| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2022 | Tseng V, Collum S, Allawzi A, Crotty K, Yeligar S, Trammell A, Ryan Smith M, Kang BY, Sutliff RL, Ingram JL, Jyothula SS, Thandavarayan RA, Huang HJ, Nozik ES, Wagner EJ, et al. 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 35671866 DOI: 10.1016/j.matbio.2022.06.001 | 0.311 | |||
| 2021 | Jang AJ, Chang SS, Park C, Lee CM, Benza RL, Passineau MJ, Ma J, Archer DR, Sutliff RL, Hart CM, Kang BY. PPARγ increases HUWE1 to attenuate NF-κB/p65 and sickle cell disease with pulmonary hypertension. Blood Advances. 5: 399-413. PMID 33496741 DOI: 10.1182/bloodadvances.2020002754 | 0.322 | |||
| 2020 | Kang B, Chang SS, Park C, Archer DR, Sutliff RL, Hart CM. Integrative Analysis of Long Non‐Coding RNAs and mRNAs in Lungs of Sickle Cell Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04319 | 0.376 | |||
| 2018 | Tseng V, Sutliff R, Hart CM. Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension. Antioxidants & Redox Signaling. PMID 30582337 DOI: 10.1089/Ars.2018.7695 | 0.39 | |||
| 2018 | Wade BE, Zhao J, Ma J, Hart CM, Sutliff RL. EXPRESS: Hypoxia-induced Alterations in the Lung Ubiquitin Proteasome System During Pulmonary Hypertension Pathogenesis. Pulmonary Circulation. 2045894018788267. PMID 29927354 DOI: 10.1177/2045894018788267 | 0.348 | |||
| 2018 | Nanami M, Pham TD, Kim YH, Yang B, Sutliff RL, Staub O, Klein JD, Lopez-Cayuqueo KI, Chambrey R, Park AY, Wang X, Pech V, Verlander JW, Wall SM. The Role of Intercalated Cell in BP Regulation, Ion Transport, and Transporter Expression. Journal of the American Society of Nephrology : Jasn. PMID 29773687 DOI: 10.1681/Asn.2017080826 | 0.318 | |||
| 2017 | Yeligar SM, Kang BY, Bijli KM, Kleinhenz JM, Murphy TC, Torres G, San Martin A, Sutliff RL, Hart CM. PPARγ Regulates Mitochondrial Structure and Function and HPASMC Proliferation. American Journal of Respiratory Cell and Molecular Biology. PMID 29182484 DOI: 10.1165/Rcmb.2016-0293Oc | 0.306 | |||
| 2017 | Chaudhry A, Carthan KA, Kang BY, Calvert J, Sutliff RL, Michael Hart C. PPARγ attenuates hypoxia-induced hypertrophic transcriptional pathways in the heart. Pulmonary Circulation. 7: 98-107. PMID 28680569 DOI: 10.1086/689749 | 0.407 | |||
| 2017 | Adesina SE, Wade BE, Bijli KM, Kang BY, Williams CR, Ma J, Go YM, Hart CM, Sutliff RL. Hypoxia Inhibits Expression and Function of Mitochondrial Thioredoxin 2 to Promote Pulmonary Hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00258.2016. PMID 28130258 DOI: 10.1152/Ajplung.00258.2016 | 0.485 | |||
| 2016 | Kang BY, Park K, Kleinhenz JM, Murphy TC, Sutliff RL, Archer D, Hart CM. PPARγ Regulates the ETS1/miR-27a Axis to Reduce ET-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. American Journal of Respiratory Cell and Molecular Biology. PMID 27612006 DOI: 10.1165/Rcmb.2016-0166Oc | 0.381 | |||
| 2016 | Sutliff RL. New insights into mechanisms regulating pulmonary adventitial fibroblast proliferation. Acta Physiologica (Oxford, England). PMID 27420025 DOI: 10.1111/Apha.12753 | 0.405 | |||
| 2016 | Bijli KM, Kang BY, Sutliff RL, Hart CM. Proline-rich tyrosine kinase 2 downregulates peroxisome proliferator-activated receptor gamma to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation. Pulmonary Circulation. 6: 202-10. PMID 27252847 DOI: 10.1086/686012 | 0.392 | |||
| 2015 | Kleinhenz JM, Murphy TC, Pokutta-Paskaleva AP, Gleason RL, Lyle AN, Taylor WR, Blount MA, Cheng J, Yang Q, Sutliff RL, Hart CM. Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. Plos One. 10: e0139756. PMID 26451838 DOI: 10.1371/Journal.Pone.0139756 | 0.346 | |||
| 2015 | Lazo-Fernandez Y, Aguilera G, Pham TD, Park AY, Beierwaltes WH, Sutliff RL, Verlander JW, Pacak K, Osunkoya AO, Ellis CL, Kim YH, Shipley GL, Wynne BM, Hoover RS, Sen SK, et al. Pendrin localizes to the adrenal medulla and modulates catecholamine release. American Journal of Physiology. Endocrinology and Metabolism. 309: E534-45. PMID 26173457 DOI: 10.1152/Ajpendo.00035.2015 | 0.392 | |||
| 2015 | Kang BY, Park KK, Kleinhenz JM, Murphy TC, Green DE, Bijli KM, Yeligar SM, Carthan KA, Searles CD, Sutliff RL, Hart CM. PPARγ Activation Reduces Hypoxia-induced Endothelin-1 Expression through Upregulation of miR-98. American Journal of Respiratory Cell and Molecular Biology. PMID 26098770 DOI: 10.1165/Rcmb.2014-0337Oc | 0.344 | |||
| 2015 | Adesina SE, Kang BY, Bijli KM, Ma J, Cheng J, Murphy T, Michael Hart C, Sutliff RL. Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension. Free Radical Biology & Medicine. PMID 26073127 DOI: 10.1016/J.Freeradbiomed.2015.05.042 | 0.378 | |||
| 2015 | Bijli KM, Kleinhenz JM, Murphy TC, Kang BY, Adesina SE, Sutliff RL, Hart CM. Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation. Free Radical Biology & Medicine. 80: 111-20. PMID 25557278 DOI: 10.1016/J.Freeradbiomed.2014.12.019 | 0.35 | |||
| 2014 | Parker IK, Roberts LM, Hansen L, Gleason RL, Sutliff RL, Platt MO. Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells. Annals of Biomedical Engineering. 42: 1185-94. PMID 24719048 DOI: 10.1007/S10439-014-1005-9 | 0.314 | |||
| 2013 | Kang BY, Park KK, Green DE, Bijli KM, Searles CD, Sutliff RL, Hart CM. Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. Plos One. 8: e79503. PMID 24244514 DOI: 10.1371/Journal.Pone.0079503 | 0.36 | |||
| 2013 | Porter KM, Walp ER, Elms SC, Raynor R, Mitchell PO, Guidot DM, Sutliff RL. Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development. Pulmonary Circulation. 3: 58-67. PMID 23662175 DOI: 10.4103/2045-8932.109915 | 0.375 | |||
| 2012 | Reddy AT, Lakshmi SP, Kleinhenz JM, Sutliff RL, Hart CM, Reddy RC. Endothelial cell peroxisome proliferator-activated receptor γ reduces endotoxemic pulmonary inflammation and injury. Journal of Immunology (Baltimore, Md. : 1950). 189: 5411-20. PMID 23105142 DOI: 10.4049/Jimmunol.1201487 | 0.368 | |||
| 2012 | Green DE, Murphy TC, Kang BY, Kleinhenz JM, Szyndralewiez C, Page P, Sutliff RL, Hart CM. The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation American Journal of Respiratory Cell and Molecular Biology. 47: 718-726. PMID 22904198 DOI: 10.1165/Rcmb.2011-0418Oc | 0.483 | |||
| 2012 | Williams CR, Lu X, Sutliff RL, Hart CM. Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells. American Journal of Physiology. Cell Physiology. 303: C213-23. PMID 22572850 DOI: 10.1152/Ajpcell.00227.2011 | 0.322 | |||
| 2011 | Reed AL, Tanaka A, Sorescu D, Liu H, Jeong EM, Sturdy M, Walp ER, Dudley SC, Sutliff RL. Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse. American Journal of Physiology. Heart and Circulatory Physiology. 301: H824-31. PMID 21724869 DOI: 10.1152/Ajpheart.00407.2010 | 0.716 | |||
| 2011 | Green DE, Sutliff RL, Hart CM. Is peroxisome proliferator-activated receptor gamma (PPARγ) a therapeutic target for the treatment of pulmonary hypertension? Pulmonary Circulation. 1: 33-47. PMID 21547012 DOI: 10.4103/2045-8932.78101 | 0.335 | |||
| 2011 | Sutliff RL, Walp ER, El-Ali AM, Elkhatib S, Lomashvili KA, O'Neill WC. Effect of medial calcification on vascular function in uremia. American Journal of Physiology. Renal Physiology. 301: F78-83. PMID 21478480 DOI: 10.1152/Ajprenal.00533.2010 | 0.323 | |||
| 2011 | Sutliff R, El-Ali A, Walp E, Predmore B, Lefer D. P47. Dietary nitrite levels influence hypoxia-induced pulmonary hypertension Nitric Oxide. 24: S32-S33. DOI: 10.1016/J.Niox.2011.03.278 | 0.375 | |||
| 2010 | Pech V, Pham TD, Hong S, Weinstein AM, Spencer KB, Duke BJ, Walp E, Kim YH, Sutliff RL, Bao HF, Eaton DC, Wall SM. Pendrin modulates ENaC function by changing luminal HCO3-. Journal of the American Society of Nephrology : Jasn. 21: 1928-41. PMID 20966128 DOI: 10.1681/Asn.2009121257 | 0.391 | |||
| 2010 | Willett NJ, Long RC, Maiellaro-Rafferty K, Sutliff RL, Shafer R, Oshinski JN, Giddens DP, Guldberg RE, Taylor WR. An in vivo murine model of low-magnitude oscillatory wall shear stress to address the molecular mechanisms of mechanotransduction--brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2099-102. PMID 20705917 DOI: 10.1161/Atvbaha.110.211532 | 0.307 | |||
| 2010 | Sutliff RL, Kang BY, Hart CM. PPAR3 as a potential therapeutic target in pulmonary hypertension Therapeutic Advances in Respiratory Disease. 4: 143-160. PMID 20530063 DOI: 10.1177/1753465809369619 | 0.36 | |||
| 2010 | Nisbet RE, Bland JM, Kleinhenz DJ, Mitchell PO, Walp ER, Sutliff RL, Hart CM. Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model. American Journal of Respiratory Cell and Molecular Biology. 42: 482-90. PMID 19520921 DOI: 10.1165/Rcmb.2008-0132Oc | 0.458 | |||
| 2010 | Lovelock JD, Tanaka A, Matsuda T, Jiao Z, Qin Q, Reed AL, Crawford BH, Wagner MB, Sutliff RL, Sorescu D. Age-Related Cardiac Dysfunction Is Associated with Enhanced Oxidative Stress in Senescence-Prone Mice Journal of Cardiac Failure. 16: S35-S36. DOI: 10.1016/J.Cardfail.2010.06.122 | 0.722 | |||
| 2009 | Kleinhenz JM, Kleinhenz DJ, You S, Ritzenthaler JD, Hansen JM, Archer DR, Sutliff RL, Hart CM. Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1647-54. PMID 19666848 DOI: 10.1152/Ajpheart.00148.2009 | 0.416 | |||
| 2009 | Xu J, Gonzalez ET, Iyer SS, Mac V, Mora AL, Sutliff RL, Reed A, Brigham KL, Kelly P, Rojas M. Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 731-9. PMID 19359440 DOI: 10.1093/Gerona/Glp040 | 0.745 | |||
| 2009 | Lassiter C, Fan X, Joshi PC, Jacob BA, Sutliff RL, Jones DP, Koval M, Guidot DM. HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. Aids Research and Therapy. 6: 1. PMID 19193217 DOI: 10.1186/1742-6405-6-1 | 0.343 | |||
| 2009 | Kline ER, Bassit L, Hernandez-Santiago BI, Detorio MA, Liang B, Kleinhenz DJ, Walp ER, Dikalov S, Jones DP, Schinazi RF, Sutliff RL. Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction. Cardiovascular Toxicology. 9: 1-12. PMID 19067249 DOI: 10.1007/S12012-008-9029-8 | 0.325 | |||
| 2009 | Nisbet RE, Graves AS, Kleinhenz DJ, Rupnow HL, Reed AL, Fan TH, Mitchell PO, Sutliff RL, Hart CM. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. American Journal of Respiratory Cell and Molecular Biology. 40: 601-9. PMID 18952568 DOI: 10.1165/2008-0145Oc | 0.739 | |||
| 2008 | Kline ER, Kleinhenz DJ, Liang B, Dikalov S, Guidot DM, Hart CM, Jones DP, Sutliff RL. Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2792-804. PMID 18456725 DOI: 10.1152/Ajpheart.91447.2007 | 0.322 | |||
| 2007 | Nisbet RE, Sutliff RL, Hart CM. The role of peroxisome proliferator-activated receptors in pulmonary vascular disease. Ppar Research. 2007: 18797. PMID 17710111 DOI: 10.1155/2007/18797 | 0.393 | |||
| 2007 | Kim YH, Pech V, Spencer KB, Beierwaltes WH, Everett LA, Green ED, Shin W, Verlander JW, Sutliff RL, Wall SM. Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice. American Journal of Physiology. Renal Physiology. 293: F1314-24. PMID 17686956 DOI: 10.1152/Ajprenal.00155.2007 | 0.313 | |||
| 2007 | Hwang J, Kleinhenz DJ, Rupnow HL, Campbell AG, Thulé PM, Sutliff RL, Hart CM. The PPARγ ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice Vascular Pharmacology. 46: 456-462. PMID 17337254 DOI: 10.1016/J.Vph.2007.01.007 | 0.405 | |||
| 2007 | Garg P, Martin CF, Elms SC, Gordon FJ, Wall SM, Garland CJ, Sutliff RL, O'Neill WC. Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. American Journal of Physiology. Heart and Circulatory Physiology. 292: H2100-5. PMID 17259435 DOI: 10.1152/Ajpheart.01402.2006 | 0.315 | |||
| 2007 | Nisbet R, Kleinhenz D, Thorson H, Walp E, Bland J, Sutliff R, Hart CM. Roziglitazone Attenuates Chronic Hypoxia-Induced Pulmonary Hypertention.: 255 Journal of Investigative Medicine. 55. DOI: 10.1097/00042871-200701010-00769 | 0.368 | |||
| 2007 | Nisbet R, Kleinhenz D, Thorson H, Walp E, Bland J, Sutliff R, Hart CM. Roziglitazone Attenuates Chronic Hypoxia-Induced Pulmonary Hypertention.: 170 Journal of Investigative Medicine. 55. DOI: 10.1097/00042871-200701010-00684 | 0.368 | |||
| 2006 | Jacob BA, Porter KM, Elms SC, Cheng PY, Jones DP, Sutliff RL. HIV-1-induced pulmonary oxidative and nitrosative stress: exacerbated response to endotoxin administration in HIV-1 transgenic mouse model. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L811-9. PMID 16728526 DOI: 10.1152/Ajplung.00468.2005 | 0.429 | |||
| 2006 | Polikandriotis JA, Rupnow HL, Elms SC, Clempus RE, Campbell DJ, Sutliff RL, Brown LAS, Guidot DM, Hart CM. Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung American Journal of Respiratory Cell and Molecular Biology. 34: 314-319. PMID 16284359 DOI: 10.1165/Rcmb.2005-0320Oc | 0.409 | |||
| 2006 | Rojas M, Sutliff R, Xu J, Reed A, Brigham KL. 301 INCREASED SEVERITY OF BLEOMYCIN-INDUCED LUNG INFLAMMATION AND FIBROSIS IN SENESCENCE-ACCELERATED MICE. Journal of Investigative Medicine. 54: S310.2-S310. DOI: 10.2310/6650.2005.X0008.300 | 0.743 | |||
| 2006 | Graves AS, Kleinhenz D, Sutliff RL, Decker M, Hart CM. 299 Vascular Consequences Of Chronic Intermittent Hypoxemia In Mice. Journal of Investigative Medicine. 54. DOI: 10.2310/6650.2005.X0008.298 | 0.459 | |||
| 2006 | Graves AS, Kleinhenz D, Sutliff RL, Decker M, Hart CM. 133 Vascular Consequences Of Chronic Intermittent Hypoxemia In Mice. Journal of Investigative Medicine. 54. DOI: 10.2310/6650.2005.X0008.132 | 0.459 | |||
| 2006 | Polikandriotis J, Hwang J, Kleinhenz DJ, Rupnow HL, Campbell AG, Thulé PM, Boutwell J, Sutliff RL, Hart CM. 2 Peroxisome Proliferator-Activated Receptor Gamma Ligand, Rosiglitazone, Attenuates Vascular Oxidative Stress In A Mouse Model Of Type 2 Diabetes. Journal of Investigative Medicine. 54. DOI: 10.2310/6650.2005.X0008.1 | 0.409 | |||
| 2005 | Gletsu N, Doan TN, Cole J, Sutliff RL, Bernstein KE. Angiotensin II-induced hypertension in mice caused an increase in insulin secretion. Vascular Pharmacology. 42: 83-92. PMID 15792925 DOI: 10.1016/J.Vph.2005.01.006 | 0.319 | |||
| 2005 | Polikandriots JA, Rupnow HL, Sutliff RL, Brown LS, Guidot DM, Hart CM. 195 The Renin Angiotensin System Mediates Chronic Ethanol-Induced Increases In Superoxide Production And Nadph Oxidase Expression In The Lung Journal of Investigative Medicine. 53. DOI: 10.2310/6650.2005.00006.194 | 0.403 | |||
| 2005 | Archer DR, Elms S, Boutwell J, Perry J, Sutliff R. Vascular Abnormalities and Pulmonary Hypertension in the Berkeley Sickle Mouse. Blood. 106: 3185-3185. DOI: 10.1182/Blood.V106.11.3185.3185 | 0.522 | |||
| 2004 | Jiang G, Akar F, Cobbs SL, Lomashvilli K, Lakkis R, Gordon FJ, Sutliff RL, O'Neill WC. Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle. American Journal of Physiology. Heart and Circulatory Physiology. 286: H1552-7. PMID 15020309 DOI: 10.1152/Ajpheart.00695.2003 | 0.308 | |||
| 2003 | Xiao HD, Fuchs S, Cole JM, Disher KM, Sutliff RL, Bernstein KE. Role of bradykinin in angiotensin-converting enzyme knockout mice. American Journal of Physiology. Heart and Circulatory Physiology. 284: H1969-77. PMID 12637363 DOI: 10.1152/Ajpheart.00010.2003 | 0.394 | |||
| 2003 | Cole JM, Khokhlova N, Sutliff RL, Adams JW, Disher KM, Zhao H, Capecchi MR, Corvol P, Bernstein KE. Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II. Hypertension. 41: 313-21. PMID 12574101 DOI: 10.1161/01.Hyp.0000050650.52007.83 | 0.405 | |||
| 2002 | Sutliff RL, Dikalov S, Weiss D, Parker J, Raidel S, Racine AK, Russ R, Haase CP, Taylor WR, Lewis W. Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide. American Journal of Physiology. Heart and Circulatory Physiology. 283: H2363-70. PMID 12388299 DOI: 10.1152/Ajpheart.00151.2002 | 0.389 | |||
| 2002 | Meyer JW, Flagella M, Sutliff RL, Lorenz JN, Nieman ML, Weber CS, Paul RJ, Shull GE. Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1846-55. PMID 12384462 DOI: 10.1152/Ajpheart.00083.2002 | 0.323 | |||
| 2002 | Raidel SM, Haase C, Jansen NR, Russ RB, Sutliff RL, Velsor LW, Day BJ, Hoit BD, Samarel AM, Lewis W. Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1672-8. PMID 11959630 DOI: 10.1152/Ajpheart.00955.2001 | 0.328 | |||
| 2001 | Lewis W, Haase CP, Raidel SM, Russ RB, Sutliff RL, Hoit BD, Samarel AM. Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 81: 1527-36. PMID 11706060 DOI: 10.1038/Labinvest.3780366 | 0.4 | |||
| 2000 | Cole J, Ertoy D, Lin H, Sutliff RL, Ezan E, Guyene TT, Capecchi M, Corvol P, Bernstein KE. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice Journal of Clinical Investigation. 106: 1391-1398. PMID 11104792 DOI: 10.1172/Jci10557 | 0.386 | |||
| 1999 | Qian J, Lorenz JN, Maeda S, Sutliff RL, Weber C, Nakayama T, Colbert MC, Paul RJ, Fagin JA, Clemens TL. Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle. Endocrinology. 140: 1826-33. PMID 10098521 DOI: 10.1210/Endo.140.4.6645 | 0.336 | |||
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