Trillo I, Bucknam J, Doolittle WF. Alternative methods for concatenation of core genes indicate a lack of resolution in deep nodes of the prokaryotic phylogeny. Molecular Biology and Evolution. 25: 83-91. PMID 17940208 DOI: 10.1093/molbev/msm229  1
2007 Papke RT, Zhaxybayeva O, Feil EJ, Sommerfeld K, Muise D, Doolittle WF. Searching for species in haloarchaea. Proceedings of the National Academy of Sciences of the United States of America. 104: 14092-7. PMID 17715057 DOI: 10.1073/pnas.0706358104  1
2007 Doolittle WF, Zhaxybayeva O. Evolution: reducible complexity -- the case for bacterial flagella. Current Biology : Cb. 17: R510-2. PMID 17610831 DOI: 10.1016/j.cub.2007.05.003  1
2007 Zhaxybayeva O, Gogarten JP, Doolittle WF. A hyperconserved protein in Prochlorococcus and marine Synechococcus. Fems Microbiology Letters. 274: 30-4. PMID 17573933 DOI: 10.1111/j.1574-6968.2007.00806.x  1
2007 Zhaxybayeva O, Nesbø CL, Doolittle WF. Systematic overestimation of gene gain through false diagnosis of gene absence. Genome Biology. 8: 402. PMID 17328791 DOI: 10.1186/gb-2007-8-2-402  1
2007 Doolittle WF, Bapteste E. Pattern pluralism and the Tree of Life hypothesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 2043-9. PMID 17261804 DOI: 10.1073/pnas.0610699104  1
2007 Case RJ, Boucher Y, Dahllöf I, Holmström C, Doolittle WF, Kjelleberg S. Use of 16S rRNA and rpoB genes as molecular markers for microbial ecology studies. Applied and Environmental Microbiology. 73: 278-88. PMID 17071787 DOI: 10.1128/AEM.01177-06  1
2007 Walsh DA, Boudreau ME, Bapteste E, Doolittle WF. The Root of the Tree: Lateral Gene Transfer and the Nature of the Domains Archaea: Evolution, Physiology, and Molecular Biology. 29-37. DOI: 10.1002/9780470750865.ch3  1
2007 Walsh DA, Boudreau ME, Bapteste E, Doolittle WF. The Root of the Tree: Lateral Gene Transfer and the Nature of the Domains Archaea: Evolution, Physiology, and Molecular Biology. 29-37. DOI: 10.1002/9780470750865.ch3  0.84
2006 Doolittle WF, Papke RT. Genomics and the bacterial species problem. Genome Biology. 7: 116. PMID 17020593 DOI: 10.1186/gb-2006-7-9-116  1
2006 Sharma AK, Spudich JL, Doolittle WF. Microbial rhodopsins: functional versatility and genetic mobility. Trends in Microbiology. 14: 463-9. PMID 17008099 DOI: 10.1016/j.tim.2006.09.006  1
2006 Gophna U, Sommerfeld K, Gophna S, Doolittle WF, Veldhuyzen van Zanten SJ. Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. Journal of Clinical Microbiology. 44: 4136-41. PMID 16988016 DOI: 10.1128/JCM.01004-06  1
2006 Zhaxybayeva O, Gogarten JP, Charlebois RL, Doolittle WF, Papke RT. Phylogenetic analyses of cyanobacterial genomes: quantification of horizontal gene transfer events. Genome Research. 16: 1099-108. PMID 16899658 DOI: 10.1101/gr.5322306  1
2006 Nesbø CL, Dlutek M, Zhaxybayeva O, Doolittle WF. Evidence for existence of "mesotogas," members of the order Thermotogales adapted to low-temperature environments. Applied and Environmental Microbiology. 72: 5061-8. PMID 16820506 DOI: 10.1128/AEM.00342-06  1
2006 Legault BA, Lopez-Lopez A, Alba-Casado JC, Doolittle WF, Bolhuis H, Rodriguez-Valera F, Papke RT. Environmental genomics of "Haloquadratum walsbyi" in a saltern crystallizer indicates a large pool of accessory genes in an otherwise coherent species. Bmc Genomics. 7: 171. PMID 16820057 DOI: 10.1186/1471-2164-7-171  1
2006 Susko E, Leigh J, Doolittle WF, Bapteste E. Visualizing and assessing phylogenetic congruence of core gene sets: a case study of the gamma-proteobacteria. Molecular Biology and Evolution. 23: 1019-30. PMID 16495350 DOI: 10.1093/molbev/msj113  1
2006 Boucher Y, Nesbø CL, Joss MJ, Robinson A, Mabbutt BC, Gillings MR, Doolittle WF, Stokes HW. Recovery and evolutionary analysis of complete integron gene cassette arrays from Vibrio. Bmc Evolutionary Biology. 6: 3. PMID 16417647 DOI: 10.1186/1471-2148-6-3  1
2006 Gophna U, Charlebois RL, Doolittle WF. Ancient lateral gene transfer in the evolution of Bdellovibrio bacteriovorus. Trends in Microbiology. 14: 64-9. PMID 16413191 DOI: 10.1016/j.tim.2005.12.008  1
2006 Nesbø CL, Dlutek M, Doolittle WF. Recombination in Thermotoga: implications for species concepts and biogeography. Genetics. 172: 759-69. PMID 16322518 DOI: 10.1534/genetics.105.049312  1
2006 Gophna U, Thompson JR, Boucher Y, Doolittle WF. Complex histories of genes encoding 3-hydroxy-3-methylglutaryl-CoenzymeA reductase. Molecular Biology and Evolution. 23: 168-78. PMID 16162862 DOI: 10.1093/molbev/msj019  1
2006 Nesbø CL, Doolittle WF, Mongodin EF, Nelson KE. Outside forces helped shape the Thermotoga metagenome Microbe. 1: 235-241.  1
2006 Nesbø CL, Doolittle WF, Mongodin EF, Nelson KE. Outside forces helped shape the Thermotoga metagenome Microbe. 1: 235-241.  0.92
2005 Mongodin EF, Nelson KE, Daugherty S, Deboy RT, Wister J, Khouri H, Weidman J, Walsh DA, Papke RT, Sanchez Perez G, Sharma AK, Nesbø CL, MacLeod D, Bapteste E, Doolittle WF, et al. The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea. Proceedings of the National Academy of Sciences of the United States of America. 102: 18147-52. PMID 16330755 DOI: 10.1073/pnas.0509073102  1
2005 Nesbø CL, Boucher Y, Dlutek M, Doolittle WF. Lateral gene transfer and phylogenetic assignment of environmental fosmid clones. Environmental Microbiology. 7: 2011-26. PMID 16309397 DOI: 10.1111/j.1462-2920.2005.00918.x  1
2005 Walsh DA, Papke RT, Doolittle WF. Archaeal diversity along a soil salinity gradient prone to disturbance. Environmental Microbiology. 7: 1655-66. PMID 16156738 DOI: 10.1111/j.1462-2920.2005.00864.x  1
2005 Gophna U, Bapteste E, Doolittle WF, Biran D, Ron EZ. Evolutionary plasticity of methionine biosynthesis. Gene. 355: 48-57. PMID 16046084 DOI: 10.1016/j.gene.2005.05.028  1
2005 Bapteste E, Susko E, Leigh J, MacLeod D, Charlebois RL, Doolittle WF. Do orthologous gene phylogenies really support tree-thinking? Bmc Evolutionary Biology. 5: 33. PMID 15913459 DOI: 10.1186/1471-2148-5-33  1
2005 Walsh DA, Doolittle WF. The real 'domains' of life. Current Biology : Cb. 15: R237-40. PMID 15823519 DOI: 10.1016/j.cub.2005.03.034  1
2005 Gophna U, Doolittle WF, Charlebois RL. Weighted genome trees: refinements and applications. Journal of Bacteriology. 187: 1305-16. PMID 15687194 DOI: 10.1128/JB.187.4.1305-1316.2005  1
2004 Papke RT, Koenig JE, Rodríguez-Valera F, Doolittle WF. Frequent recombination in a saltern population of Halorubrum. Science (New York, N.Y.). 306: 1928-9. PMID 15591201 DOI: 10.1126/science.1103289  1
2004 Charlebois RL, Doolittle WF. Computing prokaryotic gene ubiquity: rescuing the core from extinction. Genome Research. 14: 2469-77. PMID 15574825 DOI: 10.1101/gr.3024704  1
2004 Dacks JB, Doolittle WF. Molecular and phylogenetic characterization of syntaxin genes from parasitic protozoa. Molecular and Biochemical Parasitology. 136: 123-36. PMID 15478792 DOI: 10.1016/j.molbiopara.2004.02.014  1
2004 Walsh DA, Bapteste E, Kamekura M, Doolittle WF. Evolution of the RNA polymerase B' subunit gene (rpoB') in Halobacteriales: a complementary molecular marker to the SSU rRNA gene. Molecular Biology and Evolution. 21: 2340-51. PMID 15356285 DOI: 10.1093/molbev/msh248  1
2004 Bapteste E, Boucher Y, Leigh J, Doolittle WF. Phylogenetic reconstruction and lateral gene transfer. Trends in Microbiology. 12: 406-11. PMID 15337161 DOI: 10.1016/j.tim.2004.07.002  1
2004 Boucher Y, Douady CJ, Sharma AK, Kamekura M, Doolittle WF. Intragenomic heterogeneity and intergenomic recombination among haloarchaeal rRNA genes. Journal of Bacteriology. 186: 3980-90. PMID 15175312 DOI: 10.1128/JB.186.12.3980-3990.2004  1
2004 Gophna U, Charlebois RL, Doolittle WF. Have archaeal genes contributed to bacterial virulence? Trends in Microbiology. 12: 213-9. PMID 15120140 DOI: 10.1016/j.tim.2004.03.002  1
2004 Boucher Y, Kamekura M, Doolittle WF. Origins and evolution of isoprenoid lipid biosynthesis in archaea. Molecular Microbiology. 52: 515-27. PMID 15066037 DOI: 10.1111/j.1365-2958.2004.03992.x  1
2004 Doolittle WF. W. Ford Doolittle. Current Biology : Cb. 14: R176-7. PMID 15028226 DOI: 10.1016/j.cub.2004.02.010  1
2003 Doolittle WF. Some thoughts on the tree of life. Harvey Lectures. 99: 111-28. PMID 15984554  1
2003 Dacks JB, Davis LA, Sjögren AM, Andersson JO, Roger AJ, Doolittle WF. Evidence for Golgi bodies in proposed 'Golgi-lacking' lineages. Proceedings. Biological Sciences / the Royal Society. 270: S168-71. PMID 14667372 DOI: 10.1098/rsbl.2003.0058  1
2003 Nesbø CL, Doolittle WF. Targeting clusters of transferred genes in Thermotoga maritima. Environmental Microbiology. 5: 1144-54. PMID 14641594 DOI: 10.1046/j.1462-2920.2003.00515.x  1
2003 Papke RT, Douady CJ, Doolittle WF, Rodríguez-Valera F. Diversity of bacteriorhodopsins in different hypersaline waters from a single Spanish saltern. Environmental Microbiology. 5: 1039-45. PMID 14641583 DOI: 10.1046/j.1462-2920.2003.00501.x  1
2003 Boucher Y, Douady CJ, Papke RT, Walsh DA, Boudreau ME, Nesbø CL, Case RJ, Doolittle WF. Lateral gene transfer and the origins of prokaryotic groups. Annual Review of Genetics. 37: 283-328. PMID 14616063 DOI: 10.1146/annurev.genet.37.050503.084247  1
2003 Nesbø CL, Doolittle WF. Active self-splicing group I introns in 23S rRNA genes of hyperthermophilic bacteria, derived from introns in eukaryotic organelles. Proceedings of the National Academy of Sciences of the United States of America. 100: 10806-11. PMID 12947037 DOI: 10.1073/pnas.1434268100  1
2003 Papke RT, Doolittle WF. Phage evolution: new worlds of genomic diversity. Current Biology : Cb. 13: R606-7. PMID 12906814 DOI: 10.1016/S0960-9822(03)00527-X  1
2003 Moriya S, Dacks JB, Takagi A, Noda S, Ohkuma M, Doolittle WF, Kudo T. Molecular phylogeny of three oxymonad genera: Pyrsonympha, Dinenympha and Oxymonas. The Journal of Eukaryotic Microbiology. 50: 190-7. PMID 12836875 DOI: 10.1111/j.1550-7408.2003.tb00115.x  1
2003 Douady CJ, Delsuc F, Boucher Y, Doolittle WF, Douzery EJ. Comparison of Bayesian and maximum likelihood bootstrap measures of phylogenetic reliability. Molecular Biology and Evolution. 20: 248-54. PMID 12598692 DOI: 10.1093/molbev/msg042  1
2003 Allen JF, Raven JA, Douglas AE, Cavalier-Smith T, Blankenship RE, Lopez-Juez E, Bauer CE, Russell MJ, Martin W, Nisbet E, Doolittle WF, Embley TM, Whatley FR, Tovar J. General discussion Philosophical Transactions of the Royal Society B: Biological Sciences. 358: 217-222. PMID 12594929 DOI: 10.1098/rstb.2002.1196  1
2003 Cavalier-Smith T. Genomic reduction and evolution of novel genetic membranes and protein-targeting machinery in eukaryote-eukaryote chimaeras (meta-algae). Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 109-33; discussion 1. PMID 12594921 DOI: 10.1098/rstb.2002.1194  1
2003 Cavalier-Smith T. Genomic reduction and evolution of novel genetic membranes and protein-targeting machinery in eukaryote-eukaryote chimaeras (meta-algae). Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 109-33; discussion 1. PMID 12594921 DOI: 10.1098/rstb.2002.1194  1
2003 Doolittle WF, Boucher Y, Nesbø CL, Douady CJ, Andersson JO, Roger AJ. How big is the iceberg of which organellar genes in nuclear genomes are but the tip? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 39-57; discussion 57. PMID 12594917 DOI: 10.1098/rstb.2002.1185  1
2002 Gogarten JP, Doolittle WF, Lawrence JG. Prokaryotic evolution in light of gene transfer. Molecular Biology and Evolution. 19: 2226-38. PMID 12446813  1
2002 O'Malley MA, Roger AJ, Doolittle WF. Can commercial protection be good for research? Nature. 419: 111. PMID 12226635 DOI: 10.1038/419111a  1
2002 Nesbø CL, Nelson KE, Doolittle WF. Suppressive subtractive hybridization detects extensive genomic diversity in Thermotoga maritima. Journal of Bacteriology. 184: 4475-88. PMID 12142418 DOI: 10.1128/JB.184.16.4475-4488.2002  1
2002 Dacks JB, Marinets A, Ford Doolittle W, Cavalier-Smith T, Logsdon JM. Analyses of RNA Polymerase II genes from free-living protists: phylogeny, long branch attraction, and the eukaryotic big bang. Molecular Biology and Evolution. 19: 830-40. PMID 12032239  1
2002 Dacks JB, Marinets A, Ford Doolittle W, Cavalier-Smith T, Logsdon JM. Analyses of RNA Polymerase II genes from free-living protists: phylogeny, long branch attraction, and the eukaryotic big bang. Molecular Biology and Evolution. 19: 830-40. PMID 12032239  1
2002 Inagaki Y, Doolittle WF, Baldauf SL, Roger AJ. Lateral transfer of an EF-1alpha gene: origin and evolution of the large subunit of ATP sulfurylase in eubacteria. Current Biology : Cb. 12: 772-6. PMID 12007424 DOI: 10.1016/S0960-9822(02)00816-3  1
2002 Boucher Y, Doolittle WF. Something new under the sea. Nature. 417: 27-8. PMID 11986648 DOI: 10.1038/417027a  1
2002 Dacks JB, Doolittle WF. Novel syntaxin gene sequences from Giardia, Trypanosoma and algae: implications for the ancient evolution of the eukaryotic endomembrane system. Journal of Cell Science. 115: 1635-42. PMID 11950882  1
2002 Archibald JM, O'Kelly CJ, Doolittle WF. The chaperonin genes of jakobid and jakobid-like flagellates: implications for eukaryotic evolution. Molecular Biology and Evolution. 19: 422-31. PMID 11919283  1
2002 Inagaki Y, Blouin C, Doolittle WF, Roger AJ. Convergence and constraint in eukaryotic release factor 1 (eRF1) domain 1: the evolution of stop codon specificity. Nucleic Acids Research. 30: 532-44. PMID 11788716  1
2001 Noël C, Gerbod D, Fast NM, Wintjens R, Delgado-Viscogliosi P, Doolittle WF, Viscogliosi E. Tubulins in Trichomonas vaginalis: molecular characterization of alpha-tubulin genes, posttranslational modifications, and homology modeling of the tubulin dimer. The Journal of Eukaryotic Microbiology. 48: 647-54. PMID 11831773  1
2001 Dacks JB, Doolittle WF. Reconstructing/deconstructing the earliest eukaryotes: how comparative genomics can help. Cell. 107: 419-25. PMID 11719183 DOI: 10.1016/S0092-8674(01)00584-0  1
2001 Nesbø CL, Boucher Y, Doolittle WF. Defining the core of nontransferable prokaryotic genes: the euryarchaeal core. Journal of Molecular Evolution. 53: 340-50. PMID 11675594 DOI: 10.1007/s002390010224  1
2001 Archibald JM, Blouin C, Doolittle WF. Gene duplication and the evolution of group II chaperonins: implications for structure and function. Journal of Structural Biology. 135: 157-69. PMID 11580265 DOI: 10.1006/jsbi.2001.4353  1
2001 She Q, Singh RK, Confalonieri F, Zivanovic Y, Allard G, Awayez MJ, Chan-Weiher CC, Clausen IG, Curtis BA, De Moors A, Erauso G, Fletcher C, Gordon PM, Heikamp-de Jong I, Jeffries AC, ... ... Doolittle WF, et al. The complete genome of the crenarchaeon Sulfolobus solfataricus P2. Proceedings of the National Academy of Sciences of the United States of America. 98: 7835-40. PMID 11427726 DOI: 10.1073/pnas.141222098  1
2001 Boucher Y, Huber H, L'Haridon S, Stetter KO, Doolittle WF. Bacterial origin for the isoprenoid biosynthesis enzyme HMG-CoA reductase of the archaeal orders Thermoplasmatales and Archaeoglobales. Molecular Biology and Evolution. 18: 1378-88. PMID 11420376  1
2001 Boucher Y, Nesbø CL, Doolittle WF. Microbial genomes: dealing with diversity. Current Opinion in Microbiology. 4: 285-9. PMID 11378480 DOI: 10.1016/S1369-5274(00)00204-6  1
2001 Andersson JO, Doolittle WF, Nesbø CL. Genomics. Are there bugs in our genome? Science (New York, N.Y.). 292: 1848-50. PMID 11358998 DOI: 10.1126/science.1062241  1
2001 Inagaki Y, Doolittle WF. Class I release factors in ciliates with variant genetic codes. Nucleic Acids Research. 29: 921-7. PMID 11160924  1
2000 Inagaki Y, Dacks JB, Doolittle WF, Watanabe KI, Ohama T. Evolutionary relationship between dinoflagellates bearing obligate diatom endosymbionts: insight into tertiary endosymbiosis. International Journal of Systematic and Evolutionary Microbiology. 50: 2075-81. PMID 11155982  0.52
2000 Van de Peer Y, Baldauf SL, Doolittle WF, Meyer A. An updated and comprehensive rRNA phylogeny of (crown) eukaryotes based on rate-calibrated evolutionary distances. Journal of Molecular Evolution. 51: 565-76. PMID 11116330 DOI: 10.1007/s002390010120  1
2000 Baldauf SL, Roger AJ, Wenk-Siefert I, Doolittle WF. A kingdom-level phylogeny of eukaryotes based on combined protein data Science. 290: 972-977. PMID 11062127 DOI: 10.1126/science.290.5493.972  1
2000 Archibald JM, Logsdon JM, Doolittle WF. Origin and evolution of eukaryotic chaperonins: phylogenetic evidence for ancient duplications in CCT genes. Molecular Biology and Evolution. 17: 1456-66. PMID 11018153  1
2000 Boucher Y, Doolittle WF. The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways. Molecular Microbiology. 37: 703-16. PMID 10972794 DOI: 10.1046/j.1365-2958.2000.02004.x  0.64
2000 Doolittle WF. The nature of the universal ancestor and the evolution of the proteome. Current Opinion in Structural Biology. 10: 355-8. PMID 10851188 DOI: 10.1016/S0959-440X(00)00096-8  1
2000 Inagaki Y, Doolittle WF. Evolution of the eukaryotic translation termination system: Origins of release factors Molecular Biology and Evolution. 17: 882-889. PMID 10833194  1
2000 Faguy DM, Doolittle WF. Horizontal transfer of catalase-peroxidase genes between archaea and pathogenic bacteria. Trends in Genetics : Tig. 16: 196-7. PMID 10782109 DOI: 10.1016/S0168-9525(00)02007-2  1
2000 Doolittle WF. Uprooting the tree of life. Scientific American. 282: 90-5. PMID 10710791  1
2000 Charlebois RL, Singh RK, Chan-Weiher CC, Allard G, Chow C, Confalonieri F, Curtis B, Duguet M, Erauso G, Faguy D, Gaasterland T, Garrett RA, Gordon P, Jeffries AC, Kozera C, ... ... Doolittle WF, et al. Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2. Genome / National Research Council Canada = GéNome / Conseil National De Recherches Canada. 43: 116-36. PMID 10701121  1
1999 Doolittle WF. Lateral genomics. Trends in Cell Biology. 9: M5-8. PMID 10611671 DOI: 10.1016/S0168-9525(99)01877-6  1
1999 Faguy DM, Doolittle WF. Lessons from the Aeropyrum pernix genome. Current Biology : Cb. 9: R883-6. PMID 10607556  1
1999 Fast NM, Logsdon JM, Doolittle WF. Phylogenetic analysis of the TATA box binding protein (TBP) gene from Nosema locustae: evidence for a microsporidia-fungi relationship and spliceosomal intron loss. Molecular Biology and Evolution. 16: 1415-9. PMID 10563021  1
1999 Archibald JM, Logsdon JM, Doolittle WF. Recurrent paralogy in the evolution of archaeal chaperonins. Current Biology : Cb. 9: 1053-6. PMID 10508614 DOI: 10.1016/S0960-9822(99)80457-6  1
1999 Brown JR, Doolittle WF. Gene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetases. Journal of Molecular Evolution. 49: 485-95. PMID 10486006 DOI: 10.1007/PL00006571  1
1999 Doolittle WF. Phylogenetic classification and the universal tree. Science (New York, N.Y.). 284: 2124-9. PMID 10381871 DOI: 10.1126/science.284.5423.2124  1
1999 Fast NM, Doolittle WF. Trichomonas vaginalis possesses a gene encoding the essential spliceosomal component, PRP8. Molecular and Biochemical Parasitology. 99: 275-8. PMID 10340492 DOI: 10.1016/S0166-6851(99)00017-1  1
1999 Roger AJ, Sandblom O, Doolittle WF, Philippe H. An evaluation of elongation factor 1 alpha as a phylogenetic marker for eukaryotes. Molecular Biology and Evolution. 16: 218-33. PMID 10028289  1
1999 Hirt RP, Logsdon JM, Healy B, Dorey MW, Doolittle WF, Embley TM. Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 580-5. PMID 9892676 DOI: 10.1073/pnas.96.2.580  1
1999 Doolittle WF. Rethinking the origin of eukaryotes Biological Bulletin. 196: 378-380.  1
1998 Keeling PJ, Klenk HP, Singh RK, Schenk ME, Sensen CW, Zillig W, Doolittle WF. Sulfolobus islandicus plasmids pRN1 and pRN2 share distant but common evolutionary ancestry. Extremophiles : Life Under Extreme Conditions. 2: 391-3. PMID 9827327  1
1998 Sensen CW, Charlebois RL, Chow C, Clausen IG, Curtis B, Doolittle WF, Duguet M, Erauso G, Gaasterland T, Garrett RA, Gordon P, de Jong IH, Jeffries AC, Kozera C, Medina N, et al. Completing the sequence of the Sulfolobus solfataricus P2 genome. Extremophiles : Life Under Extreme Conditions. 2: 305-12. PMID 9783178 DOI: 10.1007/s007920050073  1
1998 Edgell DR, Malik SB, Doolittle WF. Evidence of independent gene duplications during the evolution of archaeal and eukaryotic family B DNA polymerases. Molecular Biology and Evolution. 15: 1207-17. PMID 9729885  1
1998 Logsdon JM, Stoltzfus A, Doolittle WF. Molecular evolution: recent cases of spliceosomal intron gain? Current Biology : Cb. 8: R560-3. PMID 9707398  1
1998 Fast NM, Roger AJ, Richardson CA, Doolittle WF. U2 and U6 snRNA genes in the microsporidian Nosema locustae: evidence for a functional spliceosome. Nucleic Acids Research. 26: 3202-7. PMID 9628919 DOI: 10.1093/nar/26.13.3202  1
1998 Faguy DM, Doolittle WF. Cytoskeletal proteins: the evolution of cell division. Current Biology : Cb. 8: R338-41. PMID 9601632  1
1998 Doolittle WF, Logsdon JM. Archaeal genomics: do archaea have a mixed heritage? Current Biology : Cb. 8: R209-11. PMID 9512414  1
1998 Doolittle WF. A paradigm gets shifty. Nature. 392: 15-6. PMID 9510239 DOI: 10.1038/32033  1
1998 Doolittle WF, Akam M. Genomes and evolution Current Opinion in Genetics and Development. 8: 613-615. DOI: 10.1016/S0959-437X(98)80027-0  1
1997 Brown JR, Doolittle WF. Archaea and the prokaryote-to-eukaryote transition. Microbiology and Molecular Biology Reviews : Mmbr. 61: 456-502. PMID 9409149  1
1997 Doolittle WF. Fun with genealogy. Proceedings of the National Academy of Sciences of the United States of America. 94: 12751-3. PMID 9398070 DOI: 10.1073/pnas.94.24.12751  1
1997 Stoltzfus A, Logsdon JM, Palmer JD, Doolittle WF. Intron "sliding" and the diversity of intron positions. Proceedings of the National Academy of Sciences of the United States of America. 94: 10739-44. PMID 9380704 DOI: 10.1073/pnas.94.20.10739  0.56
1997 Baldauf SL, Doolittle WF. Origin and evolution of the slime molds (Mycetozoa) Proceedings of the National Academy of Sciences of the United States of America. 94: 12007-12. PMID 9342353 DOI: 10.1073/pnas.94.22.12007  1
1997 Keeling PJ, Doolittle WF. Widespread and ancient distribution of a noncanonical genetic code in diplomonads. Molecular Biology and Evolution. 14: 895-901. PMID 9287422  1
1997 Edgell DR, Doolittle WF. Archaea and the origin(s) of DNA replication proteins. Cell. 89: 995-8. PMID 9215620  1
1997 Brown JR, Robb FT, Weiss R, Doolittle WF. Evidence for the early divergence of tryptophanyl- and tyrosyl-tRNA synthetases. Journal of Molecular Evolution. 45: 9-16. PMID 9211729 DOI: 10.1007/PL00006206  1
1997 Charlebois RL, Sensen CW, Doolittle WF, Brown JR. Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2. Journal of Bacteriology. 179: 4429-32. PMID 9209067  1
1997 Bochar DA, Brown JR, Doolittle WF, Klenk HP, Lam W, Schenk ME, Stauffacher CV, Rodwell VW. 3-hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product. Journal of Bacteriology. 179: 3632-8. PMID 9171410  1
1997 Logsdon JM, Doolittle WF. Origin of antifreeze protein genes: a cool tale in molecular evolution. Proceedings of the National Academy of Sciences of the United States of America. 94: 3485-7. PMID 9108001 DOI: 10.1073/pnas.94.8.3485  1
1997 Edgell DR, Klenk HP, Doolittle WF. Gene duplications in evolution of archaeal family B DNA polymerases. Journal of Bacteriology. 179: 2632-40. PMID 9098062  0.56
1997 Keeling PJ, Doolittle WF. Evidence that eukaryotic triosephosphate isomerase is of alpha-proteobacterial origin. Proceedings of the National Academy of Sciences of the United States of America. 94: 1270-5. PMID 9037042 DOI: 10.1073/pnas.94.4.1270  1
1997 Edgell DR, Doolittle WF. Archaebacterial genomics: The complete genome sequence of Methanococcus jannaschii Bioessays. 19: 1-4.  1
1996 Roger AJ, Smith MW, Doolittle RF, Doolittle WF. Evidence for the Heterolobosea from phylogenetic analysis of genes encoding glyceraldehyde-3-phosphate dehydrogenase. The Journal of Eukaryotic Microbiology. 43: 475-85. PMID 8976605  1
1996 Keeling PJ, Doherty-Kirby AL, Teh EM, Doolittle WF. Linked genes for calmodulin and E2 ubiquitin-conjugating enzyme in Trichomonas vaginalis. The Journal of Eukaryotic Microbiology. 43: 468-74. PMID 8976604  1
1996 Roger AJ, Clark CG, Doolittle WF. A possible mitochondrial gene in the early-branching amitochondriate protist Trichomonas vaginalis Proceedings of the National Academy of Sciences of the United States of America. 93: 14618-14622. PMID 8962102 DOI: 10.1073/pnas.93.25.14618  1
1996 Keeling PJ, Doolittle WF. Alpha-tubulin from early-diverging eukaryotic lineages and the evolution of the tubulin family. Molecular Biology and Evolution. 13: 1297-305. PMID 8952074  1
1996 Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF. An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes. Fems Microbiology Letters. 144: 151-5. PMID 8900058 DOI: 10.1016/0378-1097(96)00351-5  1
1996 Sensen CW, Klenk HP, Singh RK, Allard G, Chan CC, Liu QY, Penny SL, Young F, Schenk ME, Gaasterland T, Doolittle WF, Ragan MA, Charlebois RL. Organizational characteristics and information content of an archaeal genome: 156 kb of sequence from Sulfolobus solfataricus P2. Molecular Microbiology. 22: 175-91. PMID 8899719 DOI: 10.1111/j.1365-2958.1996.tb02666.x  1
1996 Doolittle WF. At the core of the archaea Proceedings of the National Academy of Sciences of the United States of America. 93: 8797-8799. PMID 8799104 DOI: 10.1073/pnas.93.17.8797  1
1996 Keeling PJ, Doolittle WF. Methionine aminopeptidase-1: the MAP of the mitochondrion? Trends in Biochemical Sciences. 21: 285-6. PMID 8772380  1
1996 Baldauf SL, Palmer JD, Doolittle WF. The root of the universal tree and the origin of eukaryotes based on elongation factor phylogeny Proceedings of the National Academy of Sciences of the United States of America. 93: 7749-7754. PMID 8755547 DOI: 10.1073/pnas.93.15.7749  1
1996 Edgell DR, Fast NM, Doolittle WF. Selfish DNA: The best defense is a good offense Current Biology. 6: 385-388. PMID 8723339  1
1996 Keeling PJ, Klenk HP, Singh RK, Feeley O, Schleper C, Zillig W, Doolittle WF, Sensen CW. Complete nucleotide sequence of the Sulfolobus islandicus multicopy plasmid pRN1. Plasmid. 35: 141-4. PMID 8700967 DOI: 10.1006/plas.1996.0016  1
1996 Charlebois RL, Gaasterland T, Ragan MA, Doolittle WF, Sensen CW. The Sulfolobus solfataricus P2 genome project. Febs Letters. 389: 88-91. PMID 8682213 DOI: 10.1016/0014-5793(96)00525-X  1
1996 Keeling PJ, Doolittle WF. A non-canonical genetic code in an early diverging eukaryotic lineage. The Embo Journal. 15: 2285-90. PMID 8641293  1
1996 Bochar DA, Brown JR, Doolittle WF, Klenk HP, Lam W, Schenk ME, Rodwell VW. HMG-CoA Reductase from the thermophilic archaeon sulfowbus solfatericus Faseb Journal. 10: A1386.  1
1996 Keeling PJ, Baldauf SL, Doolittle WF, Zillig W, Klenk HP. An infB-homolog in Sulfolobus acidocaldarius Systematic and Applied Microbiology. 19: 312-321.  1
1995 Stoltzfus A, Spencer DF, Doolittle WF. Methods for evaluating exon-protein correspondences Bioinformatics. 11: 509-515. PMID 8590174 DOI: 10.1093/bioinformatics/11.5.509  1
1995 Bertolaet BL, Seidel HM, Knowles JR. Introns and the origin of protein-coding genes. Science (New York, N.Y.). 268: 1367; author reply 1. PMID 7761859  1
1995 Brown JR, Doolittle WF. Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications Proceedings of the National Academy of Sciences of the United States of America. 92: 2441-2445. PMID 7708661 DOI: 10.1073/pnas.92.7.2441  1
1995 Keeling PJ, Doolittle WF. Archaea: narrowing the gap between prokaryotes and eukaryotes. Proceedings of the National Academy of Sciences of the United States of America. 92: 5761-4. PMID 7597025 DOI: 10.1073/pnas.92.13.5761  1
1995 Keeling PJ, Doolittle WF. An archaebacterial elF-1A: new grist for the mill. Molecular Microbiology. 17: 399-400. PMID 7494488 DOI: 10.1111/j.1365-2958.1995.mmi_17020399.x  1
1995 Keeling PJ, Doolittle WF. Concerted evolution in protists: recent homogenization of a polyubiquitin gene in Trichomonas vaginalis. Journal of Molecular Evolution. 41: 556-62. PMID 7490769 DOI: 10.1007/BF00175813  0.92
1994 Doolittle WF, Brown JR. Tempo, mode, the progenote, and the universal root Proceedings of the National Academy of Sciences of the United States of America. 91: 6721-6728. PMID 8041689 DOI: 10.1073/pnas.91.15.6721  1
1994 Stoltzfus A, Spencer DF, Zuker M, Logsdon JM, Doolittle WF. Testing the exon theory of genes: the evidence from protein structure. Science (New York, N.Y.). 265: 202-7. PMID 8023140  1
1994 Roger AJ, Keeling PJ, Doolittle WF. Introns, the broken transposons. Society of General Physiologists Series. 49: 27-37. PMID 7939900  1
1994 Brown JR, Masuchi Y, Robb FT, Doolittle WF. Evolutionary relationships of bacterial and archaeal glutamine synthetase genes. Journal of Molecular Evolution. 38: 566-76. PMID 7916055 DOI: 10.1007/BF00175876  0.92
1994 Keeling PJ, Charlebois RL, Doolittle WF. Archaebacterial genomes: eubacterial form and eukaryotic content. Current Opinion in Genetics & Development. 4: 816-22. PMID 7888750  1
1994 Klenk HP, Doolittle WF. Evolution: Archaea and eukaryotes versus bacteria? Current Biology. 4: 920-922. PMID 7850430 DOI: 10.1016/S0960-9822(00)00206-2  1
1994 Dyall-Smith ML, Doolittle WF. Construction of composite transposons for halophilic Archaea Canadian Journal of Microbiology. 40: 922-929. PMID 7804904  1
1993 Doolittle WF, Stoltzfus A. Molecular evolution. Genes-in-pieces revisited Nature. 361: 403. PMID 8429878 DOI: 10.1038/361403a0  1
1993 Roger AJ, Doolittle WF. Why introns-in-pieces? Nature. 364: 289-290. PMID 8332184 DOI: 10.1038/364289a0  1
1993 Doolittle WF. Sol's world, the RNA world, our World Faseb Journal. 7: 1-2. PMID 7678557  1
1993 Doolittle WF, Stoltzfus A. Genes-in-pieces revisited Nature. 361: 403.  1
1993 Schalkwyk LC, Charlebois RL, Doolittle WF. Insertion sequences on plasmid pHV1 of Haloferax volcanii Canadian Journal of Microbiology. 39: 201-206.  1
1992 Cline SW, Doolittle WF. Transformation of members of the genus Haloarcula with shuttle vectors based on Halobacterium halobium and Haloferax volcanii plasmid replicons Journal of Bacteriology. 174: 1076-1080. PMID 1732202  1
1992 Lam WL, Doolittle WF. Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii Journal of Biological Chemistry. 267: 5829-5834. PMID 1556098  1
1992 Lam WL, Logan SM, Doolittle WF. Genes for tryptophan biosynthesis in the halophilic archaebacterium Haloferax volcanii: the trpDFEG cluster. Journal of Bacteriology. 174: 1694-7. PMID 1537810  1
1992 Drouin G, Sévigny JM, McLaren IA, Hofman JD, Doolittle WF. Variable arrangement of 5S ribosomal genes within the ribosomal DNA repeats of arthropods. Molecular Biology and Evolution. 9: 826-35. PMID 1528109  1
1992 Doolittle WF, Lam WL, Schalkwyk LC, Charlebois RL, Cline SW, Cohen A. Progress in developing the genetics of the halobacteria Biochemical Society Symposia. 58: 73-78. PMID 1445412  1
1992 Doolittle WF. What are the archaebacteria and why are they important? Biochemical Society Symposia. 58: 1-6. PMID 1445400  1
1992 Yan B, Cline SW, Doolittle WF, Spudich JL. Transformation of a bop-hop-sop-I-sop-II-Halobacterium halobium mutant to bop+: effects of bacteriorhodopsin photoactivation on cellular proton fluxes and swimming behavior Photochemistry and Photobiology. 56: 553-561. PMID 1333616  1
1992 Cohen A, Lam WL, Charlebois RL, Doolittle WF, Schalkwyk LC. Localizing genes on the map of the genome of Haloferax volcanii, one of the Archaea Proceedings of the National Academy of Sciences of the United States of America. 89: 1602-1606. PMID 1311844  1
1991 Charlebois RL, Schalkwyk LC, Hofman JD, Doolittle WF. Detailed physical map and set of overlapping clones covering the genome of the archaebacterium Haloferax volcanii DS2 Journal of Molecular Biology. 222: 509-524. PMID 1748993 DOI: 10.1016/0022-2836(91)90493-P  1
1991 Doolittle WF. The origins of introns Current Biology. 1: 145-146. DOI: 10.1016/0960-9822(91)90214-H  1
1990 Conover RK, Doolittle WF. Characterization of a gene involved in histidine biosynthesis in Halobacterium (Haloferax) volcanii: isolation and rapid mapping by transformation of an auxotroph with cosmid DNA. Journal of Bacteriology. 172: 3244-9. PMID 2345144  1
1990 Lam WL, Cohen A, Tsouluhas D, Doolittle WF. Genes for tryptophan biosynthesis in the archaebacterium Haloferax volcanii Proceedings of the National Academy of Sciences of the United States of America. 87: 6614-6618. PMID 2118654  1
1989 Cline SW, Schalkwyk LC, Doolittle WF. Transformation of the archaebacterium Halobacterium volcanii with genomic DNA Journal of Bacteriology. 171: 4987-4991. PMID 2768194  1
1989 Lam WL, Doolittle WF. Shuttle vectors for the archaebacterium Halobacterium volcanii Proceedings of the National Academy of Sciences of the United States of America. 86: 5478-5482. PMID 2748598  1
1989 Cline SW, Lam WL, Charlebois RL, Schalkwyk LC, Doolittle WF. Transformation methods for halophilic archaebacteria Canadian Journal of Microbiology. 35: 148-152. PMID 2497937  1
1989 Charlebois RL, Hofman JD, Schalkwyk LC, Lam WL, Doolittle WF. Genome mapping in halobacteria Canadian Journal of Microbiology. 35: 21-29. PMID 2470484  1
1988 Doolittle WF. Bacterial evolution Canadian Journal of Microbiology. 34: 547-551. PMID 3052760  1
1988 Doolittle WF. Hierarchical Approaches to Genome Evolution Canadian Journal of Philosophy. 18: 101-133. DOI: 10.1080/00455091.1988.10715946  0.92
1987 Drouin G, Hofman JD, Doolittle WF. Unusual ribosomal RNA gene organization in copepods of the genus Calanus Journal of Molecular Biology. 196: 943-946. PMID 3681983 DOI: 10.1016/0022-2836(87)90417-7  1
1987 Charlebois RL, Lam WL, Cline SW, Doolittle WF. Characterization of pHV2 from Halobacterium volcanii and its use in demonstrating transformation of an archaebacterium Proceedings of the National Academy of Sciences of the United States of America. 84: 8530-8534. PMID 2825193  1
1987 Doolittle WF. What introns have to tell us: Hierarchy in genome evolution Cold Spring Harbor Symposia On Quantitative Biology. 52: 907-913. PMID 2456888  1
1987 Doolittle WF. The evolutionary significance of the Archaebacteria Annals of the New York Academy of Sciences. 503: 72-77. PMID 2441638  1
1986 Hofman JD, Schalkwyk LC, Doolittle WF. ISH51: A large, degenerate family of insertion sequence-like elements in the genome of the archaehacterium, Halobacterium volcanii Nucleic Acids Research. 14: 6983-7000. PMID 3020501 DOI: 10.1093/nar/14.17.6983  1
1986 Darnell JE, Doolittle WF. Speculations on the early course of evolution. Proceedings of the National Academy of Sciences of the United States of America. 83: 1271-5. PMID 2419905  1
1986 Daniels CJ, Douglas SE, Doolittle WF. Genes for transfer RNAs in Halobacterium volcanii Systematic and Applied Microbiology. 7: 26-29.  1
1971 Doolittle WF, Pace NR. Transcriptional organization of the ribosomal RNA cistrons in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 68: 1786-90. PMID 4942914  1
1970 Doolittle WF, Pace NR. Synthesis of 5S ribosomal RNA in Escherichia coli after rifampicin treatment. Nature. 228: 125-9. PMID 4918254  1
1968 Doolittle WF, Yanofsky C. Mutants of Escherichia coli with an altered tryptophanyl-transfer ribonucleic acid synthetase. Journal of Bacteriology. 95: 1283-94. PMID 4869215  1
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