| Year |
Citation |
Score |
| 2022 |
Wijayasinghe YS, Bhansali MP, Borkar MR, Chaturbhuj GU, Muntean BS, Viola RE, Bhansali PR. A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials. Journal of Medicinal Chemistry. 65: 3706-3728. PMID 35192360 DOI: 10.1021/acs.jmedchem.1c01737 |
0.763 |
|
| 2021 |
Friday SN, Cheng DW, Zagler SG, Zanella BS, Dietz JD, Calbat CN, Roach LT, Bagnal C, Faile IS, Halkides CJ, Viola RE. Design and testing of selective inactivators against an antifungal enzyme target. Drug Development Research. PMID 34469014 DOI: 10.1002/ddr.21875 |
0.348 |
|
| 2021 |
Hussain MS, Wang Q, Viola RE. Engineering of a critical membrane-anchored enzyme for high solubility and catalytic activity. Archives of Biochemistry and Biophysics. 108870. PMID 33831357 DOI: 10.1016/j.abb.2021.108870 |
0.326 |
|
| 2020 |
Wijayasinghe YS, Bhansali P, Viola RE, Kamal MA, Poddar NK. Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19. Current Pharmaceutical Design. PMID 33213322 DOI: 10.2174/1381612826666201118111151 |
0.746 |
|
| 2020 |
Stecula A, Hussain MS, Viola RE. Discovery of Novel Inhibitors of a Critical Brain Enzyme Using a Homology Model and a Deep Convolutional Neural Network. Journal of Medicinal Chemistry. PMID 32787146 DOI: 10.1021/Acs.Jmedchem.0C00473 |
0.356 |
|
| 2020 |
Dahal GP, Launder D, McKeone KMM, Hunter JP, Conti HR, Viola RE. Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans. Drug Development Research. PMID 32383780 DOI: 10.1002/Ddr.21682 |
0.81 |
|
| 2020 |
Viola RE. The ammonia-lyases: enzymes that use a wide range of approaches to catalyze the same type of reaction. Critical Reviews in Biochemistry and Molecular Biology. 1-17. PMID 31906712 DOI: 10.1080/10409238.2019.1708261 |
0.45 |
|
| 2019 |
Mutthamsetty V, Dahal GP, Wang Q, Viola RE. Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme. Chemical Biology & Drug Design. PMID 31260162 DOI: 10.1111/Cbdd.13586 |
0.83 |
|
| 2019 |
Ohren J, Parungao GG, Viola RE. Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum. Acta Crystallographica. Section F, Structural Biology Communications. 75: 290-298. PMID 30950830 DOI: 10.1107/S2053230X19002772 |
0.824 |
|
| 2018 |
Dahal GP, Viola RE. Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase. Biochemical and Biophysical Research Communications. PMID 30107909 DOI: 10.1016/J.Bbrc.2018.08.053 |
0.825 |
|
| 2018 |
Dahal GP, Viola RE. A Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme. Slas Discovery : Advancing Life Sciences R & D. 2472555218767844. PMID 29608391 DOI: 10.1177/2472555218767844 |
0.818 |
|
| 2017 |
Parungao GG, Zhao M, Wang Q, Zano SP, Viola RE, Blumenthal RM. Complementation of a metK-deficient E. coli strain with heterologous AdoMet synthetase genes. Microbiology (Reading, England). PMID 29111970 DOI: 10.1099/Mic.0.000565 |
0.797 |
|
| 2017 |
Dahal GP, Viola RE. Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus. Acta Crystallographica. Section F, Structural Biology Communications. 73: 36-44. PMID 28045392 DOI: 10.1107/S2053230X16020070 |
0.824 |
|
| 2017 |
Dahal GP, Qian S, Viola RE. Crystal structures and small-angle X-ray scattering analysis of antifungal drug target aspartate semialdehyde dehydrogenase Acta Crystallographica Section a Foundations and Advances. 73: a155-a155. DOI: 10.1107/S0108767317098464 |
0.756 |
|
| 2016 |
Thangavelu B, Mutthamsetty V, Wang Q, Viola RE. Design and optimization of aspartate N-acetyltransferase inhibitors for the potential treatment of Canavan disease. Bioorganic & Medicinal Chemistry. PMID 28007430 DOI: 10.1016/J.Bmc.2016.11.060 |
0.416 |
|
| 2016 |
Coburn KM, Wang Q, Rediske D, Viola RE, Hanson BL, Xue Z, Seo YY. Effects of extracellular polymeric substance composition on bacteria disinfection by monochloramine: Application of MALDI-TOF-MS and Multivariate Analysis. Environmental Science & Technology. PMID 27366970 DOI: 10.1021/Acs.Est.6B00927 |
0.303 |
|
| 2016 |
Li Q, Mu Z, Zhao R, Dahal G, Viola RE, Liu T, Jin Q, Cui S. Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species. Scientific Reports. 6: 21067. PMID 26869335 DOI: 10.1038/Srep21067 |
0.832 |
|
| 2016 |
Thangavelu B, Viola R. Alternative Microbial Routes to Homoserine Activation and Sulfuration: Critical Steps in Methionine Biosynthesis International Journal of Biochemistry Research & Review. 11: 1-22. DOI: 10.9734/Ijbcrr/2016/25074 |
0.497 |
|
| 2015 |
Wang Q, Zhao M, Parungao G, Viola RE. Purification and Characterization of Aspartate N-acetyltransferase: a critical enzyme in brain metabolism. Protein Expression and Purification. PMID 26550943 DOI: 10.1016/J.Pep.2015.11.001 |
0.454 |
|
| 2015 |
Dahal G, Viola RE. Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1365-71. PMID 26527262 DOI: 10.1107/S2053230X15017495 |
0.829 |
|
| 2015 |
Thangavelu B, Bhansali P, Viola RE. Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry. 23: 6622-31. PMID 26404410 DOI: 10.1016/J.Bmc.2015.09.017 |
0.533 |
|
| 2015 |
Zhao M, Wijayasinghe YS, Bhansali P, Viola RE, Blumenthal RM. A surprising range of modified-methionyl S-adenosylmethionine analogues support bacterial growth. Microbiology (Reading, England). 161: 674-82. PMID 25717169 DOI: 10.1099/Mic.0.000034 |
0.809 |
|
| 2015 |
Thangavelu B, Pavlovsky A, Bhansali P, Viola R. Inhibitor Development Against Aspartate-β-Semialdehyde Dehydrogenase- A Novel Target for Drug Development The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.721.5 |
0.372 |
|
| 2014 |
Pavlovsky AG, Thangavelu B, Bhansali P, Viola RE. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallographica. Section D, Biological Crystallography. 70: 3244-52. PMID 25478842 DOI: 10.1107/S1399004714023979 |
0.524 |
|
| 2014 |
Thangavelu B, Pavlovsky AG, Viola R. Structure of homoserine O-acetyltransferase from Staphylococcus aureus: the first Gram-positive ortholog structure. Acta Crystallographica. Section F, Structural Biology Communications. 70: 1340-5. PMID 25286936 DOI: 10.1107/S2053230X14018664 |
0.378 |
|
| 2014 |
Poddar NK, Zano S, Natarajan R, Yamamoto B, Viola RE. Enhanced brain distribution of modified aspartoacylase. Molecular Genetics and Metabolism. 113: 219-24. PMID 25066302 DOI: 10.1016/J.Ymgme.2014.07.002 |
0.819 |
|
| 2014 |
Wijayasinghe YS, Pavlovsky AG, Viola RE. Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective. Biochemistry. 53: 4970-8. PMID 25003821 DOI: 10.1021/Bi500719K |
0.818 |
|
| 2014 |
Wang Q, Viola RE. Reexamination of aspartoacylase: is this human enzyme really a glycoprotein? Archives of Biochemistry and Biophysics. 548: 66-73. PMID 24632142 DOI: 10.1016/J.Abb.2014.03.001 |
0.528 |
|
| 2014 |
Zano SP, Pavlovsky AG, Viola RE. Structure of an unusual S-adenosylmethionine synthetase from Campylobacter jejuni. Acta Crystallographica. Section D, Biological Crystallography. 70: 442-50. PMID 24531478 DOI: 10.1107/S139900471303023X |
0.844 |
|
| 2014 |
Wijayasinghe YS, Blumenthal RM, Viola RE. Producing proficient methyl donors from alternative substrates of S-adenosylmethionine synthetase. Biochemistry. 53: 1521-6. PMID 24528526 DOI: 10.1021/Bi401556P |
0.781 |
|
| 2013 |
Zano SP, Bhansali P, Luniwal A, Viola RE. Alternative substrates selective for S-adenosylmethionine synthetases from pathogenic bacteria. Archives of Biochemistry and Biophysics. 536: 64-71. PMID 23711747 DOI: 10.1016/J.Abb.2013.05.008 |
0.848 |
|
| 2013 |
Zano S, Wijayasinghe YS, Malik R, Smith J, Viola RE. Relationship between enzyme properties and disease progression in Canavan disease. Journal of Inherited Metabolic Disease. 36: 1-6. PMID 22850825 DOI: 10.1007/S10545-012-9520-Z |
0.81 |
|
| 2012 |
Arachea BT, Sun Z, Potente N, Malik R, Isailovic D, Viola RE. Detergent selection for enhanced extraction of membrane proteins. Protein Expression and Purification. 86: 12-20. PMID 22963795 DOI: 10.1016/J.Pep.2012.08.016 |
0.752 |
|
| 2012 |
Luniwal A, Wang L, Pavlovsky A, Erhardt PW, Viola RE. Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase. Bioorganic & Medicinal Chemistry. 20: 2950-6. PMID 22464683 DOI: 10.1016/J.Bmc.2012.03.013 |
0.421 |
|
| 2012 |
Sarver JG, Trendel JA, Bearss NR, Wang L, Luniwal A, Erhardt PW, Viola RE. Early stage efficacy and toxicology screening for antibiotics and enzyme inhibitors. Journal of Biomolecular Screening. 17: 673-82. PMID 22460173 DOI: 10.1177/1087057112438769 |
0.347 |
|
| 2012 |
Pavlovsky AG, Liu X, Faehnle CR, Potente N, Viola RE. Structural characterization of inhibitors with selectivity against members of a homologous enzyme family. Chemical Biology & Drug Design. 79: 128-36. PMID 22039970 DOI: 10.1111/J.1747-0285.2011.01267.X |
0.823 |
|
| 2012 |
Zano S, Wijayasinghe YS, Malik R, Smith J, Viola RE. Erratum to: Relationship between enzyme properties and disease progression in Canavan disease Journal of Inherited Metabolic Disease. 36: 159-160. DOI: 10.1007/S10545-012-9554-2 |
0.78 |
|
| 2011 |
Viola RE, Faehnle CR, Blanco J, Moore RA, Liu X, Arachea BT, Pavlovsky AG. The catalytic machinery of a key enzyme in amino Acid biosynthesis. Journal of Amino Acids. 2011: 352538. PMID 22332000 DOI: 10.4061/2011/352538 |
0.822 |
|
| 2011 |
Saribas AS, Arachea BT, White MK, Viola RE, Safak M. Human polyomavirus JC small regulatory agnoprotein forms highly stable dimers and oligomers: implications for their roles in agnoprotein function. Virology. 420: 51-65. PMID 21920573 DOI: 10.1016/J.Virol.2011.08.015 |
0.779 |
|
| 2011 |
Tawfik DS, Viola RE. Arsenate replacing phosphate: alternative life chemistries and ion promiscuity. Biochemistry. 50: 1128-34. PMID 21214261 DOI: 10.1021/Bi200002A |
0.446 |
|
| 2011 |
Zano S, Malik R, Szucs S, Matalon R, Viola RE. Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease. Molecular Genetics and Metabolism. 102: 176-80. PMID 21095151 DOI: 10.1016/J.Ymgme.2010.10.012 |
0.823 |
|
| 2010 |
Gao G, Liu X, Pavlovsky A, Viola RE. Identification of selective enzyme inhibitors by fragment library screening. Journal of Biomolecular Screening. 15: 1042-50. PMID 20855558 DOI: 10.1177/1087057110381383 |
0.482 |
|
| 2010 |
Malik R, Viola RE. Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions. Acta Crystallographica. Section D, Biological Crystallography. 66: 673-84. PMID 20516620 DOI: 10.1107/S0907444910008851 |
0.499 |
|
| 2010 |
Arachea BT, Liu X, Pavlovsky AG, Viola RE. Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog. Acta Crystallographica. Section D, Biological Crystallography. 66: 205-12. PMID 20124701 DOI: 10.1107/S0907444909052834 |
0.849 |
|
| 2009 |
Bearden SW, Sexton C, Pare J, Fowler JM, Arvidson CG, Yerman L, Viola RE, Brubaker RR. Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase. Microbiology (Reading, England). 155: 198-209. PMID 19118360 DOI: 10.1099/Mic.0.021170-0 |
0.368 |
|
| 2008 |
Viola RE, Yerman L, Fowler JM, Arvidson CG, Brubaker RR. A missense mutation causes aspartase deficiency in Yersinia pestis. Microbiology (Reading, England). 154: 1271-80. PMID 18451035 DOI: 10.1099/Mic.0.2007/015529-0 |
0.41 |
|
| 2008 |
Liu X, Pavlovsky AG, Viola RE. The structural basis for allosteric inhibition of a threonine-sensitive aspartokinase. The Journal of Biological Chemistry. 283: 16216-25. PMID 18334478 DOI: 10.1074/Jbc.M800760200 |
0.551 |
|
| 2008 |
Viola RE, Liu X, Ohren JF, Faehnle CR. The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae. Acta Crystallographica. Section D, Biological Crystallography. 64: 321-30. PMID 18323627 DOI: 10.1107/S0907444907068552 |
0.833 |
|
| 2008 |
Le Coq J, Pavlovsky A, Malik R, Sanishvili R, Xu C, Viola RE. Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue. Biochemistry. 47: 3484-92. PMID 18293939 DOI: 10.1021/Bi702400X |
0.824 |
|
| 2007 |
Liu X, Hanson BL, Langan P, Viola RE. The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase. Acta Crystallographica. Section D, Biological Crystallography. 63: 1000-8. PMID 17704569 DOI: 10.1107/S0907444907037705 |
0.389 |
|
| 2007 |
Coe DM, Viola RE. Assessing the roles of essential functional groups in the mechanism of homoserine succinyltransferase. Archives of Biochemistry and Biophysics. 461: 211-8. PMID 17442255 DOI: 10.1016/J.Abb.2007.03.004 |
0.807 |
|
| 2007 |
Ohren JF, Kundracik ML, Borders CL, Edmiston P, Viola RE. Structural asymmetry and intersubunit communication in muscle creatine kinase. Acta Crystallographica. Section D, Biological Crystallography. 63: 381-9. PMID 17327675 DOI: 10.1107/S0907444906056204 |
0.771 |
|
| 2007 |
Viola RE. The impact of structural biology on neurobiology. Proceedings of the National Academy of Sciences of the United States of America. 104: 399-400. PMID 17213329 DOI: 10.1073/Pnas.0610164103 |
0.388 |
|
| 2007 |
Coe DM, Viola RE. Characterization of Homoserine O‐Succinyltransferase: A Key Branch Point Enzyme in an Essential Metabolic Pathway The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A274 |
0.763 |
|
| 2006 |
Faehnle CR, Liu X, Pavlovsky A, Viola RE. The initial step in the archaeal aspartate biosynthetic pathway catalyzed by a monofunctional aspartokinase. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 962-6. PMID 17012784 DOI: 10.1107/S1744309106038279 |
0.818 |
|
| 2006 |
Faehnle CR, Le Coq J, Liu X, Viola RE. Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria. The Journal of Biological Chemistry. 281: 31031-40. PMID 16895909 DOI: 10.1074/Jbc.M605926200 |
0.845 |
|
| 2006 |
Le Coq J, An HJ, Lebrilla C, Viola RE. Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease. Biochemistry. 45: 5878-84. PMID 16669630 DOI: 10.1021/Bi052608W |
0.848 |
|
| 2006 |
Liu Q, Kirchhoff JR, Faehnle CR, Viola RE, Hudson RA. A rapid method for the purification of methanol dehydrogenase from Methylobacterium extorquens. Protein Expression and Purification. 46: 316-20. PMID 16139516 DOI: 10.1016/J.Pep.2005.07.014 |
0.796 |
|
| 2005 |
Colleluori DM, Reczkowski RS, Emig FA, Cama E, Cox JD, Scolnick LR, Compher K, Jude K, Han S, Viola RE, Christianson DW, Ash DE. Probing the role of the hyper-reactive histidine residue of arginase. Archives of Biochemistry and Biophysics. 444: 15-26. PMID 16266687 DOI: 10.1016/J.Abb.2005.09.009 |
0.658 |
|
| 2005 |
Faehnle CR, Ohren JF, Viola RE. A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii. Journal of Molecular Biology. 353: 1055-68. PMID 16225889 DOI: 10.1016/J.Jmb.2005.09.027 |
0.841 |
|
| 2004 |
Faehnle CR, Blanco J, Viola RE. Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 60: 2320-4. PMID 15583380 DOI: 10.1107/S0907444904026411 |
0.828 |
|
| 2004 |
Blanco J, Moore RA, Faehnle CR, Viola RE. Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1808-15. PMID 15388927 DOI: 10.1107/S0907444904020104 |
0.838 |
|
| 2004 |
Blanco J, Moore RA, Faehnle CR, Coe DM, Viola RE. The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1388-95. PMID 15272161 DOI: 10.1107/S0907444904012971 |
0.825 |
|
| 2004 |
Cama E, Pethe S, Boucher JL, Han S, Emig FA, Ash DE, Viola RE, Mansuy D, Christianson DW. Inhibitor coordination interactions in the binuclear manganese cluster of arginase. Biochemistry. 43: 8987-99. PMID 15248756 DOI: 10.1021/Bi0491705 |
0.684 |
|
| 2004 |
Han S, Viola RE. Splicing of unnatural amino acids into proteins: a peptide model study. Protein and Peptide Letters. 11: 107-14. PMID 15078198 DOI: 10.2174/0929866043478301 |
0.644 |
|
| 2004 |
Elder I, Han S, Tu C, Steele H, Laipis PJ, Viola RE, Silverman DN. Activation of carbonic anhydrase II by active-site incorporation of histidine analogs. Archives of Biochemistry and Biophysics. 421: 283-9. PMID 14984209 DOI: 10.1016/J.Abb.2003.11.006 |
0.675 |
|
| 2003 |
Blanco J, Moore RA, Viola RE. Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 100: 12613-7. PMID 14559965 DOI: 10.1073/Pnas.1634958100 |
0.846 |
|
| 2003 |
Moore RA, Le Coq J, Faehnle CR, Viola RE. Purification and preliminary characterization of brain aspartoacylase. Archives of Biochemistry and Biophysics. 413: 1-8. PMID 12706335 DOI: 10.1016/S0003-9861(03)00055-9 |
0.834 |
|
| 2003 |
Blanco J, Moore RA, Kabaleeswaran V, Viola RE. A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae. Protein Science : a Publication of the Protein Society. 12: 27-33. PMID 12493825 DOI: 10.1110/Ps.0230803 |
0.841 |
|
| 2003 |
Han S, Moore RA, Viola RE. A Facile Synthesis of a Difluoromethylene Analog of β-Aspartyl Phosphate as an Inhibitor of l-Aspartate-β-semialdehyde Dehydrogenase Synlett. 2003: 845-846. DOI: 10.1055/S-2003-38743 |
0.655 |
|
| 2002 |
Moore RA, Bocik WE, Viola RE. Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms. Protein Expression and Purification. 25: 189-94. PMID 12071715 DOI: 10.1006/Prep.2002.1626 |
0.496 |
|
| 2002 |
Han S, Moore RA, Viola RE. Synthesis and evaluation of alternative substrates for arginase. Bioorganic Chemistry. 30: 81-94. PMID 12020133 DOI: 10.1006/Bioo.2001.1228 |
0.707 |
|
| 2002 |
James CL, Viola RE. Production and characterization of bifunctional enzymes. Substrate channeling in the aspartate pathway. Biochemistry. 41: 3726-31. PMID 11888290 DOI: 10.1021/Bi0159074 |
0.481 |
|
| 2002 |
James CL, Viola RE. Production and characterization of bifunctional enzymes. Domain swapping to produce new bifunctional enzymes in the aspartate pathway. Biochemistry. 41: 3720-5. PMID 11888289 DOI: 10.1021/Bi015909O |
0.501 |
|
| 2002 |
Jude KM, Wright SK, Tu C, Silverman DN, Viola RE, Christianson DW. Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Biochemistry. 41: 2485-91. PMID 11851394 DOI: 10.1021/Bi015808Q |
0.341 |
|
| 2002 |
Blanco J, Viola RE. Purification, crystallization and preliminary X-ray analysis of aspartokinase III from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography. 58: 352-4. PMID 11807275 DOI: 10.1107/S0907444901020728 |
0.805 |
|
| 2001 |
Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE. Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase. Biochemistry. 40: 14475-83. PMID 11724560 DOI: 10.1021/Bi015713O |
0.553 |
|
| 2001 |
Han S, Viola RE. A spectrophotometric assay of arginase. Analytical Biochemistry. 295: 117-9. PMID 11476554 DOI: 10.1006/Abio.2001.5189 |
0.606 |
|
| 2001 |
Bell JK, Yennawar HP, Wright SK, Thompson JR, Viola RE, Banaszak LJ. Structural analyses of a malate dehydrogenase with a variable active site. The Journal of Biological Chemistry. 276: 31156-62. PMID 11389141 DOI: 10.1074/Jbc.M100902200 |
0.488 |
|
| 2001 |
Wright SK, Viola RE. Alteration of the specificity of malate dehydrogenase by chemical modulation of an active site arginine. The Journal of Biological Chemistry. 276: 31151-5. PMID 11389140 DOI: 10.1074/Jbc.M100892200 |
0.532 |
|
| 2001 |
Viola RE. The central enzymes of the aspartate family of amino acid biosynthesis. Accounts of Chemical Research. 34: 339-49. PMID 11352712 DOI: 10.1021/Ar000057Q |
0.515 |
|
| 2000 |
Wright SK, Kish MM, Viola RE. From malate dehydrogenase to phenyllactate dehydrogenase. Incorporation of unnatural amino acids to generate an improved enzyme-catalyzed activity. The Journal of Biological Chemistry. 275: 31689-94. PMID 10915786 DOI: 10.1074/Jbc.M003652200 |
0.506 |
|
| 2000 |
Viola RE. L-aspartase: new tricks from an old enzyme. Advances in Enzymology and Related Areas of Molecular Biology. 74: 295-341. PMID 10800598 DOI: 10.1002/9780470123201.Ch7 |
0.563 |
|
| 1999 |
Kish MM, Viola RE. Oxyanion Specificity of Aspartate-beta-semialdehyde Dehydrogenase. Inorganic Chemistry. 38: 818-820. PMID 11670848 DOI: 10.1021/Ic981082J |
0.444 |
|
| 1999 |
Jayasekera MM, Viola RE. Recovery of catalytic activity from an inactive aggregated mutant of l-aspartase. Biochemical and Biophysical Research Communications. 264: 596-600. PMID 10529408 DOI: 10.1006/Bbrc.1999.1570 |
0.475 |
|
| 1999 |
Hadfield A, Kryger G, Ouyang J, Petsko GA, Ringe D, Viola R. Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. Journal of Molecular Biology. 289: 991-1002. PMID 10369777 DOI: 10.1006/Jmbi.1999.2828 |
0.458 |
|
| 1999 |
Earnhardt JN, Wright SK, Qian M, Tu C, Laipis PJ, Viola RE, Silverman DN. Introduction of histidine analogs leads to enhanced proton transfer in carbonic anhydrase V. Archives of Biochemistry and Biophysics. 361: 264-70. PMID 9882455 DOI: 10.1006/Abbi.1998.0984 |
0.409 |
|
| 1998 |
Scott ME, Viola RE. The use of fluoro- and deoxy-substrate analogs to examine binding specificity and catalysis in the enzymes of the sorbitol pathway Carbohydrate Research. 313: 247-253. PMID 10209867 DOI: 10.1016/S0008-6215(98)00266-3 |
0.485 |
|
| 1998 |
Wright SK, Viola RE. Evaluation of methods for the quantitation of cysteines in proteins. Analytical Biochemistry. 265: 8-14. PMID 9866701 DOI: 10.1006/Abio.1998.2858 |
0.391 |
|
| 1997 |
Jayasekera MM, Saribaş AS, Viola RE. Enhancement of catalytic activity by gene truncation: activation of L-aspartase from Escherichia coli. Biochemical and Biophysical Research Communications. 238: 411-4. PMID 9299522 DOI: 10.1006/Bbrc.1997.7294 |
0.426 |
|
| 1997 |
Jayasekera MM, Shi W, Farber GK, Viola RE. Evaluation of functionally important amino acids in L-aspartate ammonia-lyase from Escherichia coli. Biochemistry. 36: 9145-50. PMID 9230046 DOI: 10.1021/Bi970452X |
0.479 |
|
| 1997 |
Shi W, Dunbar J, Jayasekera MM, Viola RE, Farber GK. The structure of L-aspartate ammonia-lyase from Escherichia coli. Biochemistry. 36: 9136-44. PMID 9230045 DOI: 10.1021/Bi9704515 |
0.399 |
|
| 1997 |
Giorgianni F, Beranová S, Wesdemiotis C, Viola RE. Mapping the mechanism-based modification sites in L-aspartase from Escherichia coli. Archives of Biochemistry and Biophysics. 341: 329-36. PMID 9169023 DOI: 10.1006/Abbi.1997.9983 |
0.515 |
|
| 1997 |
Viola RE. Sixteenth Midwest Enzyme Chemistry Conference Bioorganic Chemistry. 25: 43-61. DOI: 10.1006/Bioo.1996.1048 |
0.425 |
|
| 1996 |
Schindler JF, Viola RE. Conversion of cysteinyl residues to unnatural amino acid analogs. Examination in a model system. Journal of Protein Chemistry. 15: 737-42. PMID 9008297 DOI: 10.1007/Bf01887147 |
0.426 |
|
| 1996 |
Huo X, Viola RE. Substrate specificity and identification of functional groups of homoserine kinase from Escherichia colli Biochemistry. 35: 16180-16185. PMID 8973190 DOI: 10.1021/Bi962203Z |
0.521 |
|
| 1996 |
Keng YF, Viola RE. Specificity of aspartokinase III from Escherichia coli and an examination of important catalytic residues. Archives of Biochemistry and Biophysics. 335: 73-81. PMID 8914836 DOI: 10.1006/Abbi.1996.0483 |
0.49 |
|
| 1996 |
Huo X, Viola RE. Functional group characterization of homoserine kinase from Escherichia coli Archives of Biochemistry and Biophysics. 330: 373-379. PMID 8660667 DOI: 10.1006/Abbi.1996.0264 |
0.549 |
|
| 1995 |
Giorgianni F, Beranová S, Wesdemiotis C, Viola RE. Elimination of the sensitivity of L-aspartase to active-site-directed inactivation without alteration of catalytic activity. Biochemistry. 34: 3529-35. PMID 7893648 DOI: 10.1021/Bi00011A006 |
0.533 |
|
| 1995 |
Ouyang J, Viola RE. Use of structural comparisons to select mutagenic targets in aspartate-β-semialdehyde dehydrogenase Biochemistry®. 34: 6394-6399. PMID 7756269 DOI: 10.1021/Bi00019A019 |
0.566 |
|
| 1994 |
Saribaş AS, Schindler JF, Viola RE. Mutagenic investigation of conserved functional amino acids in Escherichia coli L-aspartase. The Journal of Biological Chemistry. 269: 6313-9. PMID 8119980 |
0.436 |
|
| 1994 |
Schindler JF, Viola RE. Mechanism-based inactivation of L-aspartase from Escherichia coli. Biochemistry. 33: 9365-70. PMID 8049238 DOI: 10.1021/Bi00197A042 |
0.46 |
|
| 1994 |
Shiao GC, Kathardekar V, Viola RE. Inactivation of yeast alcohol dehydrogenase by nitrilopropionamides. Journal of Enzyme Inhibition. 8: 133-46. PMID 7539073 |
0.316 |
|
| 1993 |
Bose RN, Slavin LL, Cameron JW, Luellen DL, Viola RE. Characterization of platinum(II)-phosphato complexes of uridine nucleotides Inorganic Chemistry. 32: 1795-1802. DOI: 10.1021/Ic00061A041 |
0.316 |
|
| 1992 |
Angeles TS, Hunsley JR, Viola RE. Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli Biochemistry. 31: 799-805. PMID 1731937 DOI: 10.1021/Bi00118A023 |
0.44 |
|
| 1992 |
Kryger G, Petsko GA, Ouyang J, Viola RE. Crystallization and preliminary crystallographic analysis of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Journal of Molecular Biology. 228: 300-1. PMID 1360028 DOI: 10.1016/0022-2836(92)90508-H |
0.4 |
|
| 1992 |
Karsten WE, Viola RE. Identification of an essential cysteine in the reaction catalyzed by aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Biochimica Et Biophysica Acta. 1121: 234-8. PMID 1350921 DOI: 10.1016/0167-4838(92)90360-P |
0.545 |
|
| 1991 |
Karsten WE, Viola RE. Kinetic studies of L-aspartase from Escherichia coli: pH-dependent activity changes. Archives of Biochemistry and Biophysics. 287: 60-7. PMID 1897995 DOI: 10.1016/0003-9861(91)90388-Y |
0.42 |
|
| 1991 |
Karsten WE, Viola RE. Chemical and kinetic mechanisms of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Biochimica Et Biophysica Acta. 1077: 209-19. PMID 1673060 DOI: 10.1016/0167-4838(91)90060-D |
0.514 |
|
| 1991 |
Viola RE. Twelfth Enzyme Mechanisms Conference Bioorganic Chemistry. 19: 190-224. DOI: 10.1016/0045-2068(91)90034-M |
0.463 |
|
| 1990 |
Angeles TS, Viola RE. The kinetic mechanisms of the bifunctional enzyme aspartokinase-homoserine dehydrogenase I from Escherichia coli. Archives of Biochemistry and Biophysics. 283: 96-101. PMID 2241177 DOI: 10.1016/0003-9861(90)90617-8 |
0.491 |
|
| 1989 |
Furumo NC, Viola RE. Aluminum-adenine nucleotides as alternate substrates for creatine kinase. Archives of Biochemistry and Biophysics. 275: 33-9. PMID 2817903 DOI: 10.1016/0003-9861(89)90346-9 |
0.374 |
|
| 1989 |
Angeles TS, Smanik PA, Borders CL, Viola RE. Aspartokinase-homoserine dehydrogenase I from Escherichia coli: pH and chemical modification studies of the kinase activity. Biochemistry. 28: 8771-7. PMID 2557908 DOI: 10.1021/Bi00448A014 |
0.52 |
|
| 1989 |
Furumo NC, Viola RE. Inhibition of phosphoryl-transferring enzymes by aluminum-ATP Inorganic Chemistry. 28: 820-823. DOI: 10.1021/Ic00304A005 |
0.409 |
|
| 1988 |
Falzone CJ, Karsten WE, Conley JD, Viola RE. L-aspartase from Escherichia coli: substrate specificity and role of divalent metal ions. Biochemistry. 27: 9089-93. PMID 2853974 DOI: 10.1021/Bi00426A004 |
0.472 |
|
| 1986 |
Karsten WE, Gates RB, Viola RE. Kinetic studies of L-aspartase from Escherichia coli: substrate activation. Biochemistry. 25: 1299-303. PMID 3516219 DOI: 10.1021/Bi00354A016 |
0.455 |
|
| 1985 |
Karsten WE, Hunsley JR, Viola RE. Purification of aspartase and aspartokinase-homoserine dehydrogenase I from Escherichia coli by dye-ligand chromatography Analytical Biochemistry. 147: 336-341. PMID 3893216 DOI: 10.1016/0003-2697(85)90280-5 |
0.506 |
|
| 1984 |
Viola RE. Kinetic studies of the reactions catalyzed by glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides: pH variation of kinetic parameters. Archives of Biochemistry and Biophysics. 228: 415-24. PMID 6696439 DOI: 10.1016/0003-9861(84)90005-5 |
0.355 |
|
| 1984 |
Bose RN, Cornelius RD, Viola RE. Platinum(II)-catalyzed hydrolysis of pyrophosphate and triphosphate: Phosphorus-31 NMR characterization of kinetic intermediates [1] Inorganic Chemistry. 23: 1181-1182. DOI: 10.1002/Chin.198429004 |
0.329 |
|
| 1983 |
Viola RE, Shaw RW, Ransom SC, Villafranca JJ. Solvent proton relaxation studies of cytochrome c oxidase solutions. Archives of Biochemistry and Biophysics. 220: 106-15. PMID 6299195 DOI: 10.1016/0003-9861(83)90392-2 |
0.541 |
|
| 1982 |
Viola RE, Cleland WW. Initial velocity analysis for terreactant mechanisms. Methods in Enzymology. 87: 353-66. PMID 7176920 DOI: 10.1016/S0076-6879(82)87021-3 |
0.533 |
|
| 1982 |
Viola RE, Raushel FM, Rendina AR, Cleland WW. Substrate synergism and the kinetic mechanism of yeast hexokinase. Biochemistry. 21: 1295-302. PMID 7041974 DOI: 10.1021/Bi00535A029 |
0.675 |
|
| 1980 |
Viola RE, Morrison JF, Cleland WW. Interaction of metal(III)-adenosine 5'-triphosphate complexes with yeast hexokinase. Biochemistry. 19: 3131-7. PMID 6996699 DOI: 10.1021/Bi00555A003 |
0.541 |
|
| 1980 |
Viola RE, Cleland WW. Aldehyde-induced adenosine triphosphatase activities of fructose 6-phosphate and fructose kinases. Biochemistry. 19: 1861-6. PMID 6246937 DOI: 10.1021/Bi00550A600 |
0.519 |
|
| 1979 |
Viola RE, Cook PF, Cleland WW. Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis. Analytical Biochemistry. 96: 334-40. PMID 224725 DOI: 10.1016/0003-2697(79)90590-6 |
0.578 |
|
| 1979 |
Viola RE, Hartzell CR, Villafranca JJ. Copper(II) complexes of carnosine, glycylglycine, and glycylglycine-imidazole mixtures Journal of Inorganic Biochemistry. 10: 293-307. DOI: 10.1016/S0162-0134(00)80196-8 |
0.544 |
|
| 1978 |
Viola RE, Cleland WW. Use of pH studies to elucidate the chemical mechanism of yeast hexokinase. Biochemistry. 17: 4111-7. PMID 30473 DOI: 10.1021/Bi00613A001 |
0.489 |
|
| 1976 |
Viola RE, Hartzell CR, Villafranca JJ. Temperature Dependence of the EPR Spectrum of Copper(II)- carnosine Journal of Coordination Chemistry. 6: 119-121. DOI: 10.1080/00958977608079895 |
0.512 |
|
| 1974 |
Villafranca JJ, Viola RE. Proton nuclear magnetic resonance studies of the manganese (II) binding site of concanavalin A. Effect of saccharides on the solvent relaxation rates. Archives of Biochemistry and Biophysics. 165: 51-9. PMID 4441085 DOI: 10.1016/0003-9861(74)90140-4 |
0.538 |
|
| 1974 |
Villafranca JJ, Viola RE. The use of 13C spin lattice relaxation times to study the interaction of alpha-methyl-D-glucopyranoside with concanavalin A. Archives of Biochemistry and Biophysics. 160: 465-8. PMID 4364767 DOI: 10.1016/0003-9861(74)90422-6 |
0.534 |
|
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