Paula E. Cohen, PhD - Publications

Affiliations: 
1993-2000 Developmental Biology Yeshiva University, New York, NY, United States 
 2000-2004 Genetics Albert Einstein College of Medicine, New York, New York, United States 
 2094- Biomedical Sciences Cornell University, Ithaca, NY, United States 
Area:
Genetics, Cell Biology
Website:
Meiosis.Cornell.edu

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ascenção C, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka MB. A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation. Elife. 12. PMID 38391183 DOI: 10.7554/eLife.90887  0.47
2024 Horan TS, Ascenção CFR, Mellor C, Wang M, Smolka MB, Cohen PE. The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice. Plos Genetics. 20: e1011175. PMID 38377115 DOI: 10.1371/journal.pgen.1011175  0.509
2023 Horan TS, Ascenção CFR, Mellor CA, Wang M, Smolka MB, Cohen PE. The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male mice. Biorxiv : the Preprint Server For Biology. PMID 37873301 DOI: 10.1101/2023.10.06.561296  0.822
2023 Bradley RA, Wolff ID, Cohen PE, Gray S. Dynamic regulatory phosphorylation of mouse CDK2 occurs during meiotic prophase I. Biorxiv : the Preprint Server For Biology. PMID 37546989 DOI: 10.1101/2023.07.24.550435  0.738
2023 Ascencao CFR, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka M. A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation. Biorxiv : the Preprint Server For Biology. PMID 37398453 DOI: 10.1101/2023.05.31.543071  0.47
2022 Carro MLM, Grimson A, Cohen PE. Small RNAs and their protein partners in animal meiosis. Current Topics in Developmental Biology. 151: 245-279. PMID 36681472 DOI: 10.1016/bs.ctdb.2022.06.001  0.304
2022 Wang S, Lee K, Gray S, Zhang Y, Tang C, Morrish RB, Tosti E, van Oers J, Amin MR, Cohen PE, MacCarthy T, Roa S, Scharff MD, Edelmann W, Chahwan R. Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice. Nucleic Acids Research. PMID 35849338 DOI: 10.1093/nar/gkac616  0.377
2022 Sims JR, Faça VM, Pereira C, Ascenção C, Comstock W, Badar J, Arroyo-Martinez GA, Freire R, Cohen PE, Weiss RS, Smolka MB. Phosphoproteomics of ATR signaling in mouse testes. Elife. 11. PMID 35133275 DOI: 10.7554/eLife.68648  0.361
2022 Pereira C, Arroyo-Martinez GA, Guo MZ, Downey MS, Kelly ER, Grive KJ, Mahadevaiah SK, Sims JR, Faca VM, Tsai C, Schiltz CJ, Wit N, Jacobs H, Clark NL, Freire R, ... ... Cohen PE, et al. Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. Elife. 11. PMID 35133274 DOI: 10.7554/eLife.68677  0.454
2019 Toledo M, Sun X, Brieño-Enríquez MA, Raghavan V, Gray S, Pea J, Milano CR, Venkatesh A, Patel L, Borst PL, Alani E, Cohen PE. A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I. Plos Genetics. 15: e1008177. PMID 31170160 DOI: 10.1371/Journal.Pgen.1008177  0.512
2019 Milano CR, Holloway JK, Zhang Y, Jin B, Smith C, Bergman A, Edelmann W, Cohen PE. Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis. G3 (Bethesda, Md.). PMID 30944090 DOI: 10.1534/G3.119.400074  0.476
2019 Grive KJ, Hu Y, Shu E, Grimson A, Elemento O, Grenier JK, Cohen PE. Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing. Plos Genetics. 15: e1007810. PMID 30893341 DOI: 10.1371/Journal.Pgen.1007810  0.364
2018 Brieño-Enríquez MA, Moak SL, Abud-Flores A, Cohen PE. Characterization of Telomeric Repeat-Containing RNA (TERRA) localization and protein interactions in Primordial Germ Cells of the mouse. Biology of Reproduction. PMID 30423030 DOI: 10.1093/Biolre/Ioy243  0.491
2017 Brieño-Enríquez MA, Moak SL, Holloway JK, Cohen PE. NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between α-Adducin and Myosin X. Plos One. 12: e0185780. PMID 28982183 DOI: 10.1371/Journal.Pone.0185780  0.484
2016 Hilz S, Fogarty EA, Modzelewski AJ, Cohen PE, Grimson A. Transcriptome profiling of the developing male germ line identifies the miR-29 family as a global regulator during meiosis. Rna Biology. 0. PMID 27981880 DOI: 10.1080/15476286.2016.1270002  0.718
2016 Brieño-Enríquez MA, Moak SL, Toledo M, Filter JJ, Gray S, Barbero JL, Cohen PE, Holloway JK. Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse. Cell Reports. 17: 977-986. PMID 27760328 DOI: 10.1016/J.Celrep.2016.09.059  0.503
2016 Gray S, Cohen PE. Control of Meiotic Crossovers: From Double-Stand Break Formation to Designation. Annual Review of Genetics. PMID 27648641 DOI: 10.1146/Annurev-Genet-120215-035111  0.454
2016 Hilz S, Modzelewski AJ, Cohen PE, Grimson A. The roles of microRNAs and siRNAs in mammalian spermatogenesis. Development (Cambridge, England). 143: 3061-73. PMID 27578177 DOI: 10.1242/Dev.136721  0.757
2016 Barchi M, Cohen P, Keeney S. Special issue on "recent advances in meiotic chromosome structure, recombination and segregation". Chromosoma. PMID 27022980 DOI: 10.1007/S00412-016-0586-5  0.408
2016 Burkhardt S, Borsos M, Szydlowska A, Godwin J, Williams SA, Cohen PE, Hirota T, Saitou M, Tachibana-Konwalski K. Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice. Current Biology : Cb. PMID 26898469 DOI: 10.1016/J.Cub.2015.12.073  0.502
2015 Sun X, Brieño-Enríquez MA, Cornelius A, Modzelewski AJ, Maley TT, Campbell-Peterson KM, Holloway JK, Cohen PE. FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma. PMID 26490168 DOI: 10.1007/S00412-015-0549-2  0.829
2015 Brieño-Enríquez MA, Cohen PE. Double trouble in human aneuploidy. Nature Genetics. 47: 696-8. PMID 26111508 DOI: 10.1038/Ng.3344  0.46
2015 Modzelewski AJ, Hilz S, Crate EA, Schweidenback CT, Fogarty EA, Grenier JK, Freire R, Cohen PE, Grimson A. Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males. Journal of Cell Science. 128: 2314-27. PMID 25934699 DOI: 10.1242/Dev.127498  0.802
2015 Modzelewski AJ, Hilz S, Crate EA, Schweidenback CTH, Fogarty EA, Grenier JK, Freire R, Cohen PE, Grimson A. Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males Journal of Cell Science. 128: 2314-2327. DOI: 10.1242/jcs.167148  0.767
2014 Holloway JK, Sun X, Yokoo R, Villeneuve AM, Cohen PE. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. The Journal of Cell Biology. 205: 633-41. PMID 24891606 DOI: 10.1083/Jcb.201401122  0.401
2014 Qiao H, Prasada Rao HB, Yang Y, Fong JH, Cloutier JM, Deacon DC, Nagel KE, Swartz RK, Strong E, Holloway JK, Cohen PE, Schimenti J, Ward J, Hunter N. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics. 46: 194-9. PMID 24390283 DOI: 10.1038/Ng.2858  0.482
2014 Cohen PE, Holloway JK. Mammalian Meiosis Knobil and Neill's Physiology of Reproduction: Two-Volume Set. 1: 5-57. DOI: 10.1016/B978-0-12-397175-3.00001-6  0.365
2013 Auton A, Rui Li Y, Kidd J, Oliveira K, Nadel J, Holloway JK, Hayward JJ, Cohen PE, Greally JM, Wang J, Bustamante CD, Boyko AR. Genetic recombination is targeted towards gene promoter regions in dogs. Plos Genetics. 9: e1003984. PMID 24348265 DOI: 10.1371/Journal.Pgen.1003984  0.337
2013 Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, et al. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. Plos Genetics. 9: e1003930. PMID 24204323 DOI: 10.1371/Journal.Pgen.1003930  0.459
2013 Zhang J, Bonasio R, Strino F, Kluger Y, Holloway JK, Modzelewski AJ, Cohen PE, Reinberg D. SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes & Development. 27: 749-66. PMID 23592795 DOI: 10.1101/Gad.210963.112  0.747
2013 Lyndaker AM, Lim PX, Mleczko JM, Diggins CE, Holloway JK, Holmes RJ, Kan R, Schlafer DH, Freire R, Cohen PE, Weiss RS. Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. Plos Genetics. 9: e1003320. PMID 23468651 DOI: 10.1371/Journal.Pgen.1003320  0.569
2013 Reynolds A, Qiao H, Yang Y, Chen JK, Jackson N, Biswas K, Holloway JK, Baudat F, de Massy B, Wang J, Höög C, Cohen PE, Hunter N. RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nature Genetics. 45: 269-78. PMID 23396135 DOI: 10.1038/Ng.2541  0.462
2013 Sun X, Cohen PE. Studying recombination in mouse oocytes. Methods in Molecular Biology (Clifton, N.J.). 957: 1-18. PMID 23138941 DOI: 10.1007/978-1-62703-191-2_1  0.5
2012 Modzelewski AJ, Holmes RJ, Hilz S, Grimson A, Cohen PE. AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Developmental Cell. 23: 251-64. PMID 22863743 DOI: 10.1016/J.Devcel.2012.07.003  0.811
2011 Holloway K, Roberson EC, Corbett KL, Kolas NK, Nieves E, Cohen PE. NEK1 Facilitates Cohesin Removal during Mammalian Spermatogenesis. Genes. 2: 260-79. PMID 21931878 DOI: 10.3390/Genes2010260  0.813
2011 Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE. Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. Plos Genetics. 7: e1002094. PMID 21655083 DOI: 10.1371/Journal.Pgen.1002094  0.82
2011 Holloway K, Roberson EC, Corbett KL, Kolas NK, Nieves E, Cohen PE. NEK1 facilitates cohesin removal during mammalian spermatogenesis Genes. 2: 260-279. DOI: 10.3390/genes2010260  0.721
2010 Holloway JK, Morelli MA, Borst PL, Cohen PE. Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination. The Journal of Cell Biology. 188: 779-89. PMID 20308424 DOI: 10.1083/Jcb.200909048  0.579
2008 Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proceedings of the National Academy of Sciences of the United States of America. 105: 16248-53. PMID 18854411 DOI: 10.1073/Pnas.0808182105  0.434
2008 Holloway JK, Booth J, Edelmann W, McGowan CH, Cohen PE. MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis. Plos Genetics. 4: e1000186. PMID 18787696 DOI: 10.1371/Journal.Pgen.1000186  0.561
2008 Morelli MA, Werling U, Edelmann W, Roberson MS, Cohen PE. Analysis of meiotic prophase I in live mouse spermatocytes. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 16: 743-60. PMID 18516692 DOI: 10.1007/S10577-008-1224-8  0.434
2008 Svetlanov A, Baudat F, Cohen PE, de Massy B. Distinct functions of MLH3 at recombination hot spots in the mouse. Genetics. 178: 1937-45. PMID 18430927 DOI: 10.1534/Genetics.107.084798  0.813
2008 Avdievich E, Reiss C, Scherer SJ, Zhang Y, Maier SM, Jin B, Hou H, Rosenwald A, Riedmiller H, Kucherlapati R, Cohen PE, Edelmann W, Kneitz B. Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 4247-52. PMID 18337503 DOI: 10.1073/Pnas.0800276105  0.46
2008 Kan R, Sun X, Kolas NK, Avdievich E, Kneitz B, Edelmann W, Cohen PE. Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway. Biology of Reproduction. 78: 462-71. PMID 18057311 DOI: 10.1095/Biolreprod.107.065771  0.82
2007 Holmes RJ, Cohen PE. Small RNAs and RNAi pathways in meiotic prophase I. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 15: 653-65. PMID 17674152 DOI: 10.1007/S10577-007-1144-Z  0.317
2006 Li Z, Peled JU, Zhao C, Svetlanov A, Ronai D, Cohen PE, Scharff MD. A role for Mlh3 in somatic hypermutation. Dna Repair. 5: 675-82. PMID 16564751 DOI: 10.1016/J.Dnarep.2006.02.003  0.806
2006 Cohen PE, Pollack SE, Pollard JW. Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals. Endocrine Reviews. 27: 398-426. PMID 16543383 DOI: 10.1210/Er.2005-0017  0.699
2005 Morelli MA, Cohen PE. Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis. Reproduction (Cambridge, England). 130: 761-81. PMID 16322537 DOI: 10.1530/Rep.1.00865  0.467
2005 Kolas NK, Svetlanov A, Lenzi ML, Macaluso FP, Lipkin SM, Liskay RM, Greally J, Edelmann W, Cohen PE. Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. The Journal of Cell Biology. 171: 447-58. PMID 16260499 DOI: 10.1083/Jcb.200506170  0.813
2005 Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development (Cambridge, England). 132: 1463-73. PMID 15716349 DOI: 10.1242/Dev.01658  0.487
2005 Lenzi ML, Smith J, Snowden T, Kim M, Fishel R, Poulos BK, Cohen PE. Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes. American Journal of Human Genetics. 76: 112-27. PMID 15558497 DOI: 10.1086/427268  0.491
2004 Kolas NK, Cohen PE. Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenetic and Genome Research. 107: 216-31. PMID 15467367 DOI: 10.1159/000080600  0.782
2004 Svetlanov A, Cohen PE. Mismatch repair proteins, meiosis, and mice: understanding the complexities of mammalian meiosis. Experimental Cell Research. 296: 71-9. PMID 15120996 DOI: 10.1016/J.Yexcr.2004.03.020  0.833
2003 Crackower MA, Kolas NK, Noguchi J, Sarao R, Kikuchi K, Kaneko H, Kobayashi E, Kawai Y, Kozieradzki I, Landers R, Mo R, Hui CC, Nieves E, Cohen PE, Osborne LR, et al. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science (New York, N.Y.). 300: 1291-5. PMID 12764197 DOI: 10.1126/Science.1083022  0.803
2003 Wei K, Clark AB, Wong E, Kane MF, Mazur DJ, Parris T, Kolas NK, Russell R, Hou H, Kneitz B, Yang G, Kunkel TA, Kolodner RD, Cohen PE, Edelmann W. Inactivation of exonuclease I in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility Genes and Development. 17: 603-614. PMID 12629043 DOI: 10.1101/Gad.1060603  0.809
2002 Lipkin SM, Moens PB, Wang V, Lenzi M, Shanmugarajah D, Gilgeous A, Thomas J, Cheng J, Touchman JW, Green ED, Schwartzberg P, Collins FS, Cohen PE. Meiotic arrest and aneuploidy in MLH3-deficient mice Nature Genetics. 31: 385-390. PMID 12091911 DOI: 10.1038/Ng931  0.576
2002 Moens PB, Kolas NK, Tarsounas M, Marcon E, Cohen PE, Spyropoulos B. The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination. Journal of Cell Science. 115: 1611-22. PMID 11950880  0.781
2002 Cohen PE, Zhu L, Nishimura K, Pollard JW. Colony-stimulating factor 1 regulation of neuroendocrine pathways that control gonadal function in mice. Endocrinology. 143: 1413-22. PMID 11897698 DOI: 10.1210/Endo.143.4.8754  0.567
2001 Cohen PE, Pollard JW. Regulation of meiotic recombination and prophase I progression in mammals. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 23: 996-1009. PMID 11746216 DOI: 10.1002/Bies.1145  0.623
2001 Zindy F, den Besten W, Chen B, Rehg JE, Latres E, Barbacid M, Pollard JW, Sherr CJ, Cohen PE, Roussel MF. Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d). Molecular and Cellular Biology. 21: 3244-55. PMID 11287627 DOI: 10.1128/Mcb.21.9.3244-3255.2001  0.607
2000 Kneitz B, Cohen PE, Avdievich E, Zhu L, Kane MF, Hou H, Kolodner RD, Kucherlapati R, Pollard JW, Edelmann W. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes & Development. 14: 1085-97. PMID 10809667 DOI: 10.1101/Gad.14.9.1085  0.691
1999 Cohen PE, Nishimura K, Zhu L, Pollard JW. Macrophages: important accessory cells for reproductive function. Journal of Leukocyte Biology. 66: 765-72. PMID 10577508 DOI: 10.1002/Jlb.66.5.765  0.593
1999 Edelmann W, Cohen PE, Kneitz B, Winand N, Lia M, Heyer J, Kolodner R, Pollard JW, Kucherlapati R. Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nature Genetics. 21: 123-7. PMID 9916805 DOI: 10.1038/5075  0.681
1998 Cohen PE, Pollard JW. Normal sexual function in male mice lacking a functional type I interleukin-1 (IL-1) receptor. Endocrinology. 139: 815-8. PMID 9449661 DOI: 10.1210/Endo.139.2.5914  0.494
1997 Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, et al. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 91: 467-77. PMID 9390556 DOI: 10.1016/S0092-8674(00)80433-X  0.579
1997 Cohen PE, Hardy MP, Pollard JW. Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice. Molecular Endocrinology (Baltimore, Md.). 11: 1636-50. PMID 9328346 DOI: 10.1210/Mend.11.11.0009  0.582
1997 Pollard JW, Dominguez MG, Mocci S, Cohen PE, Stanley ER. Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract. Biology of Reproduction. 56: 1290-300. PMID 9160730 DOI: 10.1095/Biolreprod56.5.1290  0.545
1997 Cohen PE, Zhu L, Pollard JW. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biology of Reproduction. 56: 110-8. PMID 9002639 DOI: 10.1095/Biolreprod56.1.110  0.586
1996 Cohen PE, Chisholm O, Arceci RJ, Stanley ER, Pollard JW. Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biology of Reproduction. 55: 310-7. PMID 8828834 DOI: 10.1095/Biolreprod55.2.310  0.6
1996 Edelmann W, Cohen PE, Kane M, Lau K, Morrow B, Bennett S, Umar A, Kunkel T, Cattoretti G, Chaganti R, Pollard JW, Kolodner RD, Kucherlapati R. Meiotic pachytene arrest in MLH1-deficient mice. Cell. 85: 1125-34. PMID 8674118 DOI: 10.1016/S0092-8674(00)81312-4  0.649
1996 Cohen P, Zhu L, Pollard J. Macrophages: Trophic roles in reproduction Placenta. 17: A6. DOI: 10.1016/S0143-4004(96)90086-7  0.438
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