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Samuel F. Bakhoum, Ph.D. - Publications

Affiliations: 
2009 Biochemistry Dartmouth College, Hanover, NH, United States 
Area:
Cell Biology
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Di Bona M, Bakhoum SF. Micronuclei and Cancer. Cancer Discovery. 14: 214-226. PMID 38197599 DOI: 10.1158/2159-8290.CD-23-1073  0.432
2023 Agustinus AS, Al-Rawi D, Dameracharla B, Raviram R, Jones BSCL, Stransky S, Scipioni L, Luebeck J, Di Bona M, Norkunaite D, Myers RM, Duran M, Choi S, Weigelt B, Yomtoubian S, ... ... Bakhoum SF, et al. Epigenetic dysregulation from chromosomal transit in micronuclei. Nature. PMID 37286593 DOI: 10.1038/s41586-023-06084-7  0.412
2023 Lin YF, Hu Q, Mazzagatti A, Valle-Inclán JE, Maurais EG, Dahiya R, Guyer A, Sanders JT, Engel JL, Nguyen G, Bronder D, Bakhoum SF, Cortés-Ciriano I, Ly P. Mitotic clustering of pulverized chromosomes from micronuclei. Nature. PMID 37165191 DOI: 10.1038/s41586-023-05974-0  0.477
2023 Bakhoum SF. Targeting the undruggable. Science (New York, N.Y.). 380: 47. PMID 37023189 DOI: 10.1126/science.adg7671  0.409
2023 Kimmel GJ, Beck RJ, Yu X, Veith T, Bakhoum S, Altrock PM, Andor N. Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction. Plos Computational Biology. 19: e1010815. PMID 36689467 DOI: 10.1371/journal.pcbi.1010815  0.383
2022 Agustinus AS, Bakhoum S. Biochemical, genomic, and epigenomic profiling of isolated cancer cell lines' micronuclei. Methods in Cell Biology. 172: 51-66. PMID 36064226 DOI: 10.1016/bs.mcb.2022.07.001  0.425
2022 Bakhoum SF. cGAS-STING and the deadly CIN: how chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers. Trends in Cancer. PMID 35915014 DOI: 10.1016/j.trecan.2022.07.006  0.382
2022 Al-Rawi DH, Bakhoum SF. Chromosomal instability as a source of genomic plasticity. Current Opinion in Genetics & Development. 74: 101913. PMID 35526333 DOI: 10.1016/j.gde.2022.101913  0.442
2021 Bakhoum MF, Francis JH, Agustinus A, Earlie EM, Di Bona M, Abramson DH, Duran M, Masilionis I, Molina E, Shoushtari AN, Goldbaum MH, Mischel PS, Bakhoum SF, Laughney AM. Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. Nature Communications. 12: 5402. PMID 34518527 DOI: 10.1038/s41467-021-25529-z  0.419
2021 Venkatesan S, Angelova M, Puttick C, Zhai H, Caswell DR, Lu WT, Dietzen M, Galanos P, Evangelou K, Bellelli R, Lim EL, Watkins TBK, Rowan A, Teixeira VH, Zhao Y, ... ... Bakhoum SF, et al. Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution. Cancer Discovery. PMID 33947663 DOI: 10.1158/2159-8290.CD-20-0725  0.358
2020 Watkins TBK, Lim EL, Petkovic M, Elizalde S, Birkbak NJ, Wilson GA, Moore DA, Grönroos E, Rowan A, Dewhurst SM, Demeulemeester J, Dentro SC, Horswell S, Au L, Haase K, ... ... Bakhoum SF, et al. Pervasive chromosomal instability and karyotype order in tumour evolution. Nature. PMID 32879494 DOI: 10.1038/S41586-020-2698-6  0.537
2020 Schonhoft JD, Zhao JL, Jendrisak A, Carbone EA, Barnett ES, Hullings MA, Gill A, Sutton R, Lee J, Dago AE, Landers M, Bakhoum SF, Wang Y, Gonen M, Dittamore R, et al. Morphology-predicted large scale transition number in circulating tumor cells identifies a chromosomal instability biomarker associated with poor outcome in castration-resistant prostate cancer. Cancer Research. PMID 32816908 DOI: 10.1158/0008-5472.Can-20-1216  0.487
2020 Bronder D, Bakhoum SF. A CINful way to overcome addiction: how chromosomal instability enables cancer to overcome its oncogene addiction. Embo Molecular Medicine. 12: e12017. PMID 32072755 DOI: 10.15252/Emmm.202012017  0.514
2019 Kwon J, Bakhoum SF. The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer. Cancer Discovery. PMID 31852718 DOI: 10.1158/2159-8290.Cd-19-0761  0.333
2018 Elizalde S, Laughney AM, Bakhoum SF. A Markov chain for numerical chromosomal instability in clonally expanding populations. Plos Computational Biology. 14: e1006447. PMID 30204765 DOI: 10.1371/Journal.Pcbi.1006447  0.574
2018 Bakhoum SF, Cantley LC. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment. Cell. 174: 1347-1360. PMID 30193109 DOI: 10.1016/J.Cell.2018.08.027  0.582
2018 Loh PR, Genovese G, Handsaker RE, Finucane HK, Reshef YA, Palamara PF, Birmann BM, Talkowski ME, Bakhoum SF, McCarroll SA, Price AL. Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations. Nature. PMID 29995854 DOI: 10.1038/S41586-018-0321-X  0.458
2018 Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. PMID 29342134 DOI: 10.1038/Nature25432  0.702
2018 Bakhoum SF, Ngo B, Bakhoum AL, Cavallo J, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBk, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, et al. Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ng03  0.564
2018 Bakhoum SF. Abstract CN01-02: Chromosomal instability as a driver of tumor metastasis Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Cn01-02  0.562
2017 Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H. Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities. Trends in Cancer. 3: 225-234. PMID 28718433 DOI: 10.1016/J.Trecan.2017.02.001  0.816
2017 Bakhoum SF, Landau DA. Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution. Cold Spring Harbor Perspectives in Medicine. PMID 28213433 DOI: 10.1101/Cshperspect.A029611  0.485
2017 Bakhoum S, Ngo B, Bakhoum A, Cavallo-Fleming J, Murphy C, Powell S, Cantley L. Radiation-Induced Activation of Innate Immune Pathways from Errors in Mitosis International Journal of Radiation Oncology*Biology*Physics. 99: S201. DOI: 10.1016/J.Ijrobp.2017.06.500  0.302
2016 Taunk NK, Laughney A, Ghossein R, Lee N, Chung C, Bakhoum SF. The Relationship of Numerical Chromosomal Instability With Clinical Characteristics and Outcomes in Head and Neck Cancers Treated With Multimodality Therapy. International Journal of Radiation Oncology, Biology, Physics. 96: E594. PMID 27675110 DOI: 10.1016/J.Ijrobp.2016.06.2117  0.416
2015 Laughney AM, Elizalde S, Genovese G, Bakhoum SF. Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution. Cell Reports. 12: 809-20. PMID 26212324 DOI: 10.1016/J.Celrep.2015.06.065  0.565
2015 Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature Communications. 6: 5990. PMID 25606712 DOI: 10.1038/Ncomms6990  0.824
2015 Laughney A, Murnane J, Genovese G, Elizalde S, Compton D, Kabeche L, Spratt D, Zaki B, Bakhoum S. Targeting the Process of Mitotic Chromosome Segregation as a Novel Sensitizing Target to Radiation Treatment International Journal of Radiation Oncology*Biology*Physics. 93: S50. DOI: 10.1016/J.Ijrobp.2015.07.122  0.778
2014 Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA. DNA-damage response during mitosis induces whole-chromosome missegregation. Cancer Discovery. 4: 1281-9. PMID 25107667 DOI: 10.1158/2159-8290.Cd-14-0403  0.817
2014 Bakhoum SF, Swanton C. Chromosomal instability, aneuploidy, and cancer. Frontiers in Oncology. 4: 161. PMID 24995162 DOI: 10.3389/Fonc.2014.00161  0.616
2014 Zaki BI, Suriawinata AA, Eastman AR, Garner KM, Bakhoum SF. Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy. Cancer. 120: 1733-42. PMID 24604319 DOI: 10.1002/Cncr.28656  0.554
2014 Bakhoum SF, Silkworth WT, Nardi IK, Nicholson JM, Compton DA, Cimini D. The mitotic origin of chromosomal instability. Current Biology : Cb. 24: R148-9. PMID 24556433 DOI: 10.1016/J.Cub.2014.01.019  0.763
2014 Bakhoum S, Zaki B, Compton D, Kabeche L. DNA Damage Response During Mitosis Induces Cancer Chromosomal Instability International Journal of Radiation Oncology*Biology*Physics. 90: S780. DOI: 10.1016/J.Ijrobp.2014.05.2257  0.763
2013 Zaki B, Suriawinata A, Bakhoum S. Chromosome Segregation Errors Predict Pathological Response of Rectal Adenocarcinoma to Chemoradiation International Journal of Radiation Oncology*Biology*Physics. 87: S188-S189. DOI: 10.1016/J.Ijrobp.2013.06.486  0.454
2013 Bakhoum S, Kabeche L, Wood M, Suriawinata A, Louie R, Chan D, Petritsch C, Murnane J, Compton D, Zaki B. A Mitotic Pathway for Radiation-Induced Genome Damage International Journal of Radiation Oncology*Biology*Physics. 87: S637. DOI: 10.1016/J.Ijrobp.2013.06.1684  0.753
2012 Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. The Journal of Clinical Investigation. 122: 1138-43. PMID 22466654 DOI: 10.1172/Jci59954  0.717
2012 Bakhoum SF, Compton DA. Kinetochores and disease: keeping microtubule dynamics in check! Current Opinion in Cell Biology. 24: 64-70. PMID 22196931 DOI: 10.1016/J.Ceb.2011.11.012  0.741
2012 Bakhoum SF, Danilova O, Kaur P, Levy N, Thompson SL, Compton DA. Abstract 4600: Examining the selective contribution of chromosomal instability to tumor evolution and prognosis Cancer Research. 72: 4600-4600. DOI: 10.1158/1538-7445.Am2012-4600  0.752
2012 Bakhoum S, Zaki B, Compton D. Examining the Cellular Mechanisms of Chromosomal Instability as Means for Enhanced Radiation-induced Cytotoxicity International Journal of Radiation Oncology*Biology*Physics. 84: S665-S666. DOI: 10.1016/J.Ijrobp.2012.07.1777  0.713
2011 Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA. Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 7704-11. PMID 22184286 DOI: 10.1158/1078-0432.Ccr-11-2049  0.741
2010 Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. The Embo Journal. 29: 3531-43. PMID 20852589 DOI: 10.1038/Emboj.2010.230  0.806
2010 Thompson SL, Bakhoum SF, Compton DA. Mechanisms of chromosomal instability. Current Biology : Cb. 20: R285-95. PMID 20334839 DOI: 10.1016/J.Cub.2010.01.034  0.759
2009 Kollu S, Bakhoum SF, Compton DA. Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells. Current Biology : Cb. 19: 2108-13. PMID 19931454 DOI: 10.1016/J.Cub.2009.10.056  0.766
2009 Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Current Biology : Cb. 19: 1937-42. PMID 19879145 DOI: 10.1016/J.Cub.2009.09.055  0.76
2009 Bakhoum SF, Compton DA. Cancer: CINful centrosomes. Current Biology : Cb. 19: R642-5. PMID 19674544 DOI: 10.1016/J.Cub.2009.06.039  0.73
2009 Bakhoum SF, Thompson SL, Manning AL, Compton DA. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nature Cell Biology. 11: 27-35. PMID 19060894 DOI: 10.1038/Ncb1809  0.817
2007 Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Molecular Biology of the Cell. 18: 2970-9. PMID 17538014 DOI: 10.1091/Mbc.E07-02-0110  0.775
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