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Paramjit S. Arora, Ph.D. - Publications

Affiliations: 
Chemistry New York University, New York, NY, United States 
Area:
Bioorganic Chemistry
Website:
http://chemistry.fas.nyu.edu/object/paramjitarora.html
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87 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Hong SH, Nguyen T, Arora P. Design and Synthesis of Crosslinked Helix Dimers as Protein Tertiary Structure Mimics. Current Protocols. 2: e315. PMID 34982512 DOI: 10.1002/cpz1.315  0.351
2021 Jedhe GS, Arora PS. Hydrogen bond surrogate helices as minimal mimics of protein α-helices. Methods in Enzymology. 656: 1-25. PMID 34325784 DOI: 10.1016/bs.mie.2021.04.007  0.369
2020 Merritt HI, Sawyer N, Arora PS. Bent Into Shape: Folded Peptides to Mimic Protein Structure and Modulate Protein Function. Peptide Science (Hoboken, N.J.). 112. PMID 33575525 DOI: 10.1002/Pep2.24145  0.406
2020 Yoo DY, Barros SA, Brown GC, Rabot C, Bar-Sagi D, Arora PS. Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells. Journal of the American Chemical Society. PMID 32786217 DOI: 10.1021/Jacs.0C02109  0.706
2020 Yoo DY, Hauser AD, Joy ST, Bar-Sagi D, Arora PS. Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics. Acs Chemical Biology. PMID 32378881 DOI: 10.1021/Acschembio.0C00204  0.383
2020 Sadek J, Wuo MG, Rooklin D, Hauenstein A, Hong SH, Gautam A, Wu H, Zhang Y, Cesarman E, Arora PS. Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nature Communications. 11: 1786. PMID 32286300 DOI: 10.1038/S41467-020-15576-3  0.385
2019 Handoko -, Satishkumar S, Panigrahi N, Arora PS. Rational Design of an Organocatalyst for Peptide Bond Formation. Journal of the American Chemical Society. PMID 31508947 DOI: 10.1021/Jacs.9B07742  0.374
2018 Wuo MG, Hong SH, Singh A, Arora PS. Synthetic Control of Tertiary Helical Structures in Short Peptides. Journal of the American Chemical Society. PMID 30395711 DOI: 10.1021/Jacs.8B10082  0.439
2018 Sawyer N, Arora PS. Hydrogen Bond Surrogate Stabilization of β-Hairpins. Acs Chemical Biology. PMID 30005156 DOI: 10.1021/Acschembio.8B00641  0.353
2018 Wuo MG, Arora PS. Engineered protein scaffolds as leads for synthetic inhibitors of protein-protein interactions. Current Opinion in Chemical Biology. 44: 16-22. PMID 29803113 DOI: 10.1016/J.Cbpa.2018.05.013  0.375
2018 Sawyer N, Arora PS. Hydrogen Bond Surrogate Beta-Hairpins to Inhibit Protein-Protein Interactions Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.362  0.391
2017 Watkins AM, Craven TW, Renfrew PD, Arora PS, Bonneau R. Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers. Structure (London, England : 1993). PMID 29033287 DOI: 10.1016/J.Str.2017.09.005  0.32
2017 Wu H, Handoko, Raj M, Arora PS. Iterative Design of a Biomimetic Catalyst for Amino Acid Thioester Condensation. Organic Letters. PMID 28891652 DOI: 10.1021/Acs.Orglett.7B02412  0.698
2017 Rooklin D, Modell AE, Li H, Berdan V, Arora PS, Zhang Y. Targeting Unoccupied Surfaces on Protein-Protein Interfaces. Journal of the American Chemical Society. PMID 28759230 DOI: 10.1021/Jacs.7B05960  0.42
2017 Sawyer N, Watkins AM, Arora PS. Protein Domain Mimics as Modulators of Protein-Protein Interactions. Accounts of Chemical Research. PMID 28561588 DOI: 10.1021/Acs.Accounts.7B00130  0.484
2017 Watkins AM, Bonneau R, Arora PS. Modeling and Design of Peptidomimetics to Modulate Protein-Protein Interactions. Methods in Molecular Biology (Clifton, N.J.). 1561: 291-307. PMID 28236245 DOI: 10.1007/978-1-4939-6798-8_17  0.394
2017 Ghosal K, Colby JM, Das D, Joy ST, Arora PS, Krantz BA. Dynamic phenylalanine clamp interactions define single-channel polypeptide translocation through the anthrax toxin protective antigen channel. Journal of Molecular Biology. PMID 28192089 DOI: 10.1016/J.Jmb.2017.02.005  0.34
2017 Sawyer N, Arora PS. Using Hydrogen Bond Surrogate Technology to Stabilize Beta-Hairpins Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.979  0.411
2016 Watkins AM, Bonneau R, Arora PS. Side Chain Conformational Preferences Govern Protein- Protein Interactions. Journal of the American Chemical Society. PMID 27483190 DOI: 10.1021/Jacs.6B04892  0.422
2016 Modell AE, Blosser SL, Arora PS. Systematic Targeting of Protein-Protein Interactions. Trends in Pharmacological Sciences. PMID 27267699 DOI: 10.1016/J.Tips.2016.05.008  0.389
2016 Joy ST, Arora PS. An optimal hydrogen-bond surrogate for α-helices. Chemical Communications (Cambridge, England). PMID 27046675 DOI: 10.1039/C6Cc01104G  0.391
2015 Wuo MG, Mahon AB, Arora PS. An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics. Journal of the American Chemical Society. 137: 11618-21. PMID 26340721 DOI: 10.1021/Jacs.5B05525  0.452
2015 Watkins AM, Wuo MG, Arora PS. Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs. Journal of the American Chemical Society. 137: 11622-30. PMID 26302018 DOI: 10.1021/Jacs.5B05527  0.383
2015 Rooklin D, Wang C, Katigbak J, Arora PS, Zhang Y. AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces. Journal of Chemical Information and Modeling. 55: 1585-99. PMID 26225450 DOI: 10.1021/Acs.Jcim.5B00103  0.391
2015 Raj M, Wu H, Blosser SL, Vittoria MA, Arora PS. Aldehyde capture ligation for synthesis of native Peptide bonds. Journal of the American Chemical Society. 137: 6932-40. PMID 25966041 DOI: 10.1021/Jacs.5B03538  0.728
2015 Watkins AM, Arora PS. Structure-based inhibition of protein-protein interactions. European Journal of Medicinal Chemistry. 94: 480-8. PMID 25253637 DOI: 10.1016/J.Ejmech.2014.09.047  0.421
2014 Lao BB, Drew K, Guarracino DA, Brewer TF, Heindel DW, Bonneau R, Arora PS. Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions. Journal of the American Chemical Society. 136: 7877-88. PMID 24972345 DOI: 10.1021/Ja502310R  0.431
2014 Miller SE, Thomson PF, Arora PS. Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions. Current Protocols in Chemical Biology. 6: 101-16. PMID 24903885 DOI: 10.1002/9780470559277.Ch130202  0.639
2014 Watkins AM, Arora PS. Anatomy of β-strands at protein-protein interfaces. Acs Chemical Biology. 9: 1747-54. PMID 24870802 DOI: 10.1021/Cb500241Y  0.345
2014 Lao BB, Grishagin I, Mesallati H, Brewer TF, Olenyuk BZ, Arora PS. In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics. Proceedings of the National Academy of Sciences of the United States of America. 111: 7531-6. PMID 24821806 DOI: 10.1073/Pnas.1402393111  0.443
2014 Miller SE, Watkins AM, Kallenbach NR, Arora PS. Effects of side chains in helix nucleation differ from helix propagation. Proceedings of the National Academy of Sciences of the United States of America. 111: 6636-41. PMID 24753597 DOI: 10.1073/Pnas.1322833111  0.564
2014 Xie X, Piao L, Bullock BN, Smith A, Su T, Zhang M, Teknos TN, Arora PS, Pan Q. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene. 33: 1037-46. PMID 23474763 DOI: 10.1038/Onc.2013.25  0.746
2013 Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS. Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 15602-7. PMID 24019500 DOI: 10.1073/Pnas.1312473110  0.791
2013 Bergey CM, Watkins AM, Arora PS. HippDB: a database of readily targeted helical protein-protein interactions. Bioinformatics (Oxford, England). 29: 2806-7. PMID 23958730 DOI: 10.1093/Bioinformatics/Btt483  0.354
2013 Drew K, Renfrew PD, Craven TW, Butterfoss GL, Chou FC, Lyskov S, Bullock BN, Watkins A, Labonte JW, Pacella M, Kilambi KP, Leaver-Fay A, Kuhlman B, Gray JJ, Bradley P, ... ... Arora PS, et al. Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. Plos One. 8: e67051. PMID 23869206 DOI: 10.1371/Journal.Pone.0067051  0.811
2013 Raj M, Bullock BN, Arora PS. Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions. Bioorganic & Medicinal Chemistry. 21: 4051-7. PMID 23267671 DOI: 10.1016/J.Bmc.2012.11.023  0.792
2013 Arora PS. 187 Plucking the high hanging fruit: a systematic approach for targeting protein interfaces Journal of Biomolecular Structure & Dynamics. 31: 120-121. DOI: 10.1080/07391102.2013.786429  0.329
2012 Miller SE, Kallenbach NR, Arora PS. Reversible α-helix formation controlled by a hydrogen bond surrogate. Tetrahedron. 68: 4434-4437. PMID 23144512 DOI: 10.1016/J.Tet.2011.12.068  0.578
2012 Wang X, Bergenfeld I, Arora PS, Canary JW. Reversible redox reconfiguration of secondary structures in a designed peptide. Angewandte Chemie (International Ed. in English). 51: 12099-101. PMID 23109367 DOI: 10.1002/Anie.201206009  0.323
2012 Patgiri A, Joy ST, Arora PS. Nucleation effects in peptide foldamers. Journal of the American Chemical Society. 134: 11495-502. PMID 22715982 DOI: 10.1021/Ja301953J  0.791
2012 Mahon AB, Arora PS. End-Capped α-Helices as Modulators of Protein Function. Drug Discovery Today. Technologies. 9: e57-e62. PMID 22712023 DOI: 10.1016/J.Ddtec.2011.07.008  0.401
2012 Jespersen C, Soragni E, James Chou C, Arora PS, Dervan PB, Gottesfeld JM. Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorganic & Medicinal Chemistry Letters. 22: 4068-71. PMID 22607671 DOI: 10.1016/J.Bmcl.2012.04.090  0.475
2012 Henchey LK, Kushal S, Dubey R, Chapman RN, Olenyuk BZ, Arora PS. Correction to Inhibition of Hypoxia Inducible Factor 1-Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix. Journal of the American Chemical Society. 134: 8000. PMID 22540322 DOI: 10.1021/Ja302676M  0.78
2012 Mahon AB, Arora PS. Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices. Chemical Communications (Cambridge, England). 48: 1416-8. PMID 21952530 DOI: 10.1039/C1Cc14730G  0.428
2012 Kushal S, Bullock B, Henchey L, Arora P, Olenyuk B. Abstract 289: Hydrogen bond surrogate (HBS) helices as orthosteric regulator of hypoxia inducible transcription Cancer Research. 72: 289-289. DOI: 10.1158/1538-7445.Am2012-289  0.79
2012 Grishagin IV, Olenyuk BZ, Bullock B, Arora PS. Abstract 283: OOPs: Novel HIF-1α mimics Cancer Research. 72: 283-283. DOI: 10.1158/1538-7445.Am2012-283  0.788
2012 Mahon AB, Miller SE, Joy ST, Arora PS. Rational design strategies for developing synthetic inhibitors of helical protein interfaces Topics in Medicinal Chemistry. 8: 197-230. DOI: 10.1007/978-3-642-28965-1_6  0.521
2011 Bullock BN, Jochim AL, Arora PS. Assessing helical protein interfaces for inhibitor design. Journal of the American Chemical Society. 133: 14220-3. PMID 21846146 DOI: 10.1021/Ja206074J  0.786
2011 Patgiri A, Yadav KK, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the Ras-Sos interaction. Nature Chemical Biology. 7: 585-7. PMID 21765406 DOI: 10.1038/Nchembio.612  0.774
2011 Guarracino DA, Bullock BN, Arora PS. Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics. Biopolymers. 95: 1-7. PMID 20882600 DOI: 10.1002/Bip.21546  0.8
2010 Patgiri A, Menzenski MZ, Mahon AB, Arora PS. Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach. Nature Protocols. 5: 1857-65. PMID 21030960 DOI: 10.1038/Nprot.2010.146  0.816
2010 Porter JR, Helmers MR, Wang P, Furman JL, Joy ST, Arora PS, Ghosh I. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chemical Communications (Cambridge, England). 46: 8020-2. PMID 20856941 DOI: 10.1039/C0Cc02969F  0.327
2010 Henchey LK, Porter JR, Ghosh I, Arora PS. High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex. Chembiochem : a European Journal of Chemical Biology. 11: 2104-7. PMID 20821791 DOI: 10.1002/Cbic.201000378  0.821
2010 Jochim AL, Arora PS. Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors. Acs Chemical Biology. 5: 919-23. PMID 20712375 DOI: 10.1021/Cb1001747  0.8
2010 Patgiri A, Witten MR, Arora PS. Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling. Organic & Biomolecular Chemistry. 8: 1773-6. PMID 20449477 DOI: 10.1039/C000905A  0.785
2010 Tosovská P, Arora PS. Oligooxopiperazines as nonpeptidic alpha-helix mimetics. Organic Letters. 12: 1588-91. PMID 20196543 DOI: 10.1021/Ol1003143  0.757
2010 Henchey LK, Kushal S, Dubey R, Chapman RN, Olenyuk BZ, Arora PS. Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix. Journal of the American Chemical Society. 132: 941-3. PMID 20041650 DOI: 10.1021/Ja9082864  0.797
2009 Arora PS, Ansari AZ. Chemical biology: A Notch above other inhibitors. Nature. 462: 171-3. PMID 19907487 DOI: 10.1038/462171A  0.337
2009 Jochim AL, Miller SE, Angelo NG, Arora PS. Evaluation of triazolamers as active site inhibitors of HIV-1 protease. Bioorganic & Medicinal Chemistry Letters. 19: 6023-6. PMID 19800230 DOI: 10.1016/J.Bmcl.2009.09.049  0.747
2009 Guarracino DA, Arora PS. Making strides in peptide-based therapeutics. Chemistry & Biology. 16: 919-20. PMID 19778718 DOI: 10.1016/J.Chembiol.2009.09.005  0.374
2009 Jochim AL, Arora PS. Assessment of helical interfaces in protein-protein interactions. Molecular Biosystems. 5: 924-6. PMID 19668855 DOI: 10.1039/B903202A  0.792
2009 Bao J, Dong XY, Zhang JZ, Arora PS. Dynamical binding of hydrogen-bond surrogate derived Bak helices to antiapoptotic protein Bcl-xL. The Journal of Physical Chemistry. B. 113: 3565-71. PMID 19231824 DOI: 10.1021/Jp809810Z  0.459
2008 Henchey LK, Jochim AL, Arora PS. Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Current Opinion in Chemical Biology. 12: 692-7. PMID 18793750 DOI: 10.1016/J.Cbpa.2008.08.019  0.812
2008 Kirshenbaum K, Arora PS. Cross-dressing proteins by olefin metathesis. Nature Chemical Biology. 4: 527-8. PMID 18711379 DOI: 10.1038/Nchembio0908-527  0.314
2008 Patgiri A, Jochim AL, Arora PS. A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation. Accounts of Chemical Research. 41: 1289-300. PMID 18630933 DOI: 10.1021/Ar700264K  0.812
2008 Chapman R, Kulp JL, Patgiri A, Kallenbach NR, Bracken C, Arora PS. Trapping a folding intermediate of the alpha-helix: stabilization of the pi-helix. Biochemistry. 47: 4189-95. PMID 18335996 DOI: 10.1021/Bi800136M  0.804
2008 Liu J, Wang D, Zheng Q, Lu M, Arora PS. Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate. Journal of the American Chemical Society. 130: 4334-7. PMID 18331030 DOI: 10.1021/Ja077704U  0.596
2008 Wang D, Lu M, Arora PS. Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices. Angewandte Chemie (International Ed. in English). 47: 1879-82. PMID 18224636 DOI: 10.1002/Anie.200704227  0.576
2007 Angelo NG, Arora PS. Solution- and solid-phase synthesis of triazole oligomers that display protein-like functionality. The Journal of Organic Chemistry. 72: 7963-7. PMID 17880241 DOI: 10.1021/Jo701292H  0.783
2007 Angelo NG, Henchey LK, Waxman AJ, Canary JW, Arora PS, Wink D. Synthesis and characterization of aldol condensation products from unknown aldehydes and ketones. An inquiry-based experiment in the undergraduate laboratory Journal of Chemical Education. 84: 1816-1818. DOI: 10.1021/Ed084P1816  0.728
2006 Wang D, Chen K, Dimartino G, Arora PS. Nucleation and stability of hydrogen-bond surrogate-based alpha-helices. Organic & Biomolecular Chemistry. 4: 4074-81. PMID 17312961 DOI: 10.1039/B612891B  0.606
2006 Chapman RN, Arora PS. Optimized synthesis of hydrogen-bond surrogate helices: surprising effects of microwave heating on the activity of Grubbs catalysts. Organic Letters. 8: 5825-8. PMID 17134282 DOI: 10.1021/Ol062443Z  0.721
2006 Wang D, Chen K, Kulp Iii JL, Arora PS. Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Journal of the American Chemical Society. 128: 9248-56. PMID 16834399 DOI: 10.1021/Ja062710W  0.628
2006 Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM. Arresting Cancer Proliferation by Small-Molecule Gene Regulation (DOI:10.1016/j.chembiol.2004.09.004) Chemistry and Biology. 13: 339. DOI: 10.1016/J.Chembiol.2006.02.006  0.75
2005 Angelo NG, Arora PS. Nonpeptidic foldamers from amino acids: synthesis and characterization of 1,3-substituted triazole oligomers. Journal of the American Chemical Society. 127: 17134-5. PMID 16332031 DOI: 10.1021/Ja056406Z  0.796
2005 Wang D, Liao W, Arora PS. Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL. Angewandte Chemie (International Ed. in English). 44: 6525-9. PMID 16172999 DOI: 10.1002/Anie.200501603  0.63
2005 Dimartino G, Wang D, Chapman RN, Arora PS. Solid-phase synthesis of hydrogen-bond surrogate-derived alpha-helices. Organic Letters. 7: 2389-92. PMID 15932205 DOI: 10.1021/Ol0506516  0.773
2005 Arora PS. Adding specificity to artificial transcription activators. Chemistry & Biology. 12: 262-3. PMID 15797208 DOI: 10.1016/J.Chembiol.2005.03.002  0.3
2004 Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM. Arresting cancer proliferation by small-molecule gene regulation. Chemistry & Biology. 11: 1583-94. PMID 15556009 DOI: 10.1016/J.Chembiol.2004.09.004  0.759
2004 Chapman RN, Dimartino G, Arora PS. A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate. Journal of the American Chemical Society. 126: 12252-3. PMID 15453743 DOI: 10.1021/Ja0466659  0.734
2004 Arora PS, Kirshenbaum K. Nano-tailoring; stitching alterations on viral coats. Chemistry & Biology. 11: 418-20. PMID 15123234 DOI: 10.1016/J.Chembiol.2004.04.003  0.324
2003 Eisenführ A, Arora PS, Sengle G, Takaoka LR, Nowick JS, Famulok M. A ribozyme with michaelase activity: synthesis of the substrate precursors. Bioorganic & Medicinal Chemistry. 11: 235-49. PMID 12470718 DOI: 10.1016/S0968-0896(02)00311-5  0.57
2002 Arora PS, Ansari AZ, Best TP, Ptashne M, Dervan PB. Design of artificial transcriptional activators with rigid poly-L-proline linkers. Journal of the American Chemical Society. 124: 13067-71. PMID 12405833 DOI: 10.1021/Ja0208355  0.775
2002 Belitsky JM, Leslie SJ, Arora PS, Beerman TA, Dervan PB. Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorganic & Medicinal Chemistry. 10: 3313-8. PMID 12150878 DOI: 10.1016/S0968-0896(02)00204-3  0.751
2001 Sengle G, Eisenführ A, Arora PS, Nowick JS, Famulok M. Novel RNA catalysts for the Michael reaction. Chemistry & Biology. 8: 459-73. PMID 11358693 DOI: 10.1016/S1074-5521(01)00026-6  0.575
2000 Sengle G, Jenne A, Arora PS, Seelig B, Nowick JS, Jäschke A, Famulok M. Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5'-ends. Bioorganic & Medicinal Chemistry. 8: 1317-29. PMID 10896110 DOI: 10.1016/S0968-0896(00)00080-8  0.537
1998 Arora PS, Van QN, Famulok M, Shaka AJ, Nowick JS. Design and synthesis of a transition state analogue for the Diels-Alder reaction. Bioorganic & Medicinal Chemistry. 6: 1421-8. PMID 9801813 DOI: 10.1016/S0968-0896(98)00072-8  0.602
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