| Year |
Citation |
Score |
| 2023 |
Yousefzadeh MJ, Huerta Guevara AP, Postmus AC, Flores RR, Sano T, Jurdzinski A, Angelini L, McGowan SJ, O'Kelly RD, Wade EA, Gonzalez-Espada LV, Henessy-Wack D, Howard S, Rozgaja TA, Trussoni CE, ... ... Niedernhofer LJ, et al. Failure to repair endogenous DNA damage in β-cells causes adult-onset diabetes in mice. Aging Biology. 1. PMID 38124711 DOI: 10.59368/agingbio.20230015 |
0.317 |
|
| 2023 |
Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell RGG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, et al. and effects of zoledronate on senescence and senescence-associated secretory phenotype markers. Biorxiv : the Preprint Server For Biology. PMID 36865244 DOI: 10.1101/2023.02.23.529777 |
0.331 |
|
| 2023 |
Henpita C, Vyas R, Healy CL, Kieu TL, Gurkar AU, Yousefzadeh MJ, Cui Y, Lu A, Angelini LA, O'Kelly RD, McGowan SJ, Chandrasekhar S, Vanderpool RR, Hennessy-Wack D, Ross MA, ... ... Niedernhofer LJ, et al. Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy. Aging Cell. e13782. PMID 36734200 DOI: 10.1111/acel.13782 |
0.319 |
|
| 2022 |
Miller W, Pruett CLH, Stone W, Eide C, Riddle M, Popp C, Yousefzadeh M, Lees C, Seelig D, Thompson E, Orr H, Niedernhofer L, Tolar J. Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model. Plos One. 17: e0275580. PMID 36251631 DOI: 10.1371/journal.pone.0275580 |
0.343 |
|
| 2022 |
Soto-Palma C, Niedernhofer LJ, Faulk CD, Dong X. Epigenetics, DNA damage, and aging. The Journal of Clinical Investigation. 132. PMID 35968782 DOI: 10.1172/JCI158446 |
0.306 |
|
| 2022 |
Zhang L, Pitcher LE, Yousefzadeh MJ, Niedernhofer LJ, Robbins PD, Zhu Y. Cellular senescence: a key therapeutic target in aging and diseases. The Journal of Clinical Investigation. 132. PMID 35912854 DOI: 10.1172/JCI158450 |
0.323 |
|
| 2022 |
Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Targeting Cellular Senescence with Senotherapeutics: Senolytics and Senomorphics. The Febs Journal. PMID 35015337 DOI: 10.1111/febs.16350 |
0.314 |
|
| 2021 |
Gladyshev VN, Kritchevsky SB, Clarke SG, Cuervo AM, Fiehn O, de Magalhães JP, Mau T, Maes M, Moritz R, Niedernhofer LJ, Van Schaftingen E, Tranah GJ, Walsh K, Yura Y, Zhang B, et al. Molecular Damage in Aging. Nature Aging. 1: 1096-1106. PMID 36846190 DOI: 10.1038/s43587-021-00150-3 |
0.36 |
|
| 2021 |
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, ... ... Niedernhofer LJ, et al. An aged immune system drives senescence and ageing of solid organs. Nature. PMID 33981041 DOI: 10.1038/s41586-021-03547-7 |
0.343 |
|
| 2021 |
Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L. DNA damage-how and why we age? Elife. 10. PMID 33512317 DOI: 10.7554/eLife.62852 |
0.428 |
|
| 2021 |
Huerta Guevara AP, McGowan SJ, Kazantzis M, Stallons TR, Sano T, Mulder NL, Jurdzinski A, van Dijk TH, Eggen BJL, Jonker JW, Niedernhofer LJ, Kruit JK. Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1 mice. Metabolism: Clinical and Experimental. 154711. PMID 33493548 DOI: 10.1016/j.metabol.2021.154711 |
0.367 |
|
| 2020 |
Mu X, Tseng C, Hambright WS, Matre P, Lin CY, Chanda P, Chen W, Gu J, Ravuri S, Cui Y, Zhong L, Cooke JP, Niedernhofer LJ, Robbins PD, Huard J. Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome. Aging Cell. PMID 32710480 DOI: 10.1111/Acel.13152 |
0.341 |
|
| 2020 |
Han Y, Zhou CM, Shen H, Tan J, Dong Q, Zhang L, McGowan SJ, Zhao J, Sowa GA, Kang JD, Niedernhofer LJ, Robbins PD, Vo NN. Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration. Aging Cell. PMID 32567210 DOI: 10.1111/Acel.13162 |
0.517 |
|
| 2020 |
Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, Dietrich J, Fuldner R, Gallicchio L, Green PA, Hurria A, Janelsins MC, Jhappan C, Kirkland JL, Kohanski R, ... ... Niedernhofer LJ, et al. Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. Journal of the National Cancer Institute. PMID 32348501 DOI: 10.1093/Jnci/Djaa060 |
0.307 |
|
| 2020 |
Yousefzadeh MJ, Wilkinson JE, Hughes B, Gadela N, Ladiges WC, Vo N, Niedernhofer LJ, Huffman DM, Robbins PD. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues. Geroscience. PMID 32285290 DOI: 10.1007/s11357-020-00185-1 |
0.368 |
|
| 2020 |
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, ... ... Niedernhofer LJ, et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging. 12. PMID 32201398 DOI: 10.18632/aging.102863 |
0.422 |
|
| 2020 |
Yousefzadeh MJ, Zhao J, Bukata C, Wade EA, McGowan SJ, Angelini LA, Bank MP, Gurkar AU, McGuckian CA, Calubag MF, Kato JI, Burd CE, Robbins PD, Niedernhofer LJ. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Aging Cell. e13094. PMID 31981461 DOI: 10.1111/Acel.13094 |
0.523 |
|
| 2019 |
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, ... ... Niedernhofer L, et al. Cellular Senescence: Defining a Path Forward. Cell. 179: 813-827. PMID 31675495 DOI: 10.1016/J.Cell.2019.10.005 |
0.403 |
|
| 2019 |
Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J. Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice. Molecular Therapy. Methods & Clinical Development. 14: 64-76. PMID 31312666 DOI: 10.1016/J.Omtm.2019.05.011 |
0.41 |
|
| 2019 |
Fuhrmann-Stroissnigg H, Santiago FE, Grassi D, Ling Y, Niedernhofer LJ, Robbins PD. SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs. Journal of Visualized Experiments : Jove. PMID 31305507 DOI: 10.3791/58133 |
0.312 |
|
| 2019 |
Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ. Creating the Next Generation of Translational Geroscientists. Journal of the American Geriatrics Society. PMID 31287934 DOI: 10.1111/Jgs.16055 |
0.305 |
|
| 2019 |
Patil P, Dong Q, Wang D, Chang J, Wiley C, Demaria M, Lee J, Kang J, Niedernhofer LJ, Robbins PD, Sowa G, Campisi J, Zhou D, Vo N. Systemic clearance of p16 -positive senescent cells mitigates age-associated intervertebral disc degeneration. Aging Cell. e12927. PMID 30900385 DOI: 10.1111/Acel.12927 |
0.403 |
|
| 2019 |
Zhang L, Yousefzadeh MJ, Suh Y, Niedernhofer LJ, Robbins PD. Signal Transduction, Ageing and Disease. Sub-Cellular Biochemistry. 91: 227-247. PMID 30888655 DOI: 10.1007/978-981-13-3681-2_9 |
0.429 |
|
| 2019 |
Hambright WS, Niedernhofer LJ, Huard J, Robbins PD. Murine models of accelerated aging and musculoskeletal disease. Bone. PMID 30844492 DOI: 10.1016/J.Bone.2019.03.002 |
0.405 |
|
| 2019 |
Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA. Measuring biological age in mice using differential mass spectrometry. Aging. 11: 1045-1061. PMID 30745468 DOI: 10.18632/aging.101810 |
0.323 |
|
| 2019 |
Yousefzadeh MJ, Melos KI, Angelini L, Burd CE, Robbins PD, Niedernhofer LJ. Mouse Models of Accelerated Cellular Senescence. Methods in Molecular Biology (Clifton, N.J.). 1896: 203-230. PMID 30474850 DOI: 10.1007/978-1-4939-8931-7_17 |
0.452 |
|
| 2018 |
Hartman R, Patil P, Tisherman R, St Croix C, Niedernhofer LJ, Robbins PD, Ambrosio F, Van Houten B, Sowa G, Vo N. Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics. European Cells & Materials. 36: 171-183. PMID 30334244 DOI: 10.22203/Ecm.V036A13 |
0.387 |
|
| 2018 |
Sharma K, Darvas M, Keene CD, Niedernhofer LJ, Ladiges W. Modeling Alzheimer's disease in progeria mice. An age-related concept. Pathobiology of Aging & Age Related Diseases. 8: 1524815. PMID 30319737 DOI: 10.1080/20010001.2018.1524815 |
0.305 |
|
| 2018 |
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, ... ... Niedernhofer LJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. Ebiomedicine. PMID 30279143 DOI: 10.1016/J.Ebiom.2018.09.015 |
0.457 |
|
| 2018 |
Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biology. 18: 191-199. PMID 30031267 DOI: 10.1016/J.Redox.2018.06.005 |
0.723 |
|
| 2018 |
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, ... ... Niedernhofer LJ, et al. Senolytics improve physical function and increase lifespan in old age. Nature Medicine. PMID 29988130 DOI: 10.1038/S41591-018-0092-9 |
0.436 |
|
| 2018 |
Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. Nuclear Genomic Instability and Aging. Annual Review of Biochemistry. 87: 295-322. PMID 29925262 DOI: 10.1146/Annurev-Biochem-062917-012239 |
0.521 |
|
| 2018 |
Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD. Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell Cycle (Georgetown, Tex.). PMID 29886783 DOI: 10.1080/15384101.2018.1475828 |
0.434 |
|
| 2018 |
Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU, McGowan SJ, ... ... Niedernhofer LJ, et al. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radical Biology & Medicine. PMID 29860127 DOI: 10.1016/J.Freeradbiomed.2018.05.088 |
0.815 |
|
| 2018 |
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, ... ... Niedernhofer LJ, et al. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biology. 17: 259-273. PMID 29747066 DOI: 10.1016/J.Redox.2018.04.007 |
0.821 |
|
| 2018 |
Niedernhofer LJ, Robbins PD. Senotherapeutics for healthy ageing. Nature Reviews. Drug Discovery. 17: 377. PMID 29651106 DOI: 10.1038/Nrd.2018.44 |
0.359 |
|
| 2018 |
Zarakowska E, Czerwinska J, Tupalska A, Yousefzadeh MJ, Gregg SQ, St Croix CM, Niedernhofer LJ, Foksinski M, Gackowski D, Szpila A, Starczak M, Tudek B, Olinski R. Oxidation Products of 5-Methyl Cytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 29415265 DOI: 10.1093/Gerona/Gly012 |
0.824 |
|
| 2018 |
Niedernhofer LJ. DNA DAMAGE: THE MOST STALWART PILLAR OF AGING Innovation in Aging. 2: 592-592. DOI: 10.1093/geroni/igy023.2198 |
0.4 |
|
| 2017 |
Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ. Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging Cell. PMID 29290100 DOI: 10.1111/Acel.12706 |
0.429 |
|
| 2017 |
Mori T, Yousefzadeh MJ, Faridounnia M, Chong JX, Hisama FM, Hudgins L, Mercado G, Wade EA, Barghouthy AS, Lee L, Martin GM, Nickerson DA, Bamshad MJ, Niedernhofer LJ, et al. ERCC4 Variants Identified in a Cohort of Patients with Segmental Progeroid Syndromes. Human Mutation. PMID 29105242 DOI: 10.1002/Humu.23367 |
0.342 |
|
| 2017 |
Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, ... ... Niedernhofer LJ, et al. Identification of HSP90 inhibitors as a novel class of senolytics. Nature Communications. 8: 422. PMID 28871086 DOI: 10.1038/S41467-017-00314-Z |
0.795 |
|
| 2017 |
Kirkland JL, Tchkonia T, Zhu Y, Niedernhofer LJ, Robbins PD. The Clinical Potential of Senolytic Drugs. Journal of the American Geriatrics Society. PMID 28869295 DOI: 10.1111/Jgs.14969 |
0.396 |
|
| 2017 |
Ngo K, Patil P, McGowan SJ, Niedernhofer LJ, Robbins PD, Kang J, Sowa G, Vo N. Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype. Mechanisms of Ageing and Development. PMID 28830687 DOI: 10.1016/J.Mad.2017.08.007 |
0.437 |
|
| 2017 |
Proto JD, Lu A, Dorronsoro A, Scibetta A, Robbins PD, Niedernhofer LJ, Huard J. Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice. Plos One. 12: e0179270. PMID 28640861 DOI: 10.1371/Journal.Pone.0179270 |
0.392 |
|
| 2017 |
Robbins PD, Niedernhofer LJ. Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2(nd) Scripps Symposium on the Biology of Aging. Aging Cell. PMID 28585366 DOI: 10.1111/Acel.12620 |
0.35 |
|
| 2017 |
Ngo K, Pohl P, Leme AS, Lee J, Di P, Roughley P, Robbins PD, Niedernhofer LJ, Sowa G, Kang JD, Shapiro SS, Vo NV. Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine. PMID 28570296 DOI: 10.1097/Brs.0000000000002258 |
0.302 |
|
| 2017 |
Ladiges W, Snyder JM, Wilkinson E, Imai DM, Snider T, Ge X, Ciol M, Pettan-Brewer C, Pillai SP, Morton J, Quarles E, Rabinovitch P, Niedernhofer L, Liggitt D. A New Preclinical Paradigm for Testing Anti-Aging Therapeutics. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28329081 DOI: 10.1093/Gerona/Glx019 |
0.41 |
|
| 2017 |
Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. PMID 28273655 DOI: 10.18632/Aging.101202 |
0.327 |
|
| 2017 |
Flores RR, Clauson CL, Cho J, Lee BC, McGowan SJ, Baker DJ, Niedernhofer LJ, Robbins PD. Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism. Aging Cell. PMID 28229533 DOI: 10.1111/Acel.12571 |
0.492 |
|
| 2017 |
Zhao J, Fuhrmann-Stroissnigg H, Gurkar AU, Flores RR, Dorronsoro A, Stolz DB, St Croix CM, Niedernhofer LJ, Robbins PD. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Current Protocols in Cytometry. 79: 9.51.1-9.51.25. PMID 28055114 DOI: 10.1002/Cpcy.16 |
0.431 |
|
| 2016 |
Yu Y, Cui Y, Niedernhofer LJ, Wang Y. Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage. Chemical Research in Toxicology. 29: 2008-2039. PMID 27989142 DOI: 10.1021/Acs.Chemrestox.6B00265 |
0.433 |
|
| 2016 |
Niedernhofer LJ, Kirkland JL, Ladiges W. MOLECULAR PATHOLOGY ENDPOINTS USEFUL FOR AGING STUDIES. Ageing Research Reviews. PMID 27721062 DOI: 10.1016/J.Arr.2016.09.012 |
0.327 |
|
| 2016 |
Takayama K, Kawakami Y, Lavasani M, Mu X, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J. mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 27572850 DOI: 10.1002/Jor.23409 |
0.5 |
|
| 2016 |
Burd CE, Gill MS, Niedernhofer LJ, Robbins PD, Austad SN, Barzilai N, Kirkland JL. Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27535964 DOI: 10.1093/Gerona/Glw112 |
0.319 |
|
| 2016 |
Rozgaja T, Yousefzadeh M, Li X, Bell-Temin H, Johnson C, Robinson RA, Wang J, Cantu-Medellin N, Czerwinska J, Harris J, Fallahi-Sichani M, Cifuentes-Pagano E, Pagano PJ, Ross M, Tudek B, ... ... Niedernhofer L, et al. Comparing Progeria to Natural Aging Reveals New Insights Regarding the Association of Time and Redox Imbalance Free Radical Biology and Medicine. 100: S84. DOI: 10.1016/J.Freeradbiomed.2016.10.210 |
0.479 |
|
| 2015 |
Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL. Identification of a Novel Senolytic Agent, Navitoclax, Targeting the Bcl-2 Family of Anti-Apoptotic Factors. Aging Cell. PMID 26711051 DOI: 10.1111/Acel.12445 |
0.303 |
|
| 2015 |
Ladiges W, Ikeno Y, Niedernhofer L, McIndoe RA, Ciol MA, Ritchey J, Liggitt D. The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 71: 431-4. PMID 26243216 DOI: 10.1093/Gerona/Glv079 |
0.359 |
|
| 2015 |
Amato NJ, Zhai Q, Navarro DC, Niedernhofer LJ, Wang Y. In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides. Nucleic Acids Research. 43: 8314-24. PMID 26202973 DOI: 10.1093/Nar/Gkv725 |
0.325 |
|
| 2015 |
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, ... ... Niedernhofer LJ, et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 14: 644-58. PMID 25754370 DOI: 10.1111/Acel.12344 |
0.419 |
|
| 2015 |
Zhao J, Li X, McGowan S, Niedernhofer LJ, Robbins PD. NF-κB activation with aging: Characterization and therapeutic inhibition Methods in Molecular Biology. 1280: 543-557. PMID 25736771 DOI: 10.1007/978-1-4939-2422-6_32 |
0.395 |
|
| 2015 |
Gurkar AU, Niedernhofer LJ. Comparison of mice with accelerated aging caused by distinct mechanisms. Experimental Gerontology. 68: 43-50. PMID 25617508 DOI: 10.1016/J.Exger.2015.01.045 |
0.393 |
|
| 2014 |
Vaezi AE, Bepler G, Bhagwat NR, Malysa A, Rubatt JM, Chen W, Hood BL, Conrads TP, Wang L, Kemp CE, Niedernhofer LJ. Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. Cancer. 120: 1898-907. PMID 24692084 DOI: 10.1002/Cncr.28643 |
0.683 |
|
| 2014 |
Nasto LA, Ngo K, Leme AS, Robinson AR, Dong Q, Roughley P, Usas A, Sowa GA, Pola E, Kang J, Niedernhofer LJ, Shapiro S, Vo NV. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. The Spine Journal : Official Journal of the North American Spine Society. 14: 416-23. PMID 24211096 DOI: 10.1016/J.Spinee.2013.08.034 |
0.612 |
|
| 2013 |
Clauson C, Schärer OD, Niedernhofer L. Advances in understanding the complex mechanisms of DNA interstrand cross-link repair. Cold Spring Harbor Perspectives in Biology. 5: a012732. PMID 24086043 DOI: 10.1101/Cshperspect.A012732 |
0.453 |
|
| 2013 |
Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson AR, Tsamardinos I, Rozgaja TA, Siakouli S, Tsatsanis C, Niedernhofer LJ, Garinis GA. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell Metabolism. 18: 403-15. PMID 24011075 DOI: 10.1016/J.Cmet.2013.08.011 |
0.709 |
|
| 2013 |
Roh DS, Du Y, Gabriele ML, Robinson AR, Niedernhofer LJ, Funderburgh JL. Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice. Aging Cell. 12: 1122-31. PMID 23927039 DOI: 10.1111/Acel.12143 |
0.741 |
|
| 2013 |
Vo N, Niedernhofer LJ, Nasto LA, Jacobs L, Robbins PD, Kang J, Evans CH. An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 831-7. PMID 23483579 DOI: 10.1002/Jor.22204 |
0.416 |
|
| 2013 |
Lavasani M, Lu A, Thompson SD, Robbins PD, Huard J, Niedernhofer LJ. Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces. Methods in Molecular Biology (Clifton, N.J.). 976: 53-65. PMID 23400434 DOI: 10.1007/978-1-62703-317-6_5 |
0.339 |
|
| 2013 |
Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, Niedernhofer LJ, Wipf P, Vo NV. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1150-7. PMID 23389888 DOI: 10.1002/Jor.22320 |
0.66 |
|
| 2013 |
Chen Q, Liu K, Robinson AR, Clauson CL, Blair HC, Robbins PD, Niedernhofer LJ, Ouyang H. DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 1214-28. PMID 23281008 DOI: 10.1002/Jbmr.1851 |
0.712 |
|
| 2013 |
Nasto LA, Wang D, Robinson AR, Clauson CL, Ngo K, Dong Q, Roughley P, Epperly M, Huq SM, Pola E, Sowa G, Robbins PD, Kang J, Niedernhofer LJ, Vo NV. Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mechanisms of Ageing and Development. 134: 35-42. PMID 23262094 DOI: 10.1016/J.Mad.2012.11.002 |
0.734 |
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| 2013 |
Cho JS, Kook SH, Robinson AR, Niedernhofer LJ, Lee BC. Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair. Stem Cells (Dayton, Ohio). 31: 511-25. PMID 23097336 DOI: 10.1002/Stem.1261 |
0.708 |
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| 2012 |
Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Reports. 2: 1137-42. PMID 23122961 DOI: 10.1016/J.Celrep.2012.10.001 |
0.405 |
|
| 2012 |
You C, Dai X, Yuan B, Wang J, Wang J, Brooks PJ, Niedernhofer LJ, Wang Y. A quantitative assay for assessing the effects of DNA lesions on transcription. Nature Chemical Biology. 8: 817-22. PMID 22902614 DOI: 10.1038/Nchembio.1046 |
0.4 |
|
| 2012 |
Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, ... ... Niedernhofer LJ, et al. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of Clinical Investigation. 122: 2601-12. PMID 22706308 DOI: 10.1172/Jci45785 |
0.809 |
|
| 2012 |
Deloia JA, Bhagwat NR, Darcy KM, Strange M, Tian C, Nuttall K, Krivak TC, Niedernhofer LJ. Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum. Gynecologic Oncology. 126: 448-54. PMID 22609620 DOI: 10.1016/J.Ygyno.2012.05.006 |
0.703 |
|
| 2012 |
Wang J, Cao H, You C, Yuan B, Bahde R, Gupta S, Nishigori C, Niedernhofer LJ, Brooks PJ, Wang Y. Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion. Nucleic Acids Research. 40: 7368-74. PMID 22581771 DOI: 10.1093/Nar/Gks357 |
0.336 |
|
| 2012 |
Su Y, Orelli B, Madireddy A, Niedernhofer LJ, Schärer OD. Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. The Journal of Biological Chemistry. 287: 21846-55. PMID 22547097 DOI: 10.1074/Jbc.M111.337899 |
0.409 |
|
| 2012 |
Wang J, Clauson CL, Robbins PD, Niedernhofer LJ, Wang Y. The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell. 11: 714-6. PMID 22530741 DOI: 10.1111/J.1474-9726.2012.00828.X |
0.539 |
|
| 2012 |
Nasto LA, Seo HY, Robinson AR, Tilstra JS, Clauson CL, Sowa GA, Ngo K, Dong Q, Pola E, Lee JY, Niedernhofer LJ, Kang JD, Robbins PD, Vo NV. ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine. 37: 1819-25. PMID 22343279 DOI: 10.1097/Brs.0B013E31824Ee8F7 |
0.686 |
|
| 2012 |
Rubatt JM, Darcy KM, Tian C, Muggia F, Dhir R, Armstrong DK, Bookman MA, Niedernhofer LJ, Deloia J, Birrer M, Krivak TC. Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: a Gynecologic Oncology Group study. Gynecologic Oncology. 125: 421-6. PMID 22261301 DOI: 10.1016/J.Ygyno.2012.01.008 |
0.346 |
|
| 2012 |
Smith SC, Robinson AR, Niedernhofer LJ, Hetman M. Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice. Neurobiology of Disease. 45: 1136-44. PMID 22245387 DOI: 10.1016/J.Nbd.2011.12.036 |
0.674 |
|
| 2012 |
Lavasani M, Robinson AR, Lu A, Song M, Feduska JM, Ahani B, Tilstra JS, Feldman CH, Robbins PD, Niedernhofer LJ, Huard J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nature Communications. 3: 608. PMID 22215083 DOI: 10.1038/Ncomms1611 |
0.668 |
|
| 2012 |
Matoka DJ, Yao V, Harya DS, Gregg JL, Robinson AR, Niedernhofer LJ, Parwani AV, Maier C, Bacich DJ. Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model. The Prostate. 72: 1214-22. PMID 22212909 DOI: 10.1002/Pros.22472 |
0.684 |
|
| 2012 |
Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (Baltimore, Md.). 55: 609-21. PMID 21953681 DOI: 10.1002/Hep.24713 |
0.801 |
|
| 2012 |
Vo NA, Nasto LA, Robinson A, Sowa G, Wipf P, Robbins P, Kang J, Niedernhofer L. Removal of Mitochondria-Generated Reactive Oxygen Species Delays Age-Associated Disk Degeneration Global Spine Journal. 2: s-0032-1319964-s-003. DOI: 10.1055/S-0032-1319964 |
0.612 |
|
| 2012 |
Dollé M, Kuiper R, Roodbergen M, Robinson J, de Vlugt S, Wijnhoven S, Beems D, de la Fonteyne L, de With P, Niedernhofer L, Hasty P, Vijg J, Hoeijmakers J, van Steeg H. Ercc1 Deficient Mice Show Segmental Progeria Journal of Comparative Pathology. 146: 51. DOI: 10.1016/J.Jcpa.2011.11.025 |
0.327 |
|
| 2011 |
Vaezi A, Feldman CH, Niedernhofer LJ. ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer. Pharmacogenomics and Personalized Medicine. 4: 47-63. PMID 23226053 DOI: 10.2147/Pgpm.S20317 |
0.369 |
|
| 2011 |
Tilstra JS, Clauson CL, Niedernhofer LJ, Robbins PD. NF-κB in Aging and Disease. Aging and Disease. 2: 449-65. PMID 22396894 |
0.312 |
|
| 2011 |
Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus (Austin, Tex.). 2: 570-9. PMID 22127259 DOI: 10.4161/Nucl.2.6.17798 |
0.773 |
|
| 2011 |
Vaezi A, Wang X, Buch S, Gooding W, Wang L, Seethala RR, Weaver DT, D'Andrea AD, Argiris A, Romkes M, Niedernhofer LJ, Grandis JR. XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5513-22. PMID 21737503 DOI: 10.1158/1078-0432.Ccr-11-0086 |
0.41 |
|
| 2011 |
Niedernhofer LJ, Bohr VA, Sander M, Kraemer KH. Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients. Mechanisms of Ageing and Development. 132: 340-7. PMID 21708183 DOI: 10.1016/J.Mad.2011.06.004 |
0.425 |
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| 2011 |
Niedernhofer LJ, Glorioso JC, Robbins PD. Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Research & Therapy. 2: 28. PMID 21639955 DOI: 10.1186/Scrt69 |
0.407 |
|
| 2011 |
Gregg SQ, Robinson AR, Niedernhofer LJ. Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease Dna Repair. 10: 781-791. PMID 21612988 DOI: 10.1016/J.Dnarep.2011.04.026 |
0.798 |
|
| 2011 |
Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ. Premature aging-related peripheral neuropathy in a mouse model of progeria. Mechanisms of Ageing and Development. 132: 437-42. PMID 21596054 DOI: 10.1016/J.Mad.2011.04.010 |
0.705 |
|
| 2011 |
Wang D, Vo NV, Sowa GA, Hartman RA, Ngo K, Choe SR, Witt WT, Dong Q, Lee JY, Niedernhofer LJ, Kang JD. Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system. The Spine Journal : Official Journal of the North American Spine Society. 11: 139-46. PMID 21296298 DOI: 10.1016/J.Spinee.2010.11.017 |
0.313 |
|
| 2010 |
Vo N, Seo HY, Robinson A, Sowa G, Bentley D, Taylor L, Studer R, Usas A, Huard J, Alber S, Watkins SC, Lee J, Coehlo P, Wang D, Loppini M, ... ... Niedernhofer LJ, et al. Accelerated aging of intervertebral discs in a mouse model of progeria. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 1600-7. PMID 20973062 DOI: 10.1002/Jor.21153 |
0.729 |
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| 2010 |
Hagelstrom RT, Blagoev KB, Niedernhofer LJ, Goodwin EH, Bailey SM. Hyper telomere recombination accelerates replicative senescence and may promote premature aging Proceedings of the National Academy of Sciences of the United States of America. 107: 15768-15773. PMID 20798040 DOI: 10.1073/Pnas.1006338107 |
0.409 |
|
| 2010 |
Ahmad A, Enzlin JH, Bhagwat NR, Wijgers N, Raams A, Appledoorn E, Theil AF, J Hoeijmakers JH, Vermeulen W, J Jaspers NG, Schärer OD, Niedernhofer LJ. Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients. Plos Genetics. 6: e1000871. PMID 20221251 DOI: 10.1371/Journal.Pgen.1000871 |
0.766 |
|
| 2010 |
Orelli B, McClendon TB, Tsodikov OV, Ellenberger T, Niedernhofer LJ, Schärer OD. The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. The Journal of Biological Chemistry. 285: 3705-12. PMID 19940136 DOI: 10.1074/Jbc.M109.067538 |
0.454 |
|
| 2010 |
Niedernhofer LJ, Bhagwat NR, Wood RD. Validation of ERCC1-XPF immunodetection - response Cancer Research. 70: 3852. DOI: 10.1158/0008-5472.Can-10-0456 |
0.693 |
|
| 2009 |
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Molecular and Cellular Biology. 29: 6427-37. PMID 19805513 DOI: 10.1128/Mcb.00086-09 |
0.77 |
|
| 2009 |
Bhagwat NR, Roginskaya VY, Acquafondata MB, Dhir R, Wood RD, Niedernhofer LJ. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Research. 69: 6831-8. PMID 19723666 DOI: 10.1158/0008-5472.Can-09-1237 |
0.76 |
|
| 2009 |
Andreassen PR, Niedernhofer LJ. Fanconi anemia: a paradigm of discovering molecular pathways from patients. Mutation Research. 668: 1-3. PMID 19540854 DOI: 10.1016/J.Mrfmmm.2009.06.007 |
0.318 |
|
| 2009 |
Parmar K, D'Andrea A, Niedernhofer LJ. Mouse models of Fanconi anemia. Mutation Research. 668: 133-40. PMID 19427003 DOI: 10.1016/J.Mrfmmm.2009.03.015 |
0.384 |
|
| 2009 |
Vo N, Tilstra J, Robison A, Usas A, Sowa G, Studer R, Lee J, Niedernhofer L, Kang J. 26. Treatment Using a Therapeutic Peptide Inhibitor Against the Stress Mediator NFkB Delayed Age-Dependent Spinal Degeneration in an Accelerated Aging Mouse Model The Spine Journal. 9: 14S-15S. DOI: 10.1016/J.Spinee.2009.08.033 |
0.345 |
|
| 2008 |
Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA. Delayed and accelerated aging share common longevity assurance mechanisms. Plos Genetics. 4: e1000161. PMID 18704162 DOI: 10.1371/Journal.Pgen.1000161 |
0.7 |
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| 2008 |
Ahmad A, Robinson AR, Duensing A, van Drunen E, Beverloo HB, Weisberg DB, Hasty P, Hoeijmakers JH, Niedernhofer LJ. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Molecular and Cellular Biology. 28: 5082-92. PMID 18541667 DOI: 10.1128/Mcb.00293-08 |
0.706 |
|
| 2008 |
Niedernhofer LJ. Tissue-specific accelerated aging in nucleotide excision repair deficiency. Mechanisms of Ageing and Development. 129: 408-15. PMID 18538374 DOI: 10.1016/J.Mad.2008.04.010 |
0.504 |
|
| 2008 |
Niedernhofer LJ. Nucleotide excision repair deficient mouse models and neurological disease. Dna Repair. 7: 1180-9. PMID 18272436 DOI: 10.1016/J.Dnarep.2007.12.006 |
0.474 |
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| 2008 |
Niedernhofer LJ. DNA repair is crucial for maintaining hematopoietic stem cell function. Dna Repair. 7: 523-9. PMID 18248857 DOI: 10.1016/J.Dnarep.2007.11.012 |
0.523 |
|
| 2008 |
Niedernhofer LJ, Robbins PD. Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. The International Journal of Biochemistry & Cell Biology. 40: 176-80. PMID 18023240 DOI: 10.1016/J.Biocel.2007.10.008 |
0.373 |
|
| 2008 |
Niedernhofer LJ. Geriatric bioscience Journal of Clinical Investigation. 118: 3245-3245. DOI: 10.1172/Jci36963 |
0.376 |
|
| 2007 |
Niedernhofer LJ, Bhagwat N, Wood RD. ERCC1 and non-small-cell lung cancer [8] New England Journal of Medicine. 356: 2538-2540. PMID 17568038 DOI: 10.1056/Nejmc070742 |
0.68 |
|
| 2007 |
van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, et al. Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. Plos Biology. 5: e2. PMID 17326724 DOI: 10.1371/Journal.Pbio.0050002 |
0.448 |
|
| 2007 |
Niedernhofer LJ. The Fanconi anemia signalosome anchor. Molecular Cell. 25: 487-90. PMID 17317622 DOI: 10.1016/J.Molcel.2007.02.002 |
0.408 |
|
| 2007 |
Jaspers NG, Raams A, Silengo MC, Wijgers N, Niedernhofer LJ, Robinson AR, Giglia-Mari G, Hoogstraten D, Kleijer WJ, Hoeijmakers JH, Vermeulen W. First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. American Journal of Human Genetics. 80: 457-66. PMID 17273966 DOI: 10.1086/512486 |
0.647 |
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| 2006 |
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 444: 1038-43. PMID 17183314 DOI: 10.1038/Nature05456 |
0.738 |
|
| 2006 |
Dollé ME, Busuttil RA, Garcia AM, Wijnhoven S, van Drunen E, Niedernhofer LJ, van der Horst G, Hoeijmakers JH, van Steeg H, Vijg J. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutation Research. 596: 22-35. PMID 16472827 DOI: 10.1016/J.Mrfmmm.2005.11.008 |
0.492 |
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| 2006 |
Hoeijmakers JH, Garinis G, van der Pluijm I, Mitchell J, Andressoo J, Diderich K, Lalai A, de Waard H, Beems D, van Steeg H, Niedernhofer L, van der Horst B. Genome instability and accelerated aging: The relevance for normal aging and life span extension Toxicology. 226: 17-18. DOI: 10.1016/J.Tox.2006.05.027 |
0.357 |
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| 2005 |
Niedernhofer LJ, Lalai AS, Hoeijmakers JH. Fanconi anemia (cross)linked to DNA repair. Cell. 123: 1191-8. PMID 16377561 DOI: 10.1016/J.Cell.2005.12.009 |
0.451 |
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| 2005 |
Prasher JM, Lalai AS, Heijmans-Antonissen C, Ploemacher RE, Hoeijmakers JH, Touw IP, Niedernhofer LJ. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. The Embo Journal. 24: 861-71. PMID 15692571 DOI: 10.1038/Sj.Emboj.7600542 |
0.549 |
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| 2004 |
Schrader CE, Vardo J, Linehan E, Twarog MZ, Niedernhofer LJ, Hoeijmakers JH, Stavnezer J. Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. The Journal of Experimental Medicine. 200: 321-30. PMID 15280420 DOI: 10.1084/Jem.20040052 |
0.435 |
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| 2004 |
Niedernhofer LJ, Odijk H, Budzowska M, van Drunen E, Maas A, Theil AF, de Wit J, Jaspers NG, Beverloo HB, Hoeijmakers JH, Kanaar R. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Molecular and Cellular Biology. 24: 5776-87. PMID 15199134 DOI: 10.1128/Mcb.24.13.5776-5787.2004 |
0.475 |
|
| 2003 |
Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Molecular Cell. 12: 1489-98. PMID 14690602 DOI: 10.1016/S1097-2765(03)00478-7 |
0.376 |
|
| 2003 |
Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. The Journal of Biological Chemistry. 278: 31426-33. PMID 12775726 DOI: 10.1074/Jbc.M212549200 |
0.419 |
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| 2003 |
Mitchell JR, Hoeijmakers JH, Niedernhofer LJ. Divide and conquer: nucleotide excision repair battles cancer and ageing. Current Opinion in Cell Biology. 15: 232-40. PMID 12648680 DOI: 10.1016/S0955-0674(03)00018-8 |
0.493 |
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| 2001 |
Niedernhofer LJ, Essers J, Weeda G, Beverloo B, De Wit J, Muijtjens M, Odijk H, Hoeijmakers JHJ, Kanaar R. The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells Embo Journal. 20: 6540-6549. PMID 11707424 DOI: 10.1093/Emboj/20.22.6540 |
0.404 |
|
| 1993 |
Basu AK, Wood ML, Niedernhofer LJ, Ramos LA, Essigmann JM. Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole. Biochemistry. 32: 12793-801. PMID 8251500 DOI: 10.1021/Bi00210A031 |
0.317 |
|
| 1987 |
Basu AK, Niedernhofer LJ, Essigmann JM. Deoxyhexanucleotide containing a vinyl chloride induced DNA lesion, 1,N6-ethenoadenine: Synthesis, physical characterization, and incorporation into a duplex bacteriophage M13 genome as part of an amber codon Biochemistry. 26: 5626-5635. PMID 3314993 DOI: 10.1021/Bi00392A007 |
0.353 |
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