| Year |
Citation |
Score |
| 2022 |
Drabeck DH, Rucavado A, Hingst-Zaher E, Dean A, Jansa SA. Ancestrally reconstructed Von Willebrand Factor (vWF) reveals evidence for trench warfare coevolution between opossums and pit vipers. Molecular Biology and Evolution. PMID 35723968 DOI: 10.1093/molbev/msac140 |
0.759 |
|
| 2020 |
Drabeck DH, Rucavado A, Hingst-Zaher E, Cruz YP, Dean A, Jansa SA. Resistance of South American opossums to vWF-binding venom C-type lectins. Toxicon : Official Journal of the International Society On Toxinology. PMID 32135198 DOI: 10.1016/J.Toxicon.2020.02.024 |
0.747 |
|
| 2019 |
Yi X, Dean AM. Adaptive Landscapes in the Age of Synthetic Biology. Molecular Biology and Evolution. PMID 30657938 DOI: 10.1093/Molbev/Msz004 |
0.309 |
|
| 2018 |
Drabeck D, Dean A, Jansa S. Opossums vs. vipers: Molecular and functional characterization of a coevolutionary arms race Toxicon. 150: 316. DOI: 10.1016/J.Toxicon.2018.06.005 |
0.721 |
|
| 2017 |
Dean AM, Lehman C, Yi X. Fluctuating Selection in the Moran. Genetics. PMID 28108586 DOI: 10.1534/Genetics.116.192914 |
0.318 |
|
| 2016 |
Yi X, Dean AM. Phenotypic plasticity as an adaptation to a functional trade-off. Elife. 5. PMID 27692064 DOI: 10.7554/Elife.19307 |
0.31 |
|
| 2016 |
Devamani T, Rauwerdink AM, Lunzer M, Jones BJ, Mooney JL, Tan MA, Zhang ZJ, Xu JH, Dean AM, Kazlauskas RJ. Catalytic promiscuity of ancestral esterases and hydroxynitrile lyases. Journal of the American Chemical Society. PMID 26736133 DOI: 10.1021/Jacs.5B12209 |
0.323 |
|
| 2015 |
Rauwerdink A, Lunzer M, Devamani T, Jones B, Mooney J, Zhang ZJ, Xu JH, Kazlauskas RJ, Dean AM. Evolution of a Catalytic Mechanism. Molecular Biology and Evolution. PMID 26681154 DOI: 10.1093/Molbev/Msv338 |
0.385 |
|
| 2015 |
Cooper JD, Neuhauser C, Dean AM, Kerr B. Tipping the mutation-selection balance: Limited migration increases the frequency of deleterious mutants. Journal of Theoretical Biology. 380: 123-133. PMID 25983046 DOI: 10.1016/J.Jtbi.2015.05.003 |
0.551 |
|
| 2015 |
Drabeck DH, Dean AM, Jansa SA. Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine receptors in mammals that survive venomous snake bites. Toxicon : Official Journal of the International Society On Toxinology. 99: 68-72. PMID 25796346 DOI: 10.1016/J.Toxicon.2015.03.007 |
0.746 |
|
| 2013 |
Brutinel ED, Dean AM, Gralnick JA. Description of a riboflavin biosynthetic gene variant prevalent in the phylum Proteobacteria. Journal of Bacteriology. 195: 5479-86. PMID 24097946 DOI: 10.1128/Jb.00651-13 |
0.335 |
|
| 2010 |
Lunzer M, Golding GB, Dean AM. Pervasive cryptic epistasis in molecular evolution. Plos Genetics. 6: e1001162. PMID 20975933 DOI: 10.1371/Journal.Pgen.1001162 |
0.384 |
|
| 2010 |
Zhang J, Yang H, Long M, Li L, Dean AM. Evolution of enzymatic activities of testis-specific short-chain dehydrogenase/reductase in Drosophila. Journal of Molecular Evolution. 71: 241-9. PMID 20809353 DOI: 10.1007/S00239-010-9384-5 |
0.627 |
|
| 2010 |
Eshelman CM, Vouk R, Stewart JL, Halsne E, Lindsey HA, Schneider S, Gualu M, Dean AM, Kerr B. Unrestricted migration favours virulent pathogens in experimental metapopulations: evolutionary genetics of a rapacious life history. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 365: 2503-13. PMID 20643740 DOI: 10.1098/Rstb.2010.0066 |
0.548 |
|
| 2010 |
Dean AM. The future of molecular evolution. Embo Reports. 11: 409. PMID 20514039 DOI: 10.1038/Embor.2010.78 |
0.312 |
|
| 2009 |
Zhong S, Miller SP, Dykhuizen DE, Dean AM. Transcription, translation, and the evolution of specialists and generalists. Molecular Biology and Evolution. 26: 2661-78. PMID 19706726 DOI: 10.1093/Molbev/Msp187 |
0.591 |
|
| 2009 |
Zhang B, Wang B, Wang P, Cao Z, Huang E, Hao J, Dean AM, Zhu G. Enzymatic characterization of a monomeric isocitrate dehydrogenase from Streptomyces lividans TK54. Biochimie. 91: 1405-10. PMID 19631711 DOI: 10.1016/J.Biochi.2009.07.011 |
0.515 |
|
| 2009 |
Dykhuizen DE, Dean AM. Experimental evolution from the bottom up Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments. 86-106. |
0.522 |
|
| 2008 |
Stoebel DM, Dean AM, Dykhuizen DE. The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products. Genetics. 178: 1653-60. PMID 18245823 DOI: 10.1534/Genetics.107.085399 |
0.754 |
|
| 2007 |
Dean AM, Thornton JW. Mechanistic approaches to the study of evolution: the functional synthesis. Nature Reviews. Genetics. 8: 675-88. PMID 17703238 DOI: 10.1038/Nrg2160 |
0.32 |
|
| 2007 |
Merlo LM, Lunzer M, Dean AM. An empirical test of the concomitantly variable codon hypothesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 10938-43. PMID 17578921 DOI: 10.1073/Pnas.0701900104 |
0.603 |
|
| 2006 |
Miller SP, Lunzer M, Dean AM. Direct demonstration of an adaptive constraint. Science (New York, N.Y.). 314: 458-61. PMID 17053145 DOI: 10.1126/Science.1133479 |
0.391 |
|
| 2006 |
Kerr B, Neuhauser C, Bohannan BJ, Dean AM. Local migration promotes competitive restraint in a host-pathogen 'tragedy of the commons'. Nature. 442: 75-8. PMID 16823452 DOI: 10.1038/Nature04864 |
0.669 |
|
| 2006 |
Merlo LM, Sadowsky MJ, Ferguson JA, Dean AM. The argRB of Escherichia coli is rare in isolates obtained from natural sources. Gene. 376: 240-7. PMID 16797147 DOI: 10.1016/J.Gene.2006.04.002 |
0.553 |
|
| 2005 |
Lunzer M, Miller SP, Felsheim R, Dean AM. The biochemical architecture of an ancient adaptive landscape. Science (New York, N.Y.). 310: 499-501. PMID 16239478 DOI: 10.1126/Science.1115649 |
0.384 |
|
| 2005 |
Suiter AM, Dean AM. Selection in a cyclical environment: possible impact of phenotypic lag on Darwinian fitness. Journal of Molecular Evolution. 61: 153-70. PMID 16132472 DOI: 10.1007/S00239-004-0210-9 |
0.319 |
|
| 2005 |
Zhu G, Golding GB, Dean AM. The selective cause of an ancient adaptation. Science (New York, N.Y.). 307: 1279-82. PMID 15653464 DOI: 10.1126/Science.1106974 |
0.528 |
|
| 2004 |
Zhang J, Dean AM, Brunet F, Long M. Evolving protein functional diversity in new genes of Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 101: 16246-50. PMID 15534206 DOI: 10.1073/Pnas.0407066101 |
0.636 |
|
| 2004 |
Dykhuizen DE, Dean AM. Evolution of specialists in an experimental microcosm. Genetics. 167: 2015-26. PMID 15342537 DOI: 10.1534/Genetics.103.025205 |
0.598 |
|
| 2004 |
Zhong S, Khodursky A, Dykhuizen DE, Dean AM. Evolutionary genomics of ecological specialization. Proceedings of the National Academy of Sciences of the United States of America. 101: 11719-24. PMID 15289609 DOI: 10.1073/Pnas.0404397101 |
0.594 |
|
| 2002 |
Dean AM, Neuhauser C, Grenier E, Golding GB. The pattern of amino acid replacements in alpha/beta-barrels. Molecular Biology and Evolution. 19: 1846-64. PMID 12411594 DOI: 10.1093/Oxfordjournals.Molbev.A004009 |
0.371 |
|
| 2002 |
Tahoe NM, Dean AM, Curtsinger JW. Nucleotide variations in the lxd region of Drosophila melanogaster: characterization of a candidate modifier of lifespan. Gene. 297: 221-8. PMID 12384303 DOI: 10.1016/S0378-1119(02)00916-2 |
0.323 |
|
| 2002 |
Lunzer M, Natarajan A, Dykhuizen DE, Dean AM. Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac. Genetics. 162: 485-99. PMID 12242256 |
0.575 |
|
| 2002 |
Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC. Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase. The Journal of Biological Chemistry. 277: 7567-73. PMID 11751849 DOI: 10.1074/Jbc.M107908200 |
0.563 |
|
| 2000 |
Watt WB, Dean AM. Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes. Annual Review of Genetics. 34: 593-622. PMID 11092840 DOI: 10.1146/Annurev.Genet.34.1.593 |
0.388 |
|
| 2000 |
Bishop JG, Dean AM, Mitchell-Olds T. Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution. Proceedings of the National Academy of Sciences of the United States of America. 97: 5322-7. PMID 10805791 DOI: 10.1073/Pnas.97.10.5322 |
0.325 |
|
| 2000 |
Kaplan RS, Mayor JA, Brauer D, Kotaria R, Walters DE, Dean AM. The yeast mitochondrial citrate transport protein. Probing the secondary structure of transmembrane domain iv and identification of residues that likely comprise a portion of the citrate translocation pathway. The Journal of Biological Chemistry. 275: 12009-16. PMID 10766832 DOI: 10.1074/Jbc.275.16.12009 |
0.323 |
|
| 2000 |
Miller SP, Chen R, Karschnia EJ, Romfo C, Dean A, LaPorte DC. Locations of the regulatory sites for isocitrate dehydrogenase kinase/phosphatase Journal of Biological Chemistry. 275: 833-839. PMID 10625615 DOI: 10.1074/Jbc.275.2.833 |
0.73 |
|
| 1998 |
Golding GB, Dean AM. The structural basis of molecular adaptation. Molecular Biology and Evolution. 15: 355-69. PMID 9549087 DOI: 10.1093/Oxfordjournals.Molbev.A025932 |
0.382 |
|
| 1997 |
Chen R, Greer AF, Dean AM. Structural constraints in protein engineering--the coenzyme specificity of Escherichia coli isocitrate dehydrogenase. European Journal of Biochemistry / Febs. 250: 578-82. PMID 9428712 DOI: 10.1111/J.1432-1033.1997.0578A.X |
0.764 |
|
| 1997 |
Dean AM, Golding GB. Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 94: 3104-9. PMID 9096353 DOI: 10.1073/Pnas.94.7.3104 |
0.449 |
|
| 1997 |
Chen R, Greer AF, Dean AM, Hurley JH. Engineering secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase Techniques in Protein Chemistry. 8: 809-816. DOI: 10.1016/S1080-8914(97)80078-6 |
0.711 |
|
| 1996 |
Chen R, Greer A, Dean AM. Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 93: 12171-6. PMID 8901552 DOI: 10.1073/Pnas.93.22.12171 |
0.755 |
|
| 1996 |
Dean AM, Shiau AK, Koshland DE. Determinants of performance in the isocitrate dehydrogenase of Escherichia coli. Protein Science : a Publication of the Protein Society. 5: 341-7. PMID 8745412 DOI: 10.1002/Pro.5560050218 |
0.333 |
|
| 1996 |
Chen R, Grobler JA, Hurley JH, Dean AM. Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase. Protein Science : a Publication of the Protein Society. 5: 287-95. PMID 8745407 DOI: 10.1002/Pro.5560050213 |
0.744 |
|
| 1996 |
Hurley JH, Chen R, Dean AM. Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant. Biochemistry. 35: 5670-8. PMID 8639526 DOI: 10.1021/Bi953001Q |
0.74 |
|
| 1995 |
Dean AM, Dvorak L. The role of glutamate 87 in the kinetic mechanism of Thermus thermophilus isopropylmalate dehydrogenase. Protein Science : a Publication of the Protein Society. 4: 2156-67. PMID 8535253 DOI: 10.1002/Pro.5560041022 |
0.365 |
|
| 1995 |
Chen R, Greer A, Dean AM. A highly active decarboxylating dehydrogenase with rationally inverted coenzyme specificity. Proceedings of the National Academy of Sciences of the United States of America. 92: 11666-70. PMID 8524825 DOI: 10.1073/Pnas.92.25.11666 |
0.762 |
|
| 1994 |
Hurley JH, Dean AM. Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity. Structure (London, England : 1993). 2: 1007-16. PMID 7881901 DOI: 10.1016/S0969-2126(94)00104-9 |
0.376 |
|
| 1994 |
Dykhuizen DE, Dean AM. Predicted fitness changes along an environmental gradient Evolutionary Ecology. 8: 524-541. DOI: 10.1007/Bf01238256 |
0.613 |
|
| 1993 |
Stoddard BL, Dean A, Koshland DE. Structure of isocitrate dehydrogenase with isocitrate, nicotinamide adenine dinucleotide phosphate, and calcium at 2.5-å resolution: a pseudo-michaelis ternary complex Biochemistry®. 32: 9310-9316. PMID 8369300 DOI: 10.1021/Bi00087A008 |
0.329 |
|
| 1993 |
Dean AM, Koshland DE. Kinetic mechanism of Escherichia coli isocitrate dehydrogenase. Biochemistry. 32: 9302-9. PMID 8369299 DOI: 10.1021/Bi00087A007 |
0.35 |
|
| 1991 |
Hurley JH, Dean AM, Koshland DE, Stroud RM. Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry. 30: 8671-8. PMID 1888729 DOI: 10.1021/Bi00099A026 |
0.358 |
|
| 1990 |
Dykhuizen DE, Dean AM. Enzyme activity and fitness: Evolution in solution. Trends in Ecology & Evolution. 5: 257-62. PMID 21232368 DOI: 10.1016/0169-5347(90)90067-N |
0.615 |
|
| 1990 |
Hurley JH, Dean AM, Thorsness PE, Koshland DE, Stroud RM. Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme. The Journal of Biological Chemistry. 265: 3599-602. PMID 2406256 DOI: 10.2210/Pdb4Icd/Pdb |
0.371 |
|
| 1990 |
Dean AM, Koshland DE. Electrostatic and steric contributions to regulation at the active site of isocitrate dehydrogenase. Science (New York, N.Y.). 249: 1044-6. PMID 2204110 DOI: 10.1126/Science.2204110 |
0.347 |
|
| 1990 |
Hurley JH, Dean AM, Sohl JL, Koshland DE, Stroud RM. Regulation of an enzyme by phosphorylation at the active site. Science (New York, N.Y.). 249: 1012-6. PMID 2204109 DOI: 10.1126/Science.2204109 |
0.387 |
|
| 1988 |
Dean AM, Dykhuizen DE, Hartl DL. Fitness effects of amino acid replacements in the beta-galactosidase of Escherichia coli. Molecular Biology and Evolution. 5: 469-85. PMID 3143044 DOI: 10.1093/Oxfordjournals.Molbev.A040513 |
0.688 |
|
| 1987 |
Dykhuizen DE, Dean AM, Hartl DL. Metabolic flux and fitness. Genetics. 115: 25-31. PMID 3104135 |
0.665 |
|
| 1986 |
Hartl DL, Dean AM, Dykhuizen DE. The molecular biology of natural selection: reply to burton and place. Genetics. 114: 1037-9. PMID 17246353 |
0.636 |
|
| 1986 |
Dean AM, Dykhuizen DE, Hartl DL. Fitness as a function of beta-galactosidase activity in Escherichia coli. Genetical Research. 48: 1-8. PMID 3096817 DOI: 10.1017/S0016672300024587 |
0.654 |
|
| 1985 |
Hartl DL, Dykhuizen DE, Dean AM. Limits of adaptation: the evolution of selective neutrality. Genetics. 111: 655-74. PMID 3932127 |
0.683 |
|
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