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Victor M. Darley-Usmar - Publications

Affiliations: 
Pathology University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Cell Biology, Biochemistry
Website:
https://www.uab.edu/medicine/diabetes/faculty/faculty-bios/93-victor-darley-usmar
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302 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Misheva M, Kotzamanis K, Davies LC, Tyrrell VJ, Rodrigues PRS, Benavides GA, Hinz C, Murphy RC, Kennedy P, Taylor PR, Rosas M, Jones SA, McLaren JE, Deshpande S, Andrews R, ... ... Darley-Usmar V, et al. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications. 13: 139. PMID 35013270 DOI: 10.1038/s41467-021-27766-8  0.31
2021 Daneshgar N, Baguley AW, Liang PI, Wu F, Chu Y, Kinter MT, Benavides GA, Johnson MS, Darley-Usmar V, Zhang J, Chan KS, Dai DF. Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants. Communications Biology. 4: 1200. PMID 34671066 DOI: 10.1038/s42003-021-02730-w  0.357
2020 Fil D, Chacko BK, Conley R, Ouyang X, Zhang J, Darley-Usmar VM, Zuberi AR, Lutz CM, Napierala M, Napierala JS. Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. Disease Models & Mechanisms. PMID 32586831 DOI: 10.1242/Dmm.045229  0.375
2020 Mia S, Kane MS, Latimer MN, Reitz CJ, Sonkar R, Benavides GA, Smith SR, Frank SJ, Martino TA, Zhang J, Darley-Usmar V, Young ME. Differential Effects of REV-ERBa/b Agonism on Cardiac Gene Expression, Metabolism, and Contractile Function in a Mouse Model of Circadian Disruption. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32357113 DOI: 10.1152/Ajpheart.00709.2019  0.341
2020 Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal J, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, et al. Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxidants & Redox Signaling. PMID 32064894 DOI: 10.1089/Ars.2019.7808  0.381
2020 Shin B, Benavides GA, Geng J, Koralov SB, Hu H, Darley-Usmar VM, Harrington LE. Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells. Cell Reports. 30: 1898-1909.e4. PMID 32049019 DOI: 10.1016/J.Celrep.2020.01.022  0.371
2020 Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, ... ... Darley-Usmar VM, et al. Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell Reports. 30: 1798-1810.e4. PMID 32049011 DOI: 10.1016/J.Celrep.2020.01.039  0.332
2020 Yeung C, Gibson AE, Issaq SH, Oshima N, Yohe ME, Lei H, Rai G, Urban DJ, Johnson MS, Benevides GA, Squadrito GL, Eldridge S, Hamre J, Mendoza A, Shern JF, ... ... Darley-Usmar VM, et al. Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Pr08  0.345
2019 Hill BG, Shiva S, Ballinger S, Zhang J, Darley-Usmar VM. Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine. Biological Chemistry. 401: 3-29. PMID 31815377 DOI: 10.1515/Hsz-2019-0268  0.356
2019 Smith MR, Chacko BK, Johnson MS, Benavides GA, Uppal K, Go YM, Jones DP, Darley-Usmar VM. A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human platelets. Redox Biology. 28: 101311. PMID 31546171 DOI: 10.1016/J.Redox.2019.101311  0.346
2019 Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J, ... ... Darley-Usmar V, et al. Targeting glycolysis through inhibition of lactate dehydrogenase impairs tumor growth in preclinical models of Ewing sarcoma. Cancer Research. PMID 31431459 DOI: 10.1158/0008-5472.Can-19-0217  0.327
2019 Ernst P, Xu N, Qu J, Chen H, Goldberg MS, Darley-Usmar V, Zhang JJ, O'Rourke B, Liu X, Zhou L. Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision. Biophysical Journal. PMID 31400914 DOI: 10.1016/J.Bpj.2019.06.038  0.431
2019 Abraham A, Qiu S, Chacko BK, Li H, Paterson A, He J, Agarwal P, Shah M, Welner R, Darley-Usmar VM, Bhatia R. SIRT1 regulates metabolism and leukemogenic potential in CML stem cells. The Journal of Clinical Investigation. 130. PMID 31180336 DOI: 10.1172/Jci127080  0.373
2019 Shanmugam G, Challa AK, Litovsky SH, Devarajan A, Wang D, Jones DP, Darley-Usmar VM, Rajasekaran NS. Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice. Redox Biology. 101212. PMID 31155513 DOI: 10.1016/J.Redox.2019.101212  0.355
2019 Spurlock B, Gupta P, Basu MK, Mukherjee A, Hjelmeland AB, Darley-Usmar V, Parker D, Foxall ME, Mitra K. New quantitative approach reveals heterogeneity in mitochondrial structure-function relations in tumor initiating cells. Journal of Cell Science. PMID 30910831 DOI: 10.1242/Jcs.230755  0.386
2019 Chacko BK, Smith MR, Johnson MS, Benavides G, Culp ML, Pilli J, Shiva S, Uppal K, Go YM, Jones DP, Darley-Usmar VM. Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets. Redox Biology. 22: 101165. PMID 30877854 DOI: 10.1016/J.Redox.2019.101165  0.39
2019 Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins HE, Zhang J, Darley-Usmar V, Chatham JC. Acute increases in O-GlcNAc indirectly impairs mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover. American Journal of Physiology. Cell Physiology. PMID 30865517 DOI: 10.1152/Ajpcell.00491.2018  0.377
2019 Chacko B, Culp ML, Bloomer J, Phillips J, Kuo YF, Darley-Usmar V, Singal AK. Feasibility of cellular bioenergetics as a biomarker in porphyria patients. Molecular Genetics and Metabolism Reports. 19: 100451. PMID 30740306 DOI: 10.1016/J.Ymgmr.2019.100451  0.433
2019 Goh KY, He L, Song J, Jinno M, Rogers AJ, Sethu P, Halade G, Soorappan RN, Liu X, Prabhu SD, Darley-Usmar V, Wende AR, Zhou L. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox Biology. 21: 101100. PMID 30641298 DOI: 10.1016/J.Redox.2019.101100  0.346
2019 Kurundkar D, Kurundkar AR, Bone NB, Becker EJ, Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. Jci Insight. 4. PMID 30626741 DOI: 10.1172/Jci.Insight.120722  0.343
2018 Paredes F, Lassègue B, Williams HC, Faidley EA, Benavides GA, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A. Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway. Proceedings of the National Academy of Sciences of the United States of America. PMID 30042216 DOI: 10.1073/Pnas.1807968115  0.312
2018 Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokland T, Ouyang X, Zhang J, Duncan SR, Thannickal VJ, Darley-Usmar VM, et al. Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells. Redox Biology. 18: 54-64. PMID 29986209 DOI: 10.1016/J.Redox.2018.06.009  0.368
2018 Gardinassi LG, Arévalo-Herrera M, Herrera S, Cordy RJ, Tran V, Smith MR, Johnson MS, Chacko B, Liu KH, Darley-Usmar VM, Go YM, Jones DP, Galinski MR, Li S. Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling. Redox Biology. 17: 158-170. PMID 29698924 DOI: 10.1016/J.Redox.2018.04.011  0.328
2018 Redmann M, Benavides GA, Wani WY, Berryhill TF, Ouyang X, Johnson MS, Ravi S, Mitra K, Barnes S, Darley-Usmar VM, Zhang J. Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture. Redox Biology. 17: 59-69. PMID 29677567 DOI: 10.1016/J.Redox.2018.04.005  0.411
2018 Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A. Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29434038 DOI: 10.1073/Pnas.1720693115  0.411
2018 Peliciari-Garcia RA, Darley-Usmar V, Young ME. An Overview of the Emerging Interface Between Cardiac Metabolism, Redox Biology and the Circadian Clock. Free Radical Biology & Medicine. PMID 29432800 DOI: 10.1016/J.Freeradbiomed.2018.02.013  0.317
2018 Zhang J, Culp ML, Craver JG, Darley-Usmar V. Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease. Journal of Neurochemistry. PMID 29341130 DOI: 10.1111/Jnc.14308  0.381
2018 Abraham A, Qiu S, Chacko BK, Li H, Paterson AJ, He J, Agarwal P, Shah M, Welner RS, Darley-Usmar VM, Bhatia R. SIRT1 Mediates Enhanced Mitochondrial Oxidative Phosphorylation in Chronic Myelogenous Leukemia Stem Cells Blood. 132: 932-932. DOI: 10.1182/Blood-2018-99-115709  0.416
2018 Smith MR, Chacko B, Johnson M, Benavides G, Uppal K, Darley-Usmar V, Go Y, Jones D. Metabolome-wide association study in human platelets for identification of metabolic signatures related to precision medicine Free Radical Biology and Medicine. 128: S93. DOI: 10.1016/J.Freeradbiomed.2018.10.218  0.361
2018 Xing D, Darley-Usmar V, Benavides G. Effects of nitric oxide and sulfide donors on stored platelet bioenergetics Free Radical Biology and Medicine. 128: S44. DOI: 10.1016/J.Freeradbiomed.2018.10.069  0.417
2017 Dodson M, Wani W, Redmann M, Benavides GA, Johnson MS, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J. Regulation of autophagy, mitochondrial dynamics and cellular bioenergetics by 4-hydroxynonenal in primary neurons. Autophagy. 0. PMID 28837411 DOI: 10.1080/15548627.2017.1356948  0.443
2017 McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Dale Abel E, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, et al. Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. Journal of Molecular and Cellular Cardiology. PMID 28736261 DOI: 10.1016/J.Yjmcc.2017.07.005  0.31
2017 Shanmugam G, Narasimhan M, Tamowski S, Darley-Usmar V, Rajasekaran NS. Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium Redox Biology. 12: 937-945. PMID 28482326 DOI: 10.1016/J.Redox.2017.04.038  0.401
2017 Lee JH, Kang M, Wang H, Naik G, Mobley JA, Sonpavde G, Garvey WT, Darley-Usmar VM, Ponnazhagan S. Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28069826 DOI: 10.1096/Fj.201601178R  0.357
2017 Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ. NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-Derived 2-like 2 (Nrf2)-Dependent Pathway. The Journal of Biological Chemistry. PMID 28049732 DOI: 10.1074/Jbc.M116.752261  0.437
2017 Shanmugam G, Narasimhan M, Tamowski S, Darley-Usmar VM, Rajasekaran NS. Cardiac-Specific Constitutive Activation of Nrf2 Induces a Stable Reductive State in Mice Free Radical Biology and Medicine. 112: 121. DOI: 10.1016/J.Freeradbiomed.2017.10.182  0.396
2017 Tran AN, Walker K, Harrison D, Chen W, Mobley J, Sedaka R, Pollock J, Darley-Usmar V, Cooper S, Yancey Gillespie G, Hackey JR, Hocevar L, Hjelmeland A. GTP Cyclohydrolase I in Tumor Initiating Cell Maintenance and Glioblastoma Growth: Functions and Mechanisms Free Radical Biology and Medicine. 112: 104. DOI: 10.1016/J.Freeradbiomed.2017.10.157  0.31
2016 Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J. Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biology. 11: 73-81. PMID 27889640 DOI: 10.1016/J.Redox.2016.11.004  0.406
2016 Chacko BK, Wall SB, Kramer PA, Ravi S, Mitchell T, Johnson MS, Wilson L, Barnes S, Landar A, Darley-Usmar VM. Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils. Redox Biology. 9: 57-66. PMID 27393890 DOI: 10.1016/J.Redox.2016.06.003  0.431
2016 Wende AR, Young ME, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM. Redox Biology and the Interface Between Bioenergetics, Autophagy and Circadian Control of Metabolism. Free Radical Biology & Medicine. PMID 27242268 DOI: 10.1016/J.Freeradbiomed.2016.05.022  0.364
2016 Slatter DA, Aldrovandi M, O'Connor A, Allen SM, Brasher CJ, Murphy RC, Mecklemann S, Ravi S, Darley-Usmar V, O'Donnell VB. Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation. Cell Metabolism. PMID 27133131 DOI: 10.1016/J.Cmet.2016.04.001  0.365
2016 Redmann M, Darley-Usmar V, Zhang J. The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases. Aging and Disease. 7: 150-62. PMID 27114848 DOI: 10.14336/Ad.2015.0820  0.424
2016 Kumar RR, Narasimhan M, Shanmugam G, Hong J, Devarajan A, Palaniappan S, Zhang J, Halade GV, Darley-Usmar VM, Hoidal JR, Rajasekaran NS. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. Journal of Translational Medicine. 14: 86. PMID 27048381 DOI: 10.1186/S12967-016-0839-3  0.343
2016 Shelar SB, Narasimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS. Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26839378 DOI: 10.1096/Fj.201500153  0.312
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Darley-Usmar VM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.314
2016 Lee JH, Kang M, Mobley JA, Sonpavde G, Garvey WT, Darley-Usmar VM, Ponnazhagan S. Abstract 1011: Endostatin regulates androgen receptor-mediated metabolic and oxido-reductive pathways in prostate cancer cells Cancer Research. 76: 1011-1011. DOI: 10.1158/1538-7445.Am2016-1011  0.342
2016 Smith MR, Chako B, Benavides G, Johnson M, Kang YG, Jones D, Darley-Usmar V. Effects of Doxorubicin on Cellular Bioenergetics and Metabolism in Platelets Free Radical Biology and Medicine. 100: S187. DOI: 10.1016/J.Freeradbiomed.2016.10.516  0.336
2016 Benavides GA, Chacko BK, Xing D, Singal AK, Darley-Usmar VM. Susceptibility of Human Platelets, Monocytes, and Neutrophils Bioenergetics to Acetaminophen Free Radical Biology and Medicine. 100: S182. DOI: 10.1016/J.Freeradbiomed.2016.10.477  0.395
2016 Rangarajan S, Locy ML, Larson-Casey JL, Chanda D, Kurundkar D, Kurundkar A, Bernard K, Zmijewski JW, Deshane JS, Darley-Usmar VM, Thannickal VJ. Mitochondrial UCP2 in Age-Related Lung Fibrosis Free Radical Biology and Medicine. 100: S87. DOI: 10.1016/J.Freeradbiomed.2016.10.217  0.34
2015 Chacko BK, Zhi D, Darley-Usmar VM, Mitchell T. The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes. Redox Biology. 8: 43-50. PMID 26748041 DOI: 10.1016/J.Redox.2015.12.008  0.43
2015 Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J. Correction: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. The Biochemical Journal. 471: 431. PMID 26475451 DOI: 10.1042/Bj4710431  0.334
2015 Ravi S, Johnson MS, Chacko BK, Kramer PA, Sawada H, Locy ML, Wilson LS, Barnes S, Marques MB, Darley-Usmar VM. Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism. Free Radical Biology & Medicine. PMID 26475426 DOI: 10.1016/J.Freeradbiomed.2015.10.408  0.382
2015 Ravi S, Chacko B, Kramer PA, Sawada H, Johnson MS, Zhi D, Marques MB, Darley-Usmar VM. Defining the effects of storage on platelet bioenergetics: The role of increased proton leak. Biochimica Et Biophysica Acta. 1852: 2525-34. PMID 26327682 DOI: 10.1016/J.Bbadis.2015.08.026  0.354
2015 Bernard K, Logsdon NJ, Ravi S, Xie N, Persons BP, Rangarajan S, Zimjewski JW, Mitra K, Liu G, Darley-Usmar VM, Thannickal VJ. Metabolic Reprogramming is Required for Myofibroblast Contractility and Differentiation. The Journal of Biological Chemistry. PMID 26318453 DOI: 10.1074/Jbc.M115.646984  0.364
2015 Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J. KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. The Biochemical Journal. 469: 347-55. PMID 26205490 DOI: 10.1042/Bj20150568  0.432
2015 Kramer PA, Chacko BK, George DJ, Zhi D, Wei CC, Dell'Italia LJ, Melby SJ, George JF, Darley-Usmar VM. Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients. Bioscience Reports. 35. PMID 26181371 DOI: 10.1042/Bsr20150161  0.394
2015 Kramer PA, Prichard L, Chacko B, Ravi S, Overton ET, Heath SL, Darley-Usmar V. Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophils. Clinical Science (London, England : 1979). 129: 489-504. PMID 25951298 DOI: 10.1042/Cs20140852  0.418
2015 Kramer PA, Darley-Usmar VM. The Emerging Theme of Redox Bioenergetics in Health and Disease. Biomedical Journal. PMID 25900929 DOI: 10.4103/2319-4170.155591  0.406
2015 Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S. Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation. Free Radical Biology & Medicine. 85: 83-94. PMID 25881550 DOI: 10.1016/J.Freeradbiomed.2015.03.039  0.381
2015 Ravi S, Chacko B, Sawada H, Kramer PA, Johnson MS, Benavides GA, O'Donnell V, Marques MB, Darley-Usmar VM. Metabolic plasticity in resting and thrombin activated platelets. Plos One. 10: e0123597. PMID 25875958 DOI: 10.1371/Journal.Pone.0123597  0.363
2015 Datta G, Kramer PA, Johnson MS, Sawada H, Smythies LE, Crossman DK, Chacko B, Ballinger SW, Westbrook DG, Mayakonda P, Anantharamaiah GM, Darley-Usmar VM, White CR. Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F. The Biochemical Journal. 467: 517-27. PMID 25742174 DOI: 10.1042/Bj20131635  0.37
2015 Jiang S, Park DW, Gao Y, Ravi S, Darley-Usmar V, Abraham E, Zmijewski JW. Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase. Cellular Signalling. 27: 1186-97. PMID 25728513 DOI: 10.1016/J.Cellsig.2015.02.024  0.409
2015 Yancey DM, Guichard JL, Ahmed MI, Zhou L, Murphy MP, Johnson MS, Benavides GA, Collawn J, Darley-Usmar V, Dell'Italia LJ. Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload. American Journal of Physiology. Heart and Circulatory Physiology. 308: H651-63. PMID 25599572 DOI: 10.1152/Ajpheart.00638.2014  0.444
2015 Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, ... ... Darley-Usmar VM, et al. Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. Molecular and Cellular Biology. 35: 831-46. PMID 25535334 DOI: 10.1128/Mcb.01109-14  0.431
2015 Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, Barnes S, Arabshahi A, Dell'Italia LJ, George DJ, Steele C, George JF, Darley-Usmar VM, Melby SJ. Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients. Laboratory Investigation; a Journal of Technical Methods and Pathology. 95: 132-41. PMID 25437645 DOI: 10.1038/Labinvest.2014.144  0.375
2015 Wani WY, Boyer-Guittaut M, Dodson M, Chatham J, Darley-Usmar V, Zhang J. Regulation of autophagy by protein post-translational modification. Laboratory Investigation; a Journal of Technical Methods and Pathology. 95: 14-25. PMID 25365205 DOI: 10.1038/Labinvest.2014.131  0.341
2015 Varghese NE, Shanmugam G, Bolus DJ, Chacko BK, Darley-Usmar VM, Namakkal-Soorappan R. Increased Mitochondrial Biogenesis and Function Is Necessary for Muscle Cell Differentiation Free Radical Biology and Medicine. 87: S131. DOI: 10.1016/J.Freeradbiomed.2015.10.341  0.363
2015 Redmann M, Wani W, Chacko B, Darley-Usmar V, Zhang J. Autophagy as an Essential Antioxidant Pathway in Neuronal Oxidative and Bioenergetic Stress Free Radical Biology and Medicine. 87: S95. DOI: 10.1016/J.Freeradbiomed.2015.10.251  0.35
2014 Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM. The Bioenergetic Health Index: a new concept in mitochondrial translational research. Clinical Science (London, England : 1979). 127: 367-73. PMID 24895057 DOI: 10.1042/Cs20140101  0.695
2014 Boyer-Guittaut M, Poillet L, Liang Q, Bôle-Richard E, Ouyang X, Benavides GA, Chakrama FZ, Fraichard A, Darley-Usmar VM, Despouy G, Jouvenot M, Delage-Mourroux R, Zhang J. The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells. Autophagy. 10: 986-1003. PMID 24879149 DOI: 10.4161/Auto.28390  0.389
2014 Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar V, Zhang J. Mitophagy mechanisms and role in human diseases. The International Journal of Biochemistry & Cell Biology. 53: 127-33. PMID 24842106 DOI: 10.1016/J.Biocel.2014.05.010  0.385
2014 Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, Darley-Usmar VM. Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets. Journal of Visualized Experiments : Jove. PMID 24747339 DOI: 10.3791/51301  0.393
2014 Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM. Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics. Free Radical Biology & Medicine. 71: 196-207. PMID 24681256 DOI: 10.1016/J.Freeradbiomed.2014.03.025  0.421
2014 Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM. A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers. Redox Biology. 2: 206-10. PMID 24494194 DOI: 10.1016/J.Redox.2013.12.026  0.389
2014 Pun PB, Logan A, Darley-Usmar V, Chacko B, Johnson MS, Huang GW, Rogatti S, Prime TA, Methner C, Krieg T, Fearnley IM, Larsen L, Larsen DS, Menger KE, Collins Y, et al. A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes. Free Radical Biology & Medicine. 67: 437-50. PMID 24316194 DOI: 10.1016/J.Freeradbiomed.2013.11.025  0.414
2014 Guichard JL, Benavides GA, Ballinger S, Darley-Usmar VM, DellItalia LJ. MITOCHONDRIAL GENETIC BACKGROUND MODULATES THE MITOCHONDRIAL AND CYTOSKELETAL RESPONSE TO CYCLICAL STRETCH IN ISOLATED ADULT CARDIOMYOCYTES Journal of the American College of Cardiology. 63: A869. DOI: 10.1016/S0735-1097(14)60869-X  0.413
2014 Locy ML, Chacko BK, Wall SB, Kramer PA, Ravi S, Mitchell T, Landar A, Darley-Usmar VM. Role of Reactive Lipid Peroxidation Products in Neutrophil Oxidative Burst Free Radical Biology and Medicine. 76: S150. DOI: 10.1016/J.Freeradbiomed.2014.10.561  0.358
2014 Dodson M, Benavides G, Darley-Usmar V, Zhang J. Metabolic Regulation of Neuronal Bioenergetics and the Autophagic Response to Oxidative Stress Free Radical Biology and Medicine. 76: S22. DOI: 10.1016/J.Freeradbiomed.2014.10.470  0.345
2014 Kramer PA, Prichard L, Chacko B, Ravi S, Turner Overton E, Heath S, Darley-Usmar V. Lymphocyte Metabolic Dysfunction and Immune Suppression by the Neutrophil Oxidative Burst Free Radical Biology and Medicine. 76: S62-S63. DOI: 10.1016/J.Freeradbiomed.2014.10.373  0.333
2014 Bernard K, Ravi S, Logsdon NJ, Persons BP, Darley-Usmar VM, Thannickal VJ. Mitochondrial Biogenesis and Reactive Oxygen Species Sustain TGF-β1-Induced Myofibroblast Differentiation and Activation Free Radical Biology and Medicine. 76: S68. DOI: 10.1016/J.Freeradbiomed.2014.10.337  0.341
2014 Oh J, Honavar J, Doran S, Benavides G, Darley-Usmar VM, Matalon S, Ford D, Patel RP. Chlorinated Fatty Acids Are Biomarkers and Potential Mediators of Chlorine Gas Toxicity Free Radical Biology and Medicine. 76: S165-S166. DOI: 10.1016/J.Freeradbiomed.2014.10.053  0.516
2013 Giordano S, Darley-Usmar V, Zhang J. Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biology. 2: 82-90. PMID 24494187 DOI: 10.1016/J.Redox.2013.12.013  0.427
2013 Grune T, Darley-Usmar V, Aw TY, Lamas S. Off to a good start and a promising future in communicating cutting edge developments in redox biology. Redox Biology. 1: 446-7. PMID 24191239 DOI: 10.1016/J.Redox.2013.09.001  0.392
2013 Dodson M, Liang Q, Johnson MS, Redmann M, Fineberg N, Darley-Usmar VM, Zhang J. Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy. 9: 1996-2008. PMID 24145463 DOI: 10.4161/Auto.26094  0.431
2013 García-Martínez V, Villanueva J, Torregrosa-Hetland CJ, Bittman R, Higdon A, Darley-Usmar VM, Davletov B, Gutiérrez LM. Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells. Plos One. 8: e75845. PMID 24073281 DOI: 10.1371/Journal.Pone.0075845  0.775
2013 Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J. Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. Free Radical Biology & Medicine. 65: 1215-28. PMID 24056030 DOI: 10.1016/J.Freeradbiomed.2013.09.006  0.444
2013 Ulasova E, Perez J, Hill BG, Bradley WE, Garber DW, Landar A, Barnes S, Prasain J, Parks DA, Dell'Italia LJ, Darley-Usmar VM. Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse. Redox Biology. 1: 381-6. PMID 24024175 DOI: 10.1016/J.Redox.2013.07.001  0.536
2013 Grune T, Darley-Usmar V, Yee Aw T, Lamas S. Launch of Redox Biology: A new venue for studies in translational, basic and applied research in the fields of antioxidants, cell signaling and redox therapeutics. Redox Biology. 1: 17-8. PMID 24024134 DOI: 10.1016/J.Redox.2013.01.010  0.39
2013 Gladden JD, Zelickson BR, Guichard JL, Ahmed MI, Yancey DM, Ballinger S, Shanmugam M, Babu GJ, Johnson MS, Darley-Usmar V, Dell'Italia LJ. Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload. American Journal of Physiology. Heart and Circulatory Physiology. 305: H1440-50. PMID 24014679 DOI: 10.1152/Ajpheart.00007.2013  0.741
2013 Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, ... ... Darley-Usmar VM, et al. Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. The Biochemical Journal. 455: 157-67. PMID 23924350 DOI: 10.1042/Bj20130029  0.78
2013 Jiang S, Park DW, Stigler WS, Creighton J, Ravi S, Darley-Usmar V, Zmijewski JW. Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis. The Journal of Biological Chemistry. 288: 26013-26. PMID 23897815 DOI: 10.1074/Jbc.M113.489468  0.41
2013 Diers AR, Vayalil PK, Oliva CR, Griguer CE, Darley-Usmar V, Hurst DR, Welch DR, Landar A. Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α. Plos One. 8: e68348. PMID 23840849 DOI: 10.1371/Journal.Pone.0068348  0.35
2013 Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM. Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells. American Journal of Physiology. Endocrinology and Metabolism. 305: E585-99. PMID 23820623 DOI: 10.1152/Ajpendo.00093.2013  0.396
2013 Liang Q, Benavides GA, Vassilopoulos A, Gius D, Darley-Usmar V, Zhang J. Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. The Biochemical Journal. 454: 249-57. PMID 23767918 DOI: 10.1042/Bj20130414  0.405
2013 Bolisetty S, Traylor A, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD, Landar A, Barnes S, Darley-Usmar V, Agarwal A. Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells. American Journal of Physiology. Renal Physiology. 305: F255-64. PMID 23720344 DOI: 10.1152/Ajprenal.00160.2013  0.474
2013 Dodson M, Darley-Usmar V, Zhang J. Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radical Biology & Medicine. 63: 207-21. PMID 23702245 DOI: 10.1016/J.Freeradbiomed.2013.05.014  0.402
2013 Reily C, Mitchell T, Chacko BK, Benavides G, Murphy MP, Darley-Usmar V. Mitochondrially targeted compounds and their impact on cellular bioenergetics. Redox Biology. 1: 86-93. PMID 23667828 DOI: 10.1016/J.Redox.2012.11.009  0.753
2013 Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW, Ballinger SW, Darley-Usmar VM. Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Laboratory Investigation; a Journal of Technical Methods and Pathology. 93: 690-700. PMID 23528848 DOI: 10.1038/Labinvest.2013.53  0.413
2013 Mitchell T, Chacko B, Ballinger SW, Bailey SM, Zhang J, Darley-Usmar V. Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. Biochemical Society Transactions. 41: 127-33. PMID 23356271 DOI: 10.1042/Bst20120231  0.432
2013 Cummins TD, Higdon AN, Kramer PA, Chacko BK, Riggs DW, Salabei JK, Dell'Italia LJ, Zhang J, Darley-Usmar VM, Hill BG. Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products. Free Radical Biology & Medicine. 59: 56-68. PMID 22954622 DOI: 10.1016/J.Freeradbiomed.2012.08.014  0.809
2013 Vayalil PK, Diers AR, Olivia CR, Griguer CE, Darley-Usmar V, Hurst DR, Welch DR, Landar A. Abstract 1864: Mitochondrial bioenergetics of metastatic breast cancer cells in response to decreasing oxygen tension. Cancer Research. 73: 1864-1864. DOI: 10.1158/1538-7445.Am2013-1864  0.318
2013 Kramer P, Chacko B, Melby S, George J, Bailey S, Singal A, Darley-Usmar V. The Prognostic Role of Metabolic and the Oxidative Burst Profiling in Human Monocytes and Neutrophils Free Radical Biology and Medicine. 65: S144. DOI: 10.1016/J.Freeradbiomed.2013.10.758  0.326
2013 Redmann M, Ouyang X, Benavides Ga, Liang Q, Darley-Usmar VM, Zhang J. Novel Contributions of the Lysosomal Pathway to Autophagy, Neuronal Bioenergetics, Oxidative Stress and Neurodegeneration; the Role of Cathepsin D Free Radical Biology and Medicine. 65: S48. DOI: 10.1016/J.Freeradbiomed.2013.10.505  0.345
2013 Giordano S, Darley-Usmar V, Zhang J. Effects of α-synuclein Overproduction on Mitochondrial Function in Intact Cells Free Radical Biology and Medicine. 65: S45-S46. DOI: 10.1016/J.Freeradbiomed.2013.10.497  0.365
2013 Ravi S, Kramer P, Chacko B, Hill B, Darley-Usmar V. Identifying Redox Sensitive Mitochondrial Dysfunction in Human Monocytes Free Radical Biology and Medicine. 65: S39. DOI: 10.1016/J.Freeradbiomed.2013.10.479  0.375
2013 Chacko BK, Kramer P, Ravi S, Benavides G, Darley-Usmar V. Oxidative Stress Generates Distinct Metabolic Signatures in Human Leukocytes and Platelets Free Radical Biology and Medicine. 65: S29. DOI: 10.1016/J.Freeradbiomed.2013.10.452  0.332
2012 Mitchell T, Chacko BK, Darley-Usmar V. Controlling radicals in the powerhouse: development of MitoSOD. Chemistry & Biology. 19: 1217-8. PMID 23102214 DOI: 10.1016/J.Chembiol.2012.10.004  0.415
2012 Hill BG, Benavides GA, Lancaster JR, Ballinger S, Dell'Italia L, Jianhua Z, Darley-Usmar VM. Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological Chemistry. 393: 1485-1512. PMID 23092819 DOI: 10.1515/Hsz-2012-0198  0.443
2012 Giordano S, Lee J, Darley-Usmar VM, Zhang J. Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. Plos One. 7: e44610. PMID 22970265 DOI: 10.1371/Journal.Pone.0044610  0.391
2012 Higdon A, Diers AR, Oh JY, Landar A, Darley-Usmar VM. Cell signalling by reactive lipid species: new concepts and molecular mechanisms. The Biochemical Journal. 442: 453-64. PMID 22364280 DOI: 10.1042/Bj20111752  0.793
2012 Higdon AN, Landar A, Barnes S, Darley-Usmar VM. The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function. Antioxidants & Redox Signaling. 17: 1580-9. PMID 22352679 DOI: 10.1089/Ars.2012.4523  0.782
2012 Higdon AN, Benavides GA, Chacko BK, Ouyang X, Johnson MS, Landar A, Zhang J, Darley-Usmar VM. Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1394-409. PMID 22245770 DOI: 10.1152/Ajpheart.00584.2011  0.829
2012 Mitchell T, Darley-Usmar V. Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant. Free Radical Biology & Medicine. 52: 838-40. PMID 22226828 DOI: 10.1016/J.Freeradbiomed.2011.12.014  0.378
2012 Liang Q, Benavides G, Darley-Usmar V, Zhang J. Neuronal hypoxia-reoxygenation and nitric oxide: A protective role of autophagy Nitric Oxide. 27: S10-S11. DOI: 10.1016/J.Niox.2012.04.039  0.421
2012 Darley-Usmar V. Nitric oxide and bioenergetic reserve capacity: Insights from alcohol induced hepatotoxicity Nitric Oxide. 27: S3-S4. DOI: 10.1016/J.Niox.2012.04.014  0.446
2012 Liang Q, Benavides GA, Darley-Usmar VM, Zhang J. Apoptosis and Cellular Bioenergetics in Response to Nitric Oxide and Autophagy Inhibition during Hypoxia-Reoxygenation Free Radical Biology and Medicine. 53: S189. DOI: 10.1016/J.Freeradbiomed.2012.10.522  0.388
2012 Benavides GA, Liang Q, Zhang J, Darley-Usmar VM. A Natural H2S Donor Found in Garlic Attenuates Ischemia-Reperfusion Damage in Neurons by Protecting Mitochondrial Respiration Free Radical Biology and Medicine. 53: S82. DOI: 10.1016/J.Freeradbiomed.2012.10.331  0.308
2012 Mitchell T, Johnson M, Koizumi A, Barnes S, Ramanadham S, Darley-Usmar V. Mitochondrial Protein and Enzyme Quality in Type I Diabetes Mellitus Pathogenesis Free Radical Biology and Medicine. 53: S96. DOI: 10.1016/J.Freeradbiomed.2012.10.176  0.308
2011 Zelickson BR, Benavides GA, Johnson MS, Chacko BK, Venkatraman A, Landar A, Betancourt AM, Bailey SM, Darley-Usmar VM. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochimica Et Biophysica Acta. 1807: 1573-82. PMID 21971515 DOI: 10.1016/J.Bbabio.2011.09.011  0.772
2011 Schneider L, Giordano S, Zelickson BR, S Johnson M, A Benavides G, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J. Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free Radical Biology & Medicine. 51: 2007-17. PMID 21945098 DOI: 10.1016/J.Freeradbiomed.2011.08.030  0.799
2011 Gladden JD, Zelickson BR, Wei CC, Ulasova E, Zheng J, Ahmed MI, Chen Y, Bamman M, Ballinger S, Darley-Usmar V, Dell'Italia LJ. Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload. Free Radical Biology & Medicine. 51: 1975-84. PMID 21925594 DOI: 10.1016/J.Freeradbiomed.2011.08.022  0.782
2011 Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham JC, Hill BG, Zhang J, Landar A, Darley-Usmar VM. Assessing bioenergetic function in response to oxidative stress by metabolic profiling. Free Radical Biology & Medicine. 51: 1621-35. PMID 21872656 DOI: 10.1016/J.Freeradbiomed.2011.08.005  0.802
2011 Gladden JD, Ahmed MI, Litovsky SH, Schiros CG, Lloyd SG, Gupta H, Denney TS, Darley-Usmar V, McGiffin DC, Dell'Italia LJ. Oxidative stress and myocardial remodeling in chronic mitral regurgitation. The American Journal of the Medical Sciences. 342: 114-9. PMID 21795957 DOI: 10.1097/Maj.0B013E318224Ab93  0.365
2011 Al Ghouleh I, Khoo NKH, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, et al. Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling Free Radical Biology and Medicine. 51: 1271-1288. PMID 21722728 DOI: 10.1016/J.Freeradbiomed.2011.06.011  0.387
2011 Diers AR, Broniowska KA, Darley-Usmar VM, Hogg N. Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells. American Journal of Physiology. Heart and Circulatory Physiology. 301: H803-12. PMID 21685262 DOI: 10.1152/Ajpheart.00210.2011  0.402
2011 Perez J, Torres RA, Rocic P, Cismowski MJ, Weber DS, Darley-Usmar VM, Lucchesi PA. PYK2 signaling is required for PDGF-dependent vascular smooth muscle cell proliferation. American Journal of Physiology. Cell Physiology. 301: C242-51. PMID 21451101 DOI: 10.1152/Ajpcell.00315.2010  0.563
2011 Lee SH, Schneider C, Higdon AN, Darley-Usmar VM, Chung CY. Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis. Traffic (Copenhagen, Denmark). 12: 878-89. PMID 21438970 DOI: 10.1111/J.1600-0854.2011.01195.X  0.776
2011 Sansbury BE, Jones SP, Riggs DW, Darley-Usmar VM, Hill BG. Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation. Chemico-Biological Interactions. 191: 288-95. PMID 21147079 DOI: 10.1016/J.Cbi.2010.12.002  0.43
2011 Ulasova E, Gladden JD, Chen Y, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ. Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload. Journal of Molecular and Cellular Cardiology. 50: 147-56. PMID 21059354 DOI: 10.1016/J.Yjmcc.2010.10.034  0.763
2011 Chacko B, Reily C, Benavides GA, Kalyanaraman B, Murphy MP, Darley-Usmar V. Alterations in Mitochondrial Bioenergetics by Mitochondrially-Targeted Compounds Free Radical Biology and Medicine. 51: S84. DOI: 10.1016/J.Freeradbiomed.2011.10.392  0.728
2011 Benavides GA, Zelickson BR, Johnson MS, Chacko BK, Landar A, Betancourt AM, Bailey SM, Darley-Usmar VM. Chronic Ethanol Consumption Increases the Sensitivity of Hepatocyte Mitochondria To NO-Dependent Bioenergetic Dysfunction Free Radical Biology and Medicine. 51: S156. DOI: 10.1016/J.Freeradbiomed.2011.10.207  0.755
2011 Ouyang X, Giordano S, Cheng G, Darley-Usmar V, Zhang J. Effects of Brain-specific Overexpression of Human Lysosomal Cathepsins D on Intracellular Reactive Oxygen Species, Mitochondrial, Autophagic and Lysosomal Activities in Mice Free Radical Biology and Medicine. 51: S71-S72. DOI: 10.1016/J.Freeradbiomed.2011.10.186  0.35
2011 Giordano S, Zelickson B, Darley-Usmar V, Zhang J. Differential Effects of Dopaminergic Neurotoxins On Cellular Bioenergetics and Mitochondrial Function Free Radical Biology and Medicine. 51: S70. DOI: 10.1016/J.Freeradbiomed.2011.10.182  0.769
2011 Mitchell T, Reily C, Lei X, Koizumi A, Ramanadham S, Darley-Usmar V. Mechanisms of B-cell Injury: the Role of Cellular Bioenergetics and Thiol Protein Modifications Free Radical Biology and Medicine. 51: S63. DOI: 10.1016/J.Freeradbiomed.2011.10.164  0.696
2011 Kramer PA, Higdon AN, Chacko BK, Johnson MS, Ye Y, Young M, Darley-Usmar V. Visualization of Myoglobin Dependent Lipid Peroxidation in the Ischemic-Reperfused Heart Free Radical Biology and Medicine. 51: S43-S44. DOI: 10.1016/J.Freeradbiomed.2011.10.108  0.76
2010 Nicholls DG, Darley-Usmar VM, Wu M, Jensen PB, Rogers GW, Ferrick DA. Bioenergetic profile experiment using C2C12 myoblast cells. Journal of Visualized Experiments : Jove. PMID 21189469 DOI: 10.3791/2511  0.421
2010 Oliva CR, Nozell SE, Diers A, McClugage SG, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE. Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. The Journal of Biological Chemistry. 285: 39759-67. PMID 20870728 DOI: 10.1074/Jbc.M110.147504  0.386
2010 Chacko BK, Reily C, Srivastava A, Johnson MS, Ye Y, Ulasova E, Agarwal A, Zinn KR, Murphy MP, Kalyanaraman B, Darley-Usmar V. Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. The Biochemical Journal. 432: 9-19. PMID 20825366 DOI: 10.1042/Bj20100308  0.725
2010 Hill BG, Dranka BP, Bailey SM, Lancaster JR, Darley-Usmar VM. What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology. The Journal of Biological Chemistry. 285: 19699-704. PMID 20410298 DOI: 10.1074/Jbc.R110.101618  0.702
2010 Perez J, Hill BG, Benavides GA, Dranka BP, Darley-Usmar VM. Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor. The Biochemical Journal. 428: 255-67. PMID 20331438 DOI: 10.1042/Bj20100090  0.786
2010 Dranka BP, Hill BG, Darley-Usmar VM. Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radical Biology & Medicine. 48: 905-14. PMID 20093177 DOI: 10.1016/J.Freeradbiomed.2010.01.015  0.752
2010 Hill BG, Higdon AN, Dranka BP, Darley-Usmar VM. Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation. Biochimica Et Biophysica Acta. 1797: 285-95. PMID 19925774 DOI: 10.1016/J.Bbabio.2009.11.005  0.816
2010 Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, Kalyanaraman B, Landar A, Darley-Usmar VM. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. The Biochemical Journal. 426: 31-41. PMID 19916962 DOI: 10.1042/Bj20091293  0.805
2010 Giordano S, Zelickson B, Benavides G, Schneider L, Ouyang X, Darley-Usmar V, Zhang J. Differentiation of SH-SY5Y cells Significantly Changes Mitochondrial Bioenergetics and Responses to Oxidative Stress Free Radical Biology and Medicine. 49: S155. DOI: 10.1016/J.Freeradbiomed.2010.10.436  0.787
2010 Higdon AN, Benavides GA, Darley-Usmar VM. Bioenergetic Dysfunction in Endothelial Cells Precedes Cell Death due to Hemin: Implications for Hemolytic Anemias Free Radical Biology and Medicine. 49: S95. DOI: 10.1016/J.Freeradbiomed.2010.10.245  0.802
2010 Benavides GA, Johnson MS, Chang MJ, Cederbaum AI, Darley-Usmar VM. Bioenergetics Changes Induced by CYP2E1 in HepG2 cells Free Radical Biology and Medicine. 49: S91-S92. DOI: 10.1016/J.Freeradbiomed.2010.10.233  0.301
2010 Chacko BK, Benavides GA, Reily C, Johnson MS, Darley-Usmar V. Chronic Hyperglycemia Induced Attenuation of Mitochondrial Reserve Capacity Mediates Mesangial Cell Dysfunction in Diabetes Free Radical Biology and Medicine. 49: S36. DOI: 10.1016/J.Freeradbiomed.2010.10.069  0.727
2010 Zelickson BR, Ulasova E, Gladden JD, Bradley WE, Wei C, Powell PC, Johnson MS, Dell'Italia LJ, Darley-Usmar VM. Cardiac Volume Overload Induces Mitochondrial Dysfunction in Murine Cardiomyocytes Free Radical Biology and Medicine. 49: S33. DOI: 10.1016/J.Freeradbiomed.2010.10.063  0.762
2009 Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar VM. Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. The Biochemical Journal. 424: 99-107. PMID 19740075 DOI: 10.1042/Bj20090934  0.743
2009 Higdon AN, Dranka BP, Hill BG, Oh JY, Johnson MS, Landar A, Darley-Usmar VM. Methods for imaging and detecting modification of proteins by reactive lipid species. Free Radical Biology & Medicine. 47: 201-12. PMID 19446632 DOI: 10.1016/J.Freeradbiomed.2009.05.009  0.791
2009 Mantena SK, Vaughn DP, Andringa KK, Eccleston HB, King AL, Abrams GA, Doeller JE, Kraus DW, Darley-Usmar VM, Bailey SM. High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. The Biochemical Journal. 417: 183-93. PMID 18752470 DOI: 10.1042/Bj20080868  0.417
2009 Darley-Usmar VM. The Wellcome world of reactive nitrogen species Biochemical Journal. DOI: 10.1042/Bj20081959  0.328
2008 Hill BG, Darley-Usmar VM. S-nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning. The Biochemical Journal. 412: e11-3. PMID 18466111 DOI: 10.1042/Bj20080716  0.405
2008 Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, McDonald JM, Chen Y. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. The Journal of Biological Chemistry. 283: 15319-27. PMID 18378684 DOI: 10.1074/Jbc.M800021200  0.39
2008 Bailey SM, Andringa KK, Landar A, Darley-Usmar VM. Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease. Methods in Molecular Biology (Clifton, N.J.). 447: 369-80. PMID 18369930 DOI: 10.1007/978-1-59745-242-7_24  0.366
2008 Oh JY, Giles N, Landar A, Darley-Usmar V. Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. The Biochemical Journal. 411: 297-306. PMID 18237271 DOI: 10.1042/Bj20071189  0.615
2007 Mantena SK, King AL, Andringa KK, Landar A, Darley-Usmar V, Bailey SM. Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease. World Journal of Gastroenterology. 13: 4967-73. PMID 17854139 DOI: 10.3748/Wjg.V13.I37.4967  0.402
2007 Landar A, Darley-Usmar VM. Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide. The Biochemical Journal. 405: e3-4. PMID 17590153 DOI: 10.1042/Bj20070590  0.361
2007 Shiva S, Huang Z, Grubina R, Sun J, Ringwood LA, MacArthur PH, Xu X, Murphy E, Darley-Usmar VM, Gladwin MT. Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circulation Research. 100: 654-61. PMID 17293481 DOI: 10.1161/01.Res.0000260171.52224.6B  0.427
2006 Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A. Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circulation Research. 99: 924-32. PMID 17068300 DOI: 10.1161/01.Res.0000248212.86638.E9  0.475
2006 Bailey SM, Robinson G, Pinner A, Chamlee L, Ulasova E, Pompilius M, Page GP, Chhieng D, Jhala N, Landar A, Kharbanda KK, Ballinger S, Darley-Usmar V. S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver American Journal of Physiology - Gastrointestinal and Liver Physiology. 291: G857-G867. PMID 16825707 DOI: 10.1152/Ajpgi.00044.2006  0.381
2006 Watanabe N, Zmijewski JW, Takabe W, Umezu-Goto M, Le Goffe C, Sekine A, Landar A, Watanabe A, Aoki J, Arai H, Kodama T, Murphy MP, Kalyanaraman R, Darley-Usmar VM, Noguchi N. Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. The American Journal of Pathology. 168: 1737-48. PMID 16651638 DOI: 10.2353/Ajpath.2006.050648  0.439
2006 Landar A, Oh JY, Giles NM, Isom A, Kirk M, Barnes S, Darley-Usmar VM. A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress. Free Radical Biology & Medicine. 40: 459-68. PMID 16443161 DOI: 10.1016/J.Freeradbiomed.2005.08.046  0.599
2006 Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1777-87. PMID 16387790 DOI: 10.1152/Ajpheart.01087.2005  0.438
2006 Landar A, Shiva S, Levonen AL, Oh JY, Zaragoza C, Johnson MS, Darley-Usmar VM. Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. The Biochemical Journal. 394: 185-95. PMID 16268779 DOI: 10.1042/Bj20051259  0.666
2006 Crawford JH, Isbell TS, Huang Z, Shiva S, Chacko BK, Schechter AN, Darley-Usmar VM, Kerby JD, Lang JD, Kraus D, Ho C, Gladwin MT, Patel RP. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood. 107: 566-74. PMID 16195332 DOI: 10.1182/Blood-2005-07-2668  0.399
2005 Zmijewski JW, Landar A, Watanabe N, Dickinson DA, Noguchi N, Darley-Usmar VM. Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium. Biochemical Society Transactions. 33: 1385-9. PMID 16246125 DOI: 10.1042/Bst20051385  0.439
2005 Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S. RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death. Alcoholism, Clinical and Experimental Research. 29: 1749-52. PMID 16205376 DOI: 10.1097/01.Alc.0000179318.48376.Cd  0.397
2005 Landar A, Darley-Usmar VM. Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis. Hepatology (Baltimore, Md.). 41: 980-2. PMID 15841446 DOI: 10.1002/Hep.20699  0.338
2005 Zmijewski JW, Moellering DR, Le Goffe C, Landar A, Ramachandran A, Darley-Usmar VM. Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. American Journal of Physiology. Heart and Circulatory Physiology. 289: H852-61. PMID 15805232 DOI: 10.1152/Ajpheart.00015.2005  0.458
2005 Shiva S, Oh JY, Landar AL, Ulasova E, Venkatraman A, Bailey SM, Darley-Usmar VM. Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway. Free Radical Biology & Medicine. 38: 297-306. PMID 15629859 DOI: 10.1016/J.Freeradbiomed.2004.10.037  0.651
2005 Bailey SM, Landar A, Darley-Usmar V. Mitochondrial proteomics in free radical research. Free Radical Biology & Medicine. 38: 175-88. PMID 15607901 DOI: 10.1016/J.Freeradbiomed.2004.10.011  0.405
2005 Landar AL, Zmijewski JW, Oh J, Darley-Usmar VM. Message from the cell's powerhouse: Mitochondrial signalling and redox therapeutics The Biochemist. 27: 9-14. DOI: 10.1042/bio02703009  0.32
2004 Shiva S, Moellering D, Ramachandran A, Levonen AL, Landar A, Venkatraman A, Ceaser E, Ulasova E, Crawford JH, Brookes PS, Patel RP, Darley-Usmar VM. Redox signalling: from nitric oxide to oxidized lipids. Biochemical Society Symposium. 107-20. PMID 15777016 DOI: 10.1042/Bss0710107  0.395
2004 Dickinson DA, Levonen AL, Moellering DR, Arnold EK, Zhang H, Darley-Usmar VM, Forman HJ. Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Radical Biology & Medicine. 37: 1152-9. PMID 15451055 DOI: 10.1016/J.Freeradbiomed.2004.06.011  0.769
2004 Darley-Usmar V. The powerhouse takes control of the cell: The role of mitochondria in signal transduction Free Radical Biology and Medicine. 37: 753-754. PMID 15304251 DOI: 10.1016/J.Freeradbiomed.2004.05.026  0.335
2004 Isom AL, Barnes S, Wilson L, Kirk M, Coward L, Darley-Usmar V. Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts. Journal of the American Society For Mass Spectrometry. 15: 1136-1147. PMID 15276160 DOI: 10.1016/J.Jasms.2004.03.013  0.322
2004 Kevil CG, Pruitt H, Kavanagh TJ, Wilkerson J, Farin F, Moellering D, Darley-Usmar VM, Bullard DC, Patel RP. Regulation of endothelial glutathione by ICAM-1: implications for inflammation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1321-3. PMID 15180961 DOI: 10.1096/Fj.03-1401Fje  0.352
2004 Venkatraman A, Landar A, Davis AJ, Chamlee L, Sanderson T, Kim H, Page G, Pompilius M, Ballinger S, Darley-Usmar V, Bailey SM. Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity. The Journal of Biological Chemistry. 279: 22092-101. PMID 15033988 DOI: 10.1074/Jbc.M402245200  0.374
2004 Ceaser EK, Moellering DR, Shiva S, Ramachandran A, Landar A, Venkartraman A, Crawford J, Patel R, Dickinson DA, Ulasova E, Ji S, Darley-Usmar VM. Mechanisms of signal transduction mediated by oxidized lipids: the role of the electrophile-responsive proteome. Biochemical Society Transactions. 32: 151-5. PMID 14748737 DOI: 10.1042/Bst0320151  0.43
2004 Shiva S, Crawford JH, Ramachandran A, Ceaser EK, Hillson T, Brookes PS, Patel RP, Darley-Usmar VM. Mechanisms of the interaction of nitroxyl with mitochondria. The Biochemical Journal. 379: 359-66. PMID 14723605 DOI: 10.1042/Bj20031758  0.453
2004 Ramachandran A, Ceaser E, Darley-Usmar VM. Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 384-9. PMID 14691259 DOI: 10.1073/Pnas.0304653101  0.414
2004 Venkatraman A, Landar A, Davis AJ, Ulasova E, Page G, Murphy MP, Darley-Usmar V, Bailey SM. Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption. American Journal of Physiology. Gastrointestinal and Liver Physiology. 286: G521-7. PMID 14670822 DOI: 10.1152/Ajpgi.00399.2003  0.303
2004 Levonen AL, Landar A, Ramachandran A, Ceaser EK, Dickinson DA, Zanoni G, Morrow JD, Darley-Usmar VM. Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. The Biochemical Journal. 378: 373-82. PMID 14616092 DOI: 10.1042/Bj20031049  0.425
2004 Brookes PS, Darley-Usmar VM. Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition. American Journal of Physiology. Heart and Circulatory Physiology. 286: H39-46. PMID 12933349 DOI: 10.1152/Ajpheart.00742.2003  0.346
2003 Shiva S, Darley-Usmar VM. Control of the nitric oxide-cytochrome c oxidase signaling pathway under pathological and physiological conditions. Iubmb Life. 55: 585-90. PMID 14711003 DOI: 10.1080/152165430310001640489  0.437
2003 Landar A, Darley-Usmar VM. Nitric oxide and cell signaling; modulation of redox tone and protein modification Amino Acids. 25: 313-321. PMID 14661093 DOI: 10.1007/S00726-003-0019-7  0.381
2003 Boersma BJ, D'Alessandro T, Benton MR, Kirk M, Wilson LS, Prasain J, Botting NP, Barnes S, Darley-Usmar VM, Patel RP. Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties. Free Radical Biology & Medicine. 35: 1417-30. PMID 14642389 DOI: 10.1016/J.Freeradbiomed.2003.08.009  0.401
2003 D'Alessandro T, Prasain J, Benton MR, Botting N, Moore R, Darley-Usmar V, Patel R, Barnes S. Polyphenols, inflammatory response, and cancer prevention: chlorination of isoflavones by human neutrophils. Journal of Nutrition. 133. PMID 14608113 DOI: 10.1093/Jn/133.11.3773S  0.31
2003 Ceaser EK, Ramachandran A, Levonen AL, Darley-Usmar VM. Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2298-308. PMID 12881207 DOI: 10.1152/Ajpheart.00508.2003  0.477
2003 Brookes PS, Kraus DW, Shiva S, Doeller JE, Barone MC, Patel RP, Lancaster JR, Darley-Usmar V. Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state. The Journal of Biological Chemistry. 278: 31603-9. PMID 12788936 DOI: 10.1074/Jbc.M211784200  0.36
2003 Dickinson DA, Moellering DR, Iles KE, Patel RP, Levonen AL, Wigley A, Darley-Usmar VM, Forman HJ. Cytoprotection against oxidative stress and the regulation of glutathione synthesis. Biological Chemistry. 384: 527-37. PMID 12751783 DOI: 10.1515/Bc.2003.061  0.403
2003 Barone MC, Darley-Usmar VM, Brookes PS. Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide. The Journal of Biological Chemistry. 278: 27520-4. PMID 12743113 DOI: 10.1074/Jbc.M304129200  0.433
2003 Cornwell TL, Ceaser EK, Li J, Marrs KL, Darley-Usmar VM, Patel RP. S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation. American Journal of Physiology. Cell Physiology. 284: C1516-24. PMID 12584112 DOI: 10.1152/Ajpcell.00268.2002  0.322
2002 Brookes PS, Shiva S, Patel RP, Darley-Usmar VM. Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide. Methods in Enzymology. 359: 305-19. PMID 12481582 DOI: 10.1016/S0076-6879(02)59194-1  0.394
2002 Ramachandran A, Levonen AL, Brookes PS, Ceaser E, Shiva S, Barone MC, Darley-Usmar V. Mitochondria, nitric oxide, and cardiovascular dysfunction. Free Radical Biology & Medicine. 33: 1465-74. PMID 12446203 DOI: 10.1016/S0891-5849(02)01142-5  0.453
2002 Cooper CE, Patel RP, Brookes PS, Darley-Usmar VM. Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species. Trends in Biochemical Sciences. 27: 489-92. PMID 12368076 DOI: 10.1016/S0968-0004(02)02191-6  0.395
2002 Fenster CP, Weinsier RL, Darley-Usmar VM, Patel RP. Obesity, aerobic exercise, and vascular disease: the role of oxidant stress. Obesity Research. 10: 964-8. PMID 12226146 DOI: 10.1038/Oby.2002.131  0.309
2002 Brookes PS, Levonen AL, Shiva S, Sarti P, Darley-Usmar VM. Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free Radical Biology & Medicine. 33: 755-64. PMID 12208364 DOI: 10.1016/S0891-5849(02)00901-2  0.432
2002 Brookes PS, Pinner A, Ramachandran A, Coward L, Barnes S, Kim H, Darley-Usmar VM. High throughput two-dimensional blue-native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexes Proteomics. 2: 969-977. PMID 12203892 DOI: 10.1002/1615-9861(200208)2:8<969::Aid-Prot969>3.0.Co;2-3  0.341
2002 Ramachandran A, Moellering D, Go YM, Shiva S, Levonen AL, Jo H, Patel RP, Parthasarathy S, Darley-Usmar VM. Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide. Biological Chemistry. 383: 693-701. PMID 12033458 DOI: 10.1515/Bc.2002.071  0.375
2002 Brookes PS, Digerness SB, Parks DA, Darley-Usmar V. Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin. Free Radical Biology & Medicine. 32: 1220-8. PMID 12031906 DOI: 10.1016/S0891-5849(02)00839-0  0.345
2002 Ramachandran A, Moellering DR, Ceaser E, Shiva S, Xu J, Darley-Usmar V. Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 6643-8. PMID 12011428 DOI: 10.1073/Pnas.102019899  0.454
2002 Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP. Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. The Journal of Biological Chemistry. 277: 17048-56. PMID 11861642 DOI: 10.1074/Jbc.M110797200  0.462
2002 Brookes P, Darley-Usmar VM. Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase. Free Radical Biology & Medicine. 32: 370-4. PMID 11841927 DOI: 10.1016/S0891-5849(01)00805-X  0.434
2002 Moellering DR, Levonen AL, Go YM, Patel RP, Dickinson DA, Forman HJ, Darley-Usmar VM. Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress. The Biochemical Journal. 362: 51-9. PMID 11829739 DOI: 10.1042/Bj3620051  0.433
2001 Boersma BJ, Patel RP, Botting N, Roger White C, Parks D, Barnes S, Darley-Usmar VM. Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolics Biofactors. 15: 79-81. PMID 12016330 DOI: 10.1002/Biof.5520150205  0.369
2001 Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B, Parks DA, Barnes S, Darley-Usmar V. Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. Free Radical Biology & Medicine. 31: 1570-81. PMID 11744331 DOI: 10.1016/S0891-5849(01)00737-7  0.38
2001 Go YM, Levonen AL, Moellering D, Ramachandran A, Patel RP, Jo H, Darley-Usmar VM. Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein. American Journal of Physiology. Heart and Circulatory Physiology. 281: H2705-13. PMID 11709440 DOI: 10.1152/Ajpheart.2001.281.6.H2705  0.349
2001 Levonen AL, Dickinson DA, Moellering DR, Mulcahy RT, Forman HJ, Darley-Usmar VM. Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1846-51. PMID 11701476 DOI: 10.1161/Hq1101.098488  0.362
2001 Go YM, Boo YC, Park H, Maland MC, Patel R, Pritchard KA, Fujio Y, Walsh K, Darley-Usmar V, Jo H. Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. Journal of Applied Physiology (Bethesda, Md. : 1985). 91: 1574-81. PMID 11568138 DOI: 10.1152/Jappl.2001.91.4.1574  0.301
2001 Zhang C, Patel R, Eiserich JP, Zhou F, Kelpke S, Ma W, Parks DA, Darley-Usmar V, White CR. Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1469-75. PMID 11557534 DOI: 10.1152/Ajpheart.2001.281.4.H1469  0.349
2001 Boersma BJ, Barnes S, Kirk M, Wang CC, Smith M, Kim H, Xu J, Patel R, Darley-Usmar VM. Soy isoflavonoids and cancer - Metabolism at the target site Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 480: 121-127. PMID 11506805 DOI: 10.1016/S0027-5107(01)00175-0  0.35
2001 Shiva S, Brookes PS, Patel RP, Anderson PG, Darley-Usmar VM. Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase Proceedings of the National Academy of Sciences of the United States of America. 98: 7212-7217. PMID 11416204 DOI: 10.1073/Pnas.131128898  0.41
2001 Levonen AL, Patel RP, Brookes P, Go YM, Jo H, Parthasarathy S, Anderson PG, Darley-Usmar VM. Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases. Antioxidants & Redox Signaling. 3: 215-29. PMID 11396477 DOI: 10.1089/152308601300185188  0.456
2001 Brookes PS, Zhang J, Dai L, Zhou F, Parks DA, Darley-Usmar VM, Anderson PG. Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy Journal of Molecular and Cellular Cardiology. 33: 69-82. PMID 11133224 DOI: 10.1006/Jmcc.2000.1276  0.407
2001 Dai L, Brookes PS, Darley-Usmar VM, Anderson PG. Bioenergetics in cardiac hypertrophy: Mitochondrial respiration as a pathological target of NO· American Journal of Physiology. 281. DOI: 10.1152/Ajpheart.2001.281.6.H2261  0.389
2001 Binsack R, Boersma BJ, Patel RP, Kirk M, White CR, Darley-Usmar V, Barnes S, Zhou F, Parks DA. Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acid. Alcoholism: Clinical and Experimental Research. 25: 434-443. DOI: 10.1111/J.1530-0277.2001.Tb02232.X  0.366
2001 Dai L, Brookes PS, Zhang J, Darley-Usmar VM, Anderson PG. Nitric oxide and mitochondrial dysfunction in cardiac hypertrophy Journal of Molecular and Cellular Cardiology. 33: A153. DOI: 10.1016/S0022-2828(01)90588-7  0.412
2000 Darley-Usmar V, Starke-Reed PE. Antioxidants: strategies for interventions in aging and age-related diseases. A workshop sponsored by the National Institute on Aging and by the Office of Dietary Supplements. Antioxidants & Redox Signaling. 2: 375-377. PMID 11229350 DOI: 10.1089/15230860050192143  0.317
2000 Patel RP, Levonen A, Crawford JH, Darley-Usmar VM. Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis. Cardiovascular Research. 47: 465-74. PMID 10963720 DOI: 10.1016/S0008-6363(00)00086-9  0.383
2000 Patel RP, Moellering D, Murphy-Ullrich J, Jo H, Beckman JS, Darley-Usmar VM. Cell signaling by reactive nitrogen and oxygen species in atherosclerosis Free Radical Biology and Medicine. 28: 1780-1794. PMID 10946220 DOI: 10.1016/S0891-5849(00)00235-5  0.435
2000 Brookes PS, Salinas EP, Darley-Usmar K, Eiserich JP, Freeman BA, Darley-Usmar VM, Anderson PG. Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. The Journal of Biological Chemistry. 275: 20474-9. PMID 10791954 DOI: 10.1074/Jbc.M001077200  0.398
2000 Pan-Zhou XR, Cui L, Zhou XJ, Sommadossi JP, Darley-Usmar VM. Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells Antimicrobial Agents and Chemotherapy. 44: 496-503. PMID 10681309 DOI: 10.1128/Aac.44.3.496-503.2000  0.425
1999 Go YM, Patel RP, Maland MC, Park H, Beckman JS, Darley-Usmar VM, Jo H. Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase. The American Journal of Physiology. 277: H1647-53. PMID 10516206 DOI: 10.1152/Ajpheart.1999.277.4.H1647  0.347
1999 Boersma BJ, Patel RP, Kirk M, Jackson PL, Muccio D, Darley-Usmar VM, Barnes S. Chlorination and nitration of soy isoflavones. Archives of Biochemistry and Biophysics. 368: 265-75. PMID 10441377 DOI: 10.1006/Abbi.1999.1330  0.325
1999 O'Donnell VB, Taylor KB, Parthasarathy S, Kühn H, Koesling D, Friebe A, Bloodsworth A, Darley-Usmar VM, Freeman BA. 15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase Journal of Biological Chemistry. 274: 20083-20091. PMID 10400618 DOI: 10.1074/Jbc.274.29.20083  0.338
1999 Moellering D, McAndrew J, Jo H, Darley-Usmar VM. Effects of pyrrolidine dithiocarbamate on endothelial cells: Protection against oxidative stress Free Radical Biology and Medicine. 26: 1138-1145. PMID 10381184 DOI: 10.1016/S0891-5849(98)00300-1  0.398
1999 Patel RP, McAndrew J, Sellak H, White CR, Jo H, Freeman BA, Darley-Usmar VM. Biological aspects of reactive nitrogen species Biochimica Et Biophysica Acta - Bioenergetics. 1411: 385-400. PMID 10320671 DOI: 10.1016/S0005-2728(99)00028-6  0.348
1999 Moellering D, Mc Andrew J, Patel RP, Forman HJ, Mulcahy RT, Jo H, Darley-Usmar VM. The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: A role for γ-glutamylcysteine synthetase and γ-glutamyl transpeptidase Febs Letters. 448: 292-296. PMID 10218495 DOI: 10.1016/S0014-5793(99)00371-3  0.407
1999 Patel RP, Darley-Usmar VM. Molecular mechanisms of the copper dependent oxidation of low-density lipoprotein Free Radical Research. 30: 1-9. PMID 10193568 DOI: 10.1080/10715769900300011  0.354
1999 Patel RP, Crawford J, Boersma B, Barnes S, Darley-Usmar VM. Antioxidant properties of phytoestrogens Journal of Medicinal Food. 2: 163-166. DOI: 10.1089/Jmf.1999.2.163  0.322
1999 Moore K, Marley R, Patel R, Darley-Usmar V. Formation of S-nitrosoalbumin in human plasma by nitric oxide Free Radical Biology and Medicine. 27: S82. DOI: 10.1016/S0891-5849(99)90779-7  0.302
1998 O'Donnell VB, Eiserich JP, Bloodsworth A, Chumley PH, Kirk M, Barnes S, Darley-Usmar VM, Freeman BA. Nitration of unsaturated fatty acids by nitric oxide-derived reactive species Methods in Enzymology. 301: 454-470. PMID 9919594 DOI: 10.1016/S0076-6879(99)01109-X  0.326
1998 Brown AS, Moro MA, Masse JM, Cramer EM, Radomski M, Darley-Usmar V. Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite. Cardiovascular Research. 40: 380-8. PMID 9893732 DOI: 10.1016/S0008-6363(98)00182-5  0.316
1998 Moore KP, Holt SG, Patel RP, Svistunenko DA, Zackert W, Goodier D, Reeder BJ, Clozel M, Anand R, Cooper CE, Morrow JD, Wilson MT, Darley-Usmar V, Roberts LJ. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. The Journal of Biological Chemistry. 273: 31731-7. PMID 9822635 DOI: 10.1074/Jbc.273.48.31731  0.311
1998 Go YM, Park H, Maland MC, Darley-Usmar VM, Stoyanov B, Wetzker R, Jo H. Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells. The American Journal of Physiology. 275: H1898-904. PMID 9815099 DOI: 10.1152/Ajpheart.1998.275.5.H1898  0.304
1998 Moellering D, McAndrew J, Patel RP, Cornwell T, Lincoln T, Cao X, Messina JL, Forman HJ, Jo H, Darley-Usmar VM. Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetase Archives of Biochemistry and Biophysics. 358: 74-82. PMID 9750167 DOI: 10.1006/Abbi.1998.0854  0.405
1998 Skinner KA, White CR, Patel R, Tan S, Barnes S, Kirk M, Darley-Usmar V, Parks DA. Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor. The Journal of Biological Chemistry. 273: 24491-7. PMID 9733742 DOI: 10.1074/Jbc.273.38.24491  0.314
1998 O'Donnell V, Bloodsworth A, Eiserich J, Chumley P, Jablonsky M, Krishna N, Kirk M, Barnes S, Darley-Usmar V, Freeman B. Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species Free Radical Biology and Medicine. 25: S64. DOI: 10.1016/S0891-5849(98)90198-8  0.331
1998 O'Donnell V, Taylor K, Parthasarathy S, Kühn H, Darley-Usmar V, Freeman B. Turnover-dependent consumption of nitric oxide by 15-lipoxygenase: Modulation of nitric oxide signalling and 15-lipoxygenase activity Free Radical Biology and Medicine. 25: S64. DOI: 10.1016/S0891-5849(98)90197-6  0.372
1997 O'Donnell VB, Chumley PH, Hogg N, Bloodsworth A, Darley-Usmar VM, Freeman BA. Nitric oxide inhibition of lipid peroxidation: Kinetics of reaction with lipid peroxyl radicals and comparison with α-tocopherol Biochemistry. 36: 15216-15223. PMID 9398249 DOI: 10.1021/Bi971891Z  0.322
1997 Darley-Usmar VM, McAndrew J, Patel R, Moellering D, Lincoln TM, Jo H, Cornwall T, Digerness S, White CR. Nitric oxide, free radicals and cell signalling in cardiovascular disease Biochemical Society Transactions. 25: 925-929. PMID 9388574 DOI: 10.1042/Bst0250925  0.348
1997 McAndrew J, Patel RP, Jo H, Cornwell T, Lincoln T, Moellering D, White CR, Matalon S, Darley-Usmar V. The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for disease Seminars in Perinatology. 21: 351-366. PMID 9352609 DOI: 10.1016/S0146-0005(97)80002-X  0.364
1997 Torres J, Davies N, Darley-Usmar VM, Wilson MT. The inhibition of cytochrome c oxidase by nitric oxide using S-nitrosoglutathione Journal of Inorganic Biochemistry. 66: 207-212. PMID 9130394 DOI: 10.1016/S0162-0134(96)00206-1  0.479
1997 Patel RP, Svistunenko D, Wilson MT, Darley-Usmar VM. Reduction of Cu(II) by lipid hydroperoxides: Implications for the copper-dependent oxidation of low-density lipoprotein Biochemical Journal. 322: 425-433. PMID 9065759 DOI: 10.1042/Bj3220425  0.445
1996 O'Leary VJ, Graham A, Stone D, Darley-Usmar VM. Oxidation of human low-density lipoprotein by soybean 15-lipoxygenase in combination with copper (II) or met-myoglobin Free Radical Biology and Medicine. 20: 525-532. PMID 8904293 DOI: 10.1016/0891-5849(95)02084-5  0.375
1996 Patel RP, Svistunenko DA, Darley-Usmar VM, Symons MCR, Wilson MT. Redox cycling of human methaemoglobin by H2O2 yields persistent ferryl iron and protein based radicals Free Radical Research. 25: 117-123. PMID 8885329 DOI: 10.3109/10715769609149916  0.474
1996 Darley-Usmar V, Halliwell B. Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharmaceutical Research. 13: 649-662. PMID 8860419 DOI: 10.1023/A:1016079012214  0.406
1996 Rubbo H, Darley-Usmar V, Freeman BA. Nitric oxide regulation of tissue free radical injury Chemical Research in Toxicology. 9: 809-820. PMID 8828915 DOI: 10.1021/Tx960037Q  0.361
1996 O'Leary VJ, Tilling L, Fleetwood G, Stone D, Darley-Usmar V. The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy. Atherosclerosis. 119: 169-179. PMID 8808494 DOI: 10.1016/0021-9150(95)05644-0  0.317
1996 Patel RP, Darley-Usmar VM. Using peroxynitrite as oxidant with low-density lipoprotein Methods in Enzymology. 269: 375-384. PMID 8791666 DOI: 10.1016/S0076-6879(96)69038-7  0.378
1996 Smith DR, Stone D, Darley-Usmar VM. Stimulation of mitochondrial oxygen consumption in isolated cardiomyocytes after hypoxia-reoxygenation Free Radical Research. 24: 159-166. PMID 8728117 DOI: 10.3109/10715769609088013  0.388
1996 White CR, Darley-Usmar V, Berrington WR, McAdams M, Gore JZ, Thompson JA, Parks DA, Tarpey MM, Freeman BA. Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits. Proceedings of the National Academy of Sciences of the United States of America. 93: 8745-9. PMID 8710942 DOI: 10.1073/Pnas.93.16.8745  0.303
1996 Jones GD, Russell L, Darley-Usmar VM, Stone D, Wilson MT. Role of lipid hydroperoxides in the activation of 15-lipoxygenase. Biochemistry. 35: 7197-203. PMID 8679548 DOI: 10.1021/Bi952425H  0.445
1996 Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose Biochemical Journal. 314: 877-880. PMID 8615783 DOI: 10.1042/Bj3140877  0.369
1995 Iwatsuki M, Niki E, Stone D, Darley-Usmar VM. α-Tocopherol mediated peroxidation in the copper (II) and met myoglobininduced oxidation of human low density lipoprotein: The influence of lipid hydroperoxides Febs Letters. 360: 271-276. PMID 7883046 DOI: 10.1016/0014-5793(95)00122-P  0.342
1995 Darley-Usmar V, Wiseman H, Halliwell B. Nitric oxide and oxygen radicals: a question of balance. Febs Letters. 369: 131-5. PMID 7649244 DOI: 10.1016/0014-5793(95)00764-Z  0.362
1995 Moore KP, Darley-Usmar V, Morrow J, Roberts LJ. Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite. Circulation Research. 77: 335-41. PMID 7614720 DOI: 10.1161/01.Res.77.2.335  0.325
1995 Torres J, Darley-Usmar V, Wilson MT. Inhibition of cytochrome c oxidase in turnover by nitric oxide: Mechanism and implications for control of respiration Biochemical Journal. 312: 169-173. PMID 7492308 DOI: 10.1042/Bj3120169  0.335
1994 Cleeter MWJ, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AHV. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases Febs Letters. 345: 50-54. PMID 8194600 DOI: 10.1016/0014-5793(94)00424-2  0.413
1994 Swain JA, Darley-Usmar V, Gutteridge JMC. Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis Febs Letters. 342: 49-52. PMID 8143848 DOI: 10.1016/0014-5793(94)80582-2  0.308
1994 Sarti P, Hogg N, Darley-Usmar VM, Sanna MT, Wilson MT. The oxidation of cytochrome-c oxidase vesicles by hemoglobin Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 1208: 38-44. PMID 8086437 DOI: 10.1016/0167-4838(94)90157-0  0.527
1994 Van der Vliet A, Smith D, O'Neill CA, Kaur H, Darley-Usmar V, Cross CE, Halliwell B. Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion. The Biochemical Journal. 303: 295-301. PMID 7945255 DOI: 10.1042/Bj3030295  0.334
1994 Villa LM, Salas E, Darley-Usmar VM, Radomski MW, Moncada S. Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart Proceedings of the National Academy of Sciences of the United States of America. 91: 12383-12387. PMID 7809045 DOI: 10.1073/Pnas.91.26.12383  0.334
1994 Moro MA, Darley-Usmar VM, Goodwin DA, Read NG, Zamora-Pino R, Feelisch M, Radomski MW, Moncada S. Paradoxical fate and biological action of peroxynitrite on human platelets Proceedings of the National Academy of Sciences of the United States of America. 91: 6702-6706. PMID 7517561 DOI: 10.1073/Pnas.91.14.6702  0.31
1993 Smith D, O'Leary VJ, Darley-Usmar VM. The role of α-tocopherol as a peroxyl radical scavenger in human low density lipoprotein Biochemical Pharmacology. 45: 2195-2201. PMID 8517860 DOI: 10.1016/0006-2952(93)90189-4  0.348
1993 Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. The oxidation of α-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide Febs Letters. 326: 199-203. PMID 8391994 DOI: 10.1016/0014-5793(93)81790-7  0.515
1993 Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S. Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. Febs Letters. 330: 181-5. PMID 8365489 DOI: 10.1016/0014-5793(93)80269-Z  0.344
1993 O'leary V, Graham A, Darley-Usmar V, Stone D. The effect of lipid hydroperoxides on the copper dependent oxidation of low density lipoprotein. Biochemical Society Transactions. 21. PMID 8359542 DOI: 10.1042/Bst021089S  0.324
1993 Gotoh N, Graham A, Niki E, Darley-Usmar VM. Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages Biochemical Journal. 296: 151-154. PMID 8250836 DOI: 10.1042/Bj2960151  0.366
1993 Hogg N, Darley-Usmar V, Graham A, Moncada S, Kalyanaraman B. The modification of low density lipoprotein (LDL) by peroxynitrite and systems generating nitric oxide (NO) and superoxide Free Radical Biology and Medicine. 15: 495. DOI: 10.1016/0891-5849(93)90275-Y  0.316
1992 O'Leary VJ, Darley-Usmar VM, Russell LJ, Stone D. Pro-oxidant effects of lipoxygenase-derived peroxides on the copper-initiated oxidation of low-density lipoprotein. The Biochemical Journal. 282: 631-4. PMID 1554346 DOI: 10.1042/Bj2820631  0.361
1992 Yeadon M, Wilkinson D, Darley-Usmar V, O'Leary VJ, Payne AN. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulmonary Pharmacology. 5: 39-50. PMID 1375522 DOI: 10.1016/0952-0600(92)90016-A  0.307
1992 Hogg N, Darley-Usmar VM, Wilson MT, Moncada S. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide Biochemical Journal. 281: 419-424. PMID 1310595 DOI: 10.1042/Bj2810419  0.328
1991 Hardy L, Clark JB, Darley-Usmar VM, Smith DR, Stone D. Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (Complex I) activity in the hypoxic/reoxygenated rat heart Biochemical Journal. 274: 133-137. PMID 1900416 DOI: 10.1042/Bj2740133  0.378
1991 Darley-Usmar VM, Severn A, O'Leary VJ, Rogers M. Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content Biochemical Journal. 278: 429-434. PMID 1898336 DOI: 10.1042/Bj2780429  0.402
1991 Jessup W, Darley-Usmar V, O'Leary V, Bedwell S. 5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein. Biochemical Journal. 278: 163-169. PMID 1883327 DOI: 10.1042/Bj2780163  0.359
1991 Darley-Usmar VM, Stone D, Smith D, Martin JF. Mitochondria, oxygen and reperfusion damage Annals of Medicine. 23: 583-588. PMID 1756028 DOI: 10.3109/07853899109150521  0.392
1990 Darley-Usmar VM, Smith DR, O'Learly VJ, Stone D, Hardy DL, Clark JB. Hypoxia-reoxygenation induced damage in the myocardium: The role of mitochondria Biochemical Society Transactions. 18: 526-528. PMID 2276424 DOI: 10.1042/Bst0180526  0.301
1990 Darley-Usmar VM, Lelchuk R, O'Leary VJ, Knowles M, Rogers MV, Severn A. Oxidation of low-density lipoprotein and macrophage derived foam cells. Biochemical Society Transactions. 18: 1064-6. PMID 2088807 DOI: 10.1042/Bst0181064  0.387
1990 Hardy DL, Clark JB, Darley-Usmar VM, Smith DR. Reoxygenation of the hypoxic myocardium causes a mitochondrial complex I defect Biochemical Society Transactions. 18: 549. PMID 1703502 DOI: 10.1042/Bst0180549  0.345
1990 Hogg N, Wilson M, Darley-Usmar V. Low levels of lipid peroxide increase the permeability of membranes to protons Free Radical Biology and Medicine. 9: 125. DOI: 10.1016/0891-5849(90)90623-Q  0.442
1989 Birch-Machin MA, Shepherd IM, Watmough NJ, Sherratt HS, Bartlett K, Darley-Usmar VM, Milligan DW, Welch RJ, Aynsley-Green A, Turnbull DM. Fatal lactic acidosis in infancy with a defect of complex III of the respiratory chain. Pediatric Research. 25: 553-9. PMID 2541396 DOI: 10.1203/00006450-198905000-00025  0.313
1989 Darley-Usmar VM, Hersey A, Garland LG. A method for the comparative assessment of antioxidants as peroxyl radical scavengers Biochemical Pharmacology. 38: 1465-1469. PMID 2497747 DOI: 10.1016/0006-2952(89)90186-X  0.305
1989 Stone D, Darley-Usmar V, Smith DR, O'Leary V. Hypoxia-reoxygenation induced increase in cellular Ca2+ in myocytes and perfused hearts: the role of mitochondria. Journal of Molecular and Cellular Cardiology. 21: 963-973. PMID 2479760 DOI: 10.1016/0022-2828(89)90795-5  0.306
1987 Darley-Usmar VM. The molecular aetiology of human mitochondrial myopathies Biochemical Society Transactions. 15: 102-103. PMID 3030834 DOI: 10.1042/Bst0150102  0.434
1986 Darley-Usmar VM, Watanabe M, Uchiyama Y, Kondo I, Kennaway NG, Gronke L, Hamaguchi H. Mitochondrial myopathy: tissue-specific expression of a defect in ubiquinol-cytochrome c reductase Clinica Chimica Acta. 158: 253-261. PMID 3021360 DOI: 10.1016/0009-8981(86)90289-5  0.334
1985 Darley-usmar VM, Watanabe M. Analyses of muscle proteins in a patient with a mitochondrial myopathy Journal of Biochemistry. 97: 1767-1775. PMID 2993273 DOI: 10.1093/Oxfordjournals.Jbchem.A135235  0.342
1984 Eleff S, Kennaway NG, Buist NR, Darley-Usmar VM, Capaldi RA, Bank WJ, Chance B. 31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 81: 3529-33. PMID 6587367 DOI: 10.1073/Pnas.81.11.3529  0.532
1984 Darley-Usmar VM, Georgevich G, Capaldi RA. Reaction of thionitrobenzoate-modified yeast cytochrome c with monomeric and dimeric forms of beef heart cytochrome c oxidase Febs Letters. 166: 131-135. PMID 6319188 DOI: 10.1016/0014-5793(84)80058-7  0.516
1984 Kennaway NG, Buist NR, Darley-Usmar VM, Papadimitriou A, Dimauro S, Kelley RI, Capaldi RA, Blank NK, D'Agostino A. Lactic acidosis and mitochondrial myopathy associated with deficiency of several components of complex III of the respiratory chain. Pediatric Research. 18: 991-9. PMID 6093035 DOI: 10.1203/00006450-198410000-00017  0.572
1983 Malatesta F, Darley-Usmar V, De Jong C, Prochaska LJ, Bisson R, Capaldi RA, Steffens GCM, Buse G. Arrangement of subunit IV in beef heart cytochrome c oxidase probed by chemical labeling and protease digestion experiments Biochemistry. 22: 4405-4411. PMID 6313039 DOI: 10.1021/Bi00288A010  0.542
1983 Capaldi RA, Malatesta F, Darley-Usmar VM. Structure of cytochrome c oxidase Bba Reviews On Bioenergetics. 726: 135-148. PMID 6307356 DOI: 10.1016/0304-4173(83)90003-4  0.5
1983 Georgevich G, Darley-Usmar VM, Malatesta F, Capaldi RA. Electron transfer in monomeric forms of beef and shark heart cytochrome c oxidase Biochemistry. 22: 1317-1323. PMID 6301544  0.463
1982 Millett F, Darley-Usmar V, Capaldi RA. Cytochrome c is cross-linked to subunit II of cytochrome c oxidase by a water-soluble carbodiimide Biochemistry. 21: 3857-3862. PMID 6291584 DOI: 10.1021/Bi00259A021  0.523
1982 Capaldi RA, Darley-Usmar V, Fuller S, Millett F. Structural and functional features of the interaction of cytochrome c with complex III and cytochrome c oxidase Febs Letters. 138: 1-7. PMID 6279436 DOI: 10.1016/0014-5793(82)80382-7  0.507
1981 Darley-Usmar VM, Capaldi RA, Wilson MT. Identification of cysteines in subunit II as ligands to the redox centers of bovine cytochrome c oxidase Biochemical and Biophysical Research Communications. 103: 1223-1230. PMID 6277330 DOI: 10.1016/0006-291X(81)90253-9  0.586
1981 Fuller SD, Darley-Usmar VM, Capaldi RA. Covalent complex between yeast cytochrome c and beef heart cytochrome c oxidase which is active in electron transfer Biochemistry. 20: 7046-7053. PMID 6274385 DOI: 10.1021/Bi00527A043  0.516
1981 Darley-Usmar VM, Wilson MT. On the identification and nomenclature of the polypeptide subunits of bovine cytochrome C oxidase Biochemical and Biophysical Research Communications. 99: 51-57. PMID 6263278 DOI: 10.1016/0006-291X(81)91711-3  0.445
1981 Silvestrini MC, Brunori M, Wilson MT, Darley-Usmar VM. The electron transfer system of Pseudomonas aeruginosa: a study of the pH-dependent transitions between redox forms of azurin and cytochrome c551 Journal of Inorganic Biochemistry. 14: 327-338. DOI: 10.1016/S0162-0134(00)80289-5  0.431
1981 Darley-Usmar VM, Alizai N, Al-Ayash AI, Jones GD, Sharpe A, Wilson MT. A comparison of the structural and functional properties of cytochrome c oxidase isolated from beef (Bos tauros), camel (Camelus dromedarius), chicken (Gallus domesticus) and rat (Rattus norvegicus) Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 68: 445-456. DOI: 10.1016/0305-0491(81)90154-1  0.46
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