Year |
Citation |
Score |
2015 |
Fiers WD, Dodge GJ, Li Y, Smith JL, Fecik RA, Aldrich CC. Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates. Chemical Science (Royal Society of Chemistry : 2010). 6: 5027-5033. PMID 26366283 DOI: 10.1039/C5Sc01505G |
0.335 |
|
2015 |
Li Y, Dodge GJ, Fiers WD, Fecik RA, Smith JL, Aldrich CC. Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase. Journal of the American Chemical Society. 137: 7003-6. PMID 26027428 DOI: 10.1021/Jacs.5B02325 |
0.394 |
|
2015 |
Murray BC, Peterson MT, Fecik RA. Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers. Natural Product Reports. 32: 654-62. PMID 25677951 DOI: 10.1039/C4Np00036F |
0.377 |
|
2014 |
Li Y, Fiers WD, Bernard SM, Smith JL, Aldrich CC, Fecik RA. Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains. Acs Chemical Biology. 9: 2914-22. PMID 25299319 DOI: 10.1021/Cb5006883 |
0.361 |
|
2010 |
Leggans EK, Akey DL, Smith JL, Fecik RA. A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins. Bioorganic & Medicinal Chemistry Letters. 20: 5939-42. PMID 20801036 DOI: 10.1016/J.Bmcl.2010.05.089 |
0.367 |
|
2009 |
Balasubramanian R, Raghavan B, Begaye A, Sackett DL, Fecik RA. Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues. Journal of Medicinal Chemistry. 52: 238-40. PMID 19102699 DOI: 10.1021/Jm8013579 |
0.523 |
|
2008 |
Gupta S, Lakshmanan V, Kim BS, Fecik R, Reynolds KA. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 1609-16. PMID 18512859 DOI: 10.1002/Cbic.200700635 |
0.373 |
|
2008 |
Balasubramanian R, Raghavan B, Steele JC, Sackett DL, Fecik RA. Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2996-9. PMID 18411048 DOI: 10.1016/J.Bmcl.2008.03.046 |
0.497 |
|
2008 |
Raghavan B, Balasubramanian R, Steele JC, Sackett DL, Fecik RA. Cytotoxic simplified tubulysin analogues. Journal of Medicinal Chemistry. 51: 1530-3. PMID 18314944 DOI: 10.1021/Jm701321P |
0.523 |
|
2007 |
Fecik RA. Natural product biosynthesis moves in vitro. Nature Chemical Biology. 3: 531-2. PMID 17710095 DOI: 10.1038/Nchembio0907-531 |
0.353 |
|
2006 |
Venkatraman L, Salomon CE, Sherman DH, Fecik RA. Total synthesis of narbonolide and biotransformation to pikromycin. The Journal of Organic Chemistry. 71: 9853-6. PMID 17168607 DOI: 10.1021/Jo062047U |
0.375 |
|
2006 |
Giraldes JW, Akey DL, Kittendorf JD, Sherman DH, Smith JL, Fecik RA. Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2: 531-6. PMID 16969373 DOI: 10.1038/Nchembio822 |
0.442 |
|
2006 |
Akey DL, Kittendorf JD, Giraldes JW, Fecik RA, Sherman DH, Smith JL. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2: 537-42. PMID 16969372 DOI: 10.1038/Nchembio824 |
0.409 |
|
2005 |
Venkatraman L, Aldrich CC, Sherman DH, Fecik RA. Formal total synthesis of the polyketide macrolactone narbonolide. The Journal of Organic Chemistry. 70: 7267-72. PMID 16122247 DOI: 10.1021/Jo050924A |
0.409 |
|
2005 |
Aldrich CC, Venkatraman L, Sherman DH, Fecik RA. Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. Journal of the American Chemical Society. 127: 8910-1. PMID 15969542 DOI: 10.1021/Ja0504340 |
0.459 |
|
2005 |
Aldrich CC, Beck BJ, Fecik RA, Sherman DH. Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. Journal of the American Chemical Society. 127: 8441-52. PMID 15941278 DOI: 10.1021/Ja042592H |
0.405 |
|
2003 |
Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society. 125: 12551-7. PMID 14531700 DOI: 10.1021/Ja034841S |
0.407 |
|
2003 |
Beck BJ, Aldrich CC, Fecik RA, Reynolds KA, Sherman DH. Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society. 125: 4682-3. PMID 12696866 DOI: 10.1021/Ja029974C |
0.421 |
|
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