Lora K. Picton, Ph.D. - Publications

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
Area:
Biochemistry, General Biophysics, Cell Biology

9/30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kennedy NW, Picton LK, Hill RB. Isolation and Analysis of Mitochondrial Fission Enzyme DNM1 from Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 2159: 3-15. PMID 32529359 DOI: 10.1007/978-1-0716-0676-6_1  0.579
2017 Starr TN, Picton LK, Thornton JW. Alternative evolutionary histories in the sequence space of an ancient protein. Nature. PMID 28902834 DOI: 10.1038/Nature23902  0.532
2017 Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, et al. The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species. Developmental Cell. 40: 583-594.e6. PMID 28350990 DOI: 10.1016/J.Devcel.2017.02.020  0.554
2015 Hill B, Harwig MC, Manlandro CM, Picton LK, Kennedy NW. FIS1 and DNM1L Cooperate in Mitochondrial Fission: Convergence of Evolution and Intelligent Design Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2052  0.65
2012 Lees JP, Manlandro CM, Picton LK, Tan AZ, Casares S, Flanagan JM, Fleming KG, Hill RB. A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. Journal of Molecular Biology. 423: 143-58. PMID 22789569 DOI: 10.1016/J.Jmb.2012.06.042  0.647
2012 Hill B, Koppenol-Raab M, Lees JPB, Manlandro CM, Picton LK, Posey A, Wells RC. Molecular Mechanisms Behind Mitochondrial Fission Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.167  0.5
2009 Picton LK, Casares S, Monahan AC, Majumdar A, Hill RB. Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae. Biochemistry. 48: 6598-609. PMID 19522466 DOI: 10.1021/Bi802221H  0.487
2009 Parrott MM, Sitarski SA, Arnold RJ, Picton LK, Hill RB, Mukhopadhyay S. Role of conserved cysteines in the alphavirus E3 protein. Journal of Virology. 83: 2584-91. PMID 19109378 DOI: 10.1128/Jvi.02158-08  0.427
2007 Wells RC, Picton LK, Williams SC, Tan FJ, Hill RB. Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm. The Journal of Biological Chemistry. 282: 33769-75. PMID 17884824 DOI: 10.1074/Jbc.M700807200  0.552
Low-probability matches (unlikely to be authored by this person)
2022 Cao L, Coventry B, Goreshnik I, Huang B, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, ... ... Picton L, et al. Design of protein binding proteins from target structure alone. Nature. PMID 35332283 DOI: 10.1038/s41586-022-04654-9  0.263
2022 Ren J, Chu AE, Jude KM, Picton LK, Kare AJ, Su L, Montano Romero A, Huang PS, Garcia KC. Interleukin-2 superkines by computational design. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117401119. PMID 35294290 DOI: 10.1073/pnas.2117401119  0.203
2023 Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell. PMID 37633268 DOI: 10.1016/j.cell.2023.07.037  0.18
2023 Siepe DH, Picton LK, Garcia KC. Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox. Acs Synthetic Biology. PMID 37011906 DOI: 10.1021/acssynbio.2c00587  0.179
2022 Yen M, Ren J, Liu Q, Glassman CR, Sheahan TP, Picton LK, Moreira FR, Rustagi A, Jude KM, Zhao X, Blish CA, Baric RS, Su LL, Garcia KC. Facile discovery of surrogate cytokine agonists. Cell. PMID 35325595 DOI: 10.1016/j.cell.2022.02.025  0.109
2021 Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, et al. An engineered IL-2 partial agonist promotes CD8 T cell stemness. Nature. PMID 34526724 DOI: 10.1038/s41586-021-03861-0  0.095
2023 Beltra JC, Abdel-Hakeem MS, Manne S, Zhang Z, Huang H, Kurachi M, Su L, Picton L, Ngiow SF, Muroyama Y, Casella V, Huang YJ, Giles JR, Mathew D, Belman J, et al. Stat5 opposes the transcription factor Tox and rewires exhausted CD8 T cells toward durable effector-like states during chronic antigen exposure. Immunity. 56: 2699-2718.e11. PMID 38091951 DOI: 10.1016/j.immuni.2023.11.005  0.079
2018 Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, et al. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science (New York, N.Y.). 359: 1037-1042. PMID 29496879 DOI: 10.1126/Science.Aar3246  0.074
2022 Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, et al. Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature. PMID 35676488 DOI: 10.1038/s41586-022-04801-2  0.074
2021 Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, et al. Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. Elife. 10. PMID 34003116 DOI: 10.7554/eLife.65777  0.069
2020 Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, et al. Immune receptor inhibition through enforced phosphatase recruitment. Nature. PMID 33087934 DOI: 10.1038/s41586-020-2851-2  0.068
2020 Zhang Q, Hresko M, Hollander MJ, Picton L, Su L, Nunez-Cruz S, Sockolosky JT, Garcia K, Milone MC. Human Orthogonal IL-2/IL-2Rβ As a Tunable Approach to Enhance CD19-Speific CAR-T Cell Antitumor Activity Blood. 136: 48-48. DOI: 10.1182/BLOOD-2020-140463  0.067
2022 Ren J, Jo Y, Picton LK, Su LL, Raulet DH, Garcia KC. Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism. Acs Synthetic Biology. PMID 36169352 DOI: 10.1021/acssynbio.2c00337  0.06
2022 Wolf NK, Blaj C, Picton LK, Snyder G, Zhang L, Nicolai CJ, Ndubaku CO, McWhirter SM, Garcia KC, Raulet DH. Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I tumors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200568119. PMID 35588144 DOI: 10.1073/pnas.2200568119  0.055
2022 Hirai T, Lin PY, Ramos TL, Simonetta F, Su LL, Picton LK, Baker J, Lohmeyer JK, Garcia KC, Negrin RS. IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 36031344 DOI: 10.1111/ajt.17181  0.055
2021 Hirai T, Ramos TL, Lin PY, Simonetta F, Su LL, Picton LK, Baker J, Lin JX, Li P, Seo K, Lohmeyer JK, Bolivar-Wagers S, Mavers M, Leonard WJ, Blazar BR, et al. Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance. The Journal of Clinical Investigation. 131. PMID 33855972 DOI: 10.1172/JCI139991  0.049
2022 Lopes Ramos T, Bolivar-Wagers S, Jin S, Thangavelu G, Simonetta F, Lin PY, Hirai T, Saha A, Koehn BH, L Su L, Picton LK, Baker J, Lohmeyer JK, Riddle MJ, Eide C, et al. Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo. Blood. PMID 36564052 DOI: 10.1182/blood.2022018440  0.048
2020 Hirai T, Simonetta F, Su LL, Picton L, Baker J, Seo K, Lohmeyer JK, Mavers M, Blazar BR, Garcia C, Negrin RS. Engineered IL-2 Cytokine-Cytokine Receptor Complex Enables Selective Expansion of Regulatory T Cells and Facilitates Establishment of Organ Transplantation Tolerance Biology of Blood and Marrow Transplantation. 26: S59-S60. DOI: 10.1016/J.Bbmt.2019.12.226  0.045
2021 Zhang Q, Hresko ME, Picton LK, Su L, Hollander MJ, Nunez-Cruz S, Zhang Z, Assenmacher CA, Sockolosky JT, Garcia KC, Milone MC. A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia. Science Translational Medicine. 13: eabg6986. PMID 34936380 DOI: 10.1126/scitranslmed.abg6986  0.04
2023 Horton BL, D'Souza AD, Zagorulya M, McCreery CV, Abhiraman GC, Picton LK, Sheen A, Agarwal Y, Momin N, Wittrup KD, White FM, Garcia KC, Spranger S. Overcoming lung cancer immunotherapy resistance by combining non-toxic variants of IL-12 and IL-2. Jci Insight. PMID 37669107 DOI: 10.1172/jci.insight.172728  0.039
2022 Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, et al. Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature. PMID 36380037 DOI: 10.1038/s41586-022-05548-6  0.035
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