| Year |
Citation |
Score |
| 2021 |
Mak S, Li W, Fu H, Luo J, Cui W, Hu S, Pang Y, Carlier PR, Tsim KW, Pi R, Han Y. Promising tacrine/huperzine A- based dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. Journal of Neurochemistry. PMID 33930191 DOI: 10.1111/jnc.15379 |
0.563 |
|
| 2020 |
Chen Q, Tu Y, Mak S, Chen J, Lu J, Chen C, Yang X, Wang S, Wen S, Ma S, Li M, Han Y, Wah-Keung Tism K, Pi R. Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo. European Journal of Pharmacology. 173361. PMID 32673674 DOI: 10.1016/J.Ejphar.2020.173361 |
0.362 |
|
| 2020 |
Lu J, Chen C, Deng X, Mak MS, Zhu Z, He X, Liang J, Maddili SK, Tsim KWK, Han Y, Pi R. Design, synthesis, and biological evaluation of novel multifunctional Rolipram-Tranilast hybrids as potential treatment for traumatic brain injury. Acs Chemical Neuroscience. PMID 32644771 DOI: 10.1021/Acschemneuro.0C00339 |
0.317 |
|
| 2020 |
Hu S, Xian Y, Fan Y, Mak S, Wang J, Tang J, Pang Y, Pi R, Tsim KW, Liu F, Lin Z, Han Y. Significant combination of Aβ aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer's agent. European Journal of Pharmacology. 173065. PMID 32171792 DOI: 10.1016/J.Ejphar.2020.173065 |
0.367 |
|
| 2020 |
Liu Z, Qiu X, Shinghung MAK, Guo B, Hu S, Wang J, Luo F, Xu D, Sun Y, Zhang G, Cui G, Wang Y, Zhang Z, Han Y. Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway. Chemico-Biological Interactions. 109020. PMID 32092300 DOI: 10.1016/J.Cbi.2020.109020 |
0.419 |
|
| 2020 |
Mak S, Liu Z, Wu L, Guo B, Luo F, Liu Z, Hu S, Wang J, Cui G, Sun Y, Wang Y, Zhang G, Han Y, Zhang Z. Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in vitro and in vivo. Acs Chemical Neuroscience. PMID 31922720 DOI: 10.1021/Acschemneuro.9B00242 |
0.359 |
|
| 2019 |
Zuo X, Hu S, Tang Y, Zhan L, Sun W, Zheng J, Han Y, Xu E. Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer. Neuropharmacology. 107786. PMID 31726074 DOI: 10.1016/J.Neuropharm.2019.107786 |
0.338 |
|
| 2019 |
Li HQ, Ip SP, Yuan QJ, Zheng GQ, Kw Tsim K, Tx Dong T, Lin G, Han Y, Liu Y, Xian YF, Lin ZX. Isorhynchophylline Ameliorates Cognitive Impairment via Modulating Amyloid Pathology, Tau Hyperphosphorylation and Neuroinflammation: Studies in a Transgenic Mouse Model of Alzheimer's Disease. Brain, Behavior, and Immunity. PMID 31476414 DOI: 10.1016/J.Bbi.2019.08.194 |
0.353 |
|
| 2019 |
Luo F, Wu L, Zhang Z, Zhu Z, Liu Z, Guo B, Li N, Ju J, Zhou Q, Li S, Yang X, Mak S, Han Y, Sun Y, Wang Y, et al. A dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid hemorrhage models. British Journal of Pharmacology. PMID 31180578 DOI: 10.1111/Bph.14763 |
0.326 |
|
| 2018 |
Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak S, Carlier PR, Cui W, Han Y. Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice. Frontiers in Cellular Neuroscience. 12: 396. PMID 30483056 DOI: 10.3389/Fncel.2018.00396 |
0.308 |
|
| 2018 |
Hu S, Mak S, Zuo X, Li H, Wang Y, Han Y. Neuroprotection Against MPP-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From . Frontiers in Pharmacology. 9: 768. PMID 30072894 DOI: 10.3389/Fphar.2018.00768 |
0.39 |
|
| 2018 |
Qian S, He L, Wang Q, Wong YC, Mak M, Ho CY, Han Y, Zuo Z. Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease. Life Sciences. PMID 29966606 DOI: 10.1016/J.Lfs.2018.06.032 |
0.323 |
|
| 2018 |
Hu S, Hu H, Mak S, Cui G, Lee M, Shan L, Wang Y, Lin H, Zhang Z, Han Y. A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of-Methyl-D-aspartate Receptor. Frontiers in Pharmacology. 9: 73. PMID 29483871 DOI: 10.3389/fphar.2018.00073 |
0.308 |
|
| 2017 |
Chen L, Huang C, Shentu J, Wang M, Yan S, Zhou F, Zhang Z, Wang C, Han Y, Wang Q, Cui W. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Frontiers in Molecular Neuroscience. 10: 393. PMID 29234273 DOI: 10.3389/Fnmol.2017.00393 |
0.373 |
|
| 2017 |
Chen J, Yin W, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Pi R. L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation. European Journal of Pharmacology. PMID 28320516 DOI: 10.1016/J.Ejphar.2017.03.025 |
0.321 |
|
| 2017 |
Chen J, Sun Z, Jin M, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Pi R. Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway. Journal of Neuroimmunology. 305: 108-114. PMID 28284330 DOI: 10.1016/J.Jneuroim.2017.02.010 |
0.324 |
|
| 2016 |
Chen Z, Digiacomo M, Tu Y, Gu Q, Wang S, Yang X, Chu J, Chen Q, Han Y, Chen J, Nesi G, Sestito S, Macchia M, Rapposelli S, Pi R. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. European Journal of Medicinal Chemistry. 125: 784-792. PMID 27736684 DOI: 10.1016/J.Ejmech.2016.09.052 |
0.341 |
|
| 2016 |
Zheng CY, Guo BJ, Cai W, Cui W, Mak SH, Wang YQ, Lee SM, Han YF, Zhang ZJ. No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice. Neural Regeneration Research. 11: 1339-1346. PMID 27651784 DOI: 10.4103/1673-5374.189201 |
0.358 |
|
| 2016 |
Hu S, Wang L, Mak S, Zhang Z, Xu D, Li H, Li Y, Hu Y, Lee SM, Wang Y, Han Y. Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine. Neuromolecular Medicine. PMID 27277280 DOI: 10.1007/s12017-016-8399-5 |
0.311 |
|
| 2016 |
Guo B, Zheng C, Cheng J, Wang H, Cai W, Sun Y, Cui W, Wang Y, Han YF, Lee SM, Zhang Z. Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of Agricultural and Food Chemistry. PMID 27245668 DOI: 10.1021/Acs.Jafc.6B01707 |
0.397 |
|
| 2016 |
Gao XY, Wang SN, Yang XH, Lan WJ, Chen ZW, Chen JK, Xie JH, Han YF, Pi RB, Yang XB. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochemical Research. PMID 27161377 DOI: 10.1007/S11064-016-1941-X |
0.423 |
|
| 2016 |
Han Y, Lin J, Liu Y, Fu H, Ma Y, Jin P, Tan J. Crackle template based metallic mesh with highly homogeneous light transmission for high-performance transparent EMI shielding. Scientific Reports. 6: 25601. PMID 27151578 DOI: 10.1038/srep25601 |
0.427 |
|
| 2016 |
Cheng Y, Tse HF, Li X, Han Y, Rong J. Gallic acid-l-leucine (GAL) conjugate enhances macrophage phagocytosis via inducing leukotriene B4 12-hydroxydehydrogenase (LTB4DH) expression. Molecular Immunology. 74: 39-46. PMID 27148819 DOI: 10.1016/J.Molimm.2016.04.012 |
0.325 |
|
| 2016 |
Wang SN, Li Q, Jing MH, Alba E, Yang XH, Sabaté R, Han YF, Pi RB, Lan WJ, Yang XB, Chen JK. Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease. Neurochemical Research. PMID 27038926 DOI: 10.1007/S11064-016-1896-Y |
0.373 |
|
| 2016 |
Cheng Y, Xia Z, Han Y, Rong J. Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3β Phosphorylation. Oxidative Medicine and Cellular Longevity. 2016: 2060874. PMID 27034732 DOI: 10.1155/2016/2060874 |
0.311 |
|
| 2015 |
Fu H, Gu ZT, Fang WT, Fu JH, Shen Y, Han YT, Yu ZT, Li Y, Tan LJ, Pang LW, Chen KN. Long-Term Survival After Surgical Treatment of Thymic Carcinoma: A Retrospective Analysis from the Chinese Alliance for Research of Thymoma Database. Annals of Surgical Oncology. PMID 26474558 DOI: 10.1245/s10434-015-4825-4 |
0.425 |
|
| 2015 |
Zhou XY, Zhu FM, Li JP, Mao W, Zhang DM, Liu ML, Hei AL, Dai DP, Jiang P, Shan XY, Zhang BW, Zhu CF, Shen J, Deng ZH, Wang ZL, ... ... Han Y, et al. High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program. Plos One. 10: e0139485. PMID 26421847 DOI: 10.1371/Journal.Pone.0139485 |
0.426 |
|
| 2015 |
Zhao Y, Xu P, Hu S, Du L, Xu Z, Zhang H, Cui W, Mak S, Xu D, Shen J, Han Y, Liu Y, Xue M. TanshinoneⅡA，a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation. European Journal of Pharmacology. PMID 26363255 DOI: 10.1016/J.Ejphar.2015.09.006 |
0.359 |
|
| 2015 |
Hu S, Cui W, Zhang Z, Mak S, Xu D, Li G, Hu Y, Wang Y, Lee M, Tsim KW, Han Y. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. Journal of Molecular Neuroscience : Mn. PMID 26346600 DOI: 10.1007/S12031-015-0638-Y |
0.442 |
|
| 2015 |
Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang Y, ... ... Han Y, et al. Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Scientific Reports. 5: 10256. PMID 26194093 DOI: 10.1038/Srep10256 |
0.594 |
|
| 2015 |
Hu S, Cui W, Mak S, Xu D, Hu Y, Tang J, Choi C, Lee M, Pang YP, Han Y. Substantial neuroprotective and neurite outgrowth-promoting activities by bis(propyl)-cognitin via the activation of alpha7-nAChR, a promising anti-Alzheimer's dimer. Acs Chemical Neuroscience. PMID 26147504 DOI: 10.1021/acschemneuro.5b00108 |
0.307 |
|
| 2015 |
Wang L, Zhang X, Chan JY, Shan L, Cui G, Cui Q, Wang Y, Li J, Chen H, Zhang Q, Yu P, Han Y, Wang Y, Lee SM. A novel danshensu derivative prevents cardiac dysfunction and improves the chemotherapeutic efficacy of doxorubicin in breast cancer cells. Journal of Cellular Biochemistry. PMID 26058377 DOI: 10.1002/Jcb.25253 |
0.332 |
|
| 2015 |
Chen HY, Xu DP, Tan GL, Cai W, Zhang GX, Cui W, Wang JZ, Long C, Sun YW, Yu P, Tsim KW, Zhang ZJ, Han YF, Wang YQ. A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine. Journal of Molecular Neuroscience : Mn. PMID 25982925 DOI: 10.1007/S12031-015-0566-X |
0.358 |
|
| 2015 |
Zhang Z, Li G, Szeto SS, Chong CM, Quan Q, Huang C, Cui W, Guo B, Wang Y, Han Y, Michael Siu KW, Yuen Lee SM, Chu IK. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radical Biology & Medicine. 84: 331-43. PMID 25769424 DOI: 10.1016/J.Freeradbiomed.2015.02.030 |
0.402 |
|
| 2015 |
Du WJ, Guo JJ, Gao MT, Hu SQ, Dong XY, Han YF, Liu FF, Jiang S, Sun Y. Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. Scientific Reports. 5: 7992. PMID 25613018 DOI: 10.1038/Srep07992 |
0.327 |
|
| 2015 |
Digiacomo M, Chen Z, Wang S, Lapucci A, Macchia M, Yang X, Chu J, Han Y, Pi R, Rapposelli S. Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD. Bioorganic & Medicinal Chemistry Letters. 25: 807-10. PMID 25597007 DOI: 10.1016/J.Bmcl.2014.12.084 |
0.356 |
|
| 2015 |
Hu S, Wang R, Cui W, Zhang Z, Mak S, Xu D, Choi C, Tsim KW, Carlier PR, Lee M, Han Y. Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. Journal of Molecular Neuroscience : Mn. 55: 1014-21. PMID 25407821 DOI: 10.1007/S12031-014-0458-5 |
0.368 |
|
| 2014 |
Wang H, Han YF, Chan YS, He J. Stimulus-specific adaptation at the synapse level in vitro. Plos One. 9: e114537. PMID 25486252 DOI: 10.1371/Journal.Pone.0114537 |
0.325 |
|
| 2014 |
Qian S, He L, Mak M, Han Y, Ho CY, Zuo Z. Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. International Journal of Pharmaceutics. 477: 442-53. PMID 25445524 DOI: 10.1016/J.Ijpharm.2014.10.058 |
0.35 |
|
| 2014 |
Fu H, Zhang Y, Wang X, Han Y, Peng X, Efferth T, Fu Y. Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin. Molecules (Basel, Switzerland). 19: 17715-26. PMID 25365296 DOI: 10.3390/molecules191117715 |
0.488 |
|
| 2014 |
Xu DP, Zhang K, Zhang ZJ, Sun YW, Guo BJ, Wang YQ, Hoi PM, Han YF, Lee SM. A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways. Neurochemistry International. 78: 76-85. PMID 25217805 DOI: 10.1016/J.Neuint.2014.09.001 |
0.31 |
|
| 2014 |
Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF, Pi RB. Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway. Cns Neuroscience & Therapeutics. 20: 840-50. PMID 24922524 DOI: 10.1111/Cns.12286 |
0.432 |
|
| 2014 |
Mak S, Luk WW, Cui W, Hu S, Tsim KW, Han Y. Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. Journal of Molecular Neuroscience : Mn. 53: 511-6. PMID 24793543 DOI: 10.1007/S12031-014-0288-5 |
0.342 |
|
| 2014 |
Cui W, Zhang ZJ, Hu SQ, Mak SH, Xu DP, Choi CL, Wang YQ, Tsim WK, Lee MY, Rong JH, Han YF. Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction. Cns Neuroscience & Therapeutics. 20: 244-52. PMID 24393200 DOI: 10.1111/Cns.12203 |
0.427 |
|
| 2014 |
Xu D, Duan H, Zhang Z, Cui W, Wang L, Sun Y, Lang M, Hoi PM, Han Y, Wang Y, Lee SM. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 245-58. PMID 24233519 DOI: 10.1007/S11481-013-9514-0 |
0.378 |
|
| 2013 |
Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF. Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway. Cns Neuroscience & Therapeutics. 19: 764-72. PMID 23826635 DOI: 10.1111/cns.12141 |
0.301 |
|
| 2013 |
Hu S, Cui W, Mak S, Tang J, Choi C, Pang Y, Han Y. Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways. Neurochemistry International. 62: 468-77. PMID 23357479 DOI: 10.1016/J.Neuint.2013.01.022 |
0.442 |
|
| 2013 |
Liu H, Han Y, Fu H, Liu M, Wu J, Chen X, Zhang S, Chen Y. Construction and expression of sTRAIL-melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli. Applied Microbiology and Biotechnology. 97: 2877-84. PMID 23149754 DOI: 10.1007/s00253-012-4541-y |
0.514 |
|
| 2013 |
Cui W, Hu S, Chan HH, Luo J, Li W, Mak S, Choi TC, Rong J, Carlier PR, Han Y. Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. Chemico-Biological Interactions. 203: 365-70. PMID 23085120 DOI: 10.1016/J.Cbi.2012.10.003 |
0.421 |
|
| 2013 |
Cui W, Zhang Z, Li W, Hu S, Mak S, Zhang H, Han R, Yuan S, Li S, Sa F, Xu D, Lin Z, Zuo Z, Rong J, Ma ED, ... ... Han Y, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. British Journal of Pharmacology. 168: 1201-14. PMID 23062100 DOI: 10.1111/Bph.12004 |
0.428 |
|
| 2013 |
Chang I, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Choi TC, Pang Y, Anwyl R, Han Y, Wang Q. Protection against beta-amyloid–induced synaptic impairments via promotion of beta-amyloid oligomer aggregation by bis(heptyl)-cognitin Alzheimers & Dementia. 9: 299-300. DOI: 10.1016/J.Jalz.2013.05.612 |
0.516 |
|
| 2012 |
Cui W, Zhang Z, Li W, Mak S, Hu S, Zhang H, Yuan S, Rong J, Choi TC, Lee SM, Han Y. Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. Plos One. 7: e46253. PMID 23049997 DOI: 10.1371/Journal.Pone.0046253 |
0.431 |
|
| 2012 |
Yao L, Li W, She H, Dou J, Jia L, He Y, Yang Q, Zhu J, Cápiro NL, Walker DI, Pennell KD, Pang Y, Liu Y, Han Y, Mao Z. Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects Journal of Biological Chemistry. 287: 34246-34255. PMID 22891246 DOI: 10.1074/Jbc.M112.367540 |
0.387 |
|
| 2012 |
Zhang Z, Cui W, Li G, Yuan S, Xu D, Hoi MP, Lin Z, Dou J, Han Y, Lee SM. Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways. Journal of Agricultural and Food Chemistry. 60: 8171-82. PMID 22838648 DOI: 10.1021/Jf301511M |
0.409 |
|
| 2012 |
Pi R, Mao X, Chao X, Cheng Z, Liu M, Duan X, Ye M, Chen X, Mei Z, Liu P, Li W, Han Y. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. Plos One. 7: e31921. PMID 22384101 DOI: 10.1371/Journal.Pone.0031921 |
0.376 |
|
| 2012 |
Qi H, Han Y, Rong J. Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation. Neuropharmacology. 62: 1659-70. PMID 22146407 DOI: 10.1016/J.Neuropharm.2011.11.012 |
0.326 |
|
| 2011 |
Zhao Y, Dou J, Luo J, Li W, Chan HH, Cui W, Zhang H, Han R, Carlier PR, Zhang X, Han Y. Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets. Brain Research. 1421: 100-9. PMID 21978549 DOI: 10.1016/J.Brainres.2011.09.014 |
0.39 |
|
| 2011 |
Zhang H, Mak S, Cui W, Li W, Han R, Hu S, Ye M, Pi R, Han Y. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry International. 59: 981-8. PMID 21939707 DOI: 10.1016/J.Neuint.2011.09.001 |
0.393 |
|
| 2011 |
Cui W, Li W, Han R, Mak S, Zhang H, Hu S, Rong J, Han Y. PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry International. 59: 945-53. PMID 21781996 DOI: 10.1016/J.Neuint.2011.07.005 |
0.378 |
|
| 2011 |
Hu S, Han R, Mak S, Han Y. Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. Journal of Ethnopharmacology. 135: 34-42. PMID 21349320 DOI: 10.1016/J.Jep.2011.02.017 |
0.367 |
|
| 2011 |
Cui W, Li W, Zhao Y, Mak S, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han Y. Preventing Hâ‚‚Oâ‚‚-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. Brain Research. 1394: 14-23. PMID 21315693 DOI: 10.1016/J.Brainres.2011.02.006 |
0.408 |
|
| 2010 |
Luo J, Li W, Zhao Y, Fu H, Ma DL, Tang J, Li C, Peoples RW, Li F, Wang Q, Huang P, Xia J, Pang Y, Han Y. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. The Journal of Biological Chemistry. 285: 19947-58. PMID 20404346 DOI: 10.1074/Jbc.M110.111286 |
0.585 |
|
| 2010 |
Dou J, Li X, Cai Y, Chen H, Zhu S, Wang Q, Zou X, Mei Y, Yang Q, Li W, Han Y. Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway. International Journal of Hematology. 91: 620-9. PMID 20376580 DOI: 10.1007/S12185-010-0560-6 |
0.357 |
|
| 2010 |
Choi RC, Zhu JT, Leung KW, Chu GK, Xie HQ, Chen VP, Zheng KY, Lau DT, Dong TT, Chow PC, Han YF, Wang ZT, Tsim KW. A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons: signaling transduction and drug development for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 795-811. PMID 20157237 DOI: 10.3233/Jad-2010-1293 |
0.399 |
|
| 2010 |
Qi H, Wei L, Han Y, Zhang Q, Lau AS, Rong J. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. International Journal of Oncology. 36: 725-35. PMID 20126993 DOI: 10.3892/Ijo_00000548 |
0.302 |
|
| 2010 |
Qi H, Siu SO, Chen Y, Han Y, Chu IK, Tong Y, Lau AS, Rong J. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Chemico-Biological Interactions. 183: 380-9. PMID 19961840 DOI: 10.1016/J.Cbi.2009.11.029 |
0.333 |
|
| 2009 |
Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. European Journal of Pharmacology. 623: 14-21. PMID 19765582 DOI: 10.1016/J.Ejphar.2009.09.013 |
0.601 |
|
| 2009 |
Chen X, Lan X, Mo S, Qin J, Li W, Liu P, Han Y, Pi R. p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochemical and Biophysical Research Communications. 379: 944-8. PMID 19138669 DOI: 10.1016/J.Bbrc.2008.12.177 |
0.319 |
|
| 2009 |
Li W, Mak M, Jiang H, Wang Q, Pang Y, Chen K, Han Y. Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 187-201. PMID 19110209 DOI: 10.1016/J.Nurt.2008.10.040 |
0.36 |
|
| 2008 |
Lin R, Chen X, Li W, Han Y, Liu P, Pi R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neuroscience Letters. 440: 344-7. PMID 18583042 DOI: 10.1016/J.Neulet.2008.05.070 |
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| 2008 |
Zhao Y, Li W, Chow PC, Lau DT, Lee NT, Pang Y, Zhang X, Wang X, Han Y. Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia. Neuroscience Letters. 439: 160-4. PMID 18515007 DOI: 10.1016/J.Neulet.2008.05.007 |
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| 2008 |
Hu Q, Fu H, Ren T, Wang S, Zhou W, Song H, Han Y, Dong S. Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups. Neurotoxicology. 29: 675-81. PMID 18499259 DOI: 10.1016/j.neuro.2008.04.002 |
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Liu YW, Li CY, Luo JL, Li WM, Fu HJ, Lao YZ, Liu LJ, Pang YP, Chang DC, Li ZW, Peoples RW, Ai YX, Han YF. Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. Biochemical and Biophysical Research Communications. 369: 1007-11. PMID 18328812 DOI: 10.1016/J.Bbrc.2008.02.133 |
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Fu H, Dou J, Li W, Luo J, Li KC, Lam CS, Lee NT, Li M, Han Y. Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms. Neuropharmacology. 54: 755-65. PMID 18222492 DOI: 10.1016/J.Neuropharm.2007.12.003 |
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Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochemical and Biophysical Research Communications. 366: 631-6. PMID 18039469 DOI: 10.1016/J.Bbrc.2007.11.068 |
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Luo J, Li W, Liu Y, Zhang W, Fu H, Lee NT, Yu H, Pang Y, Huang P, Xia J, Li ZW, Li C, Han Y. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochemical and Biophysical Research Communications. 361: 505-9. PMID 17655827 DOI: 10.1016/J.Bbrc.2007.07.043 |
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| 2007 |
Fu H, Li W, Liu Y, Lao Y, Liu W, Chen C, Yu H, Lee NT, Chang DC, Li P, Pang Y, Tsim KW, Li M, Han Y. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. Journal of Proteome Research. 6: 2435-46. PMID 17530875 DOI: 10.1021/Pr060615G |
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Wang W, Yang Y, Ying C, Li W, Ruan H, Zhu X, You Y, Han Y, Chen R, Wang Y, Li M. Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology. 52: 1678-84. PMID 17517424 DOI: 10.1016/J.Neuropharm.2007.03.017 |
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Li W, Xue J, Niu C, Fu H, Lam CS, Luo J, Chan HH, Xue H, Kan KK, Lee NT, Li C, Pang Y, Li M, Tsim KW, Jiang H, ... ... Han Y, et al. Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Molecular Pharmacology. 71: 1258-67. PMID 17299028 DOI: 10.1124/Mol.106.029108 |
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Song B, Ma C, Gong S, Yuan Z, Li D, Liu W, Li W, Chen R, Zhu X, Zeng J, Han Y, Li M. Extracellular signal-regulated kinases are not involved in activity-dependent survival or apoptosis in cerebellar granule neurons. Neuroscience Letters. 407: 214-8. PMID 16973276 DOI: 10.1016/J.Neulet.2006.08.040 |
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Fu H, Li W, Lao Y, Luo J, Lee NT, Kan KK, Tsang HW, Tsim KW, Pang Y, Li Z, Chang DC, Li M, Han Y. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. Journal of Neurochemistry. 98: 1400-10. PMID 16771827 DOI: 10.1111/J.1471-4159.2006.03960.X |
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Deng R, Li W, Guan Z, Zhou JM, Wang Y, Mei YP, Li MT, Feng GK, Huang W, Liu ZC, Han Y, Zeng YX, Zhu XF. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis Oncogene. 25: 7070-7077. PMID 16715131 DOI: 10.1038/Sj.Onc.1209686 |
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Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KW, Li X, Han Y. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport. 17: 471-4. PMID 16543809 DOI: 10.1097/01.Wnr.0000209014.09094.72 |
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Yu Y, Chen B, Chen Z, Fan C, Han Y, Zhang J, He L, Ingram A, Kapoor A, Wang JH, Tang D. Identification of a novel Wee1 isoform. Biochimica Et Biophysica Acta. 1729: 1-9. PMID 15804487 DOI: 10.1016/J.Bbaexp.2005.02.006 |
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Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, ... ... Han Y, et al. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 280: 18179-88. PMID 15710623 DOI: 10.1074/Jbc.M411085200 |
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Shi L, Gong S, Yuan Z, Ma C, Liu Y, Wang C, Li W, Pi R, Huang S, Chen R, Han Y, Mao Z, Li M. Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons. Neuroscience Letters. 375: 7-12. PMID 15664113 DOI: 10.1016/J.Neulet.2004.10.082 |
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Pi R, Li W, Lee NT, Chan HH, Pu Y, Chan LN, Sucher NJ, Chang DC, Li M, Han Y. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. Journal of Neurochemistry. 91: 1219-30. PMID 15569265 DOI: 10.1111/J.1471-4159.2004.02796.X |
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Wang W, Shi L, Xie Y, Ma C, Li W, Su X, Huang S, Chen R, Zhu Z, Mao Z, Han Y, Li M. SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neuroscience Research. 48: 195-202. PMID 14741394 DOI: 10.1016/J.Neures.2003.10.012 |
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Dong Z, Guo X, Chen L, Han Y, Jin G. Dual actions of (−)-stepholidine on the dopamine receptor-mediated adenylate cyclase activity in rat corpus striatum Life Sciences. 61: 465-472. PMID 9244373 DOI: 10.1016/S0024-3205(97)00404-9 |
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