David T. Okou, M.S., Ph.D. - Publications

Affiliations: 
Pediatrics Emory University, Atlanta, GA 
Area:
Human Genetics

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, Baras A, Barrett JC, Barzilai N, Beaugerie L, Beecham A, ... ... Okou DT, et al. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Nature Genetics. PMID 36038634 DOI: 10.1038/s41588-022-01156-2  0.779
2022 Jurickova I, Bonkowski E, Angerman E, Novak E, Huron A, Akers G, Iwasawa K, Braun T, Hadar R, Hooker M, Han S, Cutler DJ, Okou DT, Kugathasan S, Jegga A, et al. Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures. Inflammatory Bowel Diseases. PMID 35259271 DOI: 10.1093/ibd/izac037  0.697
2022 Venkateswaran S, Somineni HK, Kilaru V, Katrinli S, Prince J, Okou DT, Hyams JS, Denson LA, Kellermayer R, Gibson G, Cutler DJ, Smith AK, Kugathasan S, Conneely KN. Methylation Quantitative Trait Loci are Largely Consistent across Disease States in Crohn's disease. G3 (Bethesda, Md.). PMID 35172000 DOI: 10.1093/g3journal/jkac041  0.787
2021 Somineni HK, Weitzner JH, Venkateswaran S, Dodd A, Prince J, Karikaran A, Sauer CG, Abramowicz S, Zwick ME, Cutler DJ, Okou DT, Chopra P, Kugathasan S. Site- and Taxa-Specific Disease-Associated Oral Microbial Structures Distinguish Inflammatory Bowel Diseases. Inflammatory Bowel Diseases. PMID 34002220 DOI: 10.1093/ibd/izab082  0.769
2021 Somineni HK, Nagpal S, Venkateswaran S, Cutler DJ, Okou DT, Haritunians T, Simpson CL, Begum F, Datta LW, Quiros AJ, Seminerio J, Mengesha E, Alexander JS, Baldassano RN, Dudley-Brown S, et al. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. American Journal of Human Genetics. PMID 33600772 DOI: 10.1016/j.ajhg.2021.02.001  0.826
2021 Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hübenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang SK, Ye BD, ... ... Okou DT, et al. Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations. Human Molecular Genetics. PMID 33555323 DOI: 10.1093/hmg/ddab017  0.657
2020 Shankar S, Bhandari I, Okou DT, Srinivasa G, Athri P. Predicting adverse drug reactions of two-drug combinations using structural and transcriptomic drug representations to train an artificial neural network. Chemical Biology & Drug Design. PMID 33006799 DOI: 10.1111/cbdd.13802  0.693
2019 Venkateswaran S, Denson LA, Jurickova I, Dodd A, Zwick ME, Cutler DJ, Kugathasan S, Okou DT. Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants. Scientific Reports. 9: 9168. PMID 31235766 DOI: 10.1038/S41598-019-45701-2  0.802
2019 Wright M, Chandrakasan S, Okou DT, Yin H, Jurickova I, Denson LA, Kugathasan S. Early Onset Granulomatous Colitis Associated with a Mutation in NCF4 Resolved with Hematopoietic Stem Cell Transplantation. The Journal of Pediatrics. PMID 31027832 DOI: 10.1016/J.Jpeds.2019.03.042  0.612
2019 Somineni HK, Venkateswaran S, Kilaru V, Marigorta UM, Mo A, Okou DT, Kellermayer R, Mondal K, Cobb D, Walters TD, Griffiths A, Noe JD, Crandall WV, Rosh JR, Mack DR, et al. Blood-derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Gastroenterology. PMID 30779925 DOI: 10.1053/J.Gastro.2019.01.270  0.775
2019 Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH, Bull LN, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, et al. Identification of PKD1L1 Gene Variants in Children with the Biliary Atresia Splenic Malformation Syndrome. Hepatology (Baltimore, Md.). PMID 30664273 DOI: 10.1002/Hep.30515  0.567
2019 Somineni HK, Haritunians T, Simpson CL, Cutler DJ, Okou D, Itan Y, Venkateswaran S, Stevens C, Datta LW, Dhere TA, Lazarev M, Consortium EAAI, Zwick ME, Cho JH, Daly MJ, et al. Su1028 – Whole-Genome Sequencing of African Americans Identifies Novel Rare Variants Associated with Inflammatory Bowel Disease Gastroenterology. 156: S-488-S-489. DOI: 10.1016/S0016-5085(19)38082-5  0.821
2018 Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Alexander Valencia C, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, et al. Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. PMID 30124884 DOI: 10.1093/Ibd/Izy265  0.802
2018 Shaw KA, Cutler DJ, Okou D, Dodd A, Aronow BJ, Haberman Y, Stevens C, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, et al. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes and Immunity. PMID 29593342 DOI: 10.1038/S41435-018-0015-2  0.836
2018 Venkateswaran S, Prince J, Cutler DJ, Marigorta UM, Okou DT, Prahalad S, Mack D, Boyle B, Walters T, Griffiths A, Sauer CG, LeLeiko N, Keljo D, Markowitz J, Baker SS, et al. Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis. Inflammatory Bowel Diseases. 24: 829-838. PMID 29562276 DOI: 10.1093/Ibd/Izx084  0.816
2018 Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Dodd A, Quinn K, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, et al. Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients with Crohn's Disease. Gastroenterology. PMID 29454792 DOI: 10.1053/J.Gastro.2018.02.016  0.801
2018 Somineni HK, Venkateswaran S, Kilaru V, Chopra P, Okou DT, Hyams JS, Denson LA, Cutler DJ, Gibson G, Conneely KN, Smith AK, Kugathasan S. 10 EPIGENOME-WIDE ASSOCIATION STUDY IDENTIFIED SHARED METHYLOMIC CONTRIBUTIONS TO SUSCEPTIBILITY AND PROGRESSION IN PEDIATRIC CROHN’S DISEASE Inflammatory Bowel Diseases. 24: S71-S71. DOI: 10.1093/ibd/izy038.017  0.744
2018 Somineni HK, Venkateswaran S, Kilaru V, Chopra P, Okou DT, Hyams JS, Denson LA, Cutler DJ, Gibson G, Conneely KN, Smith AK, Kugathasan S. 10 EPIGENOME-WIDE ASSOCIATION STUDY IDENTIFIED SHARED METHYLOMIC CONTRIBUTIONS TO SUSCEPTIBILITY AND PROGRESSION IN PEDIATRIC CROHN'S DISEASE Gastroenterology. 154: S101. DOI: 10.1053/J.Gastro.2017.11.238  0.792
2018 Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, et al. 27 CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE Gastroenterology. 154: S10-S11. DOI: 10.1053/j.gastro.2017.11.051  0.781
2018 Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, et al. 27 CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE Inflammatory Bowel Diseases. 24: S7-S8. DOI: 10.1053/J.Gastro.2017.11.051  0.808
2018 Jurickova I, Karns R, Cutler DJ, Okou D, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths AM, et al. 378 - Genomic Correlates of Reduced Neutrophil Granulocytemacrophage Colony Stimulating Factor Signaling in Stricturing Pediatric Crohn Disease Gastroenterology. 154: S-89-S-90. DOI: 10.1016/S0016-5085(18)30746-7  0.812
2017 Bertha M, Vasantharoopan A, Kumar A, Bruce BB, Prince J, Hofmekler T, Okou D, Chopra P, Wang G, Sauer C, Landers CJ, Hussain SZ, Cross RK, Baldassano RN, Kappelman MD, et al. IBD Serology and Disease Outcomes in African Americans With Crohn's Disease. Inflammatory Bowel Diseases. 24: 209-216. PMID 29272484 DOI: 10.1093/Ibd/Izx021  0.632
2017 Okou DT, Brant SR, Simpson CL, Haritunians T, Huang C, McGovern DPB, Kugathasan S. Reply. Gastroenterology. PMID 28482170 DOI: 10.1053/j.gastro.2017.05.006  0.532
2017 Denson LA, Jurickova I, Shaw K, Linn A, Dodd A, Okou D, Chalk C, Bonkowski E, Griffiths AM, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Heyman MB, Snapper SB, et al. Low Neutrophil Reactive Oxygen Species Production is Associated with Nicotinamide-Adenine Dinucleotide Phosphate (NADPH) Oxidase Gene Mutations and Refractory Colonic Involvement in Pediatric Crohn Disease Gastroenterology. 152: S955. DOI: 10.1016/S0016-5085(17)33247-X  0.774
2017 Denson LA, Jurickova I, Shaw K, Linn A, Dodd A, Okou D, Chalk C, Bonkowski E, Griffiths AM, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Heyman MB, Snapper SB, et al. Reduced Neutrophil Granulocyte-Macrophage Colony Stimulating Factor Signaling is Associated with Granulocyte-Macrophage Colony Stimulating Factor Receptor Alpha Chain Gene Mutations and Stricturing Disease Complications in Pediatric Crohn Disease Gastroenterology. 152: S955. DOI: 10.1016/S0016-5085(17)33246-8  0.786
2017 Prince J, Venkateswaran S, Cutler DJ, Okou D, Chopra P, Davis S, Baker SS, Strople JA, Hommel KA, Evans JS, Sauer CG, Markowitz J, Rufo PA, Pfefferkorn MD, Ziring D, et al. Greater Contribution of HLA to Risk for Pediatric-Onset Ulcerative Colitis Can be Narrowed to 3 Independent Classic HLA Variants and Corresponding Amino Acid Changes Gastroenterology. 152: S954. DOI: 10.1016/S0016-5085(17)33244-4  0.697
2016 Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, et al. Genome-wide Association Study Identifies African-Specific Susceptibility Loci in African Americans with Inflammatory Bowel Disease. Gastroenterology. PMID 27693347 DOI: 10.1053/J.Gastro.2016.09.032  0.831
2015 Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Taylor KD, Datta LW, Maranville JC, Liu Z, Ellis S, Chopra P, Alexander JS, Baldassano RN, Cross RK, Dassopoulos T, et al. Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans. Gastroenterology. PMID 26278503 DOI: 10.1053/J.Gastro.2015.07.065  0.813
2015 Cutler DJ, Zwick ME, Okou DT, Prahalad S, Walters T, Guthery SL, Dubinsky M, Baldassano R, Crandall WV, Rosh J, Markowitz J, Stephens M, Kellermayer R, Pfefferkorn M, Heyman MB, et al. Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping. Plos One. 10: e0128074. PMID 26098103 DOI: 10.1371/Journal.Pone.0128074  0.812
2015 Brant SR, Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Datta LW, Taylor KD, Rotter JI, Bridges S, Kimberly RP, Rich SS, McGovern D, Kugathasan S. 387 Immunochip Implicates Multiple Genetic Loci for African American IBD Including HLA-DRB1*1502 for UC, NOD2, PTGER4, IL23R, LZKF3 and STAT5A/STAT3 for CD and Several Regions of Significant Admixture Linkage Disequilibrium Gastroenterology. 148: S-80. DOI: 10.1016/S0016-5085(15)30281-X  0.798
2014 Okou DT, Kugathasan S. Role of genetics in pediatric inflammatory bowel disease. Inflammatory Bowel Diseases. 20: 1878-84. PMID 25118609 DOI: 10.1097/Mib.0000000000000085  0.623
2014 Okou DT, Mondal K, Faubion WA, Kobrynski LJ, Denson LA, Mulle JG, Ramachandran D, Xiong Y, Svingen P, Patel V, Bose P, Waters JP, Prahalad S, Cutler DJ, Zwick ME, et al. Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition. 58: 561-8. PMID 24792626 DOI: 10.1097/Mpg.0000000000000302  0.803
2013 Kaalla MJ, Broadaway KA, Rohani-Pichavant M, Conneely KN, Whiting A, Ponder L, Okou DT, Angeles-Han S, Rouster-Stevens K, Brown MR, Vogler LB, Jorde LB, Bohnsack JF, Epstein MP, Prahalad S. Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA. Pediatric Rheumatology Online Journal. 11: 40. PMID 24160187 DOI: 10.1186/1546-0096-11-40  0.305
2013 Middleton JP, Bhagavathula AP, Gaye B, Alvarez JA, Huang CS, Sauer CG, Tenjarla G, Schoen BT, Kumar A, Prasad M, Okou DT, Ifeadike WC, Dhere TA, Conneely KN, Ziegler TR, et al. Vitamin D status and bone mineral density in African American children with Crohn disease. Journal of Pediatric Gastroenterology and Nutrition. 57: 587-93. PMID 23760229 DOI: 10.1097/Mpg.0B013E31829E0B89  0.515
2013 Waters J, Dhere V, Benjamin A, Sekar A, Kumar A, Prahalad S, Okou DT, Kugathasan S. A practical and novel method to extract genomic DNA from blood collection kits for plasma protein preservation. Journal of Visualized Experiments : Jove. e4241. PMID 23711730 DOI: 10.3791/4241  0.459
2013 Kugathasan S, Okou DT, Mondal K, Benjamin AL, Kumar A, Hussain SZ, Katz J, Cross R, Moulton DE, Cutler DJ, Zwick ME. Su1743 Exome Sequencing Identify Novel Variants in African-Americans With Severe Perianal and Colonic Crohn's Disease Gastroenterology. 144: S-465. DOI: 10.1016/S0016-5085(13)61720-5  0.744
2013 Kugathasan S, Dubinsky M, Guthery SL, Okou DT, Bose P, Zwick ME, Cutler DJ, Waters JP, Hyams JS, Baldassano R, Stephens MC, Heyman MB, Griffiths AM, Crandall W, Markowitz J, et al. 976 Early Onset Crohn's Disease Exhibit Distinct Allele Architecture Differences and Reveal New IBD Loci Gastroenterology. 144: S-178. DOI: 10.1016/S0016-5085(13)60634-4  0.8
2012 Adeyanju O, Okou DT, Huang C, Kumar A, Sauer C, Galloway C, Prasad M, Waters J, Cutler DJ, Zwick ME, Dhere T, Kugathasan S. Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture. Inflammatory Bowel Diseases. 18: 2357-9. PMID 22447396 DOI: 10.1002/Ibd.22944  0.783
2011 Adeyanju O, Okou D, Huang C, Sauer C, Prasad M, Waters J, Ifeadike W, Benjamin A, Labaze S, Cutler D, Zwick M, Dhere T, Kugathasan S. Risk of NOD2 in African-American subjects with Crohnʼs disease is exclusively contributed by Caucasian admixture Inflammatory Bowel Diseases. 17: S77-S78. DOI: 10.1097/00054725-201112002-00255  0.752
2011 Dhere T, Hofmeckler T, Griglione N, Huang C, Sauer C, Tenjarla G, Schoen B, Ifeadike W, Olejeme H, Prasad M, Kumar A, Okou D, Galloway C, kugathasan S. Crohnʼs disease is 3 fold higher compared with ulcerative colitis among African-Americans; combined pediatric and adult data from the greater Atlanta area Inflammatory Bowel Diseases. 17: S56. DOI: 10.1097/00054725-201112002-00178  0.555
2011 Bhagavathula A, Gaye B, Alvarez J, Huang C, Tenjarla G, Sauer C, Schoen B, Prasad M, Waters J, Ifeadike W, Okou D, Ziegler T, Tangprincha V, Kugathasan S. Vitamin D deficiency is found in 2/3 of African American population regardless of underlying IBD or not and the Vitamin D levels are not influenced by disease severity or location in AA population Inflammatory Bowel Diseases. 17: S6. DOI: 10.1097/00054725-201112002-00015  0.482
2009 Okou DT, Locke AE, Steinberg KM, Hagen K, Athri P, Shetty AC, Patel V, Zwick ME. Combining microarray-based genomic selection (MGS) with the Illumina Genome Analyzer platform to sequence diploid target regions. Annals of Human Genetics. 73: 502-13. PMID 19573206 DOI: 10.1111/J.1469-1809.2009.00530.X  0.764
2009 Passalacqua KD, Varadarajan A, Ondov BD, Okou DT, Zwick ME, Bergman NH. Structure and complexity of a bacterial transcriptome. Journal of Bacteriology. 191: 3203-11. PMID 19304856 DOI: 10.1128/Jb.00122-09  0.619
2008 Hegde MR, Chin EL, Mulle JG, Okou DT, Warren ST, Zwick ME. Microarray-based mutation detection in the dystrophin gene. Human Mutation. 29: 1091-9. PMID 18663755 DOI: 10.1002/Humu.20831  0.609
2008 Steinberg KM, Okou DT, Zwick ME. Applying rapid genome sequencing technologies to characterize pathogen genomes. Analytical Chemistry. 80: 520-8. PMID 18320606 DOI: 10.1021/Ac086027Z  0.621
2007 Okou DT, Steinberg KM, Middle C, Cutler DJ, Albert TJ, Zwick ME. Microarray-based genomic selection for high-throughput resequencing. Nature Methods. 4: 907-9. PMID 17934469 DOI: 10.1038/Nmeth1109  0.7
2001 Chiang CF, Okou DT, Griffin TB, Verret CR, Williams MN. Green fluorescent protein rendered susceptible to proteolysis: positions for protease-sensitive insertions. Archives of Biochemistry and Biophysics. 394: 229-35. PMID 11594737 DOI: 10.1006/Abbi.2001.2537  0.599
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