James E. Darnell, Jr., M.D. - Publications

Affiliations: 
1961-1964 Massachusetts Institute of Technology, Cambridge, MA, United States 
 1964-1967 Albert Einstein College of Medicine, New York, New York, United States 
 1967-1974 Columbia University, New York, NY 
 1974- Rockefeller University, New York, NY, United States 
Area:
STATs, development
Website:
https://www.rockefeller.edu/our-scientists/emeritus-faculty/865-james-e-darnell-jr/

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kuśnierczyk A, Klungland A, Darnell JE, Darnell RB. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development. PMID 26404942 DOI: 10.1101/Gad.269415.115  0.507
2011 Schindler C, Shuai K, Prezioso VR, Darnell JE. Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813. Journal of Immunology (Baltimore, Md. : 1950). 187: 5489-94. PMID 22102732  0.687
2008 Betz A, Ryoo HD, Steller H, Darnell JE. STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 13805-10. PMID 18779571 DOI: 10.1073/Pnas.0806291105  0.525
2007 Ginsberg M, Czeko E, Müller P, Ren Z, Chen X, Darnell JE. Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos. Molecular and Cellular Biology. 27: 6300-8. PMID 17636030 DOI: 10.1128/Mcb.00613-07  0.465
2006 Mertens C, Zhong M, Krishnaraj R, Zou W, Chen X, Darnell JE. Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes & Development. 20: 3372-81. PMID 17182865 DOI: 10.1101/Gad.1485406  0.429
2006 Betz A, Darnell JE. A Hopscotch-chromatin connection. Nature Genetics. 38: 977-9. PMID 16941005 DOI: 10.1038/Ng0906-977  0.481
2005 Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W, McMurray JS, Demeler B, Darnell JE, Chen X. Structural bases of unphosphorylated STAT1 association and receptor binding. Molecular Cell. 17: 761-71. PMID 15780933 DOI: 10.1016/J.Molcel.2005.02.021  0.422
2005 Zhong M, Henriksen MA, Takeuchi K, Schaefer O, Liu B, ten Hoeve J, Ren Z, Mao X, Chen X, Shuai K, Darnell JE. Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proceedings of the National Academy of Sciences of the United States of America. 102: 3966-71. PMID 15753310 DOI: 10.1073/Pnas.0501063102  0.702
2003 Chen X, Bhandari R, Vinkemeier U, Van Den Akker F, Darnell JE, Kuriyan J. A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Science : a Publication of the Protein Society. 12: 361-5. PMID 12538899 DOI: 10.1110/Ps.0218903  0.565
2002 Henriksen MA, Betz A, Fuccillo MV, Darnell JE. Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. Genes & Development. 16: 2379-89. PMID 12231627 DOI: 10.1101/Gad.1020702  0.56
2001 Betz A, Lampen N, Martinek S, Young MW, Darnell JE. A Drosophila PIAS homologue negatively regulates stat92E. Proceedings of the National Academy of Sciences of the United States of America. 98: 9563-8. PMID 11504941 DOI: 10.1073/Pnas.171302098  0.549
1999 Kuriyan J, Darnell JE. An SH2 domain in disguise. Nature. 398: 22-3, 25. PMID 10078523 DOI: 10.1038/17916  0.454
1998 Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE, Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 93: 827-39. PMID 9630226 DOI: 10.1016/S0092-8674(00)81443-9  0.587
1998 Vinkemeier U, Moarefi I, Darnell JE, Kuriyan J. Structure of the amino-terminal protein interaction domain of STAT-4. Science (New York, N.Y.). 279: 1048-52. PMID 9461439 DOI: 10.1126/Science.279.5353.1048  0.509
1996 Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. The Embo Journal. 15: 5616-26. PMID 8896455 DOI: 10.1002/J.1460-2075.1996.Tb00946.X  0.492
1996 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics. 14: 95-7. PMID 8782827 DOI: 10.1038/Ng0996-95  0.665
1995 Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE, Mui AL, Miyajima A, Quelle FW, Ihle JN. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics. 29: 225-8. PMID 8530075 DOI: 10.1006/Geno.1995.1235  0.393
1995 Schindler C, Darnell JE. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annual Review of Biochemistry. 64: 621-51. PMID 7574495 DOI: 10.1146/annurev.bi.64.070195.003201  0.439
1994 Improta T, Schindler C, Horvath CM, Kerr IM, Stark GR, Darnell JE. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 4776-80. PMID 8197134 DOI: 10.1073/Pnas.91.11.4776  0.484
1994 Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell. 76: 821-8. PMID 7510216 DOI: 10.1016/0092-8674(94)90357-3  0.742
1993 Pearse RN, Feinman R, Shuai K, Darnell JE, Ravetch JV. Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proceedings of the National Academy of Sciences of the United States of America. 90: 4314-8. PMID 8483949  0.662
1993 Sadowski HB, Shuai K, Darnell JE, Gilman MZ. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (New York, N.Y.). 261: 1739-44. PMID 8397445 DOI: 10.1126/Science.8397445  0.647
1993 Kanno Y, Kozak CA, Schindler C, Driggers PH, Ennist DL, Gleason SL, Darnell JE, Ozato K. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Molecular and Cellular Biology. 13: 3951-63. PMID 8321202 DOI: 10.1128/Mcb.13.7.3951  0.464
1993 Müller M, Laxton C, Briscoe J, Schindler C, Improta T, Darnell JE, Stark GR, Kerr IM. Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. The Embo Journal. 12: 4221-8. PMID 7693454 DOI: 10.1002/j.1460-2075.1993.tb06106.x  0.455
1993 Shuai K, Stark GR, Kerr IM, Darnell JE. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (New York, N.Y.). 261: 1744-6. PMID 7690989 DOI: 10.1126/Science.7690989  0.676
1993 Khan KD, Shuai K, Lindwall G, Maher SE, Darnell JE, Bothwell AL. Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proceedings of the National Academy of Sciences of the United States of America. 90: 6806-10. PMID 7688129 DOI: 10.1073/PNAS.90.14.6806  0.732
1993 Shuai K, Ziemiecki A, Wilks AF, Harpur AG, Sadowski HB, Gilman MZ, Darnell JE. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature. 366: 580-3. PMID 7504784 DOI: 10.1038/366580A0  0.662
1992 Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE, Levy DE. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Molecular and Cellular Biology. 12: 3315-24. PMID 1630447  0.478
1992 Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 89: 7840-3. PMID 1502204  0.474
1992 Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proceedings of the National Academy of Sciences of the United States of America. 89: 7836-9. PMID 1502203  0.452
1992 Schindler C, Shuai K, Prezioso VR, Darnell JE. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science (New York, N.Y.). 257: 809-13. PMID 1496401 DOI: 10.1126/Science.1496401  0.722
1992 Mirkovitch J, Darnell JE. Mapping of RNA polymerase on mammalian genes in cells and nuclei. Molecular Biology of the Cell. 3: 1085-94. PMID 1384813  0.354
1992 Shuai K, Schindler C, Prezioso VR, Darnell JE. Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (New York, N.Y.). 258: 1808-12. PMID 1281555 DOI: 10.1126/Science.1281555  0.72
1991 Lew DJ, Decker T, Strehlow I, Darnell JE. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Molecular and Cellular Biology. 11: 182-91. PMID 1898761 DOI: 10.1128/mcb.11.1.182-191.1991  0.477
1991 Decker T, Lew DJ, Darnell JE. Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene. Molecular and Cellular Biology. 11: 5147-53. PMID 1833631 DOI: 10.1128/mcb.11.10.5147-5153.1991  0.489
1991 Decker T, Lew DJ, Mirkovitch J, Darnell JE. Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. The Embo Journal. 10: 927-932. DOI: 10.1002/J.1460-2075.1991.Tb08026.X  0.514
1990 Levy D, Lew D, Decker T, Kessler D, Darnell J. Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. The Embo Journal. 9: 1105-1111. DOI: 10.1002/j.1460-2075.1990.tb08216.x  0.476
1989 Xanthopoulos KG, Mirkovitch J, Decker T, Kuo CF, Darnell JE. Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. Proceedings of the National Academy of Sciences of the United States of America. 86: 4117-21. PMID 2726767  0.308
1989 Xanthopoulos KG, Mirkovitch J, Friedman JM, Darnell JE. The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenetics and Cell Genetics. 50: 174-5. PMID 2570675  0.394
1989 Lew DJ, Decker T, Darnell JE. Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. Molecular and Cellular Biology. 9: 5404-11. PMID 2555698 DOI: 10.1128/mcb.9.12.5404-5411.1989  0.499
1989 Decker T, Lew DJ, Cheng YS, Levy DE, Darnell JE. Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. The Embo Journal. 8: 2009-2014. DOI: 10.1002/j.1460-2075.1989.tb03608.x  0.485
1987 Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome. Effect of viral DNA replication on endogenous and exogenous gene transcription. Journal of Molecular Biology. 193: 643-50. PMID 3612788 DOI: 10.1016/0022-2836(87)90347-0  0.47
1987 Friedman JM, Babiss LE, Weiss M, Darnell JE. Hepatoma variants (C2) are defective for transcriptional and post-transcriptional actions from both endogenous and viral genomes. The Embo Journal. 6: 1727-31. PMID 2956094 DOI: 10.1002/J.1460-2075.1987.Tb02424.X  0.463
1986 Babiss LE, Bennett A, Friedman JM, Darnell JE. DNase I-hypersensitive sites in the 5'-flanking region of the rat serum albumin gene: correlation between chromatin structure and transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 6504-8. PMID 3462709 DOI: 10.1073/Pnas.83.17.6504  0.444
1986 Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters. Molecular and Cellular Biology. 6: 3798-806. PMID 2948109 DOI: 10.1128/Mcb.6.11.3798  0.483
1986 Friedman JM, Babiss LE, Clayton DF, Darnell JE. Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Molecular and Cellular Biology. 6: 3791-7. PMID 2948108 DOI: 10.1128/Mcb.6.11.3791  0.472
1984 Friedman JM, Chung EY, Darnell JE. Gene expression during liver regeneration. Journal of Molecular Biology. 179: 37-53. PMID 6502711 DOI: 10.1016/0022-2836(84)90305-X  0.512
1984 Powell DJ, Friedman JM, Oulette AJ, Krauter KS, Darnell JE. Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. Journal of Molecular Biology. 179: 21-35. PMID 6502710 DOI: 10.1016/0022-2836(84)90304-8  0.474
1984 Larner AC, Jonak G, Cheng YS, Korant B, Knight E, Darnell JE. Transcriptional induction of two genes in human cells by beta interferon. Proceedings of the National Academy of Sciences of the United States of America. 81: 6733-7. PMID 6436820 DOI: 10.1073/pnas.81.21.6733  0.311
1984 Citron B, Falck-Pedersen E, Salditt-Georgieff M, Darnell JE. Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse beta-globin (major) gene. Nucleic Acids Research. 12: 8723-31. PMID 6095210 DOI: 10.1093/Nar/12.22.8723  0.305
1983 Salditt-Georgieff M, Darnell JE. A precise termination site in the mouse beta major-globin transcription unit. Proceedings of the National Academy of Sciences of the United States of America. 80: 4694-8. PMID 6192441  0.325
1982 Salditt-Georgieff M, Darnell JE. Further evidence that the majority of primary nuclear RNA transcripts in mammalian cells do not contribute to mRNA. Molecular and Cellular Biology. 2: 701-7. PMID 14582165  0.335
1982 Zeevi M, Nevins JR, Darnell JE. Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid. Molecular and Cellular Biology. 2: 517-25. PMID 6981059 DOI: 10.1128/MCB.2.5.517  0.313
1982 Chen-Kiang S, Wolgemuth DJ, Hsu MT, Darnell JE. Transcription and accurate polyadenylation in vitro of RNA from the major late adenovirus 2 transcription unit. Cell. 28: 575-84. PMID 6280876 DOI: 10.1016/0092-8674(82)90212-4  0.308
1981 Wilson MC, Darnell JE. Control of messenger RNA concentration by differential cytoplasmic half-life. Adenovirus messenger RNAs from transcription units 1A and 1B. Journal of Molecular Biology. 148: 231-51. PMID 7299816  0.459
1981 Derman E, Krauter K, Walling L, Weinberger C, Ray M, Darnell JE. Transcriptional control in the production of liver-specific mRNAs. Cell. 23: 731-9. PMID 7226226 DOI: 10.1016/0092-8674(81)90436-0  0.776
1981 Zeevi M, Nevins JR, Darnell JE. Nuclear RNA is spliced in the absence of poly(A) addition. Cell. 26: 39-46. PMID 6976837 DOI: 10.1016/0092-8674(81)90031-3  0.347
1981 Harpold MM, Wilson MC, Darnell JE. Chinese hamster polyadenylated messenger ribonucleic acid: relationship to non-polyadenylated sequences and relative conservation during messenger ribonucleic acid processing. Molecular and Cellular Biology. 1: 188-98. PMID 6152853  0.478
1981 Salditt-Georgieff M, Harpold MM, Wilson MC, Darnell JE. Large heterogeneous nuclear ribonucleic acid has three times as many 5' caps as polyadenylic acid segments, and most caps do not enter polyribosomes. Molecular and Cellular Biology. 1: 179-87. PMID 6152852  0.487
1980 Babich A, Nevins JR, Darnell JE. Early capping of transcripts from the adenovirus major late transcription unit. Nature. 287: 246-8. PMID 7432461 DOI: 10.1038/287246a0  0.322
1980 Soreq H, Harpold M, Wilson M, Darnell JE. Rate of synthesis and concentration of specific mRNA sequences in cultured Chinese hamster ovary cells compared to liver cells. Biochemical and Biophysical Research Communications. 92: 485-91. PMID 7356477 DOI: 10.1016/0006-291X(80)90359-9  0.45
1980 Wilson MC, Nevins JR, Blanchard JM, Ginsberg HS, Darnell JE. Metabolism of mRNA from the transforming region of adenovirus 2. Cold Spring Harbor Symposia On Quantitative Biology. 44: 447-55. PMID 6933041 DOI: 10.1101/SQB.1980.044.01.048  0.334
1980 Weber J, Blanchard JM, Ginsberg H, Darnell JE. Order of polyadenylic acid addition and splicing events in early adenovirus mRNA formation. Journal of Virology. 33: 286-91. PMID 6245233 DOI: 10.1128/JVI.33.1.286-291.1980  0.355
1980 Salditt-Georgieff M, Harpold M, Sawicki S, Nevins J, Darnell JE. Addition of poly(A) to nuclear RNA occurs soon after RNA synthesis. The Journal of Cell Biology. 86: 844-8. PMID 6157696  0.321
1979 Nevins JR, Ginsberg HS, Blanchard JM, Wilson MC, Darnell JE. Regulation of the primary expression of the early adenovirus transcription units. Journal of Virology. 32: 727-33. PMID 513202 DOI: 10.1128/Jvi.32.3.727-733.1979  0.513
1979 Harpold MM, Dobner PR, Evans R, Bancroft FC, Darnell JE. The synthesis and processing of a nuclear RNA precursor to rat pregrowth hormone messenger RNA. Nucleic Acids Research. 6: 3133-44. PMID 493135 DOI: 10.1093/NAR/6.9.3133  0.504
1979 Harpold MM, Evans RM, Salditt-Georgieff M, Darnell JE. Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell. 17: 1025-35. PMID 487428 DOI: 10.1016/0092-8674(79)90341-6  0.512
1979 Fraser NW, Nevins JR, Ziff E, Darnell JE. The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. Journal of Molecular Biology. 129: 643-56. PMID 480353 DOI: 10.1016/0022-2836(79)90474-1  0.332
1979 Soreq H, Harpold M, Evans R, Darnell JE, Bancroft FC. Rat growth hormone gene: intervening sequences separate the mRNA regions. Nucleic Acids Research. 6: 2471-82. PMID 461195 DOI: 10.1093/Nar/6.7.2471  0.538
1979 Sehgal PB, Fraser NW, Darnell JE. Early Ad-2 transcription units: only promoter-proximal RNA continues to be made in the presence of DRB. Virology. 94: 185-91. PMID 442531 DOI: 10.1016/0042-6822(79)90448-3  0.304
1979 Wilson MC, Fraser NW, Darnell JE. Mapping of RNA initiation sites by high doses of uv irradiation: evidence for three independent promoters within the left 11% of the Ad-2 genome. Virology. 94: 175-84. PMID 442530 DOI: 10.1016/0042-6822(79)90447-1  0.491
1979 Evans R, Weber J, Ziff E, Darnell JE. Premature termination during adenovirus transcription. Nature. 278: 367-70. PMID 423992 DOI: 10.1038/278367A0  0.427
1978 Wilson MC, Sawicki SG, White PA, Darnell JE. A correlation between the rate of poly(A) shortening and half-life of messenger RNA in adenovirus transformed cells. Journal of Molecular Biology. 126: 23-36. PMID 739542  0.453
1978 Nevins JR, Darnell JE. Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell. 15: 1477-93. PMID 729004 DOI: 10.1016/0092-8674(78)90071-5  0.308
1978 Fraser NW, Sehgal PB, Darnell JE. DRB-induced premature termination of late adenovirus transcription. Nature. 272: 590-3. PMID 643052 DOI: 10.1038/272590A0  0.347
1978 Goldberg S, Nevins J, Darnell JE. Evidence from UV transcription mapping that late adenovirus type 2 mRNA is derived from a large precursor molecule. Journal of Virology. 25: 806-10. PMID 642074 DOI: 10.1128/jvi.25.3.806-810.1978  0.317
1978 Wilson MC, Sawicki SG, Salditt-Georgieff M, Darnell JE. Adenovirus type 2 mRNA in transformed cells: map positions and difference in transport time. Journal of Virology. 25: 97-103. PMID 621789  0.423
1978 Darnell JE. Implications of RNA-RNA splicing in evolution of eukaryotic cells. Science (New York, N.Y.). 202: 1257-60. PMID 364651  0.301
1978 Blanchard JM, Weber J, Jelinek W, Darnell JE. In vitro RNA-RNA splicing in adenovirus 2 mRNA formation. Proceedings of the National Academy of Sciences of the United States of America. 75: 5344-8. PMID 281684  0.323
1978 Darnell JE, Evans R, Fraser N, Goldberg S, Nevins J, Salditt-Georgieff M, Schwartz H, Weber J, Ziff E. The definition of transcription units for mRNA. Cold Spring Harbor Symposia On Quantitative Biology. 42: 515-22. PMID 277360 DOI: 10.1101/Sqb.1978.042.01.054  0.489
1978 Jelinek W, Evans R, Wilson M, Salditt-Georgieff M, Darnell JE. Oligonucleotides in heterogeneous nuclear RNA: similarity of inverted repeats and RNA from repetitious DNA sites. Biochemistry. 17: 2776-83. PMID 99161 DOI: 10.1021/Bi00607A012  0.421
1977 Evans RM, Fraser N, Ziff E, Weber J, Wilson M, Darnell JE. The initiation sites for RNA transcription in Ad2 DNA. Cell. 12: 733-9. PMID 922890 DOI: 10.1016/0092-8674(77)90273-2  0.497
1977 Puckett L, Darnell JE. Essential factors in the kinetic analysis of RNA synthesis in HeLa cells. Journal of Cellular Physiology. 90: 521-34. PMID 853064 DOI: 10.1002/jcp.1040900315  0.336
1976 Sehgal PB, Darnell JE, Tamm I. The inhibition by DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells. Cell. 9: 473-80. PMID 1086720 DOI: 10.1016/0092-8674(76)90092-1  0.313
1976 Derman E, Goldberg S, Darnell JE. hnRNA in HeLa cells: distribution of transcript sizes estimated from nascent molecule profile. Cell. 9: 465-72. PMID 991275  0.775
1976 Sehgal PB, Derman E, Molloy GR, Tamm I, Darnell JE. 5,6-Dichloro-1-Beta-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneous RNA chains in HeLa cells. Science (New York, N.Y.). 194: 431-3. PMID 982026 DOI: 10.1126/Science.982026  0.782
1976 Bachenheimer S, Darnell JE. Hybridization of mRNA from adenovirus-transformed cells to segments of the adenovirus genome. Journal of Virology. 19: 286-9. PMID 950687  0.321
1976 Darnell JE, Jelinek W, Puckett L, Derman E, Bachenheimer S. Biochemical events in mRNA formation in mammalian cells. The Symposium / the Society For Developmental Biology. Society For Developmental Biology. Symposium. 53-74. PMID 798344  0.764
1975 Bachenheimer S, Darnell JE. Adenovirus-2 mRNA is transcribed as part of a high-molecular-weight precursor RNA. Proceedings of the National Academy of Sciences of the United States of America. 72: 4445-9. PMID 1060124 DOI: 10.1073/PNAS.72.11.4445  0.306
1974 Derman E, Darnell JE. Relationship of chain transcription to poly(A) addition and processing of hnRNA in HeLa cells. Cell. 3: 255-64. PMID 4434473 DOI: 10.1016/0092-8674(74)90140-8  0.758
1973 Wall R, Weber J, Gage Z, Darnell JE. Production of viral mRNA in adenovirus- transformed cells by the post- transcriptional processing of heterogeneous nuclear RNA containing viral and cell sequences. Journal of Virology. 11: 953-60. PMID 4736534  0.331
1972 Molloy GR, Thomas WL, Darnell JE. Occurrence of uridylate-rich oligonucleotide regions in heterogeneous nuclear RNA of HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 69: 3684-8. PMID 4509331  0.321
1972 Jelinek W, Darnell JE. Double-stranded regions in heterogeneous nuclear RNA from Hela cells. Proceedings of the National Academy of Sciences of the United States of America. 69: 2537-41. PMID 4506771  0.313
1971 Philipson L, Wall R, Glickman G, Darnell JE. Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. Proceedings of the National Academy of Sciences of the United States of America. 68: 2806-9. PMID 5315962 DOI: 10.1073/Pnas.68.11.2806  0.321
1971 Darnell JE, Philipson L, Wall R, Adesnik M. Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA. Science (New York, N.Y.). 174: 507-10. PMID 5110429 DOI: 10.1126/Science.174.4008.507  0.328
1970 Darnell JE, Balint R. The distribution of rapidly hybridizing RNA sequences in heterogeneous nuclear RNA and mRNA from HeLa cells. Journal of Cellular Physiology. 76: 349-56. PMID 5502353 DOI: 10.1002/jcp.1040760312  0.316
1970 Pagoulatos GN, Darnell JE. A comparison of the heterogeneous nuclear RNA of HeLa cells in different periods of the cell growth cycle. The Journal of Cell Biology. 44: 476-83. PMID 5415232 DOI: 10.1083/Jcb.44.3.476  0.425
1970 Soeiro R, Darnell JE. A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization. The Journal of Cell Biology. 44: 467-75. PMID 5415231 DOI: 10.1083/Jcb.44.3.467  0.706
1970 Lindberg U, Darnell JE. SV40-specific RNA in the nucleus and polyribosomes of transformed cells. Proceedings of the National Academy of Sciences of the United States of America. 65: 1089-96. PMID 4314900 DOI: 10.1073/Pnas.65.4.1089  0.569
1970 Darnell JE, Pagoulatos GN, Lindberg U, Balint R. Studies on the Relationship of mRNA to Heterogeneous Nuclear RNA in Mammalian Cells Cold Spring Harbor Symposia On Quantitative Biology. 35: 555-560. DOI: 10.1101/SQB.1970.035.01.071  0.325
1969 Strauss JH, Burge BW, Darnell JE. Sindbis virus infection of chick and hamster cells: Synthesis of virus-specific proteins Virology. 37: 367-376. PMID 5777557 DOI: 10.1016/0042-6822(69)90220-7  0.309
1969 Pene JJ, Knight E, Darnell JE. Characterization of a new low molecular weight RNA in HeLa cell ribosomes. Journal of Molecular Biology. 33: 609-23. PMID 5700415 DOI: 10.1016/0022-2836(68)90309-4  0.352
1969 Soeiro R, Darnell JE. Competition hybridization by "pre-saturation" of HeLa cell DNA. Journal of Molecular Biology. 44: 551-62. PMID 5388124 DOI: 10.1016/0022-2836(69)90379-9  0.693
1969 Maden BE, Vaughan MH, Warner JR, Darnell JE. Effects of valine deprivation on ribosome formation in HeLa cells. Journal of Molecular Biology. 45: 265-75. PMID 5367028 DOI: 10.1016/0022-2836(69)90104-1  0.8
1969 Bernhardt D, Darnell JE. tRNA synthesis in HeLa cells: a precursor to tRNA and the effects of methionine starvation on tRNA synthesis. Journal of Molecular Biology. 42: 43-56. PMID 4185508 DOI: 10.1016/0022-2836(69)90485-9  0.342
1968 Soeiro R, Vaughan MH, Darnell JE. The effect of puromycin on intranuclear steps in ribosome biosynthesis. The Journal of Cell Biology. 36: 91-101. PMID 19866729 DOI: 10.1083/Jcb.36.1.91  0.693
1968 Soeiro R, Vaughan MH, Darnell JE. The effect of puromycin on intranuclear steps in ribosome biosynthesis. The Journal of Cell Biology. 36: 91-101. PMID 19806696 DOI: 10.1083/jcb.36.1.91  0.664
1968 Soeiro R, Vaughan MH, Warner JR, Darnell JE. The turnover of nuclear DNA-like RNA in HeLa cells. The Journal of Cell Biology. 39: 112-8. PMID 5678443 DOI: 10.1083/Jcb.39.1.112  0.761
1968 Dubnau D, Kanan E, Mindich L, Novick R, Smith I, Darnell J, Hurwitz J, Rubin H, Abbott J, Holtzman E, Zipser D, Beckwith J, Gorini L, Sager R, Duerksen J, et al. A Moral Duty Bioscience. 18: 367-368. DOI: 10.2307/1294112  0.714
1967 Knight E, Darnell JE. Distribution of 5 s RNA in HeLa cells. Journal of Molecular Biology. 28: 491-502. PMID 6052648 DOI: 10.1016/S0022-2836(67)80099-8  0.414
1967 Vaughan MH, Warner JR, Darnell JE. Ribosomal precursor particles in the HeLa cell nucleus. Journal of Molecular Biology. 25: 235-51. PMID 6034101 DOI: 10.1016/0022-2836(67)90140-4  0.564
1967 Vaughan MH, Soeiro R, Warner JR, Darnell JE. The effects of methionine deprivation on ribosome synthesis in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 58: 1527-34. PMID 5237886 DOI: 10.1073/Pnas.58.4.1527  0.741
1967 Birnboim HC, Pène JJ, Darnell JE. Studies on HeLa cell nuclear DNA-like RNA by RNA-DNA hybridization. Proceedings of the National Academy of Sciences of the United States of America. 58: 320-7. PMID 5231612 DOI: 10.1073/Pnas.58.1.320  0.459
1967 Summers DF, Maizel JV, Darnell JE. The decrease in size and synthetic activity of poliovirus polysomes late in the infectious cycle. Virology. 31: 427-35. PMID 4290171 DOI: 10.1016/0042-6822(67)90222-X  0.4
1967 Girard M, Baltimore D, Darnell JE. The poliovirus replication complex: Site for synthesis of poliovirus RNA Journal of Molecular Biology. 24: 59-74. DOI: 10.1016/0022-2836(67)90090-3  0.556
1966 Warner JR, Girard M, Latham H, Darnell JE. Ribosome formation in HeLa cells in the absence of protein synthesis. Journal of Molecular Biology. 19: 373-82. PMID 5969072 DOI: 10.1016/S0022-2836(66)80011-6  0.656
1966 Soeiro R, Birnboim HC, Darnell JE. Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. Journal of Molecular Biology. 19: 362-72. PMID 5969071  0.66
1966 Warner JR, Soeiro R, Birnboim HC, Girard M, Darnell JE. Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. Journal of Molecular Biology. 19: 349-61. PMID 5969070 DOI: 10.1016/S0022-2836(66)80009-8  0.749
1966 Baltimore D, Girard M, Darnell JE. Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology. 29: 179-89. PMID 4287327 DOI: 10.1016/0042-6822(66)90024-9  0.538
1966 Summers DF, Maizel JV, Darnell JE. Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 54: 505-13. PMID 4285933 DOI: 10.1073/PNAS.54.2.505  0.301
1965 GIRARD M, LATHAM H, PENMAN S, DARNELL JE. ENTRANCE OF NEWLY FORMED MESSENGER RNA AND RIBOSOMES INTO HELA CELL CYTOPLASM. Journal of Molecular Biology. 11: 187-201. PMID 14290358 DOI: 10.1016/S0022-2836(65)80050-X  0.566
1964 PENMAN S, BECKER Y, DARNELL JE. A CYTOPLASMIC STRUCTURE INVOLVED IN THE SYNTHESIS AND ASSEMBLY OF POLIOVIRUS COMPONENTS. Journal of Molecular Biology. 8: 541-55. PMID 14153525 DOI: 10.1016/S0022-2836(64)80010-3  0.561
1964 GIRARD M, PENMAN S, DARNELL JE. THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLS. Proceedings of the National Academy of Sciences of the United States of America. 51: 205-11. PMID 14124318 DOI: 10.1073/Pnas.51.2.205  0.505
1964 BALTIMORE D, BECKER Y, DARNELL JE. VIRUS-SPECIFIC DOUBLE-STRANDED RNA IN POLIOVIRUS-INFECTED CELLS. Science (New York, N.Y.). 143: 1034-6. PMID 14107425 DOI: 10.1126/Science.143.3610.1034  0.484
1963 Penman S, Scherrer K, Becker Y, Darnell JE. POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA. Proceedings of the National Academy of Sciences of the United States of America. 49: 654-62. PMID 16591084 DOI: 10.1073/Pnas.49.5.654  0.675
1963 BECKER Y, PENMAN S, DARNELL JE. A CYTOPLASMIC PARTICULATE INVOLVED IN POLIOVIRUS SYNTHESIS. Virology. 21: 274-6. PMID 14070183 DOI: 10.1016/0042-6822(63)90271-X  0.472
1963 WARNER J, MADDEN MJ, DARNELL JE. The interaction of poliovirus RNA with Escherichia coli ribosomes. Virology. 19: 393-9. PMID 13998949  0.578
1963 SCHERRER K, LATHAM H, DARNELL JE. Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 49: 240-8. PMID 13991616 DOI: 10.1073/Pnas.49.2.240  0.586
1963 Darnell JE, Penman S, Scherrer K, Becker Y. A Description of Various Classes of RNA from HeLa Cells Cold Spring Harbor Symposia On Quantitative Biology. 28: 211-214. DOI: 10.1101/Sqb.1963.028.01.034  0.681
1962 SCHERRER K, DARNELL JE. Sedimentation characteristics of rapidly labelled RNA from HeLa cells. Biochemical and Biophysical Research Communications. 7: 486-90. PMID 14498283 DOI: 10.1016/0006-291X(62)90341-8  0.579
1962 LEVINTOW L, THOREN MM, DARNELL JE, HOOPER JL. Effect of p-fluorophenylalanine and puromycin on the replication of poliovirus. Virology. 16: 220-9. PMID 14464692 DOI: 10.1016/0042-6822(62)90241-6  0.308
1960 DARNELL JE, EAGLE H. The biosynthesis of poliovirus in cell cultures. Advances in Virus Research. 7: 1-26. PMID 13719801 DOI: 10.1016/S0065-3527(08)60004-4  0.502
1959 DARNELL JE, EAGLE H, SAWYER TK. The effect of cell population density on the amino acid requirements for poliovirus synthesis in HeLa cells. The Journal of Experimental Medicine. 110: 445-50. PMID 13814142 DOI: 10.1084/Jem.110.3.445  0.486
1958 DARNELL JE, EAGLE H. Glucose and glutamine in poliovirus production by HeLa cells. Virology. 6: 556-66. PMID 13593191 DOI: 10.1016/0042-6822(58)90102-8  0.458
1956 GLASER RJ, THOMAS WA, MORSE SI, DARNELL JE. The incidence and pathogenesis of myocarditis in rabbits after group A streptococcal pharyngeal infections. The Journal of Experimental Medicine. 103: 173-88. PMID 13278463 DOI: 10.1084/Jem.103.1.173  0.586
1955 MORSE SI, DARNELL JE, THOMAS WA, GLASER RJ. Cardiac lesions in rabbits after pharyngeal infections with group A streptococci. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 89: 613-6. PMID 13254842 DOI: 10.3181/00379727-89-21892  0.587
1955 DARNELL JE, PESCH BB, GLASER RJ. Effect of penicillin on group A streptococci in vivo in the absence of leucocytes. The Journal of Clinical Investigation. 34: 1237-41. PMID 13242655 DOI: 10.1172/Jci103169  0.577
1954 MORSE SI, DARNELL JE, GLASER RJ. Production of streptococcal infections in pharynx of rabbit. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 87: 582-5. PMID 13237313 DOI: 10.3181/00379727-87-21451  0.588
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