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Nathan N. Alder, Ph.D. - Publications

Affiliations: 
2002 University of California, Davis, Davis, CA 
Area:
Biochemistry, Cell Biology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Reed AL, Mitchell W, Alexandrescu AT, Alder NN. Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases. Frontiers in Physiology. 14: 1263420. PMID 38028797 DOI: 10.3389/fphys.2023.1263420  0.321
2023 Tamucci JD, Alder NN, May ER. Peptide Power: Mechanistic Insights into the Effect of Mitochondria-Targeted Tetrapeptides on Membrane Electrostatics from Molecular Simulations. Molecular Pharmaceutics. PMID 37904323 DOI: 10.1021/acs.molpharmaceut.3c00480  0.381
2023 Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM. Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant. Biorxiv : the Preprint Server For Biology. PMID 37205478 DOI: 10.1101/2023.05.05.539595  0.378
2022 Mitchell W, Tamucci JD, Ng EL, Liu S, Birk AV, Szeto HH, May ER, Alexandrescu AT, Alder NN. Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds. Elife. 11. PMID 35913044 DOI: 10.7554/eLife.75531  0.355
2021 Iovine JC, Claypool SM, Alder NN. Mitochondrial compartmentalization: emerging themes in structure and function. Trends in Biochemical Sciences. PMID 34244035 DOI: 10.1016/j.tibs.2021.06.003  0.306
2020 Mitchell W, Ng EA, Tamucci JD, Boyd KJ, Sathappa M, Coscia A, Pan M, Han X, Eddy NA, May ER, Szeto HH, Alder NN. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. The Journal of Biological Chemistry. 295: 7452-7469. PMID 33516364 DOI: 10.1074/jbc.RA119.012094  0.351
2020 Mitchell W, Ng EA, Tamucci JD, Boyd KJ, Sathappa M, Coscia A, Pan M, Han X, Eddy NA, May ER, Szeto HH, Alder NN. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. The Journal of Biological Chemistry. PMID 32273339 DOI: 10.1074/Jbc.Ra119.012094  0.443
2020 Alder N, Peixoto P, Modak A. Functional Assembly of the Mitochondrial Protein Transport Machinery The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00154  0.45
2019 Bae M, Lee Y, Park YK, Shin DG, Joshi P, Hong SH, Alder N, Koo SI, Lee JY. Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells. The Journal of Nutritional Biochemistry. 71: 82-89. PMID 31302374 DOI: 10.1016/J.Jnutbio.2019.06.001  0.361
2019 Calzada E, Avery E, Sam PN, Modak A, Wang C, McCaffery JM, Han X, Alder NN, Claypool SM. Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc complex function. Nature Communications. 10: 1432. PMID 30926815 DOI: 10.1038/S41467-019-09425-1  0.461
2019 Alder NN, Mitchell W, Ng E, Boyd K, Tamucci J, May E, Eddy N, Szeto H. Biophysical Approaches Toward Understanding the Molecular Mechanism of Action of the Mitochondrial Therapeutic SS-31 (Elamipretide) Biophysical Journal. 116: 511a-512a. DOI: 10.1016/J.Bpj.2018.11.2759  0.322
2019 Boyd KJ, Alder NN, May ER. Interplay of Curvature, Lipid Segregation and Stability Modulation in Complex Lipid Bilayers Biophysical Journal. 116: 363a. DOI: 10.1016/J.Bpj.2018.11.1976  0.335
2018 Boyd KJ, Alder NN, May ER. Molecular Dynamics Analysis of Cardiolipin and Monolysocardiolipin on Bilayer Properties. Biophysical Journal. 114: 2116-2127. PMID 29742405 DOI: 10.1016/J.Bpj.2018.04.001  0.443
2017 Malhotra K, Modak A, Nangia S, Daman TH, Gunsel U, Robinson VL, Mokranjac D, May ER, Alder NN. Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50. Science Advances. 3: e1700532. PMID 28879236 DOI: 10.1126/Sciadv.1700532  0.514
2017 Boyd KJ, Alder NN, May ER. Buckling Under Pressure: Curvature Based Lipid Segregation and Stability Modulation in Cardiolipin Containing Bilayers. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 28628337 DOI: 10.1021/Acs.Langmuir.7B01185  0.484
2017 Malhotra K, Alder NN. Reconstitution of Mitochondrial Membrane Proteins into Nanodiscs by Cell-Free Expression. Methods in Molecular Biology (Clifton, N.J.). 1567: 155-178. PMID 28276018 DOI: 10.1007/978-1-4939-6824-4_10  0.525
2017 Skoryk MK, Boyd KJ, May ER, Alder NN. Lipid-Dependence of the Membrane Interactions of the Tim23 Channel Subunit of the Mitochondrial Protein Import Machinery Biophysical Journal. 112: 84a-85a. DOI: 10.1016/J.Bpj.2016.11.501  0.469
2017 Sathappa M, Mitchell W, Coscia A, Boyd K, May E, Szeto HH, Alder NN. Investigation of the Interactions of the SS-31 Peptides with Cardiolipin Variants: A Potential Therapeutic for Barth Syndrome Biophysical Journal. 112: 438a. DOI: 10.1016/J.Bpj.2016.11.2339  0.439
2017 Boyd KJ, Alder NN, May ER. Molecular Dynamics Investigation into the Distribution of Cardiolipin Variants in Flat and Buckled Heterogeneous Bilayers Biophysical Journal. 112: 221a. DOI: 10.1016/J.Bpj.2016.11.1218  0.504
2016 Sathappa M, Alder NN. Ionization Properties of Phospholipids Determined by Zeta Potential Measurements. Bio-Protocol. 6. PMID 27928550 DOI: 10.21769/BioProtoc.e2030  0.319
2016 Sathappa M, Alder NN. The ionization properties of cardiolipin and its variants in model bilayers. Biochimica Et Biophysica Acta. 1858: 1362-72. PMID 26965987 DOI: 10.1016/J.Bbamem.2016.03.007  0.477
2016 Sathappa M, Greenwood M, Alder N. Investigation of the Physiochemical Properties of the Phospholipid Cardiolipin: Implications for Oxphos Regulation and Barth Syndrome Biophysical Journal. 110: 422a-423a. DOI: 10.1016/J.Bpj.2015.11.2284  0.433
2016 Alder NN, Malhotra K, Sathappa M, Nangia S, Daman T, Mokranjac D, May E. Energy Coupling Mechanisms and Lipid-Mediated Subunit Interactions of the Mitochondrial Protein Transport Machinery Biophysical Journal. 110: 230a. DOI: 10.1016/J.Bpj.2015.11.1271  0.507
2015 Lee KK, Imaizumi N, Chamberland SR, Alder NN, Boelsterli UA. Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury. Hepatology (Baltimore, Md.). 61: 326-36. PMID 25142022 DOI: 10.1002/Hep.27385  0.377
2015 Mitra K, Schwall C, Albert AA, Alder N. Thermotropic Behavior of Cardiolipin and Dimyristoylphosphatidylcholine Bilayers in the Presence and Absence of Calcium Biophysical Journal. 108: 89a. DOI: 10.1016/J.Bpj.2014.11.516  0.418
2015 Sathappa M, Schwall CT, Greenwood MR, Baile MG, Claypool SM, Alder NN. Investigation of the Role of the Phospholipid Cardiolipin in Activating Respiratory Complex Activity Biophysical Journal. 108: 367a. DOI: 10.1016/J.Bpj.2014.11.2015  0.502
2014 Malhotra K, Alder NN. Advances in the use of nanoscale bilayers to study membrane protein structure and function. Biotechnology & Genetic Engineering Reviews. 30: 79-93. PMID 25023464 DOI: 10.1080/02648725.2014.921502  0.409
2014 Baile MG, Sathappa M, Lu YW, Pryce E, Whited K, McCaffery JM, Han X, Alder NN, Claypool SM. Unremodeled and remodeled cardiolipin are functionally indistinguishable in yeast. The Journal of Biological Chemistry. 289: 1768-78. PMID 24285538 DOI: 10.1074/Jbc.M113.525733  0.384
2014 Malhotra K, Sathappa M, Landin JS, Johnson AE, Alder NN. The Mitochondrial Tim23 Protein Transport Complex Undergoes Conformational Dynamics Coupled to the Energized State of the Inner Membrane Biophysical Journal. 106: 370a-371a. DOI: 10.1016/J.Bpj.2013.11.2098  0.515
2014 Schwall C, Alder N. Cation-Dependent Behavior of Cardiolipin-Containing Membranes and Implications for Respiratory Complex II Assembly and Activity Biophysical Journal. 106: 303a. DOI: 10.1016/J.Bpj.2013.11.1762  0.469
2013 Schwall CT, Alder NN. Site-specific fluorescent probe labeling of mitochondrial membrane proteins. Methods in Molecular Biology (Clifton, N.J.). 1033: 103-20. PMID 23996173 DOI: 10.1007/978-1-62703-487-6_7  0.478
2013 Lee KK, Fujimoto K, Zhang C, Schwall CT, Alder NN, Pinkert CA, Krueger W, Rasmussen T, Boelsterli UA. Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes. Free Radical Biology & Medicine. 65: 584-94. PMID 23911619 DOI: 10.1016/J.Freeradbiomed.2013.07.038  0.35
2013 Malhotra K, Sathappa M, Landin JS, Johnson AE, Alder NN. Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force. Nature Structural & Molecular Biology. 20: 965-72. PMID 23832274 DOI: 10.1038/Nsmb.2613  0.443
2013 Long AR, O'Brien CC, Malhotra K, Schwall CT, Albert AD, Watts A, Alder NN. A detergent-free strategy for the reconstitution of active enzyme complexes from native biological membranes into nanoscale discs. Bmc Biotechnology. 13: 41. PMID 23663692 DOI: 10.1186/1472-6750-13-41  0.499
2013 Schwall C, Alder N. Assembly and Activity of Respiratory Complex II in Nanolipoprotein Particles Biophysical Journal. 104: 594a. DOI: 10.1016/J.Bpj.2012.11.3299  0.459
2013 Long AR, O'Brien CC, Malhotra K, Albert AD, Watts A, Alder NN. The Styrene-Maleic Acid Copolymer Extracts Active Complexes from Native Biomembranes Biophysical Journal. 104: 523a. DOI: 10.1016/J.Bpj.2012.11.2892  0.5
2012 Long AR, O'Brien CC, Alder NN. The cell-free integration of a polytopic mitochondrial membrane protein into liposomes occurs cotranslationally and in a lipid-dependent manner. Plos One. 7: e46332. PMID 23050015 DOI: 10.1371/Journal.Pone.0046332  0.545
2012 Schwall CT, Greenwood VL, Alder NN. The stability and activity of respiratory Complex II is cardiolipin-dependent. Biochimica Et Biophysica Acta. 1817: 1588-96. PMID 22575443 DOI: 10.1016/J.Bbabio.2012.04.015  0.43
2011 Deshmukh L, Meller N, Alder N, Byzova T, Vinogradova O. Tyrosine phosphorylation as a conformational switch: a case study of integrin β3 cytoplasmic tail. The Journal of Biological Chemistry. 286: 40943-53. PMID 21956114 DOI: 10.1074/Jbc.M111.231951  0.351
2011 Ranaghan MJ, Schwall CT, Alder NN, Birge RR. Green proteorhodopsin reconstituted into nanoscale phospholipid bilayers (nanodiscs) as photoactive monomers. Journal of the American Chemical Society. 133: 18318-27. PMID 21951206 DOI: 10.1021/Ja2070957  0.44
2008 Alder NN, Jensen RE, Johnson AE. Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface. Cell. 134: 439-50. PMID 18692467 DOI: 10.1016/J.Cell.2008.06.007  0.464
2008 Alder NN, Sutherland J, Buhring AI, Jensen RE, Johnson AE. Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits. Molecular Biology of the Cell. 19: 159-70. PMID 17959826 DOI: 10.1091/Mbc.E07-07-0669  0.455
2007 Davis AJ, Alder NN, Jensen RE, Johnson AE. The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import. Molecular Biology of the Cell. 18: 475-86. PMID 17122363 DOI: 10.1091/Mbc.E06-06-0546  0.478
2005 Alder NN, Shen Y, Brodsky JL, Hendershot LM, Johnson AE. The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum. The Journal of Cell Biology. 168: 389-99. PMID 15684029 DOI: 10.1083/Jcb.200409174  0.424
2004 Alder NN, Johnson AE. Cotranslational membrane protein biogenesis at the endoplasmic reticulum. The Journal of Biological Chemistry. 279: 22787-90. PMID 15028726 DOI: 10.1074/Jbc.R400002200  0.486
2003 Alder NN, Theg SM. Energy use by biological protein transport pathways. Trends in Biochemical Sciences. 28: 442-51. PMID 12932733 DOI: 10.1016/S0968-0004(03)00167-1  0.622
2003 Alder NN, Theg SM. Protein transport via the cpTat pathway displays cooperativity and is stimulated by transport-incompetent substrate. Febs Letters. 540: 96-100. PMID 12681490 DOI: 10.1016/S0014-5793(03)00231-X  0.59
2003 Alder NN, Theg SM. Energetics of protein transport across biological membranes. a study of the thylakoid DeltapH-dependent/cpTat pathway. Cell. 112: 231-42. PMID 12553911 DOI: 10.1016/S0092-8674(03)00032-1  0.642
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