Laurence Hurst, Ph.D - Publications

Biology and Biochemistry Bath 
Genetics, Genomics

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lewin LE, Daniels KG, Hurst LD. Genes for highly abundant proteins in Escherichia coli avoid 5' codons that promote ribosomal initiation. Plos Computational Biology. 19: e1011581. PMID 37878567 DOI: 10.1371/journal.pcbi.1011581  0.319
2022 Ho AT, Hurst LD. Unusual mammalian usage of TGA stop codons reveals that sequence conservation need not imply purifying selection. Plos Biology. 20: e3001588. PMID 35550630 DOI: 10.1371/journal.pbio.3001588  0.379
2022 Vance Z, Niezabitowski L, Hurst LD, McLysaght A. Evidence from Drosophila Supports Higher Duplicability of Faster Evolving Genes. Genome Biology and Evolution. 14. PMID 35018456 DOI: 10.1093/gbe/evac003  0.36
2021 Lima de Oliveira J, Castillo Morales A, Hurst LD, Urrutia AO, Thompson CRL, Wolf JB. Inferring adaptive codon preference to understand sources of selection shaping codon usage bias. Molecular Biology and Evolution. PMID 33871580 DOI: 10.1093/molbev/msab099  0.353
2020 Rice AM, Morales AC, Ho AT, Mordstein C, Mühlhausen S, Watson S, Cano L, Young B, Kudla G, Hurst LD. Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design. Molecular Biology and Evolution. PMID 32687176 DOI: 10.1093/molbev/msaa188  0.35
2020 Nützmann HW, Doerr D, Ramírez-Colmenero A, Sotelo-Fonseca JE, Wegel E, Di Stefano M, Wingett SW, Fraser P, Hurst L, Fernandez-Valverde SL, Osbourn A. Active and repressed biosynthetic gene clusters have spatially distinct chromosome states. Proceedings of the National Academy of Sciences of the United States of America. PMID 32493747 DOI: 10.1073/Pnas.1920474117  0.32
2020 Mordstein C, Savisaar R, Young RS, Bazile J, Talmane L, Luft J, Liss M, Taylor MS, Hurst LD, Kudla G. Codon Usage and Splicing Jointly Influence mRNA Localization. Cell Systems. PMID 32275854 DOI: 10.1016/J.Cels.2020.03.001  0.326
2019 Abrahams L, Hurst LD. A depletion of stop codons in lincRNA is owing to transfer of selective constraint from coding sequences. Molecular Biology and Evolution. PMID 31841162 DOI: 10.1093/molbev/msz299  0.332
2019 Ho AT, Hurst LD. In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons. Plos Genetics. 15: e1008386. PMID 31527909 DOI: 10.1371/journal.pgen.1008386  0.384
2018 Savisaar R, Hurst LD. Exonic splice regulation imposes strong selection at synonymous sites. Genome Research. PMID 30143596 DOI: 10.1101/gr.233999.117  0.34
2018 Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li WH, Tian D. Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout. Proceedings of the National Academy of Sciences of the United States of America. PMID 30037991 DOI: 10.1073/Pnas.1806110115  0.327
2018 Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li WH, Tian D. Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout. Proceedings of the National Academy of Sciences of the United States of America. PMID 30037991 DOI: 10.1073/Pnas.1806110115  0.327
2017 Liu H, Huang J, Sun X, Li J, Hu Y, Yu L, Liti G, Tian D, Hurst LD, Yang S. Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias. Nature Ecology & Evolution. PMID 29158556 DOI: 10.1038/S41559-017-0372-7  0.314
2017 O'Toole ÁN, Hurst LD, McLysaght A. Faster Evolving Primate Genes are More Likely to Duplicate. Molecular Biology and Evolution. PMID 29126243 DOI: 10.1093/Molbev/Msx270  0.367
2017 Abrahams L, Hurst LD. Adenine enrichment at the fourth CDS residue in bacterial genes is consistent with error proofing for +1 frameshifts. Molecular Biology and Evolution. PMID 28961919 DOI: 10.1093/molbev/msx223  0.314
2017 Savisaar R, Hurst LD. Estimating the prevalence of functional exonic splice regulatory information. Human Genetics. PMID 28405812 DOI: 10.1007/s00439-017-1798-3  0.301
2016 McLysaght A, Hurst LD. Open questions in the study of de novo genes: what, how and why. Nature Reviews. Genetics. PMID 27452112 DOI: 10.1038/Nrg.2016.78  0.329
2016 Savisaar R, Hurst LD. Purifying selection on exonic splice enhancers in intronless genes. Molecular Biology and Evolution. PMID 26802218 DOI: 10.1093/molbev/msw018  0.409
2015 Hurst LD, Ghanbarian AT, Forrest AR, Huminiecki L. The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome. Plos Biology. 13: e1002315. PMID 26685068 DOI: 10.1371/journal.pbio.1002315  0.772
2015 Yang S, Wang L, Huang J, Zhang X, Yuan Y, Chen JQ, Hurst LD, Tian D. Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature. PMID 26176923 DOI: 10.1038/Nature14649  0.317
2015 Ghanbarian AT, Hurst LD. Neighboring Genes Show Correlated Evolution in Gene Expression. Molecular Biology and Evolution. 32: 1748-66. PMID 25743543 DOI: 10.1093/molbev/msv053  0.786
2014 Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD, et al. Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells. Nature. 516: 405-9. PMID 25317556 DOI: 10.1038/nature13804  0.741
2014 Schüler A, Ghanbarian AT, Hurst LD. Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs. Molecular Biology and Evolution. 31: 3164-83. PMID 25158797 DOI: 10.1093/molbev/msu249  0.793
2013 Cáceres EF, Hurst LD. The evolution, impact and properties of exonic splice enhancers. Genome Biology. 14: R143. PMID 24359918 DOI: 10.1186/gb-2013-14-12-r143  0.301
2013 Zhang Y, Castillo-Morales A, Jiang M, Zhu Y, Hu L, Urrutia AO, Kong X, Hurst LD. Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Molecular Biology and Evolution. 30: 2588-601. PMID 24023392 DOI: 10.1093/molbev/mst148  0.302
2013 Woods S, Coghlan A, Rivers D, Warnecke T, Jeffries SJ, Kwon T, Rogers A, Hurst LD, Ahringer J. Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses. Plos Genetics. 9: e1003330. PMID 23675306 DOI: 10.1371/Journal.Pgen.1003330  0.614
2012 Yang S, Yuan Y, Wang L, Li J, Wang W, Liu H, Chen JQ, Hurst LD, Tian D. Great majority of recombination events in Arabidopsis are gene conversion events. Proceedings of the National Academy of Sciences of the United States of America. 109: 20992-7. PMID 23213238 DOI: 10.1073/Pnas.1211827110  0.352
2012 Fehér T, Bogos B, Méhi O, Fekete G, Csörgo B, Kovács K, Pósfai G, Papp B, Hurst LD, Pál C. Competition between transposable elements and mutator genes in bacteria. Molecular Biology and Evolution. 29: 3153-9. PMID 22527906 DOI: 10.1093/Molbev/Mss122  0.622
2012 Weber CC, Pink CJ, Hurst LD. Late-replicating domains have higher divergence and diversity in Drosophila melanogaster. Molecular Biology and Evolution. 29: 873-82. PMID 22046001 DOI: 10.1093/Molbev/Msr265  0.588
2011 Warnecke T, Hurst LD. Error prevention and mitigation as forces in the evolution of genes and genomes. Nature Reviews. Genetics. 12: 875-81. PMID 22094950 DOI: 10.1038/Nrg3092  0.587
2011 Nahorski MS, Reiman A, Lim DH, Nookala RK, Seabra L, Lu X, Fenton J, Boora U, Nordenskjöld M, Latif F, Hurst LD, Maher ER. Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability. Human Mutation. 32: 921-9. PMID 21538689 DOI: 10.1002/humu.21519  0.3
2011 Weber CC, Hurst LD. Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation. Genome Biology. 12: R23. PMID 21414197 DOI: 10.1186/Gb-2011-12-3-R23  0.57
2011 Wang GZ, Lercher MJ, Hurst LD. Transcriptional coupling of neighboring genes and gene expression noise: evidence that gene orientation and noncoding transcripts are modulators of noise. Genome Biology and Evolution. 3: 320-31. PMID 21402863 DOI: 10.1093/gbe/evr025  0.302
2010 Weber CC, Hurst LD. Intronic AT skew is a defendable proxy for germline transcription but does not predict crossing-over or protein evolution rates in Drosophila melanogaster. Journal of Molecular Evolution. 71: 415-26. PMID 20938653 DOI: 10.1007/S00239-010-9395-2  0.615
2010 Warnecke T, Huang Y, Przytycka TM, Hurst LD. Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness. Genome Biology and Evolution. 2: 636-45. PMID 20688751 DOI: 10.1093/Gbe/Evq049  0.499
2010 Warnecke T, Hurst LD. GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution. Molecular Systems Biology. 6: 340. PMID 20087338 DOI: 10.1038/Msb.2009.94  0.572
2009 Weber CC, Hurst LD. Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates. Genome Biology and Evolution. 1: 340-9. PMID 20333203 DOI: 10.1093/Gbe/Evp033  0.563
2009 Necsulea A, Sémon M, Duret L, Hurst LD. Monoallelic expression and tissue specificity are associated with high crossover rates. Trends in Genetics : Tig. 25: 519-22. PMID 19850368 DOI: 10.1016/J.Tig.2009.10.001  0.335
2009 Warnecke T, Wang GZ, Lercher MJ, Hurst LD. Does negative auto-regulation increase gene duplicability? Bmc Evolutionary Biology. 9: 193. PMID 19664220 DOI: 10.1186/1471-2148-9-193  0.581
2009 Warnecke T, Weber CC, Hurst LD. Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence. Biochemical Society Transactions. 37: 756-61. PMID 19614589 DOI: 10.1042/Bst0370756  0.655
2009 Chamary JV, Hurst LD. The price of silent mutations. Scientific American. 300: 46-53. PMID 19485088 DOI: 10.1038/scientificamerican0609-46  0.751
2009 Zhang Z, Xin D, Wang P, Zhou L, Hu L, Kong X, Hurst LD. Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay. Bmc Biology. 7: 23. PMID 19442261 DOI: 10.1186/1741-7007-7-23  0.341
2009 Chamary JV, Hurst LD. Clarifications Scientific American. 301: 12.  0.716
2008 Warnecke T, Batada NN, Hurst LD. The impact of the nucleosome code on protein-coding sequence evolution in yeast. Plos Genetics. 4: e1000250. PMID 18989456 DOI: 10.1371/Journal.Pgen.1000250  0.578
2008 Warnecke T, Parmley JL, Hurst LD. Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes. Genome Biology. 9: R29. PMID 18257921 DOI: 10.1186/Gb-2008-9-2-R29  0.55
2008 Urrutia AO, Ocaña LB, Hurst LD. Do Alu repeats drive the evolution of the primate transcriptome? Genome Biology. 9: R25. PMID 18241332 DOI: 10.1186/gb-2008-9-2-r25  0.345
2007 Poyatos JF, Hurst LD. The determinants of gene order conservation in yeasts. Genome Biology. 8: R233. PMID 17983469 DOI: 10.1186/gb-2007-8-11-r233  0.306
2007 Warnecke T, Hurst LD. Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster. Molecular Biology and Evolution. 24: 2755-62. PMID 17905999 DOI: 10.1093/Molbev/Msm210  0.596
2007 Batada NN, Urrutia AO, Hurst LD. Chromatin remodelling is a major source of coexpression of linked genes in yeast. Trends in Genetics : Tig. 23: 480-4. PMID 17822800 DOI: 10.1016/J.Tig.2007.08.003  0.326
2007 Parmley JL, Hurst LD. Exonic splicing regulatory elements skew synonymous codon usage near intron-exon boundaries in mammals. Molecular Biology and Evolution. 24: 1600-3. PMID 17525472 DOI: 10.1093/molbev/msm104  0.323
2006 Poyatos JF, Hurst LD. Is optimal gene order impossible? Trends in Genetics : Tig. 22: 420-3. PMID 16806566 DOI: 10.1016/j.tig.2006.06.003  0.309
2006 Pál C, Papp B, Lercher MJ, Csermely P, Oliver SG, Hurst LD. Chance and necessity in the evolution of minimal metabolic networks. Nature. 440: 667-70. PMID 16572170 DOI: 10.1038/Nature04568  0.601
2006 Chamary JV, Parmley JL, Hurst LD. Hearing silence: non-neutral evolution at synonymous sites in mammals. Nature Reviews. Genetics. 7: 98-108. PMID 16418745 DOI: 10.1038/nrg1770  0.775
2006 Parmley JL, Chamary JV, Hurst LD. Evidence for purifying selection against synonymous mutations in mammalian exonic splicing enhancers. Molecular Biology and Evolution. 23: 301-9. PMID 16221894 DOI: 10.1093/molbev/msj035  0.799
2005 Chamary JV, Hurst LD. Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals. Genome Biology. 6: R75. PMID 16168082 DOI: 10.1186/Gb-2005-6-9-R75  0.781
2005 Chen J, Sun M, Rowley JD, Hurst LD. The small introns of antisense genes are better explained by selection for rapid transcription than by "genomic design". Genetics. 171: 2151-5. PMID 16143605 DOI: 10.1534/genetics.105.048066  0.324
2005 Seoighe C, Gehring C, Hurst LD. Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction. Plos Genetics. 1: e13. PMID 16110339 DOI: 10.1371/journal.pgen.0010013  0.376
2005 Pinto JP, Conceição NM, Viegas CS, Leite RB, Hurst LD, Kelsh RN, Cancela ML. Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 1440-53. PMID 16007341 DOI: 10.1359/JBMR.050318  0.311
2005 Chamary JV, Hurst LD. Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else? Trends in Genetics : Tig. 21: 256-9. PMID 15851058 DOI: 10.1016/J.Tig.2005.03.001  0.784
2005 Chen J, Sun M, Hurst LD, Carmichael GG, Rowley JD. Human antisense genes have unusually short introns: evidence for selection for rapid transcription. Trends in Genetics : Tig. 21: 203-7. PMID 15797613 DOI: 10.1016/j.tig.2005.02.003  0.327
2005 Hurst LD, Pál C. Dissecting dispensability. Nature Genetics. 37: 214-5. PMID 15731753 DOI: 10.1038/ng0305-214  0.504
2004 Papp B, Pál C, Hurst LD. Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature. 429: 661-4. PMID 15190353 DOI: 10.1038/Nature02636  0.611
2004 Lercher MJ, Chamary JV, Hurst LD. Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile. Genome Research. 14: 1002-13. PMID 15173108 DOI: 10.1101/Gr.1597404  0.791
2004 Pál C, Hurst LD. Evidence against the selfish operon theory. Trends in Genetics : Tig. 20: 232-4. PMID 15145575 DOI: 10.1016/J.Tig.2004.04.001  0.641
2004 Hurst LD, Pál C, Lercher MJ. The evolutionary dynamics of eukaryotic gene order. Nature Reviews. Genetics. 5: 299-310. PMID 15131653 DOI: 10.1038/Nrg1319  0.64
2004 Chamary JV, Hurst LD. Similar rates but different modes of sequence evolution in introns and at exonic silent sites in rodents: evidence for selectively driven codon usage. Molecular Biology and Evolution. 21: 1014-23. PMID 15014158 DOI: 10.1093/Molbev/Msh087  0.787
2003 Urrutia AO, Hurst LD. The signature of selection mediated by expression on human genes. Genome Research. 13: 2260-4. PMID 12975314 DOI: 10.1101/gr.641103  0.328
2003 Papp B, Pál C, Hurst LD. Evolution of cis-regulatory elements in duplicated genes of yeast. Trends in Genetics : Tig. 19: 417-22. PMID 12902158 DOI: 10.1016/S0168-9525(03)00174-4  0.654
2003 Papp B, Pál C, Hurst LD. Dosage sensitivity and the evolution of gene families in yeast. Nature. 424: 194-7. PMID 12853957 DOI: 10.1038/Nature01771  0.62
2003 Pál C, Hurst LD. Evidence for co-evolution of gene order and recombination rate. Nature Genetics. 33: 392-5. PMID 12577060 DOI: 10.1038/Ng1111  0.634
2003 Lercher MJ, Blumenthal T, Hurst LD. Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Research. 13: 238-43. PMID 12566401 DOI: 10.1101/Gr.553803  0.345
2003 Pál C, Papp B, Hurst LD, Hirsh AE, Fraser HB. Genomic function: Rate of evolution and gene dispensability Nature. 421: 496-498. PMID 12556881 DOI: 10.1038/421496B  0.622
2002 Lercher MJ, Hurst LD. Can mutation or fixation biases explain the allele frequency distribution of human single nucleotide polymorphisms (SNPs)? Gene. 300: 53-8. PMID 12468085 DOI: 10.1016/S0378-1119(02)01040-5  0.325
2002 Hurst LD, Williams EJ, Pál C. Natural selection promotes the conservation of linkage of co-expressed genes. Trends in Genetics : Tig. 18: 604-6. PMID 12446137 DOI: 10.1016/S0168-9525(02)02813-5  0.658
2002 Williams EJ, Hurst LD. Is the synonymous substitution rate in mammals gene-specific? Molecular Biology and Evolution. 19: 1395-8. PMID 12140253 DOI: 10.1093/oxfordjournals.molbev.a004202  0.313
2002 Williams EJ, Hurst LD. Clustering of tissue-specific genes underlies much of the similarity in rates of protein evolution of linked genes. Journal of Molecular Evolution. 54: 511-8. PMID 11956689 DOI: 10.1007/s00239-001-0043-8  0.342
2000 Williams EJ, Pal C, Hurst LD. The molecular evolution of signal peptides. Gene. 253: 313-22. PMID 10940569 DOI: 10.1016/S0378-1119(00)00233-X  0.57
2000 Woodward ER, Buchberger A, Clifford SC, Hurst LD, Affara NA, Maher ER. Comparative sequence analysis of the VHL tumor suppressor gene. Genomics. 65: 253-65. PMID 10857749 DOI: 10.1006/geno.2000.6144  0.339
1999 Hurst LD, Smith NG. Do essential genes evolve slowly? Current Biology : Cb. 9: 747-50. PMID 10421576 DOI: 10.1016/S0960-9822(99)80334-0  0.363
1998 Hurst LD, Pomiankowski A. The eyes have it Nature. 391: 223-224. DOI: 10.1038/34523  0.506
1997 McVean GT, Hurst LD. Molecular evolution of imprinted genes: no evidence for antagonistic coevolution. Proceedings. Biological Sciences. 264: 739-46. PMID 9178545 DOI: 10.1098/rspb.1997.0105  0.313
1995 Hurst LD. Evolutionary genetics. The silence of the genes. Current Biology : Cb. 5: 459-61. PMID 7583087 DOI: 10.1016/S0960-9822(95)00090-X  0.342
1993 Pomiankowski A, Hurst LD. Evolutionary genetics. Siberian mice upset Mendel. Nature. 363: 396-7. PMID 8502293 DOI: 10.1038/363396A0  0.444
1993 Hurst LD, Grafen A. Unusual mutational mechanisms and evolution. Science (New York, N.Y.). 260: 1959; author reply 1. PMID 8316838  0.582
1992 Hurst LD, Hamilton WD, Ladle RJ. Covert sex. Trends in Ecology & Evolution. 7: 144-5. PMID 21235987 DOI: 10.1016/0169-5347(92)90205-P  0.368
1992 Hurst LD, Dawkins R. Evolutionary chemistry. Life in a test tube. Nature. 357: 198-9. PMID 1375346 DOI: 10.1038/357198a0  0.344
1992 Hurst LD, Pomiankowski A. Speciation events. Nature. 359: 781. PMID 1285801 DOI: 10.1038/359781b0  0.447
1991 Hurst LD, Pomiankowski A. Maintaining Mendelism: might prevention be better than cure? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 13: 489-90. PMID 1796911 DOI: 10.1002/Bies.950130910  0.435
1990 Hurst L, Grafen A. Sex and flagellation. Trends in Ecology & Evolution. 5: 419-22. PMID 21232406 DOI: 10.1016/0169-5347(90)90029-D  0.56
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