| Year |
Citation |
Score |
| 2023 |
Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, ... ... Pearson CE, et al. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Cell. PMID 37827155 DOI: 10.1016/j.cell.2023.09.008 |
0.818 |
|
| 2023 |
Abdi MH, Zamiri B, Pazuki G, Sardari S, Pearson CE. Pathogenic CANVAS-causing but not non-pathogenic RFC1 DNA/RNA repeat motifs form quadruplex or triplex structures. The Journal of Biological Chemistry. 105202. PMID 37660923 DOI: 10.1016/j.jbc.2023.105202 |
0.338 |
|
| 2022 |
Mirceta M, Shum N, Schmidt MHM, Pearson CE. Fragile sites, chromosomal lesions, tandem repeats, and disease. Frontiers in Genetics. 13: 985975. PMID 36468036 DOI: 10.3389/fgene.2022.985975 |
0.791 |
|
| 2021 |
Hasuike Y, Tanaka H, Gall-Duncan T, Mehkary M, Nakatani K, Pearson CE, Tsuji S, Mochizuki H, Nakamori M. CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral-pallidoluysian atrophy. Neurobiology of Disease. 163: 105604. PMID 34968706 DOI: 10.1016/j.nbd.2021.105604 |
0.807 |
|
| 2021 |
Gall-Duncan T, Sato N, Yuen RKC, Pearson CE. Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences. Genome Research. PMID 34965938 DOI: 10.1101/gr.269530.120 |
0.781 |
|
| 2021 |
Deshmukh AL, Caron MC, Mohiuddin M, Lanni S, Panigrahi GB, Khan M, Engchuan W, Shum N, Faruqui A, Wang P, Yuen RKC, Nakamori M, Nakatani K, Masson JY, Pearson CE. FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability. Cell Reports. 37: 110078. PMID 34879276 DOI: 10.1016/j.celrep.2021.110078 |
0.83 |
|
| 2021 |
Scott WA, Dhanji EZ, Dyakov BJA, Dreseris ES, Asa JS, Grange LJ, Mirceta M, Pearson CE, Stewart GS, Gingras AC, Campos EI. ATRX proximal protein associations boast roles beyond histone deposition. Plos Genetics. 17: e1009909. PMID 34780483 DOI: 10.1371/journal.pgen.1009909 |
0.81 |
|
| 2021 |
Qaiser F, Sadoway T, Yin Y, Zulfiqar Ali Q, Nguyen CM, Shum N, Backstrom I, Marques PT, Tabarestani S, Munhoz RP, Krings T, Pearson CE, Yuen RKC, Andrade DM. Genome sequencing identifies rare tandem repeat expansions and copy number variants in Lennox-Gastaut syndrome. Brain Communications. 3: fcab207. PMID 34622207 DOI: 10.1093/braincomms/fcab207 |
0.787 |
|
| 2021 |
Porro A, Mohiuddin M, Zurfluh C, Spegg V, Dai J, Iehl F, Ropars V, Collotta G, Fishwick KM, Mozaffari NL, Guérois R, Jiricny J, Altmeyer M, Charbonnier JB, Pearson CE, et al. FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats. Science Advances. 7. PMID 34330701 DOI: 10.1126/sciadv.abf7906 |
0.379 |
|
| 2021 |
Deshmukh AL, Porro A, Mohiuddin M, Lanni S, Panigrahi GB, Caron MC, Masson JY, Sartori AA, Pearson CE. FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders. Journal of Huntington's Disease. 10: 95-122. PMID 33579867 DOI: 10.3233/JHD-200448 |
0.422 |
|
| 2021 |
Jones L, Wheeler V, Pearson CE. Special Issue: DNA Repair and Somatic Repeat Expansion in Huntington's Disease. Journal of Huntington's Disease. PMID 33554921 DOI: 10.3233/JHD-219001 |
0.376 |
|
| 2020 |
Wright GEB, Black HF, Collins JA, Gall-Duncan T, Caron NS, Pearson CE, Hayden MR. Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies. The Lancet. Neurology. 19: 930-939. PMID 33098802 DOI: 10.1016/S1474-4422(20)30343-4 |
0.793 |
|
| 2020 |
Trost B, Engchuan W, Nguyen CM, Thiruvahindrapuram B, Dolzhenko E, Backstrom I, Mirceta M, Mojarad BA, Yin Y, Dov A, Chandrakumar I, Prasolava T, Shum N, Hamdan O, Pellecchia G, ... ... Pearson CE, et al. Genome-wide detection of tandem DNA repeats that are expanded in autism. Nature. PMID 32717741 DOI: 10.1038/S41586-020-2579-Z |
0.794 |
|
| 2020 |
Nakamori M, Panigrahi GB, Lanni S, Gall-Duncan T, Hayakawa H, Tanaka H, Luo J, Otabe T, Li J, Sakata A, Caron MC, Joshi N, Prasolava T, Chiang K, Masson JY, ... ... Pearson CE, et al. A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo. Nature Genetics. PMID 32060489 DOI: 10.1038/S41588-019-0575-8 |
0.805 |
|
| 2019 |
Lanni S, Pearson CE. Molecular genetics of congenital myotonic dystrophy. Neurobiology of Disease. 104533. PMID 31326502 DOI: 10.1016/J.Nbd.2019.104533 |
0.387 |
|
| 2019 |
Mohiuddin M, Rahman MM, Sale JE, Pearson CE. CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs. Nucleic Acids Research. PMID 30657944 DOI: 10.1093/Nar/Gkz009 |
0.469 |
|
| 2019 |
Shuen AY, Lanni S, Panigrahi GB, Edwards M, Yu L, Campbell BB, Mandel A, Zhang C, Zhukova N, Alharbi M, Bernstein M, Bowers DC, Carroll S, Cole KA, Constantini S, ... ... Pearson CE, et al. Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1800474. PMID 30608896 DOI: 10.1200/Jco.18.00474 |
0.753 |
|
| 2018 |
Zamiri B, Mirceta M, Abu-Ghazalah R, Wold MS, Pearson CE, Macgregor RB. Stress-induced acidification may contribute to formation of unusual structures in C9orf72-repeats. Biochimica Et Biophysica Acta. PMID 29550431 DOI: 10.1016/J.Bbagen.2018.03.001 |
0.808 |
|
| 2017 |
Alniss H, Zamiri B, Khalaj M, Pearson CE, Macgregor RB. Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72. Biochemical and Biophysical Research Communications. PMID 29274339 DOI: 10.1016/J.Bbrc.2017.12.108 |
0.456 |
|
| 2017 |
Ishiguro T, Sato N, Ueyama M, Fujikake N, Sellier C, Kanegami A, Tokuda E, Zamiri B, Gall-Duncan T, Mirceta M, Furukawa Y, Yokota T, Wada K, Taylor JP, Pearson CE, et al. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. Neuron. PMID 28343865 DOI: 10.1016/J.Neuron.2017.02.046 |
0.778 |
|
| 2017 |
Ishiguro T, Sato N, Ueyama M, Fujikake N, Sellier C, Tokuda E, Zamiri B, Gall-Duncan T, Mirceta M, Furukawa Y, Yokota T, Wada K, Taylor P, Pearson CE, Charlet-Berguerand N, et al. Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models Journal of the Neurological Sciences. 381: 56. DOI: 10.1016/J.Jns.2017.08.218 |
0.766 |
|
| 2016 |
Slean MM, Panigrahi GB, Castel AL, Pearson AB, Tomkinson AE, Pearson CE. Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks. Dna Repair. PMID 27155933 DOI: 10.1016/J.Dnarep.2016.04.002 |
0.832 |
|
| 2015 |
Schmidt MH, Pearson CE. Disease-associated repeat instability and mismatch repair. Dna Repair. PMID 26774442 DOI: 10.1016/J.Dnarep.2015.11.008 |
0.728 |
|
| 2015 |
Kansal R, Li X, Shen J, Samuel D, Laningham F, Lee H, Panigrahi GB, Shuen A, Kantarci S, Dorrani N, Reiss J, Shintaku P, Deignan JL, Strom SP, Pearson CE, et al. An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study. Genes, Chromosomes & Cancer. PMID 26542077 DOI: 10.1002/Gcc.22319 |
0.748 |
|
| 2015 |
Zamiri B, Mirceta M, Bomsztyk K, Macgregor RB, Pearson CE. Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation. Nucleic Acids Research. PMID 26432832 DOI: 10.1093/Nar/Gkv1008 |
0.81 |
|
| 2015 |
Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, ... ... Pearson CE, et al. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers. Nature Genetics. 47: 257-62. PMID 25642631 DOI: 10.1038/Ng.3202 |
0.38 |
|
| 2015 |
Trang H, Stanley SY, Thorner P, Faghfoury H, Schulze A, Hawkins C, Pearson CE, Yoon G. Massive CAG repeat expansion and somatic instability in maternally transmitted infantile spinocerebellar ataxia type 7. Jama Neurology. 72: 219-23. PMID 25506882 DOI: 10.1001/Jamaneurol.2014.1902 |
0.312 |
|
| 2015 |
Shlien A, Campbell BB, Borja Rd, Alexandrov LB, Merico D, Wedge D, Loo PV, Tarpey PS, Coupland P, Pollett A, Lipman T, Heidari A, Deshmukh S, Gerstung M, Merino D, ... ... Pearson CE, et al. Abstract B09: DNA polymerase mutations trigger rapid onset of ultra-hypermutant malignant brain tumors in children with biallelic mismatch repair deficiency Brain. 75. DOI: 10.1158/1538-7445.Brain15-B09 |
0.367 |
|
| 2015 |
Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merino DM, Remke M, Bakry D, Dirks P, Huang A, Grundy RG, Durno C, Aronson M, Taylor MD, Pursell ZF, Pearson CE, et al. GE-09 * COMBINED HEREDITARY AND SOMATIC MUTATIONS OF REPLICATION ERROR REPAIR GENES RESULT IN RAPID ONSET OF ULTRA-HYPERMUTATED MALIGNANT BRAIN TUMORS IN CHILDREN Neuro-Oncology. 17: iii9-iii9. DOI: 10.1093/Neuonc/Nov061.33 |
0.378 |
|
| 2014 |
Reddy K, Schmidt MH, Geist JM, Thakkar NP, Panigrahi GB, Wang YH, Pearson CE. Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability. Nucleic Acids Research. 42: 10473-87. PMID 25147206 DOI: 10.1093/Nar/Gku658 |
0.803 |
|
| 2014 |
Martins S, Pearson CE, Coutinho P, Provost S, Amorim A, Dubé MP, Sequeiros J, Rouleau GA. Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes. Human Genetics. 133: 1311-8. PMID 25026993 DOI: 10.1007/S00439-014-1467-8 |
0.476 |
|
| 2014 |
Zamiri B, Reddy K, Macgregor RB, Pearson CE. TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins. The Journal of Biological Chemistry. 289: 4653-9. PMID 24371143 DOI: 10.1074/Jbc.C113.502336 |
0.783 |
|
| 2014 |
Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR. Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Human Molecular Genetics. 23: 1606-18. PMID 24191263 DOI: 10.1093/Hmg/Ddt551 |
0.435 |
|
| 2014 |
Zamiri B, Reddy K, Pearson CE, Macgregor RB. The Structure of the Disease-Associated (GGGGCC)N Repeat from the C9ORF72 Gene Biophysical Journal. 106: 283a. DOI: 10.1016/J.Bpj.2013.11.1655 |
0.785 |
|
| 2013 |
Axford MM, Wang YH, Nakamori M, Zannis-Hadjopoulos M, Thornton CA, Pearson CE. Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues. Plos Genetics. 9: e1003866. PMID 24367268 DOI: 10.1371/Journal.Pgen.1003866 |
0.832 |
|
| 2013 |
Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, et al. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. Plos Genetics. 9: e1003930. PMID 24204323 DOI: 10.1371/Journal.Pgen.1003930 |
0.42 |
|
| 2013 |
Reddy K, Pearson CE. RAN translation: fragile X in the running. Neuron. 78: 405-8. PMID 23664607 DOI: 10.1016/J.Neuron.2013.04.034 |
0.747 |
|
| 2013 |
Tomé S, Manley K, Simard JP, Clark GW, Slean MM, Swami M, Shelbourne PF, Tillier ER, Monckton DG, Messer A, Pearson CE. MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice. Plos Genetics. 9: e1003280. PMID 23468640 DOI: 10.1371/Journal.Pgen.1003280 |
0.812 |
|
| 2013 |
Axford MM, Pearson CE. Illuminating CNS and cognitive issues in myotonic dystrophy: Workshop report. Neuromuscular Disorders : Nmd. 23: 370-4. PMID 23453858 DOI: 10.1016/J.Nmd.2013.01.003 |
0.758 |
|
| 2013 |
Reddy K, Zamiri B, Stanley SY, Macgregor RB, Pearson CE. The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures. The Journal of Biological Chemistry. 288: 9860-6. PMID 23423380 DOI: 10.1074/Jbc.C113.452532 |
0.781 |
|
| 2013 |
Slean MM, Reddy K, Wu B, Nichol Edamura K, Kekis M, Nelissen FH, Aspers RL, Tessari M, Schärer OD, Wijmenga SS, Pearson CE. Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome. Biochemistry. 52: 773-85. PMID 23339280 DOI: 10.1021/Bi301369B |
0.822 |
|
| 2013 |
Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. Dna Repair. 12: 46-52. PMID 23228367 DOI: 10.1016/J.Dnarep.2012.10.006 |
0.789 |
|
| 2012 |
Pearson CE. Repeat-associated diseases, mutagenesis, pathogenesis, and therapeutic avenues. Rinshå Shinkeigaku = Clinical Neurology. 52: 1023. PMID 23196503 DOI: 10.5692/Clinicalneurol.52.1023 |
0.459 |
|
| 2012 |
Panigrahi GB, Slean MM, Simard JP, Pearson CE. Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats. The Journal of Biological Chemistry. 287: 41844-50. PMID 23086927 DOI: 10.1074/Jbc.M112.420398 |
0.816 |
|
| 2012 |
Goula AV, Pearson CE, Della Maria J, Trottier Y, Tomkinson AE, Wilson DM, Merienne K. The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats. Biochemistry. 51: 3919-32. PMID 22497302 DOI: 10.1021/Bi300410D |
0.502 |
|
| 2012 |
Rudnicki DD, Margolis RL, Pearson CE, Krzyzosiak WJ. Diced triplets expose neurons to RISC. Plos Genetics. 8: e1002545. PMID 22383898 DOI: 10.1371/Journal.Pgen.1002545 |
0.418 |
|
| 2012 |
Eyries M, Coulet F, Girerd B, Montani D, Humbert M, Lacombe P, Chinet T, Gouya L, Roume J, Axford MM, Pearson CE, Soubrier F. ACVRL1 germinal mosaic with two mutant alleles in hereditary hemorrhagic telangiectasia associated with pulmonary arterial hypertension. Clinical Genetics. 82: 173-9. PMID 21651515 DOI: 10.1111/J.1399-0004.2011.01727.X |
0.799 |
|
| 2011 |
Axford MM, López-Castel A, Nakamori M, Thornton CA, Pearson CE. Replacement of the myotonic dystrophy type 1 CTG repeat with 'non-CTG repeat' insertions in specific tissues. Journal of Medical Genetics. 48: 438-43. PMID 21622935 DOI: 10.1136/Jmg.2010.085944 |
0.807 |
|
| 2011 |
Pearson CE. Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities! Plos Genetics. 7: e1002018. PMID 21423665 DOI: 10.1371/Journal.Pgen.1002018 |
0.47 |
|
| 2011 |
Tomé S, Panigrahi GB, López Castel A, Foiry L, Melton DW, Gourdon G, Pearson CE. Maternal germline-specific effect of DNA ligase I on CTG/CAG instability. Human Molecular Genetics. 20: 2131-43. PMID 21378394 DOI: 10.1093/Hmg/Ddr099 |
0.473 |
|
| 2011 |
López Castel A, Nakamori M, Thornton CA, Pearson CE. Identification of restriction endonucleases sensitive to 5-cytosine methylation at non-CpG sites, including expanded (CAG)n/(CTG)n repeats. Epigenetics : Official Journal of the Dna Methylation Society. 6: 416-20. PMID 21364324 DOI: 10.4161/Epi.6.4.14953 |
0.362 |
|
| 2011 |
Nakamori M, Pearson CE, Thornton CA. Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats. Human Molecular Genetics. 20: 580-8. PMID 21088112 DOI: 10.1093/Hmg/Ddq501 |
0.433 |
|
| 2011 |
Reddy K, Tam M, Bowater RP, Barber M, Tomlinson M, Nichol Edamura K, Wang YH, Pearson CE. Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Research. 39: 1749-62. PMID 21051337 DOI: 10.1093/Nar/Gkq935 |
0.777 |
|
| 2011 |
López Castel A, Nakamori M, Tomé S, Chitayat D, Gourdon G, Thornton CA, Pearson CE. Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues. Human Molecular Genetics. 20: 1-15. PMID 21044947 DOI: 10.1093/Hmg/Ddq427 |
0.324 |
|
| 2011 |
Seriola A, Spits C, Simard JP, Hilven P, Haentjens P, Pearson CE, Sermon K. Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation. Human Molecular Genetics. 20: 176-85. PMID 20935170 DOI: 10.1093/Hmg/Ddq456 |
0.415 |
|
| 2010 |
Pearson CE. FSHD: a repeat contraction disease finally ready to expand (our understanding of its pathogenesis). Plos Genetics. 6: e1001180. PMID 21060814 DOI: 10.1371/Journal.Pgen.1001180 |
0.481 |
|
| 2010 |
Cleary JD, Tomé S, López Castel A, Panigrahi GB, Foiry L, Hagerman KA, Sroka H, Chitayat D, Gourdon G, Pearson CE. Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. Nature Structural & Molecular Biology. 17: 1079-87. PMID 20711191 DOI: 10.1038/Nsmb.1876 |
0.802 |
|
| 2010 |
Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE. Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proceedings of the National Academy of Sciences of the United States of America. 107: 12593-8. PMID 20571119 DOI: 10.1073/Pnas.0909087107 |
0.817 |
|
| 2010 |
López Castel A, Cleary JD, Pearson CE. Repeat instability as the basis for human diseases and as a potential target for therapy. Nature Reviews. Molecular Cell Biology. 11: 165-70. PMID 20177394 DOI: 10.1038/Nrm2854 |
0.694 |
|
| 2009 |
Warby SC, Visscher H, Butland S, Pearson CE, Hayden MR. Response to Falush: a role for cis-element polymorphisms in HD. American Journal of Human Genetics. 85: 942-5. PMID 20004773 DOI: 10.1016/J.Ajhg.2009.11.006 |
0.303 |
|
| 2009 |
López Castel A, Tomkinson AE, Pearson CE. CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair. The Journal of Biological Chemistry. 284: 26631-45. PMID 19628465 DOI: 10.1074/Jbc.M109.034405 |
0.497 |
|
| 2009 |
Tomé S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G. MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. Plos Genetics. 5: e1000482. PMID 19436705 DOI: 10.1371/Journal.Pgen.1000482 |
0.413 |
|
| 2009 |
Hagerman KA, Ruan H, Edamura KN, Matsuura T, Pearson CE, Wang YH. The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions. Gene. 434: 29-34. PMID 19171184 DOI: 10.1016/J.Gene.2008.12.011 |
0.829 |
|
| 2008 |
Libby RT, Hagerman KA, Pineda VV, Lau R, Cho DH, Baccam SL, Axford MM, Cleary JD, Moore JM, Sopher BL, Tapscott SJ, Filippova GN, Pearson CE, La Spada AR. CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. Plos Genetics. 4: e1000257. PMID 19008940 DOI: 10.1371/Journal.Pgen.1000257 |
0.801 |
|
| 2008 |
Slean MM, Panigrahi GB, Ranum LP, Pearson CE. Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability. Dna Repair. 7: 1135-54. PMID 18485833 DOI: 10.1016/J.Dnarep.2008.03.014 |
0.836 |
|
| 2006 |
Christodoulou J, Craig HJ, Walker DC, Weaving LS, Pearson CE, McInnes RR. Deletion hotspot in the argininosuccinate lyase gene: association with topoisomerase II and DNA polymerase alpha sites. Human Mutation. 27: 1065-71. PMID 16941645 DOI: 10.1002/Humu.20352 |
0.441 |
|
| 2006 |
Matsuura T, Fang P, Pearson CE, Jayakar P, Ashizawa T, Roa BB, Nelson DL. Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier? American Journal of Human Genetics. 78: 125-9. PMID 16385455 DOI: 10.1086/498654 |
0.389 |
|
| 2006 |
Cleary JD, Pearson CE, Spada ARL. 23 DNA Replication, Repeat Instability, and Human Disease Cold Spring Harbor Monograph Archive. 47: 461-480. DOI: 10.1101/087969766.47.461 |
0.523 |
|
| 2006 |
Panigrahi GB, Lau R, Montgomery SE, Leonard MR, Marcadier JL, Kekis M, Vosch C, Todd A, Pearson CE. Error-prone repair of slipped (CTG)·(CAG) repeats and disease-associated expansions Genetic Instabilities and Neurological Diseases, Second Edition. 645-666. DOI: 10.1016/B978-012369462-1/50042-9 |
0.364 |
|
| 2005 |
Pearson CE, Nichol Edamura K, Cleary JD. Repeat instability: mechanisms of dynamic mutations. Nature Reviews. Genetics. 6: 729-42. PMID 16205713 DOI: 10.1038/Nrg1689 |
0.691 |
|
| 2005 |
Nichol Edamura K, Pearson CE. DNA methylation and replication: implications for the "deletion hotspot" region of FMR1. Human Genetics. 118: 301-4. PMID 16133176 DOI: 10.1007/S00439-005-0037-5 |
0.466 |
|
| 2005 |
Panigrahi GB, Lau R, Montgomery SE, Leonard MR, Pearson CE. Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nature Structural & Molecular Biology. 12: 654-62. PMID 16025129 DOI: 10.1038/Nsmb959 |
0.439 |
|
| 2005 |
Cleary JD, Pearson CE. Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability. Trends in Genetics : Tig. 21: 272-80. PMID 15851063 DOI: 10.1016/J.Tig.2005.03.008 |
0.658 |
|
| 2005 |
Nichol Edamura K, Leonard MR, Pearson CE. Role of replication and CpG methylation in fragile X syndrome CGG deletions in primate cells. American Journal of Human Genetics. 76: 302-11. PMID 15625623 DOI: 10.1086/427928 |
0.425 |
|
| 2005 |
Mulvihill DJ, Nichol Edamura K, Hagerman KA, Pearson CE, Wang YH. Effect of CAT or AGG interruptions and CpG methylation on nucleosome assembly upon trinucleotide repeats on spinocerebellar ataxia, type 1 and fragile X syndrome. The Journal of Biological Chemistry. 280: 4498-503. PMID 15574425 DOI: 10.1074/Jbc.M413239200 |
0.794 |
|
| 2003 |
Pearson CE. Slipping while sleeping? Trinucleotide repeat expansions in germ cells. Trends in Molecular Medicine. 9: 490-5. PMID 14604827 DOI: 10.1016/J.Molmed.2003.09.006 |
0.373 |
|
| 2003 |
Yang Z, Lau R, Marcadier JL, Chitayat D, Pearson CE. Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells. American Journal of Human Genetics. 73: 1092-105. PMID 14574643 DOI: 10.1086/379523 |
0.46 |
|
| 2003 |
Cleary JD, Pearson CE. The contribution of cis-elements to disease-associated repeat instability: clinical and experimental evidence. Cytogenetic and Genome Research. 100: 25-55. PMID 14526163 DOI: 10.1159/000072837 |
0.646 |
|
| 2003 |
Tam M, Erin Montgomery S, Kekis M, Stollar BD, Price GB, Pearson CE. Slipped (CTG).(CAG) repeats of the myotonic dystrophy locus: surface probing with anti-DNA antibodies. Journal of Molecular Biology. 332: 585-600. PMID 12963369 DOI: 10.1016/S0022-2836(03)00880-5 |
0.456 |
|
| 2003 |
Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K, Warren ST. RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron. 39: 739-47. PMID 12948442 DOI: 10.1016/S0896-6273(03)00533-6 |
0.395 |
|
| 2003 |
Marcadier JL, Pearson CE. Fidelity of primate cell repair of a double-strand break within a (CTG).(CAG) tract. Effect of slipped DNA structures. The Journal of Biological Chemistry. 278: 33848-56. PMID 12807901 DOI: 10.1074/Jbc.M304284200 |
0.47 |
|
| 2003 |
Libby RT, Monckton DG, Fu YH, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, La Spada AR. Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice. Human Molecular Genetics. 12: 41-50. PMID 12490531 DOI: 10.1093/Hmg/Ddg006 |
0.365 |
|
| 2002 |
Pearson CE, Tam M, Wang YH, Montgomery SE, Dar AC, Cleary JD, Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucleic Acids Research. 30: 4534-47. PMID 12384601 DOI: 10.1093/Nar/Gkf572 |
0.688 |
|
| 2002 |
Nichol K, Pearson CE. CpG methylation modifies the genetic stability of cloned repeat sequences. Genome Research. 12: 1246-56. PMID 12176932 DOI: 10.1101/Gr.74502 |
0.431 |
|
| 2002 |
Cleary JD, Nichol K, Wang YH, Pearson CE. Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells. Nature Genetics. 31: 37-46. PMID 11967533 DOI: 10.1038/Ng870 |
0.642 |
|
| 2002 |
Sinden RR, Potaman VN, Oussatcheva EA, Pearson CE, Lyubchenko YL, Shlyakhtenko LS. Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA. Journal of Biosciences. 27: 53-65. PMID 11927777 DOI: 10.1007/Bf02703683 |
0.513 |
|
| 2002 |
Panigrahi GB, Cleary JD, Pearson CE. In vitro (CTG)*(CAG) expansions and deletions by human cell extracts. The Journal of Biological Chemistry. 277: 13926-34. PMID 11832482 DOI: 10.1074/Jbc.M109761200 |
0.686 |
|
| 2002 |
Novac O, Alvarez D, Pearson CE, Price GB, Zannis-Hadjopoulos M. The human cruciform-binding protein, CBP, is involved in DNA replication and associates in vivo with mammalian replication origins. The Journal of Biological Chemistry. 277: 11174-83. PMID 11805087 DOI: 10.1074/Jbc.M107902200 |
0.816 |
|
| 2000 |
LeProust EM, Pearson CE, Sinden RR, Gao X, Pearso CE. Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich's ataxia. Journal of Molecular Biology. 302: 1063-80. PMID 11183775 DOI: 10.1006/Jmbi.2000.4073 |
0.451 |
|
| 2000 |
Ashizawa T, Gonzales I, Ohsawa N, Singer RH, Devillers M, Balasubramanyam A, Cooper TA, Khajavi M, Lia-Baldini AS, Miller G, Philips AV, Timchenko LT, Waring J, Yamagata H, Barbet JP, ... ... Pearson CE, et al. New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1) Neurology. 54: 1218-1221. PMID 10746587 DOI: 10.1212/Wnl.54.6.1218 |
0.359 |
|
| 1998 |
Pearson CE, Sinden RR. Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA. Current Opinion in Structural Biology. 8: 321-30. PMID 9666328 DOI: 10.1016/S0959-440X(98)80065-1 |
0.457 |
|
| 1998 |
Pearson CE, Eichler EE, Lorenzetti D, Kramer SF, Zoghbi HY, Nelson DL, Sinden RR. Interruptions in the triplet repeats of SCA1 and FRAXA reduce the propensity and complexity of slipped strand DNA (S-DNA) formation. Biochemistry. 37: 2701-8. PMID 9485421 DOI: 10.1021/Bi972546C |
0.505 |
|
| 1998 |
Pearson CE, Wang YH, Griffith JD, Sinden RR. Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus. Nucleic Acids Research. 26: 816-23. PMID 9443975 DOI: 10.1093/Nar/26.3.816 |
0.483 |
|
| 1997 |
Pearson CE, Ewel A, Acharya S, Fishel RA, Sinden RR. Human MSH2 binds to trinucleotide repeat DNA structures associated with neurodegenerative diseases Human Molecular Genetics. 6: 1117-1123. PMID 9215683 DOI: 10.1093/Hmg/6.7.1117 |
0.526 |
|
| 1996 |
Pearson CE, Zorbas H, Price GB, Zannis-Hadjopoulos M. Inverted repeats, stem-loops, and cruciforms: Significance for initiation of DNA replication Journal of Cellular Biochemistry. 63: 1-22. PMID 8891900 DOI: 10.1002/(Sici)1097-4644(199610)63:1<1::Aid-Jcb1>3.0.Co;2-3 |
0.711 |
|
| 1996 |
Kramer PR, Pearson CE, Sinden RR. Stability of triplet repeats of myotonic dystrophy and fragile X loci in human mutator mismatch repair cell lines. Human Genetics. 98: 151-7. PMID 8698331 DOI: 10.1007/S004390050179 |
0.416 |
|
| 1996 |
Pearson CE, Sinden RR. Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci. Biochemistry. 35: 5041-53. PMID 8664297 DOI: 10.1021/Bi9601013 |
0.497 |
|
| 1995 |
Todd A, Landry S, Pearson CE, Khoury V, Zannis-Hadjopoulos M. Deletion analysis of minimal sequence requirements for autonomous replication of ors8, a monkey early-replicating DNA sequence Journal of Cellular Biochemistry. 57: 280-289. PMID 7759565 DOI: 10.1002/Jcb.240570212 |
0.695 |
|
| 1995 |
Pearson CE, Zannis-Hadjopoulos M, Price GB, Zorbas H. A novel type of interaction between cruciform DNA and a cruciform binding protein from HeLa cells Embo Journal. 14: 1571-1580. PMID 7729431 DOI: 10.1002/J.1460-2075.1995.Tb07143.X |
0.698 |
|
| 1995 |
Ruiz MT, Pearson CE, Nielsen T, Price GB, Zannis-Hadjopoulos M. Cofractionation of HeLa cell replication proteins with ors-binding activity Journal of Cellular Biochemistry. 58: 221-236. PMID 7673329 DOI: 10.1002/Jcb.240580211 |
0.673 |
|
| 1994 |
Pearson CE, Ruiz MT, Price GB, Zannis-Hadjopoulos M. Cruciform DNA binding protein in HeLa cell Extracts Biochemistry. 33: 14185-14196. PMID 7947830 DOI: 10.1021/Bi00251A030 |
0.696 |
|
| 1994 |
Pearson CE, Shihab-El-Deen A, Price GB, Zannis-Hadjopoulos M. Electron microscopic analysis of in vitro replication products of ors 8, a mammalian origin enriched sequence Somatic Cell and Molecular Genetics. 20: 147-152. PMID 7940016 DOI: 10.1007/Bf02254755 |
0.684 |
|
| 1991 |
Pearson CE, Frappier L, Zannis-Hadjopoulos M. Plasmids bearing mammalian DNA-replication origin-enriched (ors) fragments initiate semiconservative replication in a cell-free system Bba - Gene Structure and Expression. 1090: 156-166. PMID 1657184 DOI: 10.1016/0167-4781(91)90096-5 |
0.687 |
|
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