| Year |
Citation |
Score |
| 2023 |
Lisauskaitė M, Nixon GL, Woodley CM, Berry NG, Coninckx A, Qie LC, Leung SC, Taramelli D, Basilico N, Parapini S, Ward SA, Vadas O, Soldati-Favre D, Hong WD, O'Neill PM. Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in . Rsc Chemical Biology. 5: 19-29. PMID 38179191 DOI: 10.1039/d3cb00109a |
0.357 |
|
| 2023 |
Stachulski AV, Rossignol JF, Pate S, Taujanskas J, Iggo JA, Aerts R, Pascal E, Piacentini S, La Frazia S, Santoro MG, van Vooren L, Sintubin L, Cooper M, Swift K, O'Neill PM. Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity. Acs Bio & Med Chem Au. 3: 327-334. PMID 37599793 DOI: 10.1021/acsbiomedchemau.2c00083 |
0.553 |
|
| 2021 |
Stachulski AV, Rossignol JF, Pate S, Taujanskas J, Robertson CM, Aerts R, Pascal E, Piacentini S, Frazia S, Santoro MG, O'Neill PM. Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts. Future Medicinal Chemistry. PMID 34402654 DOI: 10.4155/fmc-2021-0055 |
0.573 |
|
| 2021 |
Woodley CM, Amado PSM, Cristiano MLS, O'Neill PM. Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies. Medicinal Research Reviews. PMID 34355414 DOI: 10.1002/med.21849 |
0.343 |
|
| 2020 |
Stachulski AV, Taujanskas J, Pate SL, Rajoli RKR, Aljayyoussi G, Pennington SH, Ward SA, Hong WD, Biagini GA, Owen A, Nixon GL, Leung SC, O'Neill PM. Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2? Acs Infectious Diseases. PMID 33352056 DOI: 10.1021/acsinfecdis.0c00478 |
0.609 |
|
| 2020 |
Alghamdi A, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana J, Martin Abril ME, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, et al. Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter . Elife. 9. PMID 32762841 DOI: 10.7554/Elife.56416 |
0.34 |
|
| 2020 |
Secrieru A, Costa ICC, O'Neill PM, Cristiano MLS. Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis-A Short Bridge between Two Distant Illnesses. Molecules (Basel, Switzerland). 25. PMID 32235463 DOI: 10.3390/Molecules25071574 |
0.371 |
|
| 2019 |
Rolt A, O'Neill PM, Liang TJ, Stachulski AV. Synthesis of MeBmt and related derivatives syn-selective ATH-DKR. Rsc Advances. 9: 40336-40339. PMID 32864110 DOI: 10.1039/C9Ra08256E |
0.604 |
|
| 2019 |
Zhu Q, Yang Y, Lao Z, Zhong Y, Zhang B, Cui X, O'Neill P, Hong D, Zhang K, Zhao S. Synthesis, Insecticidal Activities, Resistance in Aedes albopictus and Cytotoxicity of Novel Dihaloacetylated Heterocyclic Pyrethroids. Pest Management Science. PMID 31318140 DOI: 10.1002/Ps.5559 |
0.39 |
|
| 2019 |
Panmanee J, Bradley-Clarke J, Mato JM, O'Neill PM, Antonyuk SV, Hasnain SS. Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds. The Febs Journal. PMID 30776190 DOI: 10.1111/Febs.14790 |
0.345 |
|
| 2019 |
Clare RH, Bardelle C, Harper P, Hong WD, Börjesson U, Johnston KL, Collier M, Myhill L, Cassidy A, Plant D, Plant H, Clark R, Cook DAN, Steven A, Archer J, et al. Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. Nature Communications. 10: 11. PMID 30602718 DOI: 10.1038/S41467-018-07826-2 |
0.742 |
|
| 2018 |
David Hong W, Leung SC, Amporndanai K, Davies J, Priestley RS, Nixon GL, Berry NG, Samar Hasnain S, Antonyuk S, Ward SA, Biagini GA, O'Neill PM. Potent Antimalarial 2-Pyrazolyl Quinolone (Q) Inhibitors with Improved Drug-like Properties. Acs Medicinal Chemistry Letters. 9: 1205-1210. PMID 30613327 DOI: 10.1021/acsmedchemlett.8b00371 |
0.337 |
|
| 2018 |
Wong SQ, Pontifex MG, Phelan MM, Pidathala C, Kraemer BC, Barclay JW, Berry NG, O'Neill PM, Burgoyne RD, Morgan A. α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy. Neurobiology of Disease. PMID 29940336 DOI: 10.1016/J.Nbd.2018.06.013 |
0.415 |
|
| 2018 |
Amporndanai K, Johnson RM, O'Neill PM, Fishwick CWG, Jamson AH, Rawson S, Muench SP, Hasnain SS, Antonyuk SV. X-ray and cryo-EM structures of inhibitor-bound cytochrome complexes for structure-based drug discovery. Iucrj. 5: 200-210. PMID 29765610 DOI: 10.1107/S2052252518001616 |
0.419 |
|
| 2018 |
Capper MJ, Wright GSA, Barbieri L, Luchinat E, Mercatelli E, McAlary L, Yerbury JJ, O'Neill PM, Antonyuk SV, Banci L, Hasnain SS. The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. Nature Communications. 9: 1693. PMID 29703933 DOI: 10.1038/S41467-018-04114-X |
0.314 |
|
| 2018 |
Stachulski AV, Santoro MG, Piacentini S, Belardo G, Frazia S, Pidathala C, Row EC, Berry NG, Iqbal M, Allman SA, Semple JE, Eklov BM, O'Neill PM, Rossignol JF. Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. Future Medicinal Chemistry. PMID 29629834 DOI: 10.4155/Fmc-2017-0217 |
0.567 |
|
| 2017 |
Hong WD, Gibbons PD, Leung SC, Amewu R, Stocks PA, Stachulski AV, Horta PC, Cristiano ML, Shone AE, Moss D, Ardrey A, Sharma R, Warman AJ, Bedingfield PT, Fisher NE, et al. Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 28304162 DOI: 10.1021/Acs.Jmedchem.6B01718 |
0.594 |
|
| 2016 |
Price KE, Armstrong CM, Imlay LS, Hodge DM, Pidathala C, Roberts NJ, Park J, Mikati M, Sharma R, Lawrenson AS, Tolia NH, Berry NG, O'Neill PM, John AR. Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD. Scientific Reports. 6: 36777. PMID 27857147 DOI: 10.1038/Srep36777 |
0.315 |
|
| 2016 |
Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM. Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. Angewandte Chemie (International Ed. in English). 55: 10548. PMID 27552550 DOI: 10.1002/Anie.201607032 |
0.77 |
|
| 2016 |
Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM. A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 128: 6511-6515. PMID 27397940 DOI: 10.1002/ange.201512062 |
0.761 |
|
| 2016 |
Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM. A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. Angewandte Chemie (International Ed. in English). PMID 27089538 DOI: 10.1002/anie.201512062 |
0.761 |
|
| 2016 |
Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858419 DOI: 10.1073/Pnas.1600459113 |
0.768 |
|
| 2015 |
Horta P, Kuş N, Henriques MS, Paixão JA, Coelho L, Nogueira F, O'Neill PM, Fausto R, Cristiano ML. Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity. The Journal of Organic Chemistry. 80: 12244-57. PMID 26551438 DOI: 10.1021/acs.joc.5b02169 |
0.309 |
|
| 2015 |
O'Neill PM, Ward SA. A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle. Angewandte Chemie (International Ed. in English). 54: 13504-6. PMID 26426264 DOI: 10.1002/Anie.201507264 |
0.379 |
|
| 2015 |
McConville M, Fernández J, Angulo-Barturen Í, Bahamontes-Rosa N, Ballell-Pages L, Castañeda P, de Cózar C, Crespo B, Guijarro L, Jiménez-Díaz MB, Martínez-Martínez MS, de Mercado J, Santos-Villarejo Á, Sanz LM, Frigerio M, et al. Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials. Journal of Medicinal Chemistry. 58: 6448-55. PMID 26222445 DOI: 10.1021/acs.jmedchem.5b00434 |
0.314 |
|
| 2015 |
Oliveira R, Miranda D, Magalhães J, Capela R, Perry MJ, O'Neill PM, Moreira R, Lopes F. From hybrid compounds to targeted drug delivery in antimalarial therapy. Bioorganic & Medicinal Chemistry. PMID 25913864 DOI: 10.1016/j.bmc.2015.04.017 |
0.354 |
|
| 2015 |
Charoensutthivarakul S, Hong WD, Leung SC, Gibbons PD, Bedingfield PTP, Nixon GL, Lawrenson AS, Berry NG, Ward SA, Biagini GA, O'Neill PM. 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties Medchemcomm. 6: 1252-1259. DOI: 10.1039/C5Md00062A |
0.773 |
|
| 2014 |
Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, et al. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. Acs Medicinal Chemistry Letters. 5: 108-12. PMID 24900781 DOI: 10.1021/ml4002985 |
0.303 |
|
| 2014 |
Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O'Neill PM, Lopes F. Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. Journal of Medicinal Chemistry. 57: 4916-23. PMID 24824551 DOI: 10.1021/Jm5004528 |
0.451 |
|
| 2014 |
Stocks PA, Barton V, Antoine T, Biagini GA, Ward SA, O'Neill PM. Novel inhibitors of the Plasmodium falciparum electron transport chain. Parasitology. 141: 50-65. PMID 24401337 DOI: 10.1017/S0031182013001571 |
0.417 |
|
| 2014 |
Antoine T, Fisher N, Amewu R, O'Neill PM, Ward SA, Biagini GA. Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. The Journal of Antimicrobial Chemotherapy. 69: 1005-16. PMID 24335485 DOI: 10.1093/Jac/Dkt486 |
0.377 |
|
| 2014 |
Alhaidari M, Yang E, Berry N, Owen A, Clarke S, O'Neill P, Naisbitt D, Park K. Chemical modification of the 6'-amino cyclopropyl of abacavir eliminates HLA-B*57:01-restricted CD8+ T-cell activation without loss of antiviral activity Clinical and Translational Allergy. 4. DOI: 10.1186/2045-7022-4-S3-P40 |
0.321 |
|
| 2014 |
Capper M, O'Neill P, Biagini G, Hasnain S, Antonyuk S. Overcoming drug-resistant malaria through rational drug design in cytochrome bc1 Acta Crystallographica Section a Foundations and Advances. 70: C806-C806. DOI: 10.1107/S2053273314091931 |
0.31 |
|
| 2013 |
Elliott EC, Maggs JL, Park BK, O'Neill PM, Stachulski AV. Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles. Organic & Biomolecular Chemistry. 11: 8426-34. PMID 24193242 DOI: 10.1039/C3Ob41252K |
0.636 |
|
| 2013 |
Nixon GL, Pidathala C, Shone AE, Antoine T, Fisher N, O'Neill PM, Ward SA, Biagini GA. Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era. Future Medicinal Chemistry. 5: 1573-91. PMID 24024949 DOI: 10.4155/fmc.13.121 |
0.301 |
|
| 2013 |
Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O'Neill PM, Ward SA, Lopes F, Moreira R. An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. Chemmedchem. 8: 1528-36. PMID 23853126 DOI: 10.1002/Cmdc.201300202 |
0.459 |
|
| 2013 |
Nixon GL, Moss DM, Shone AE, Lalloo DG, Fisher N, O'Neill PM, Ward SA, Biagini GA. Antimalarial pharmacology and therapeutics of atovaquone. The Journal of Antimicrobial Chemotherapy. 68: 977-85. PMID 23292347 DOI: 10.1093/Jac/Dks504 |
0.331 |
|
| 2013 |
Kershaw NM, Wright GS, Sharma R, Antonyuk SV, Strange RW, Berry NG, O'Neill PM, Hasnain SS. X-ray crystallography and computational docking for the detection and development of protein-ligand interactions. Current Medicinal Chemistry. 20: 569-75. PMID 23278398 DOI: 10.2174/0929867311320040008 |
0.304 |
|
| 2013 |
Warman AJ, Rito TS, Fisher NE, Moss DM, Berry NG, O'Neill PM, Ward SA, Biagini GA. Antitubercular pharmacodynamics of phenothiazines. The Journal of Antimicrobial Chemotherapy. 68: 869-80. PMID 23228936 DOI: 10.1093/Jac/Dks483 |
0.379 |
|
| 2012 |
Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, et al. Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proceedings of the National Academy of Sciences of the United States of America. 109: 8298-303. PMID 22566611 DOI: 10.1073/Pnas.1205651109 |
0.77 |
|
| 2012 |
Vallières C, Fisher N, Antoine T, Al-Helal M, Stocks P, Berry NG, Lawrenson AS, Ward SA, O'Neill PM, Biagini GA, Meunier B. HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex. Antimicrobial Agents and Chemotherapy. 56: 3739-47. PMID 22547613 DOI: 10.1128/Aac.00486-12 |
0.337 |
|
| 2012 |
Sharma R, Lawrenson AS, Fisher NE, Warman AJ, Shone AE, Hill A, Mbekeani A, Pidathala C, Amewu RK, Leung S, Gibbons P, Hong DW, Stocks P, Nixon GL, Chadwick J, et al. Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods. Journal of Medicinal Chemistry. 55: 3144-54. PMID 22380711 DOI: 10.1021/Jm3001482 |
0.397 |
|
| 2012 |
Leung SC, Gibbons P, Amewu R, Nixon GL, Pidathala C, Hong WD, Pacorel B, Berry NG, Sharma R, Stocks PA, Srivastava A, Shone AE, Charoensutthivarakul S, Taylor L, Berger O, et al. Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). Journal of Medicinal Chemistry. 55: 1844-57. PMID 22364417 DOI: 10.1021/jm201184h |
0.767 |
|
| 2012 |
Pidathala C, Amewu R, Pacorel B, Nixon GL, Gibbons P, Hong WD, Leung SC, Berry NG, Sharma R, Stocks PA, Srivastava A, Shone AE, Charoensutthivarakul S, Taylor L, Berger O, et al. Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). Journal of Medicinal Chemistry. 55: 1831-43. PMID 22364416 DOI: 10.1021/Jm201179H |
0.778 |
|
| 2012 |
Fisher N, Abd Majid R, Antoine T, Al-Helal M, Warman AJ, Johnson DJ, Lawrenson AS, Ranson H, O'Neill PM, Ward SA, Biagini GA. Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. The Journal of Biological Chemistry. 287: 9731-41. PMID 22282497 DOI: 10.1074/Jbc.M111.324319 |
0.354 |
|
| 2012 |
Hale I, O'Neill PM, Berry NG, Odom A, Sharma R. The MEP pathway and the development of inhibitors as potential anti-infective agents Medchemcomm. 3: 418-433. DOI: 10.1039/C2Md00298A |
0.329 |
|
| 2011 |
Salcedo-Sora JE, Ochong E, Beveridge S, Johnson D, Nzila A, Biagini GA, Stocks PA, O'Neill PM, Krishna S, Bray PG, Ward SA. The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. The Journal of Biological Chemistry. 286: 44659-68. PMID 21998306 DOI: 10.1074/Jbc.M111.286054 |
0.331 |
|
| 2011 |
Rodrigues T, Moreira R, Gut J, Rosenthal PJ, O'Neill PM, Biagini GA, Lopes F, Dos Santos DJVA, Guedes RC. Identification of new antimalarial leads by use of virtual screening against cytochrome bc 1 Bioorganic and Medicinal Chemistry. 19: 6302-6308. PMID 21958736 DOI: 10.1016/j.bmc.2011.09.004 |
0.324 |
|
| 2011 |
Elliott EC, Bowkett ER, Maggs JL, Bacsa J, Park BK, Regan SL, O'Neill PM, Stachulski AV. Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles. Organic Letters. 13: 5592-5. PMID 21939196 DOI: 10.1021/Ol202318W |
0.597 |
|
| 2011 |
Berger O, Kaniti A, van Ba CT, Vial H, Ward SA, Biagini GA, Bray PG, O'Neill PM. Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues. Chemmedchem. 6: 2094-108. PMID 21905228 DOI: 10.1002/Cmdc.201100265 |
0.429 |
|
| 2011 |
Chadwick J, Amewu RK, Marti F, Garah FB, Sharma R, Berry NG, Stocks PA, Burrell-Saward H, Wittlin S, Rottmann M, Brun R, Taramelli D, Parapini S, Ward SA, O'Neill PM. Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. Chemmedchem. 6: 1357-61. PMID 21692184 DOI: 10.1002/Cmdc.201100196 |
0.379 |
|
| 2011 |
Stevenson BJ, Bibby J, Pignatelli P, Muangnoicharoen S, O'Neill PM, Lian LY, Müller P, Nikou D, Steven A, Hemingway J, Sutcliffe MJ, Paine MJ. Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed. Insect Biochemistry and Molecular Biology. 41: 492-502. PMID 21324359 DOI: 10.1016/J.Ibmb.2011.02.003 |
0.323 |
|
| 2011 |
Mercer AE, Copple IM, Maggs JL, O'Neill PM, Park BK. The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials. The Journal of Biological Chemistry. 286: 987-96. PMID 21059641 DOI: 10.1074/Jbc.M110.144188 |
0.368 |
|
| 2011 |
Marti F, Chadwick J, Amewu RK, Burrell-Saward H, Srivastava A, Ward SA, Sharma R, Berry N, O'Neill PM. Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities Medchemcomm. 2: 661-665. DOI: 10.1039/C1Md00102G |
0.409 |
|
| 2010 |
O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, et al. Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie (International Ed. in English). 49: 5693-7. PMID 20629058 DOI: 10.1002/Anie.201001026 |
0.347 |
|
| 2010 |
Barton V, Fisher N, Biagini GA, Ward SA, O'Neill PM. Inhibiting Plasmodium cytochrome bc1: a complex issue. Current Opinion in Chemical Biology. 14: 440-6. PMID 20570550 DOI: 10.1016/j.cbpa.2010.05.005 |
0.324 |
|
| 2010 |
Amewu R, Gibbons P, Mukhtar A, Stachulski AV, Ward SA, Hall C, Rimmer K, Davies J, Vivas L, Bacsa J, Mercer AE, Nixon G, Stocks PA, O'Neill PM. Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols. Organic & Biomolecular Chemistry. 8: 2068-77. PMID 20401383 DOI: 10.1039/B924319D |
0.646 |
|
| 2010 |
Pacorel B, Leung SC, Stachulski AV, Davies J, Vivas L, Lander H, Ward SA, Kaiser M, Brun R, O'Neill PM. Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. Journal of Medicinal Chemistry. 53: 633-40. PMID 19957999 DOI: 10.1021/jm901216v |
0.646 |
|
| 2010 |
Castrejon JL, Lavergne SN, El-Sheikh A, Farrell J, Maggs JL, Sabbani S, O'Neill PM, Park BK, Naisbitt DJ. Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives. Chemical Research in Toxicology. 23: 184-92. PMID 19954178 DOI: 10.1021/Tx900329B |
0.323 |
|
| 2010 |
Biagini GA, Hill A, Mbekeani A, Shone A, Nixon G, Stocks P, Gibbons P, Amewu R, Hong DW, Barton V, Pidathala C, Chadwick J, Le Pensee L, Warman A, Sharma R, et al. Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase Malaria Journal. 9. DOI: 10.1186/1475-2875-9-S2-O4 |
0.465 |
|
| 2010 |
Ward SA, Fisher N, Hill A, Mbekeani A, Shone A, Nixon G, Stocks P, Gibbons P, Amewu R, Hong DW, Barton V, Pidathala C, Chadwick J, Le Pensee L, Warman A, et al. A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum Malaria Journal. 9. DOI: 10.1186/1475-2875-9-S2-I14 |
0.415 |
|
| 2010 |
Fisher N, Hill A, Mbekeani A, Shone A, Nixon G, Stocks P, Gibbons P, Amewu R, Hong WD, Barton V, Pidathala C, Chadwick J, Le Pensee L, Warman A, Sharma R, et al. A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1797: 80. DOI: 10.1016/J.Bbabio.2010.04.241 |
0.332 |
|
| 2010 |
O'Neill PM, Miller A, Ward SA, Park BK, Scheinmann F, Stachulski AV. ChemInform Abstract: Application of the TMSOTf-AgClO4 Activator System to the Synthesis of Novel, Potent, C-10 Phenoxy Derivatives of Dihydroartemisinin. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200010164 |
0.6 |
|
| 2009 |
O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, et al. Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. Journal of Medicinal Chemistry. 52: 1828-44. PMID 19284751 DOI: 10.1021/jm8012757 |
0.336 |
|
| 2009 |
Araújo NC, Barton V, Jones M, Stocks PA, Ward SA, Davies J, Bray PG, Shone AE, Cristiano ML, O'Neill PM. Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates. Bioorganic & Medicinal Chemistry Letters. 19: 2038-43. PMID 19251414 DOI: 10.1016/j.bmcl.2009.02.013 |
0.33 |
|
| 2009 |
O'Neill PM, Chadwick J, Rawe SL. Biomimetic Fe(II) Chemistry and Synthetic Studies on Antimalarial and Antitumour Endoperoxides Patai's Chemistry of Functional Groups. 1279-1346. DOI: 10.1002/9780470682531.Pat0363 |
0.372 |
|
| 2008 |
Biagini GA, Fisher N, Berry N, Stocks PA, Meunier B, Williams DP, Bonar-Law R, Bray PG, Owen A, O'Neill PM, Ward SA. Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex. Molecular Pharmacology. 73: 1347-55. PMID 18319379 DOI: 10.1124/Mol.108.045120 |
0.418 |
|
| 2007 |
Stocks PA, Bray PG, Barton VE, Al-Helal M, Jones M, Araujo NC, Gibbons P, Ward SA, Hughes RH, Biagini GA, Davies J, Amewu R, Mercer AE, Ellis G, O'Neill PM. Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angewandte Chemie (International Ed. in English). 46: 6278-83. PMID 17640025 DOI: 10.1002/Anie.200604697 |
0.322 |
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| 2007 |
Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O'Neill PM, Park BK. Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. The Journal of Biological Chemistry. 282: 9372-82. PMID 17227762 DOI: 10.1074/Jbc.M610375200 |
0.333 |
|
| 2006 |
Amewu R, Stachulski AV, Ward SA, Berry NG, Bray PG, Davies J, Labat G, Vivas L, O'Neill PM. Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin. Organic & Biomolecular Chemistry. 4: 4431-6. PMID 17268634 DOI: 10.1039/B613565J |
0.654 |
|
| 2006 |
Amewu R, Stachulski AV, Berry NG, Ward SA, Davies J, Labat G, Rossignol JF, O'Neill PM. Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology. Bioorganic & Medicinal Chemistry Letters. 16: 6124-30. PMID 16978862 DOI: 10.1016/j.bmcl.2006.08.098 |
0.566 |
|
| 2006 |
O'Neill PM, Ward SA, Berry NG, Jeyadevan JP, Biagini GA, Asadollaly E, Park BK, Bray PG. A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. Current Topics in Medicinal Chemistry. 6: 479-507. PMID 16719804 DOI: 10.2174/156802606776743147 |
0.446 |
|
| 2006 |
Biagini GA, Viriyavejakul P, O'neill PM, Bray PG, Ward SA. Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria. Antimicrobial Agents and Chemotherapy. 50: 1841-51. PMID 16641458 DOI: 10.1128/Aac.50.5.1841-1851.2006 |
0.365 |
|
| 2005 |
Bray PG, Ward SA, O'Neill PM. Quinolines and artemisinin: chemistry, biology and history. Current Topics in Microbiology and Immunology. 295: 3-38. PMID 16265885 DOI: 10.1007/3-540-29088-5_1 |
0.389 |
|
| 2005 |
O'Neill PM, Rawe SL, Borstnik K, Miller A, Ward SA, Bray PG, Davies J, Oh CH, Posner GH. Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. Chembiochem : a European Journal of Chemical Biology. 6: 2048-54. PMID 16222725 DOI: 10.1002/Cbic.200500048 |
0.781 |
|
| 2005 |
O'Neill PM. The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opinion On Investigational Drugs. 14: 1117-28. PMID 16144496 DOI: 10.1517/13543784.14.9.1117 |
0.344 |
|
| 2005 |
O'Neill PM, Rawe SL, Storr RC, Ward SA, Posner GH. Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues Tetrahedron Letters. 46: 3029-3032. DOI: 10.1016/J.Tetlet.2005.03.022 |
0.475 |
|
| 2004 |
O'Neill PM, Mukhtar A, Ward SA, Bickley JF, Davies J, Bachi MD, Stocks PA. Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. Organic Letters. 6: 3035-8. PMID 15330581 DOI: 10.1021/Ol0492142 |
0.307 |
|
| 2004 |
O'Neill PM. Medicinal chemistry: a worthy adversary for malaria. Nature. 430: 838-9. PMID 15318201 DOI: 10.1038/430838A |
0.321 |
|
| 2004 |
Biagini GA, Pasini EM, Hughes R, De Koning HP, Vial HJ, O'Neill PM, Ward SA, Bray PG. Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs. Blood. 104: 3372-7. PMID 15205262 DOI: 10.1182/Blood-2004-03-1084 |
0.388 |
|
| 2004 |
Posner GH, O'Neill PM. Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides Accounts of Chemical Research. 37: 397-404. PMID 15196049 DOI: 10.1021/Ar020227U |
0.54 |
|
| 2004 |
O'Neill PM, Posner GH. A medicinal chemistry perspective on artemisinin and related endoperoxides Journal of Medicinal Chemistry. 47: 2945-2964. PMID 15163175 DOI: 10.1021/Jm030571C |
0.444 |
|
| 2004 |
Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry. 47: 1290-8. PMID 14971909 DOI: 10.1021/Jm030974C |
0.575 |
|
| 2003 |
O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK. Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. Journal of Medicinal Chemistry. 46: 4933-45. PMID 14584944 DOI: 10.1021/Jm030796N |
0.426 |
|
| 2003 |
Biagini GA, O'Neill PM, Nzila A, Ward SA, Bray PG. Antimalarial chemotherapy: young guns or back to the future? Trends in Parasitology. 19: 479-87. PMID 14580958 DOI: 10.1016/J.Pt.2003.09.011 |
0.395 |
|
| 2003 |
Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S. Artemisinins target the SERCA of Plasmodium falciparum. Nature. 424: 957-61. PMID 12931192 DOI: 10.1038/Nature01813 |
0.419 |
|
| 2002 |
Stocks PA, Raynes KJ, Bray PG, Park BK, O'Neill PM, Ward SA. Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum. Journal of Medicinal Chemistry. 45: 4975-83. PMID 12408708 DOI: 10.1021/Jm0108707 |
0.38 |
|
| 2002 |
Hindley S, Ward SA, Storr RC, Searle NL, Bray PG, Park BK, Davies J, O'Neill PM. Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. Journal of Medicinal Chemistry. 45: 1052-63. PMID 11855985 DOI: 10.1021/Jm0109816 |
0.507 |
|
| 2001 |
O'Neill PM, Scheinmann F, Stachulski AV, Maggs JL, Park BK. Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite. Journal of Medicinal Chemistry. 44: 1467-70. PMID 11311070 DOI: 10.1021/jm001061a |
0.514 |
|
| 2001 |
Park BK, Kitteringham NR, O'Neill PM. Metabolism of fluorine-containing drugs. Annual Review of Pharmacology and Toxicology. 41: 443-70. PMID 11264465 DOI: 10.1146/Annurev.Pharmtox.41.1.443 |
0.326 |
|
| 2001 |
O'Neill PM, Miller A, Bishop LP, Hindley S, Maggs JL, Ward SA, Roberts SM, Scheinmann F, Stachulski AV, Posner GH, Park BK. Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin. Journal of Medicinal Chemistry. 44: 58-68. PMID 11141088 DOI: 10.1021/jm000987f |
0.7 |
|
| 2001 |
O'Neill PM, Pugh M, Stachulski AV, Ward SA, Davies J, Park BK. Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues Journal of the Chemical Society-Perkin Transactions 1. 2682-2689. DOI: 10.1039/B104340B |
0.428 |
|
| 2001 |
O'Neill PM, Pugh M, Davies J, Ward SA, Park BK. Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: Application to a new synthesis of 1,2,4-trioxanes Tetrahedron Letters. 42: 4569-4571. DOI: 10.1016/S0040-4039(01)00791-2 |
0.342 |
|
| 1999 |
O'Neill PM, Searle NL, Kan KW, Storr RC, Maggs JL, Ward SA, Raynes K, Park BK. Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether. Journal of Medicinal Chemistry. 42: 5487-93. PMID 10639291 DOI: 10.1021/jm9903545 |
0.342 |
|
| 1999 |
O'Neill PM, Miller A, Ward SA, Park B, Scheinmann F, Stachulski AV. Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin Tetrahedron Letters. 40: 9129-9132. DOI: 10.1016/S0040-4039(99)01891-2 |
0.626 |
|
| 1998 |
Ruscoe JE, Tingle MD, O'Neill PM, Ward SA, Park BK. Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology. Antimicrobial Agents and Chemotherapy. 42: 2410-6. PMID 9736572 DOI: 10.1128/AAC.42.9.2410 |
0.319 |
|
| 1998 |
O'Neill PM, Bray PG, Hawley SR, Ward SA, Park BK. 4-Aminoquinolines--past, present, and future: a chemical perspective. Pharmacology & Therapeutics. 77: 29-58. PMID 9500158 DOI: 10.1016/S0163-7258(97)00084-3 |
0.444 |
|
| 1998 |
O'Neill PM, Searle NL, Raynes KJ, Maggs JL, Ward SA, Storr RC, Park BK, Posner GH. A carbonyl oxide route to antimalarial Yingzhaosu A analogues: Synthesis and antimalarial activity Tetrahedron Letters. 39: 6065-6068. DOI: 10.1016/S0040-4039(98)01248-9 |
0.45 |
|
| 1998 |
O'Neill PM, Storr RC, Park BK. Synthesis of the 8-aminoquinoline antimalarial 5-fluoroprimaquine Tetrahedron. 54: 4615-4622. DOI: 10.1016/S0040-4020(98)00177-X |
0.314 |
|
| 1997 |
O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK. Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues. Journal of Medicinal Chemistry. 40: 437-48. PMID 9046333 DOI: 10.1021/Jm960370R |
0.46 |
|
| 1996 |
O'Neill PM, Bishop LP, Storr RC, Hawley SR, Maggs JL, Ward SA, Park BK. Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin. Journal of Medicinal Chemistry. 39: 4511-4. PMID 8893847 DOI: 10.1021/Jm9604944 |
0.453 |
|
| 1996 |
Hawley SR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward SA. Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. Antimicrobial Agents and Chemotherapy. 40: 2345-9. PMID 8891142 DOI: 10.1128/Aac.40.10.2345 |
0.383 |
|
| 1996 |
Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA. The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties. Biochemical Pharmacology. 52: 723-33. PMID 8765470 DOI: 10.1016/0006-2952(96)00354-1 |
0.424 |
|
| 1996 |
Naisbitt DJ, O'Neill PM, Pirmohamed M, Kevin Park B. Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity Bioorganic & Medicinal Chemistry Letters. 6: 1511-1516. DOI: 10.1016/S0960-894X(96)00260-0 |
0.32 |
|
| 1996 |
O'Neill PM, Hawley SR, Storr RC, Ward SA, Park BK. The effect of fluorine substitution on the antimalarial activity of tebuquine Bioorganic and Medicinal Chemistry Letters. 6: 391-392. DOI: 10.1016/0960-894X(96)00040-6 |
0.373 |
|
| 1995 |
Jewell H, Maggs JL, Harrison AC, O'neill PM, Ruscoe JE, Park BK. Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine Xenobiotica. 25: 199-217. PMID 7618347 DOI: 10.3109/00498259509061845 |
0.349 |
|
| 1995 |
Tingle MD, Jewell H, Maggs JL, O'Neill PM, Park BK. The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution Biochemical Pharmacology. 50: 1113-1119. PMID 7575670 DOI: 10.1016/0006-2952(95)00236-S |
0.377 |
|
| 1994 |
O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK. The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine. Journal of Medicinal Chemistry. 37: 1362-70. PMID 8176713 DOI: 10.1021/Jm00035A017 |
0.422 |
|
| 1993 |
Barnard S, Storr RC, O'Neill PM, Park BK. The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol. The Journal of Pharmacy and Pharmacology. 45: 736-44. PMID 7901373 DOI: 10.1111/J.2042-7158.1993.Tb07099.X |
0.344 |
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