Felipe Simon, PhD - Publications

Affiliations: 
Physiology Universidad Andrés Bello, Santiago, Región Metropolitana, Chile 
Area:
Oxidative stress

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F. Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Biological Research. 56: 24. PMID 37165417 DOI: 10.1186/s40659-023-00433-6  0.554
2023 Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F. Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Biological Research. 56: 8. PMID 36869357 DOI: 10.1186/s40659-023-00419-4  0.611
2022 Echeverría C, Martin A, Simon F, Salas CO, Nazal M, Varela D, Pérez-Castro RA, Santibanez JF, Valdés-Valdés RO, Forero-Doria O, Echeverría J. and antitumor activity of tomatine in hepatocellular carcinoma. Frontiers in Pharmacology. 13: 1003264. PMID 36160442 DOI: 10.3389/fphar.2022.1003264  0.564
2020 Jimenez I, Prado Y, Marchant F, Otero C, Eltit F, Cabello-Verrugio C, Cerda O, Simon F. TRPM Channels in Human Diseases. Cells. 9. PMID 33291725 DOI: 10.3390/cells9122604  0.632
2020 Ramírez-Barrantes R, Carvajal-Zamorano K, Rodriguez B, Cordova C, Lozano C, Simon F, Díaz P, Muñoz P, Marchant I, Latorre R, Castillo K, Olivero P. TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death. Frontiers in Physiology. 11: 444. PMID 32528302 DOI: 10.3389/Fphys.2020.00444  0.65
2020 Aravena J, Abrigo J, Gonzalez F, Aguirre F, Gonzalez A, Simon F, Cabello-Verrugio C. Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy. International Journal of Molecular Sciences. 21. PMID 32050585 DOI: 10.3390/Ijms21031167  0.308
2020 Pérez L, Vallejos A, Echeverria C, Varela D, Cabello-Verrugio C, Simon F. Correction: OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 31942005 DOI: 10.1038/S41374-020-0375-X  0.582
2019 Barrionuevo N, Gatica S, Olivares P, Cabello-Verrugio C, Simon F. Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative Conditions. The Protein Journal. PMID 31512093 DOI: 10.1007/S10930-019-09865-0  0.33
2019 Gatica S, Villegas V, Vallejos A, Olivares P, Aballai V, Lagos-Meza F, Echeverria C, Cabello-Verrugio C, Varela D, Simon F. TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 31444399 DOI: 10.1038/S41374-019-0304-Z  0.611
2019 Gatica S, Eltit F, Santibanez JF, Varela D, Cabello-Verrugio C, Simon F. Expression suppression and activity inhibition of TRPM7 regulates cytokine production and multiple organ dysfunction syndrome during endotoxemia: A new target for sepsis. Current Molecular Medicine. PMID 31288723 DOI: 10.2174/1566524019666190709181726  0.595
2019 Tapia P, Gatica S, Cortés-Rivera C, Otero C, Becerra A, Riedel CA, Cabello-Verrugio C, Kalergis AM, Simon F. Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction. Critical Care Medicine. PMID 30998606 DOI: 10.1097/Ccm.0000000000003778  0.303
2019 Vallejos A, Olivares P, Gatica S, Villegas V, Echeverria C, Cabello-Verrugio C, Simon F. Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30911151 DOI: 10.1038/S41374-019-0237-6  0.348
2019 Pérez L, Vallejos A, Echeverria C, Varela D, Cabello-Verrugio C, Simon F. OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30664710 DOI: 10.1038/S41374-018-0151-3  0.611
2018 Vallejos A, Olivares P, Varela D, Echeverria C, Cabello-Verrugio C, Pérez-Leighton C, Simon F. Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival. Frontiers in Physiology. 9: 1800. PMID 30618812 DOI: 10.3389/Fphys.2018.01800  0.547
2018 Jensen EL, Gonzalez-Ibanez AM, Mendoza P, Ruiz LM, Riedel CA, Simon F, Schuringa JJ, Elorza AA. Copper deficiency-induced anemia is caused by a mitochondrial metabolic reprograming in erythropoietic cells. Metallomics : Integrated Biometal Science. PMID 30358789 DOI: 10.1039/C8Mt00224J  0.308
2018 Sagredo AI, Sagredo EA, Pola V, Echeverría C, Andaur R, Michea L, Stutzin A, Simon F, Marcelain K, Armisén R. TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines. Journal of Cellular Physiology. PMID 30343491 DOI: 10.1002/Jcp.27371  0.801
2018 Ramírez-Barrantes R, Córdova C, Gatica S, Rodriguez B, Lozano C, Marchant I, Echeverria C, Simon F, Olivero P. Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death. Frontiers in Physiology. 9: 682. PMID 29922176 DOI: 10.3389/Fphys.2018.00682  0.694
2018 Simon F, Perez L. P565Vascular endothelial cells exposed to oxidized HDL increases LOX-1 destination at the plasma membrane through a mechanism involving ROS/NOX/NF-kB/LOX-1 pathway Cardiovascular Research. 114. DOI: 10.1093/Cvr/Cvy060.419  0.336
2017 Lillo MA, Gaete PS, Puebla M, Ardiles NM, Poblete I, Becerra A, Simon F, Figueroa XF. Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29217667 DOI: 10.1096/Fj.201700365Rr  0.376
2017 Hermosilla T, Encina M, Morales D, Moreno C, Conejeros C, Alfaro-Valdés HM, Lagos-Meza F, Simon F, Altier C, Varela D. Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes. Scientific Reports. 7: 10131. PMID 28860469 DOI: 10.1038/S41598-017-10474-Z  0.624
2017 Becerra A, Rojas M, Vallejos A, Villegas V, Pérez L, Cabello-Verrugio C, Simon F. Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 28737766 DOI: 10.1038/Labinvest.2017.61  0.333
2017 Simon F, Tapia P, Armisen R, Echeverria C, Gatica S, Vallejos A, Pacheco A, Sanhueza ME, Alvo M, Segovia E, Torres R. Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca(2+) and Na(+) Ions and Oxidative Stress with the Participation of PKC/NOX2 and PI3K/Akt Pathways. Frontiers in Physiology. 8: 379. PMID 28659813 DOI: 10.3389/Fphys.2017.00379  0.698
2017 Sagredo AI, Sagredo EA, Cappelli C, Báez P, Rodrigo AM, Blanco C, Tapia JC, Echeverría C, Cerda O, Stutzin A, Simon F, Marcelain K, Armisén R. TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells. Molecular Oncology. PMID 28614631 DOI: 10.1002/1878-0261.12100  0.765
2016 Pérez L, Muñoz-Durango N, Riedel CA, Echeverría C, Kalergis AM, Cabello-Verrugio C, Simon F. Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Cytokine & Growth Factor Reviews. PMID 27692608 DOI: 10.1016/J.Cytogfr.2016.09.002  0.352
2016 Echeverría C, Romero V, Arancibia R, Klahn H, Montorfano I, Armisen R, Borgna V, Simon F, Ramirez-Tagle R. The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. PMID 27460450 DOI: 10.1007/S10534-016-9953-1  0.644
2016 Ramirez-Tagle R, Escobar CA, Romero V, Montorfano I, Armisén R, Borgna V, Jeldes E, Pizarro L, Simon F, Echeverria C. Chalcone-Induced Apoptosis through Caspase-Dependent Intrinsic Pathways in Human Hepatocellular Carcinoma Cells. International Journal of Molecular Sciences. 17. PMID 26907262 DOI: 10.3390/Ijms17020260  0.694
2015 Muñoz-Durango N, Vecchiola A, Gonzalez-Gomez LM, Simon F, Riedel CA, Fardella CE, Kalergis AM. Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone. Biomed Research International. 2015: 652738. PMID 26448944 DOI: 10.1155/2015/652738  0.317
2015 Moreno C, Hermosilla T, Morales D, Encina M, Torres-Díaz L, Díaz P, Sarmiento D, Simon F, Varela D. Cavβ 2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes. Pflugers Archiv : European Journal of Physiology. PMID 26265381 DOI: 10.1007/S00424-015-1723-3  0.582
2015 Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, et al. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. Plos One. 10: e0130540. PMID 26110647 DOI: 10.1371/Journal.Pone.0130540  0.789
2015 Echeverría C, Montorfano I, Cabello-Verrugio C, Armisén R, Varela D, Simon F. Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway. Journal of Hypertension. 33: 981-92. PMID 25909699 DOI: 10.1097/Hjh.0000000000000496  0.738
2015 Arriagada AA, Albornoz E, Opazo MC, Becerra A, Vidal G, Fardella C, Michea L, Carrasco N, Simon F, Elorza AA, Bueno SM, Kalergis AM, Riedel CA. Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Endocrinology. 156: 1540-51. PMID 25594695 DOI: 10.1210/En.2014-1371  0.323
2015 Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F. Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Microvascular Research. 98: 187-96. PMID 24518820 DOI: 10.1016/J.Mvr.2014.02.001  0.773
2014 Sarmiento D, Montorfano I, Cáceres M, Echeverría C, Fernández R, Cabello-Verrugio C, Cerda O, Tapia P, Simon F. Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity. The International Journal of Biochemistry & Cell Biology. 55: 11-23. PMID 25130439 DOI: 10.1016/J.Biocel.2014.08.001  0.713
2014 Montorfano I, Becerra A, Cerro R, Echeverría C, Sáez E, Morales MG, Fernández R, Cabello-Verrugio C, Simon F. Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway. Laboratory Investigation; a Journal of Technical Methods and Pathology. 94: 1068-82. PMID 25068653 DOI: 10.1038/Labinvest.2014.100  0.33
2014 Echeverría C, Montorfano I, Tapia P, Riedel C, Cabello-Verrugio C, Simon F. Endotoxin-induced endothelial fibrosis is dependent on expression of transforming growth factors β1 and β2. Infection and Immunity. 82: 3678-86. PMID 24935972 DOI: 10.1128/Iai.02158-14  0.348
2014 Echeverría C, Montorfano I, Hermosilla T, Armisén R, Velásquez LA, Cabello-Verrugio C, Varela D, Simon F. Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. Plos One. 9: e94146. PMID 24710004 DOI: 10.1371/Journal.Pone.0094146  0.665
2014 Morales MG, Abrigo J, Meneses C, Simon F, Cisternas F, Rivera JC, Vazquez Y, Cabello-Verrugio C. The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle. Clinical Science (London, England : 1979). 127: 251-64. PMID 24588264 DOI: 10.1042/Cs20130585  0.352
2014 Simon F, Echeverria C, Montorfano I, Becerra A, Varela D, Hermosilla T, Cabello-Verrugio C, Armisen R. P173Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives Cardiovascular Research. 103: S30.4-S30. DOI: 10.1093/Cvr/Cvu082.109  0.779
2013 Echeverría C, Montorfano I, Sarmiento D, Becerra A, Nuñez-Villena F, Figueroa XF, Cabello-Verrugio C, Elorza AA, Riedel C, Simon F. Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells. Journal of Cellular and Molecular Medicine. 17: 800-14. PMID 23635013 DOI: 10.1111/Jcmm.12066  0.336
2013 Simon F, Varela D, Cabello-Verrugio C. Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans. Cellular Signalling. 25: 1614-24. PMID 23602937 DOI: 10.1016/J.Cellsig.2013.03.023  0.614
2013 Echeverría C, Montorfano I, Sarmiento D, Becerra A, Cabello-Verrugio C, Simon F. Endotoxin induces conversion of endothelial cells into activated fibroblasts Critical Care. 17: P78. DOI: 10.1186/Cc12977  0.381
2012 Morales MG, Vazquez Y, Acuña MJ, Rivera JC, Simon F, Salas JD, Alvarez Ruf J, Brandan E, Cabello-Verrugio C. Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells. The International Journal of Biochemistry & Cell Biology. 44: 1993-2002. PMID 22964022 DOI: 10.1016/J.Biocel.2012.07.028  0.318
2012 Echeverría C, Becerra A, Nuñez-Villena F, Muñoz-Castro A, Stehberg J, Zheng Z, Arratia-Perez R, Simon F, Ramírez-Tagle R. The paramagnetic and luminescent [Re 6Se 8I 6] 3- cluster. Its potential use as an antitumoral and biomarker agent New Journal of Chemistry. 36: 927-932. DOI: 10.1039/C2Nj21016A  0.304
2011 Cabello-Verrugio C, Acuña MJ, Morales MG, Becerra A, Simon F, Brandan E. Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells. Biochemical and Biophysical Research Communications. 410: 665-70. PMID 21693104 DOI: 10.1016/J.Bbrc.2011.06.051  0.312
2011 Becerra A, Echeverría C, Varela D, Sarmiento D, Armisén R, Nuñez-Villena F, Montecinos M, Simon F. Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death. Cardiovascular Research. 91: 677-84. PMID 21565835 DOI: 10.1093/Cvr/Cvr135  0.631
2011 Nuñez-Villena F, Becerra A, Echeverría C, Briceño N, Porras O, Armisén R, Varela D, Montorfano I, Sarmiento D, Simon F. Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death. Antioxidants & Redox Signaling. 15: 2425-38. PMID 21539414 DOI: 10.1089/Ars.2010.3825  0.764
2011 Armisén R, Marcelain K, Simon F, Tapia JC, Toro J, Quest AF, Stutzin A. TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway. Journal of Cellular Physiology. 226: 103-9. PMID 20625999 DOI: 10.1002/Jcp.22310  0.693
2010 Simon F, Leiva-Salcedo E, Armisén R, Riveros A, Cerda O, Varela D, Eguiguren AL, Olivero P, Stutzin A. Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death. The Journal of Biological Chemistry. 285: 37150-8. PMID 20884614 DOI: 10.1074/Jbc.M110.155390  0.754
2010 Varela D, Penna A, Simon F, Eguiguren AL, Leiva-Salcedo E, Cerda O, Sala F, Stutzin A. P2X4 activation modulates volume-sensitive outwardly rectifying chloride channels in rat hepatoma cells. The Journal of Biological Chemistry. 285: 7566-74. PMID 20056605 DOI: 10.1074/Jbc.M109.063693  0.791
2009 Simon F, Fernández R. Early Iipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells Journal of Hypertension. 27: 1202-1216. PMID 19307985 DOI: 10.1097/Hjh.0B013E328329E31C  0.375
2008 Simon F, Stutzin A. Protein kinase C-mediated phosphorylation of p47 phox modulates platelet-derived growth factor-induced H2O2 generation and cell proliferation in human umbilical vein endothelial cells. Endothelium : Journal of Endothelial Cell Research. 15: 175-88. PMID 18663621 DOI: 10.1080/10623320802174480  0.684
2007 Varela D, Simon F, Olivero P, Armisén R, Leiva-Salcedo E, Jørgensen F, Sala F, Stutzin A. Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 20: 773-80. PMID 17982259 DOI: 10.1159/000110437  0.798
2004 Varela D, Simon F, Riveros A, Jørgensen F, Stutzin A. The volume-activated chloride current depends on phospholipase C activation and intracellular calcium mobilization. Advances in Experimental Medicine and Biology. 559: 141-5. PMID 18727235 DOI: 10.1007/0-387-23752-6_13  0.752
2004 Simon F, Varela D, Eguiguren AL, Díaz LF, Sala F, Stutzin A. Hydroxyl radical activation of a Ca(2+)-sensitive nonselective cation channel involved in epithelial cell necrosis. American Journal of Physiology. Cell Physiology. 287: C963-70. PMID 15163619 DOI: 10.1152/Ajpcell.00041.2004  0.786
2004 Varela D, Simon F, Riveros A, Jørgensen F, Stutzin A. NAD(P)H oxidase-derived H(2)O(2) signals chloride channel activation in cell volume regulation and cell proliferation. The Journal of Biological Chemistry. 279: 13301-4. PMID 14761962 DOI: 10.1074/Jbc.C400020200  0.792
2002 Simon F, Varela D, Riveros A, Eguiguren AL, Stutzin A. Non-selective cation channels and oxidative stress-induced cell swelling. Biological Research. 35: 215-22. PMID 12415739 DOI: 10.4067/S0716-97602002000200013  0.794
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