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Steven L. Castle, Ph.D. - Publications

Affiliations: 
Chemistry & Biochemistry Brigham Young University, Provo, UT, United States 
Area:
Organic Chemistry, Organic Synthesis, Total Synthesis
Website:
http://www.chem.byu.edu/users/scastle
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ramos A, Griffin ED, Ho KH, Singh J, Jones SA, Walter SN, Castle SL. Synthesis of the Indolizidine Core of Virosinine A via a Microwave-Promoted Cascade Cyclization Involving Iminyl Radicals. Organic Letters. PMID 38197784 DOI: 10.1021/acs.orglett.3c03852  0.367
2023 Singh J, Jones SA, Nelson TJ, Botello JA, Castle SL. Formal γ-C(sp)-H Activation of Ketones via Microwave-Promoted and Iminyl-Radical-Mediated 1,5-Hydrogen Atom Transfer. The Journal of Organic Chemistry. PMID 37390469 DOI: 10.1021/acs.joc.3c00915  0.648
2022 Singh J, Nelson TJ, Mansfield SA, Nickel GA, Cai Y, Jones DD, Small JE, Ess DH, Castle SL. Microwave- and Thermally Promoted Iminyl Radical Cyclizations: A Versatile Method for the Synthesis of Functionalized Pyrrolines. The Journal of Organic Chemistry. PMID 36472924 DOI: 10.1021/acs.joc.2c01806  0.423
2021 Singh J, Nickel GA, Cai Y, Jones DD, Nelson TJ, Small JE, Castle SL. Synthesis of Functionalized Pyrrolines via Microwave-Promoted Iminyl Radical Cyclizations. Organic Letters. PMID 33955760 DOI: 10.1021/acs.orglett.1c01148  0.369
2020 Cai Y, Ma Z, Jiang J, Lo C, Luo S, Jalan A, Cardon J, Ramos A, Moya D, Joaquin D, Castle SL. Convergent Total Synthesis of Yaku'amide A. Angewandte Chemie (International Ed. in English). PMID 33336547 DOI: 10.1002/anie.202014238  0.377
2019 Zhang CT, Zhu R, Wang Z, Ma B, Zajac A, Smiglak M, Xia CN, Castle SL, Wang WL. Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran. Rsc Advances. 9: 2199-2204. PMID 35516141 DOI: 10.1039/c8ra07447j  0.329
2019 Cardon JM, Coombs JC, Ess DH, Castle SL. Insights into base-free OsO-catalyzed aminohydroxylations employing chiral ligands. Tetrahedron. 75: 945-948. PMID 30774161 DOI: 10.1016/J.Tet.2019.01.018  0.361
2019 Zhang C, Zhu R, Wang Z, Ma B, Zajac A, Smiglak M, Xia C, Castle S, Wang W. Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran Rsc Advances. 9: 2199-2204. DOI: 10.1039/C8Ra07447J  0.393
2017 Jackman MM, Im S, Bohman SR, Lo CCL, Garrity AL, Castle SL. Synthesis of Functionalized Nitriles via Microwave-Promoted Fragmentations of Cyclic Iminyl Radicals. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29207207 DOI: 10.1002/Chem.201705728  0.5
2017 Castle S, Jackman M, Cai Y. Recent Advances in Iminyl Radical Cyclizations Synthesis. 49: 1785-1795. DOI: 10.1055/S-0036-1588707  0.417
2015 Borges RS, Castle SL. The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters. 25: 4808-11. PMID 26183083 DOI: 10.1016/J.Bmcl.2015.07.001  0.334
2015 Cai Y, Jalan A, Kubosumi AR, Castle SL. Microwave-promoted tin-free iminyl radical cyclization with TEMPO trapping: a practical synthesis of 2-acylpyrroles. Organic Letters. 17: 488-91. PMID 25594391 DOI: 10.1021/Ol5035047  0.492
2015 Jiang J, Luo S, Castle SL. Solid-phase synthesis of peptides containing bulky dehydroamino acids Tetrahedron Letters. 56: 3311-3313. DOI: 10.1016/J.Tetlet.2014.12.097  0.32
2014 Castle SL. Organic synthesis: Better chemistry through radicals. Nature. 516: 332-3. PMID 25519124 DOI: 10.1038/516332A  0.429
2014 Ma Z, Jiang J, Luo S, Cai Y, Cardon JM, Kay BM, Ess DH, Castle SL. Selective access to E- and Z-ΔIle-containing peptides via a stereospecific E2 dehydration and an O → N acyl transfer. Organic Letters. 16: 4044-7. PMID 25029355 DOI: 10.1021/Ol5018933  0.345
2014 Castle SL. Total synthesis of the congested propellane alkaloid (-)-acutumine. Chemical Record (New York, N.Y.). 14: 580-91. PMID 24863243 DOI: 10.1002/Tcr.201400005  0.538
2014 Wu J, Ma B, Wang Y, Zhang Y, Yan S, Castle SL. Lewis acid facilitated regioselective synthesis of τ-histidinoalanine Tetrahedron Letters. 55: 3114-3116. DOI: 10.1016/J.Tetlet.2014.04.008  0.454
2014 Loertscher BM, Castle SL. Radical Cyclizations and Sequential Radical Reactions Comprehensive Organic Synthesis: Second Edition. 4: 742-809. DOI: 10.1016/B978-0-08-097742-3.00419-5  0.765
2013 Loertscher BM, Zhang Y, Castle SL. Exploration of an epoxidation-ring-opening strategy for the synthesis of lyconadin A and discovery of an unexpected Payne rearrangement. Beilstein Journal of Organic Chemistry. 9: 1179-84. PMID 23843911 DOI: 10.3762/Bjoc.9.132  0.78
2013 Loertscher BM, Young PR, Evans PR, Castle SL. Diastereoselective synthesis of vicinal tertiary diols. Organic Letters. 15: 1930-3. PMID 23574012 DOI: 10.1021/Ol4005799  0.788
2013 Castle SL, Ma B. Total synthesis of the unusual peptide celogentin C Strategies and Tactics in Organic Synthesis. 9: 45-77. DOI: 10.1016/B978-0-08-099362-1.00002-3  0.443
2012 Ma Z, Naylor BC, Loertscher BM, Hafen DD, Li JM, Castle SL. Regioselective base-free intermolecular aminohydroxylations of hindered and functionalized alkenes. The Journal of Organic Chemistry. 77: 1208-14. PMID 22188212 DOI: 10.1021/Jo202375A  0.767
2011 Johnson AG, Loertscher BM, Moeck AR, Matthews SS, Ess DH, Castle SL. Experimental and theoretical investigation of the scope of enantioselective ketone allylations employing Nakamura's allylzinc-bisoxazoline reagent. Bioorganic & Medicinal Chemistry Letters. 21: 2706-10. PMID 21185181 DOI: 10.1016/J.Bmcl.2010.11.121  0.769
2010 Loertscher BM, Castle SL. Alkaloid synthesis: back to basics. Nature Chemistry. 2: 807-8. PMID 20861893 DOI: 10.1038/Nchem.851  0.78
2010 Banerjee B, Litvinov DN, Kang J, Bettale JD, Castle SL. Stereoselective additions of thiyl radicals to terminal ynamides. Organic Letters. 12: 2650-2. PMID 20438051 DOI: 10.1021/Ol1008679  0.646
2010 Ma B, Banerjee B, Litvinov DN, He L, Castle SL. Total synthesis of the antimitotic bicyclic peptide celogentin C. Journal of the American Chemical Society. 132: 1159-71. PMID 20038144 DOI: 10.1021/Ja909870G  0.691
2010 Boger DL, Miyazaki S, Kim SH, Wu JH, Castle SL, Loiseleur O, Jin Q. ChemInform Abstract: Total Synthesis of the Vancomycin Aglycon. Cheminform. 31: no-no. DOI: 10.1002/chin.200006233  0.466
2010 Boger DL, Miyazaki S, Kim SH, Wu JH, Loiseleur O, Castle SL. ChemInform Abstract: Diastereoselective Total Synthesis of the Vancomycin Aglycon with Ordered Atropisomer Equilibrations. Cheminform. 30: no-no. DOI: 10.1002/chin.199929189  0.44
2009 Li F, Tartakoff SS, Castle SL. Enantioselective total synthesis of (-)-acutumine. The Journal of Organic Chemistry. 74: 9082-93. PMID 19904909 DOI: 10.1021/Jo902006Q  0.555
2009 Ma B, Litvinov DN, He L, Banerjee B, Castle SL. Total synthesis of celogentin C. Angewandte Chemie (International Ed. in English). 48: 6104-7. PMID 19554590 DOI: 10.1002/Anie.200902425  0.651
2009 Li F, Tartakoff SS, Castle SL. Total synthesis of (-)-acutumine. Journal of the American Chemical Society. 131: 6674-5. PMID 19397370 DOI: 10.1021/Ja9024403  0.48
2009 Nielsen DK, Nielsen LL, Jones SB, Toll L, Asplund MC, Castle SL. Synthesis of isohasubanan alkaloids via enantioselective ketone allylation and discovery of an unexpected rearrangement. The Journal of Organic Chemistry. 74: 1187-99. PMID 19072324 DOI: 10.1021/Jo802370V  0.513
2009 Zhang Y, Loertscher BM, Castle SL. An annulation method for the synthesis of alkyl-substituted 6-carbomethoxy-2-pyridones Tetrahedron. 65: 6584-6590. DOI: 10.1016/J.Tet.2009.06.006  0.791
2008 Banerjee B, Capps SG, Kang J, Robinson JW, Castle SL. Second-generation DBFOX ligands for the synthesis of beta-substituted alpha-amino acids via enantioselective radical conjugate additions. The Journal of Organic Chemistry. 73: 8973-8. PMID 18947256 DOI: 10.1021/Jo801721Z  0.4
2007 Ma B, Parkinson JL, Castle SL. Novel Cinchona alkaloid derived ammonium salts as catalysts for the asymmetric synthesis of beta-hydroxy alpha-amino acids via aldol reactions. Tetrahedron Letters. 48: 2083-2086. PMID 18350108 DOI: 10.1016/J.Tetlet.2007.01.132  0.389
2007 Li F, Castle SL. Synthesis of the acutumine spirocycle via a radical-polar crossover reaction. Organic Letters. 9: 4033-6. PMID 17760457 DOI: 10.1021/Ol701757F  0.497
2006 Jones SB, He L, Castle SL. Total synthesis of (+/-)-hasubanonine. Organic Letters. 8: 3757-60. PMID 16898810 DOI: 10.1021/Ol0613564  0.495
2006 Grant SW, Zhu K, Zhang Y, Castle SL. Stereoselective cascade reactions that incorporate a 7-exo acyl radical cyclization. Organic Letters. 8: 1867-70. PMID 16623571 DOI: 10.1021/Ol0604264  0.486
2006 He L, Yang L, Castle SL. Synthesis of the celogentin C right-hand ring. Organic Letters. 8: 1165-8. PMID 16524294 DOI: 10.1021/Ol060016F  0.489
2006 Bing M, Litvinov DN, Srikanth GSC, Castle SL. Use of nitro chemistry to synthesize unusual peptides: Application to the left-hand segment of celogentin C Synthesis. 3291-3294. DOI: 10.1055/S-2006-950199  0.563
2005 He L, Srikanth GS, Castle SL. Synthesis of beta-substituted alpha-amino acids via Lewis acid promoted enantioselective radical conjugate additions. The Journal of Organic Chemistry. 70: 8140-7. PMID 16277340 DOI: 10.1021/Jo051334F  0.397
2005 Reeder MD, Srikanth GS, Jones SB, Castle SL. Synthesis of the core structure of acutumine. Organic Letters. 7: 1089-92. PMID 15760146 DOI: 10.1021/Ol050020B  0.438
2005 Srikanth GSC, Castle SL. Advances in radical conjugate additions Tetrahedron. 61: 10377-10441. DOI: 10.1016/J.Tet.2005.07.077  0.456
2004 Mettath S, Srikanth GS, Dangerfield BS, Castle SL. Asymmetric synthesis of beta-hydroxy amino acids via aldol reactions catalyzed by chiral ammonium salts. The Journal of Organic Chemistry. 69: 6489-92. PMID 15357616 DOI: 10.1021/Jo049283U  0.471
2004 Srikanth GS, Castle SL. Synthesis of beta-substituted alpha-amino acids via Lewis acid promoted radical conjugate additions to alpha,beta-unsaturated alpha-nitro esters and amides. Organic Letters. 6: 449-52. PMID 14748615 DOI: 10.1021/Ol036461H  0.308
2003 Castle SL, Srikanth GS. Catalytic asymmetric synthesis of the central tryptophan residue of celogentin C. Organic Letters. 5: 3611-4. PMID 14507185 DOI: 10.1021/Ol035236X  0.488
2002 McAtee JJ, Castle SL, Jin Q, Boger DL. Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine. Bioorganic & Medicinal Chemistry Letters. 12: 1319-22. PMID 11965380 DOI: 10.1016/S0960-894X(02)00130-0  0.485
2001 Boger DL, Kim SH, Mori Y, Weng JH, Rogel O, Castle SL, McAtee JJ. First and second generation total synthesis of the teicoplanin aglycon. Journal of the American Chemical Society. 123: 1862-71. PMID 11456806 DOI: 10.1021/Ja003835I  0.539
2001 Boger DL, Weng J, Miyazaki S, McAtee JJ, Castle SL, Kim SH, Mori Y, Rogel O, Strittmatter H, Jin Q. ChemInform Abstract: Thermal Atropisomerism of Teicoplanin Aglycon Derivatives. Preparation of the P,P,P and M,P,P Atropisomers of the Teicoplanin Aglycon via Selective Equilibration of the DE Ring System. Cheminform. 32: no-no. DOI: 10.1002/chin.200108186  0.311
2000 Boger DL, Weng JH, Miyazaki S, McAtee JJ, Castle SL, Kim SH, Mori Y, Rogel O, Strittmatter H, Jin Q. Thermal atropisomerism of teicoplanin aglycon derivatives: Preparation of the P,P,P and M,P,P atropisomers of the teicoplanin aglycon via selective equilibration of the DE ring system Journal of the American Chemical Society. 122: 10047-10055. DOI: 10.1021/Ja002376I  0.497
2000 Boger DL, Kim SH, Miyazaki S, Strittmatter H, Weng JH, Mori Y, Rogel O, Castle SL, McAtee JJ. Total synthesis of the teicoplanin aglycon [16] Journal of the American Chemical Society. 122: 7416-7417. DOI: 10.1021/Ja001663J  0.468
2000 Boger DL, Kim SH, Miyazaki S, Strittmatter H, Weng J, Mori Y, Rogel O, Castle SL, McAtee JJ. ChemInform Abstract: Total Synthesis of the Teicoplanin Aglycon. Cheminform. 31: no-no. DOI: 10.1002/chin.200045243  0.469
1999 Boger DL, Castle SL, Miyazaki S, Wu JH, Beresis RT, Loiseleur O. Vancomycin CD and DE Macrocyclization and Atropisomerism Studies. The Journal of Organic Chemistry. 64: 70-80. PMID 11674087 DOI: 10.1021/Jo980880O  0.571
1999 Boger DL, Miyazaki S, Kim SH, Wu JH, Castle SL, Loiseleur O, Jin Q. Total synthesis of the vancomycin aglycon Journal of the American Chemical Society. 121: 10004-10011. DOI: 10.1021/Ja992577Q  0.553
1999 Boger DL, Miyazaki S, Kim SH, Wu JH, Loiseleur O, Castle SL. Diastereoselective total synthesis of the vancomycin aglycon with ordered atropisomer equilibrations [5] Journal of the American Chemical Society. 121: 3226-3227. DOI: 10.1021/Ja990189I  0.502
1998 Boger DL, Beresis RT, Loiseleur O, Wu JH, Castle SL. Synthesis of the vancomycin CDE ring system. Bioorganic & Medicinal Chemistry Letters. 8: 721-4. PMID 9871529 DOI: 10.1016/S0960-894X(98)00110-3  0.542
1998 Boger DL, Miyazaki S, Loiseleur O, Beresis RT, Castle SL, Wu JH, Jin Q. Thermal Atropisomerism of Aglucovancomycin Derivatives:  Preparation of (M,M,M)- and (P,M,M)-Aglucovancomycins Journal of the American Chemical Society. 120: 8920-8926. DOI: 10.1021/Ja981928I  0.445
1997 Boger DL, Zhou J, Borzilleri RM, Nukui S, Castle SL. Synthesis of (9R,12S)- and (9S,12S)-Cycloisodityrosine and Their N-Methyl Derivatives. The Journal of Organic Chemistry. 62: 2054-2069. PMID 11671510 DOI: 10.1021/Jo961346O  0.564
1997 Boger DL, Loiseleur O, Castle SL, Beresis RT, Wu JH. Thermal atropisomerism of fully functinalized vancomycin CD, DE, and CDE ring systems Bioorganic and Medicinal Chemistry Letters. 7: 3199-3202. DOI: 10.1016/S0960-894X(97)10182-2  0.471
1996 Habata Y, Bradshaw JS, Young JJ, Castle SL, Huszthy P, Pyo T, Lee ML, Izatt RM. New pyridino-18-crown-6 ligands containing two methyl, two tert-butyl, or two allyl substituents on chiral positions next to the pyridine ring Journal of Organic Chemistry. 61: 8391-8396. DOI: 10.1021/Jo960474+  0.36
1993 Luo JK, Castle SL, Castle RN. The synthesis of novel polycyclic heterocyclic ring systems via photocyclization. 12. Benzo[h]naphtho-[2′,1′:4,5]thieno[2,3-c] quinoline and benzo[f]-naphtho[2′,1′:4,5]thieno[2,3-c]quinoline Journal of Heterocyclic Chemistry. 30: 653-658. DOI: 10.1002/Jhet.5570300312  0.396
1990 Luo J, Castle SL, Castle RN. The synthesis of difluoro[1]benzothieno[2,3-c]quinolines and theirN-methyl quaternary salts Journal of Heterocyclic Chemistry. 27: 2047-2052. DOI: 10.1002/Jhet.5570270737  0.412
1988 Castle SL, Luo J, Kudo H, Castle RN, Lee ML. The synthesis of novel polycyclic heterocyclic ring systemsviaphotocyclization.1. Thieno[3′,2′:4,5]thieno[2,3-c]quinoline and thieno[2′,3′:4,5]thieno[2,3-c]quinoline Journal of Heterocyclic Chemistry. 25: 1363-1365. DOI: 10.1002/Jhet.5570250517  0.406
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