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Leor S. Weinberger - Publications

Affiliations: 
2011 Chemistry and Biochemistry University of California, San Diego, La Jolla, CA 
 2011- University of California, San Francisco, San Francisco, CA 
Area:
Systems Biology, Virology, Single-Cell Imaging, and Computational Modeling
Website:
https://gladstone.org/our-science/people/leor-weinberger
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Khetan N, Zuckerman B, Calia GP, Chen X, Arceo XG, Weinberger LS. Quantitative comparison of single-cell RNA sequencing versus single-molecule RNA imaging for quantifying transcriptional noise. Biorxiv : the Preprint Server For Biology. PMID 39149226 DOI: 10.1101/2024.08.09.607289  0.313
2024 Pitchai FNN, Tanner EJ, Khetan N, Vasen G, Levrel C, Kumar AJ, Pandey S, Ordonez T, Barnette P, Spencer D, Jung SY, Glazier J, Thompson C, Harvey-Vera A, Son HI, ... ... Weinberger LS, et al. Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates. Science (New York, N.Y.). 385: eadn5866. PMID 39116226 DOI: 10.1126/science.adn5866  0.561
2023 Calia GP, Chen X, Zuckerman B, Weinberger L. Comparative analysis between RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise. Biorxiv : the Preprint Server For Biology. PMID 36993609 DOI: 10.1101/2023.03.14.532632  0.308
2021 Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, ... ... Weinberger LS, et al. Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance. Cell. PMID 34838159 DOI: 10.1016/j.cell.2021.11.004  0.435
2021 Notton T, Glazier JJ, Saykally VR, Thompson CE, Weinberger LS. RanDeL-Seq: a High-Throughput Method to Map Viral - and -Acting Elements. Mbio. 12. PMID 33468683 DOI: 10.1128/mBio.01724-20  0.317
2020 Chaturvedi S, Engel R, Weinberger L. The HSV-1 ICP4 Transcriptional Auto-Repression Circuit Functions as a Transcriptional "Accelerator" Circuit. Frontiers in Cellular and Infection Microbiology. 10: 265. PMID 32670890 DOI: 10.3389/Fcimb.2020.00265  0.461
2020 Chaturvedi S, Klein J, Vardi N, Bolovan-Fritts C, Wolf M, Du K, Mlera L, Calvert M, Moorman NJ, Goodrum F, Huang B, Weinberger LS. A molecular mechanism for probabilistic bet hedging and its role in viral latency. Proceedings of the National Academy of Sciences of the United States of America. PMID 32632017 DOI: 10.1073/Pnas.1914430117  0.378
2020 Li Y, Shan Y, Desai RV, Cox KH, Weinberger LS, Takahashi JS. Noise-driven cellular heterogeneity in circadian periodicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32358201 DOI: 10.1073/Pnas.1922388117  0.365
2019 Hansen MMK, Martin B, Weinberger LS. HIV Latency: Stochastic across Multiple Scales. Cell Host & Microbe. 26: 703-705. PMID 31951580 DOI: 10.1016/J.Chom.2019.11.010  0.486
2019 Herzig E, Kim KC, Packard TA, Vardi N, Schwarzer R, Gramatica A, Deeks SG, Williams SR, Landgraf K, Killeen N, Martin DW, Weinberger LS, Greene WC. Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform. Cell. 179: 880-894.e10. PMID 31668804 DOI: 10.1016/J.Cell.2019.10.002  0.463
2019 Hansen MMK, Weinberger LS. Post-Transcriptional Noise Control. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 41: e1900044. PMID 31222776 DOI: 10.1002/Bies.201900044  0.548
2018 Hansen MMK, Desai RV, Simpson ML, Weinberger LS. Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability. Cell Systems. PMID 30243562 DOI: 10.1016/J.Cels.2018.08.002  0.446
2018 Vardi N, Chaturvedi S, Weinberger LS. Feedback-mediated signal conversion promotes viral fitness. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150412 DOI: 10.1073/Pnas.1802905115  0.431
2018 Hansen MMK, Wen WY, Ingerman E, Razooky BS, Thompson CE, Dar RD, Chin CW, Simpson ML, Weinberger LS. A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization. Cell. PMID 29754821 DOI: 10.1016/J.Cell.2018.04.005  0.77
2017 Razooky BS, Cao Y, Hansen MMK, Perelson AS, Simpson ML, Weinberger LS. Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean. Plos Biology. 15: e2000841. PMID 29045398 DOI: 10.1371/Journal.Pbio.2000841  0.809
2017 Pai A, Weinberger LS. Viral Master Circuits: From Discovery to New Therapy Targets. Annual Review of Virology. PMID 28800289 DOI: 10.1146/Annurev-Virology-110615-035606  0.423
2017 Aull KH, Tanner EJ, Thomson M, Weinberger LS. Transient Thresholding: A Mechanism Enabling Noncooperative Transcriptional Circuitry to Form a Switch. Biophysical Journal. 112: 2428-2438. PMID 28591615 DOI: 10.1016/J.Bpj.2017.05.002  0.459
2016 Dar RD, Shaffer SM, Singh A, Razooky BS, Simpson ML, Raj A, Weinberger LS. Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels. Plos One. 11: e0158298. PMID 27467384 DOI: 10.1371/Journal.Pone.0158298  0.781
2016 Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aul K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. The HIV-1 Tat protein is monomethylated at lysine-71 by the lysine methyltransferase KMT7. The Journal of Biological Chemistry. PMID 27235396 DOI: 10.1074/Jbc.M116.735415  0.441
2016 Rast LI, Rouzine IM, Rozhnova G, Bishop L, Weinberger AD, Weinberger LS. Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals. Plos Computational Biology. 12: e1004799. PMID 27152856 DOI: 10.1371/Journal.Pcbi.1004799  0.449
2016 Tanner EJ, Kirkegaard KA, Weinberger LS. Exploiting Genetic Interference for Antiviral Therapy. Plos Genetics. 12: e1005986. PMID 27149616 DOI: 10.1371/Journal.Pgen.1005986  0.345
2015 Weinberger LS. A minimal fate-selection switch. Current Opinion in Cell Biology. 37: 111-8. PMID 26611210 DOI: 10.1016/J.Ceb.2015.10.005  0.533
2015 Dar RD, Razooky BS, Weinberger LS, Cox CD, Simpson ML. The Low Noise Limit in Gene Expression. Plos One. 10: e0140969. PMID 26488303 DOI: 10.1371/Journal.Pone.0140969  0.747
2015 Rouzine IM, Weinberger AD, Weinberger LS. An evolutionary role for HIV latency in enhancing viral transmission. Cell. 160: 1002-12. PMID 25723173 DOI: 10.1016/J.Cell.2015.02.017  0.497
2015 Razooky BS, Pai A, Aull K, Rouzine IM, Weinberger LS. A hardwired HIV latency program. Cell. 160: 990-1001. PMID 25723172 DOI: 10.1016/J.Cell.2015.02.009  0.779
2014 Rouzine IM, Razooky BS, Weinberger LS. Stochastic variability in HIV affects viral eradication. Proceedings of the National Academy of Sciences of the United States of America. 111: 13251-2. PMID 25201951 DOI: 10.1073/Pnas.1413362111  0.748
2014 Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Screening for noise in gene expression identifies drug synergies. Science (New York, N.Y.). 344: 1392-6. PMID 24903562 DOI: 10.1126/Science.1250220  0.52
2014 Rouzine IM, Coffin JM, Weinberger LS. Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo. Plos Genetics. 10: e1004179. PMID 24586204 DOI: 10.1371/Journal.Pgen.1004179  0.421
2014 Dar R, Bolovan-Fritts C, Teng M, Linhares B, Simpson M, Weinberger LS. Structure and Function of a Transcriptional ‘Accelerator’ Circuit Biophysical Journal. 106: 375a. DOI: 10.1016/J.Bpj.2013.11.2122  0.384
2014 Dar RD, Weinberger LS. Altering Stochastic Noise in Gene Expression for HIV Therapy Biophysical Journal. 106: 374a. DOI: 10.1016/J.Bpj.2013.11.2117  0.573
2013 Weinberger AD, Weinberger LS. Stochastic fate selection in HIV-infected patients. Cell. 155: 497-9. PMID 24243007 DOI: 10.1016/J.Cell.2013.09.039  0.504
2013 Rouzine IM, Weinberger LS. Reply to "Coadaptive stability of interfering particles with HIV-1 when there is an evolutionary conflict". Journal of Virology. 87: 9960-2. PMID 23943740 DOI: 10.1128/Jvi.00932-13  0.372
2013 Gardner TJ, Bolovan-Fritts C, Teng MW, Redmann V, Kraus TA, Sperling R, Moran T, Britt W, Weinberger LS, Tortorella D. Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies. Clinical and Vaccine Immunology : Cvi. 20: 540-50. PMID 23389931 DOI: 10.1128/Cvi.00644-12  0.334
2013 Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 452-62. PMID 23255218 DOI: 10.4161/Cc.23309  0.519
2013 Rouzine IM, Weinberger LS. Design requirements for interfering particles to maintain coadaptive stability with HIV-1. Journal of Virology. 87: 2081-93. PMID 23221552 DOI: 10.1128/Jvi.02741-12  0.503
2013 Rouzine IM, Weinberger LS. The quantitative theory of within-host viral evolution Journal of Statistical Mechanics: Theory and Experiment. 2013. DOI: 10.1088/1742-5468/2013/01/P01009  0.307
2013 Teng MW, Bolovan-Fritts C, Dar RD, Womack A, Simpson ML, Shenk T, Weinberger LS. Erratum: An endogenous accelerator for viral gene expression confers a fitness advantage (Cell (2012) 151 (1569-1580)) Cell. 152. DOI: 10.1016/J.Cell.2013.01.048  0.766
2012 Teng MW, Bolovan-Fritts C, Dar RD, Womack A, Simpson ML, Shenk T, Weinberger LS. An endogenous accelerator for viral gene expression confers a fitness advantage. Cell. 151: 1569-80. PMID 23260143 DOI: 10.1016/J.Cell.2012.11.051  0.775
2012 Dar RD, Razooky BS, Singh A, Trimeloni TV, McCollum JM, Cox CD, Simpson ML, Weinberger LS. Transcriptional burst frequency and burst size are equally modulated across the human genome. Proceedings of the National Academy of Sciences of the United States of America. 109: 17454-9. PMID 23064634 DOI: 10.1073/Pnas.1213530109  0.728
2012 Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab On a Chip. 12: 4305-12. PMID 22976503 DOI: 10.1039/C2Lc40170C  0.74
2012 Singh A, Razooky BS, Dar RD, Weinberger LS. Dynamics of protein noise can distinguish between alternate sources of gene-expression variability. Molecular Systems Biology. 8: 607. PMID 22929617 DOI: 10.1038/Msb.2012.38  0.775
2011 Franz K, Singh A, Weinberger LS. Lentiviral vectors to study stochastic noise in gene expression. Methods in Enzymology. 497: 603-22. PMID 21601105 DOI: 10.1016/B978-0-12-385075-1.00026-3  0.505
2011 Metzger VT, Lloyd-Smith JO, Weinberger LS. Autonomous targeting of infectious superspreaders using engineered transmissible therapies. Plos Computational Biology. 7: e1002015. PMID 21483468 DOI: 10.1371/Journal.Pcbi.1002015  0.407
2011 Razooky BS, Weinberger LS. Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise. Methods (San Diego, Calif.). 53: 68-77. PMID 21167940 DOI: 10.1016/J.Ymeth.2010.12.006  0.785
2010 Singh A, Razooky B, Cox CD, Simpson ML, Weinberger LS. Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression. Biophysical Journal. 98: L32-4. PMID 20409455 DOI: 10.1016/J.Bpj.2010.03.001  0.81
2009 Weinberger AD, Perelson AS, Ribeiro RM, Weinberger LS. Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection. Plos Computational Biology. 5: e1000467. PMID 19680436 DOI: 10.1371/Journal.Pcbi.1000467  0.421
2009 Singh A, Weinberger LS. Stochastic gene expression as a molecular switch for viral latency. Current Opinion in Microbiology. 12: 460-6. PMID 19595626 DOI: 10.1016/J.Mib.2009.06.016  0.568
2009 Wong ML, Bolovan-Fritts C, Weinberger LS. Negative Feedback Speeds Transcriptional Response-Time In Human Cytomegalovirus Biophysical Journal. 96: 305a. DOI: 10.1016/J.Bpj.2008.12.1519  0.461
2008 Weinberger LS, Dar RD, Simpson ML. Transient-mediated fate determination in a transcriptional circuit of HIV. Nature Genetics. 40: 466-70. PMID 18344999 DOI: 10.1038/Npre.2007.1198.1  0.594
2007 Weinberger LS, Shenk T. An HIV feedback resistor: auto-regulatory circuit deactivator and noise buffer. Plos Biology. 5: e9. PMID 17194214 DOI: 10.1371/Journal.Pbio.0050009  0.674
2005 Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell. 122: 169-82. PMID 16051143 DOI: 10.1016/J.Cell.2005.06.006  0.743
2005 Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive feedback loop: HIV-1 tat fluctuations drive phenotypic diversity Aiche Annual Meeting, Conference Proceedings. 10416.  0.707
2003 Weinberger LS, Schaffer DV, Arkin AP. Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection. Journal of Virology. 77: 10028-36. PMID 12941913 DOI: 10.1128/Jvi.77.18.10028-10036.2003  0.649
2001 Mohri H, Perelson AS, Tung K, Ribeiro RM, Ramratnam B, Markowitz M, Kost R, Hurley A, Weinberger L, Cesar D, Hellerstein MK, Ho DD. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy Journal of Experimental Medicine. 194: 1277-1287. PMID 11696593 DOI: 10.1084/Jem.194.9.1277  0.4
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