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Thomas R. Webb - Publications

Affiliations: 
Molecular Therapeutics and Cell Signaling University of Tennessee Health Science Center, Memphis, TN, United States 
Area:
Molecular Chemistry
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kumar G, Cuypers M, Webby RR, Webb TR, White SW. Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism. Nucleic Acids Research. PMID 33469660 DOI: 10.1093/nar/gkaa1294  0.304
2020 Shi Y, Bray W, Smith AJ, Zhou W, Calaoagan J, Lagisetti C, Sambucetti L, Crews P, Lokey RS, Webb TR. An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications. Plos One. 15: e0233672. PMID 32469945 DOI: 10.1371/Journal.Pone.0233672  0.36
2019 Repellin CE, Patel P, Shi Y, Gong H, Webb TR, Sambucetti L, Sinha S. Abstract 4015: Synthetic lethality-based predictive biomarker identification of splicing modulators in lung cancer Cancer Research. 79: 4015-4015. DOI: 10.1158/1538-7445.Am2019-4015  0.386
2019 Repellin CE, Patel P, Shi Y, Gong H, Shewade L, Webb T, Sambucetti L, Sinha S. Abstract C018: Primary tumor data analysis reveals novel synthetic lethal dependencies between KRAS mutation and the spliceosome Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-C018  0.353
2018 Wu G, Fan L, Edmonson MN, Shaw T, Boggs K, Easton J, Rusch MC, Webb TR, Zhang J, Potter PM. Corrigendum: Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping. Rna (New York, N.Y.). 24: 1886. PMID 30446591 DOI: 10.1261/Rna.068544.118  0.364
2018 Kyei GB, Meng S, Ramani R, Niu A, Lagisetti C, Webb TR, Ratner L. Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency. Mbio. 9. PMID 30401776 DOI: 10.1128/Mbio.01423-18  0.304
2017 Vigevani L, Gohr A, Webb T, Irimia M, Valcárcel J. Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP. Nature Communications. 8: 2100. PMID 29235465 DOI: 10.1038/S41467-017-02007-Z  0.325
2017 Beylkin D, Kumar G, Zhou W, Park J, Jeevan T, Lagisetti C, Harfoot R, Webby RJ, White SW, Webb TR. Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease. Scientific Reports. 7: 17139. PMID 29215062 DOI: 10.2210/Pdb5Wfm/Pdb  0.488
2017 Shi Y, Park J, Lagisetti C, Zhou W, Sambucetti LC, Webb TR. Erratum to "A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore" [Bioorg. Med. Chem. Lett. 27 (2017) 406-412]. Bioorganic & Medicinal Chemistry Letters. PMID 28214076 DOI: 10.1016/J.Bmcl.2017.02.009  0.392
2017 Fraile JM, Manchado E, Lujambio A, Quesada V, Campos-Iglesias D, Webb T, Lowe SW, Lopez-Otin C, Freije JM. USP39 Deubiquitinase Is Essential for KRAS-Driven cancer. The Journal of Biological Chemistry. PMID 28154181 DOI: 10.1074/Jbc.M116.762757  0.404
2017 Shirai CL, White BS, Tripathi M, Tapia R, Ley JN, Ndonwi M, Kim S, Shao J, Carver A, Saez B, Fulton RS, Fronick C, O'Laughlin M, Lagisetti C, Webb TR, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nature Communications. 8: 14060. PMID 28067246 DOI: 10.1038/Ncomms14060  0.316
2017 Shi Y, Park J, Lagisetti C, Zhou W, Sambucetti LC, Webb TR. Abstract 4193: A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor scaffold Cancer Research. 77: 4193-4193. DOI: 10.1158/1538-7445.Am2017-4193  0.5
2017 Kumar G, Beylkin D, Zhou W, Park J, Jeevan T, Lagisetti C, Harfoot R, Webby RJ, Webb TR, White SW. Structure-based drug discovery for influenza by targeting the cap-snatching endonuclease activity Acta Crystallographica Section a Foundations and Advances. 73: a394-a394. DOI: 10.1107/S0108767317096167  0.439
2016 Shi Y, Park J, Lagisetti C, Zhou W, Sambucetti LC, Webb TR. A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorganic & Medicinal Chemistry Letters. PMID 28049589 DOI: 10.1016/J.Bmcl.2016.12.056  0.504
2016 Song MS, Kumar G, Shadrick WR, Zhou W, Jeevan T, Li Z, Slavish PJ, Fabrizio TP, Yoon SW, Webb TR, Webby RJ, White SW. Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976575 DOI: 10.1073/Pnas.1519772113  0.447
2015 Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, ... ... Webb TR, et al. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. PMID 26331541 DOI: 10.1038/Nature14985  0.345
2015 Shi Y, Joyner AS, Shadrick W, Palacios G, Lagisetti C, Potter PM, Sambucetti LC, Stamm S, Webb TR. Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates. Pharmacology Research & Perspectives. 3: e00158. PMID 26171237 DOI: 10.1002/Prp2.158  0.447
2015 Xargay-Torrent S, López-Guerra M, Rosich L, Montraveta A, Roldán J, Rodríguez V, Villamor N, Aymerich M, Lagisetti C, Webb TR, López-Otín C, Campo E, Colomer D. The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia. Oncotarget. 6: 22734-49. PMID 26068951 DOI: 10.18632/Oncotarget.4212  0.377
2015 Shirai CL, Tripathi M, Ley JN, Ndonwi M, White BS, Tapia R, Saez B, Bertino A, Shao J, Kim S, Webb TR, Graubert TA, Walter MJ. Preclinical Activity of Splicing Modulators in U2AF1 Mutant MDS/AML Blood. 126: 1653-1653. DOI: 10.1182/Blood.V126.23.1653.1653  0.342
2015 Shi Y, Lagisetti CL, Joyner AS, Sambucetti LC, Webb TR. Abstract 4365: Targeting the SF3B1 spliceosome protein: Development of a reporter for HTS screen and pharmacodynamic profiling of small molecule drug leads Cancer Research. 75: 4365-4365. DOI: 10.1158/1538-7445.Am2015-4365  0.437
2015 Xargay-Torrent S, López-Guerra M, Rosich L, Montraveta A, Roldán J, Rodríguez V, Villamor N, Aymerich M, Lagisetti C, Webb TR, Campo E, Colomer D. Abstract 2584: Specific antitumor activity of the splicing modulator sudemycin and cooperation with ibrutinib in chronic lymphocytic leukemia Cancer Research. 75: 2584-2584. DOI: 10.1158/1538-7445.Am2015-2584  0.393
2014 Kasinathan RS, Sharma LK, Cunningham C, Webb TR, Greenberg RM. Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel. Plos Neglected Tropical Diseases. 8: e3265. PMID 25330312 DOI: 10.1371/Journal.Pntd.0003265  0.338
2014 Mallipeddi PL, Kumar G, White SW, Webb TR. Recent advances in computer-aided drug design as applied to anti-influenza drug discovery. Current Topics in Medicinal Chemistry. 14: 1875-89. PMID 25262796 DOI: 10.2174/1568026614666140929153812  0.441
2014 Lagisetti C, Yermolina MV, Sharma LK, Palacios G, Prigaro BJ, Webb TR. Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives. Acs Chemical Biology. 9: 643-8. PMID 24377313 DOI: 10.1021/Cb400695J  0.434
2013 Lagisetti C, Palacios G, Goronga T, Freeman B, Caufield W, Webb TR. Optimization of antitumor modulators of pre-mRNA splicing. Journal of Medicinal Chemistry. 56: 10033-44. PMID 24325474 DOI: 10.1021/Jm401370H  0.364
2013 Webb TR, Joyner AS, Potter PM. The development and application of small molecule modulators of SF3b as therapeutic agents for cancer. Drug Discovery Today. 18: 43-9. PMID 22885522 DOI: 10.1016/j.drudis.2012.07.013  0.307
2012 DuBois RM, Slavish PJ, Baughman BM, Yun MK, Bao J, Webby RJ, Webb TR, White SW. Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease. Plos Pathogens. 8: e1002830. PMID 22876176 DOI: 10.1371/Journal.Ppat.1002830  0.688
2012 Baughman BM, Jake Slavish P, DuBois RM, Boyd VA, White SW, Webb TR. Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. Acs Chemical Biology. 7: 526-34. PMID 22211528 DOI: 10.1021/Cb200439Z  0.685
2011 Gundluru MK, Pourpak A, Cui X, Morris SW, Webb TR. Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold. Medchemcomm. 2: 904-908. PMID 21927710 DOI: 10.1039/C1MD00040C  0.313
2011 Slavish PJ, Price JE, Jiang Q, Cui X, Morris SW, Webb TR. Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition. Bioorganic & Medicinal Chemistry Letters. 21: 4592-6. PMID 21708465 DOI: 10.1016/J.Bmcl.2011.05.103  0.366
2011 Fan L, Lagisetti C, Edwards CC, Webb TR, Potter PM. Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. Acs Chemical Biology. 6: 582-9. PMID 21344922 DOI: 10.1021/Cb100356K  0.418
2010 Zhang Y, Anderson M, Weisman JL, Lu M, Choy CJ, Boyd VA, Price J, Sigal M, Clark J, Connelly M, Zhu F, Guiguemde WA, Jeffries C, Yang L, Lemoff A, ... ... Webb TR, et al. Evaluation of Diarylureas for Activity Against Plasmodium falciparum. Acs Medicinal Chemistry Letters. 1: 460-465. PMID 21243104 DOI: 10.1021/Ml100083C  0.31
2010 Young BM, Hyatt JL, Bouck DC, Chen T, Hanumesh P, Price J, Boyd VA, Potter PM, Webb TR. Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2- ethanediones: Potent, selective carboxylesterase inhibitors Journal of Medicinal Chemistry. 53: 8709-8715. PMID 21105730 DOI: 10.1021/Jm101101Q  0.445
2010 Kasinathan RS, Goronga T, Messerli SM, Webb TR, Greenberg RM. Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 128-35. PMID 19726755 DOI: 10.1096/Fj.09-137091  0.315
2009 Lagisetti C, Pourpak A, Goronga T, Jiang Q, Cui X, Hyle J, Lahti JM, Morris SW, Webb TR. Synthetic mRNA splicing modulator compounds with in vivo antitumor activity. Journal of Medicinal Chemistry. 52: 6979-90. PMID 19877647 DOI: 10.1021/jm901215m  0.331
2009 Boyd VA, Mason J, Hanumesh P, Price J, Russell CJ, Webb TR. 2-Substituted-4,5-dihydroxypyrimidine-6-carboxamide antiviral targeted libraries. Journal of Combinatorial Chemistry. 11: 1100-4. PMID 19754047 DOI: 10.1021/Cc900111U  0.447
2008 Lagisetti C, Pourpak A, Jiang Q, Cui X, Goronga T, Morris SW, Webb TR. Antitumor compounds based on a natural product consensus pharmacophore. Journal of Medicinal Chemistry. 51: 6220-4. PMID 18788726 DOI: 10.1021/Jm8006195  0.386
2007 Webb TR, Jiang L, Sviridov S, Venegas RE, Vlaskina AV, McGrath D, Tucker J, Wang J, Deschenes A, Li R. Application of a novel design paradigm to generate general nonpeptide combinatorial templates mimicking beta-turns: synthesis of ligands for melanocortin receptors. Journal of Combinatorial Chemistry. 9: 704-10. PMID 17429950 DOI: 10.1021/Cc0601581  0.327
2006 Zhu T, Yan Z, Chucholowski A, Webb TR, Li R. Polymer-supported synthesis of pyridone-focused libraries as inhibitors of anaplastic lymphoma kinase. Journal of Combinatorial Chemistry. 8: 401-9. PMID 16677010 DOI: 10.1021/Cc060018R  0.39
2006 Li R, Xue L, Zhu T, Jiang Q, Cui X, Yan Z, McGee D, Wang J, Gantla VR, Pickens JC, McGrath D, Chucholowski A, Morris SW, Webb TR. Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase. Journal of Medicinal Chemistry. 49: 1006-15. PMID 16451066 DOI: 10.1021/Jm050824X  0.426
2004 Chen C, Wilcoxen KM, Huang CQ, Xie YF, McCarthy JR, Webb TR, Zhu YF, Saunders J, Liu XJ, Chen TK, Bozigian H, Grigoriadis DE. Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. Journal of Medicinal Chemistry. 47: 4787-98. PMID 15341493 DOI: 10.1021/Jm040058E  0.327
2004 Webb TR, Moran T, Huang CQ, McCarthy JR, Grigoriadis DE, Chen C. Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor. Bioorganic & Medicinal Chemistry Letters. 14: 3869-73. PMID 15225687 DOI: 10.1016/J.Bmcl.2004.05.072  0.35
2003 Chianelli D, Kim YC, Lvovskiy D, Webb TR. Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors. Bioorganic & Medicinal Chemistry. 11: 5059-68. PMID 14604669 DOI: 10.1016/J.Bmc.2003.08.022  0.336
2003 Webb TR, Lvovskiy D, Kim SA, Ji Xd, Melman N, Linden J, Jacobson KA. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorganic & Medicinal Chemistry. 11: 77-85. PMID 12467710 DOI: 10.1016/S0968-0896(02)00323-1  0.331
2000 Webb TR, Melman N, Lvovskiy D, Ji XD, Jacobson KA. The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family. Bioorganic & Medicinal Chemistry Letters. 10: 31-4. PMID 10636237 DOI: 10.1016/S0960-894X(99)00583-1  0.348
1984 McMurry JE, Webb TR. Synthesis of a tricyclic aphidicolin analogue that inhibits DNA synthesis in vitro. Journal of Medicinal Chemistry. 27: 1367-9. PMID 6090666 DOI: 10.1021/Jm00376A028  0.344
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